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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 10
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Research Article

EFFECTS OF SUBCHRONIC INHALATION EXPOSURE OF RATS TO EMISSIONS FROM A DIESEL ENGINE BURNING SOYBEAN OIL-DERIVED BIODIESEL FUEL

G. L. Finch Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
C. H. Hobbs Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
L. F. Blair Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
E. B. Barr Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
F. F. Hahn Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
R. J. Jaramillo Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
J. E. Kubatko Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
T. H. March Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
R. K. White Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
J. R. Krone Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
M. G. Ménache Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
K. J. Nikula Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
J. L. Mauderly Lovelace Respiratory Research Institute, Albuquerque, New Mexico, USA
,
J. Van Gerpen Department of Mechanical Engineering, Iowa State University, Ames, Iowa, USA
,
M. D. Merceica Pathology Associates International, Frederick, Maryland, USA
,
B. Zielinska Desert Research Institute, Reno, Nevada, USA
,
L. Stankowski Chrysalis Preclinical Services, Olyphant, Pennsylvania, USA
,
K. Burling Animal Eye Specialists of San Jose, San Jose, California, USA
&
S. Howell MARC-IV Consulting, Kearny, Missouri, USA
 show all
Pages 1017-1048 | Published online: 01 Oct 2008

  • Ajiwe, V. I. E., and Obika, A. E. 2000. African pear seed oil: Potential alternative source to diesel oil. Energy Fuels 14(1):112-116.
  • Altin, R., Çetinkaya, S., and Yücesu, H. S. 2001. The potential of using vegetable oil fuels as fuel for diesel engines. Energy Conversion Manage. 42:529-538.
  • Ames, N., McCann, J., and Yamasaki, E. 1975. Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat. Res. 31:347-364.
  • Barr, E. B., Cheng, Y.-S., Yeh, H.-C, and Wolff, R. K. 1989. Size characterization of carbonaceous particles using a Lovelace multijet cascade impactor/parallel-flow diffusion battery serial sampling train. Aerosol Sei. Technol. 10:205-212.
  • Brightwell, J., Fou il let, X., Cassano-Zoppi, A.-L, Gatz, R., and Duchosal, F. 1986. Neoplastic and functional changes in rodents after chronic inhalation of engine exhaust emissions. In Carcinogenic and mutagenic effects of diesel engine exhaust, eds. N. lshinishi, A. Koizumi, R. O. McClellan, and W. Stöber, pp. 471-485. New York: Elsevier.
  • Bünger, J., Krahl, J., Franke, H.-U., Munack, A., and Hallier, E. 1998. Mutagenic and cytotoxic effects of exhaust particulate matter of biodiesel compared to fossil diesel fuel. Mutt. Res. 415:13-23.
  • Bünger, J., Krahl, J., Baum, K., Schröder, O., Müller, M., Westphal, G., Ruhnau, P., Schulz, T. G., and Hallier, E. 2000a. Cytotoxic and mutagenic effects, particle size and concentration analysis of diesel engine emissions using biodiesel and petrol diesel as fuel. Arch. Toxicol. 74(8):490-498.
  • Bünger, J., Müller, M. M., Krahl, J., Baum, K., Weigel, A., Hallier, E., and Schulz, T. G. 2000b. Mutagenicity of diesel exhaust particles from two fossil and two plant oil fuels. Mutagenesis 15(5): 391-397.
  • Cheng, Y. S., Yeh, H. C, Mauderly, J. L., and Mokier, B. V. 1984. Characterization of diesel exhaust in a chronic inhalation study. Am. Ind. Hyg. Assoc.J. 45(8):547-555.
  • Dawson, A. B. 1926. A note on the staining of cleared specimens with alizarin red S. Stain Technol. 1:123-124.
  • Diesel, R. 1913. Die Entstehung des Dieselmotors. Berlin: Springer.
  • Dungworth, D. L., Ernst, H., Nolte, T., and Mohr, U. 1992. Nonneoplastic lesions in the lungs. In Pathobiology of the aging rat, eds. U. Mohr, D. L. Dungworth, and C. C. Capen, vol. 1, pp. 143-160. Washington, DC: ILSI Press.
  • Eckl, P. M., Leikermoser, P., Wörgetter, M., Prankl, H., and Wurst, F. 1998. The mutagenic potential of diesel and biodiesel exhausts. In Plant oils as fuels-Present state of science and future developments, eds. N. Martini and J. Schell, pp. 123-140. Berlin: Springer.
  • Evans, M. J., Stephens, R. J., Cabrai, L. J., and Freeman, G. 1972. Cell renewal in the lungs of rats exposed to low levels of NO2. Arch. Environ. Health 24:180-188.
  • Freeman, G., Stephens, R. J., Crane, S. C., and Furiosi, N. J. 1968. Lesion of the lung in rats continuously exposed to two parts per million of nitrogen dioxide. Arch. Environ. Health 17:181-192.
  • Gomez, M. E. G., Howard-Hildige, R., Leahy, J. J., O'Reilly, T., Supple, B., and Malone, M. 2000. Emission and performance characteristics of a 2 litre Toyota diesel van operating on esterified waste cooking oil and mineral diesel fuel. Environ. Monit. Assess. 65(1-2):13-20.
  • Henderson, R. F., Pickrell, J. A., Jones, R. K., Sun, J. D., Benson, J. M., Mauderly, J. L., and McClellan, R. O. 1988. Response of rodents to inhaled diluted diesel exhaust: Biochemical and cy to logical changes in bronchoalveolar lavage fluid and in lung tissue. Fundam. Appl. Toxicol. 11:546-567.
  • ILSI [International Life Sciences Institute] Risk Science Institute Workshop Participants. 2000. The relevance of the rat lung response to particle overload for human risk assessment: A workshop consensus report, lnhal. Toxicol. 12:1-17.
  • lshihara, T. 1988. Diesel exhaust and health risks. Final Report of HERP Studies. Tsukuba, Japan: Health Effects Research Program.
  • Kaplan, H. L, Mackenzie, W. F., Springer, K. J., Schreck, R. M., and Vostal, J. J. 1982. A subchronic study of the effects of exposure of three species of rodents to diesel exhaust. In Toxicological effects of emissions from diesel engines, ed. J. Lewtas, pp. 161-200. New York: Elsevier.
  • Karagianes, M. T., Palmer, R. F., and Busch, R. H. 1981. Effects of inhaled diesel emissions and coal dust in rats. Am. lnd. Hyg. Assoc.J. 42:382-391.
  • K rah I, J., Bünger, J., and Munack, A. 1998. Biodiesel exhaust emissions and determination of their environmental and health effects. In Plant oils as fuels-Present state of science and future development, eds. N. Martini and J. Schell, pp. 104-122. Berlin: Springer.
  • Krahl, J., Baum, K., Hackbarth, U., Jeberien, H.-E., Munack, A., Schutt, C, and Schröder, O. 2001. Gaseous compounds, ozone precursors, particle number and particle size distributions, and mutagenic effects due to biodiesel. Trans. Am. Soc. Agric. Eng. 44(2):179-191.
  • Lewis, T. R., Green, F. H. Y., Moorman, W. J., Burg, J. A. R., and Lynch, D. W. 1986. A chronic inhalation toxicity study of diesel engine emissions and coal dust, alone and combined. In Carcinogenic and mutagenic effects of diesel engine exhaust, eds. N. lshinishi, A. Koizumi, R. O. McClellan, and W. Stöber, pp. 361-380. New York: Elsevier.
  • Lewis, T. R., Green, F. H. Y., Moorman, W. J., Burg. J. R., and Lynch, D. W. 1989. A chronic inhalation toxicity study of diesel engine emissions and coal dust, alone and combined. J. Am. Coll. Toxicol. 8:345-375.
  • Lloyd, A. C, and Cackette, T. A. 2001. Diesel engines: Environmental impact and control. J. Air Waste Manage. Assoc. 51:809-847.
  • Losco, P. E., and Troup, C. M. 1988. Corneal dystrophy in Fischer 344 rats. Lab. Anim. Sei. 38:702710.
  • Lue, Y.-F., Yeh, Y.-Y., and Wu, C.-H. 2001. The emission characteristics of a small D. I. diesel engine using biodiesel blended fuels. J. Environ. Sd. Health A Tox. Hazard Subst. Environ. Eng. 36(5): 845-859.
  • Machacon, H. T. C., Shiga, S., Karasawa, T., and Nakamura, H. 2001. Performance and emission characteristics of a diesel engine fueled with coconut oil-diesel fuel blend. Biomass Bioenergy 20:6369.
  • Maejima, K., and Nagase, S. 1989. Hematological and clinico-biochemical studies on F344 rats that inhaled diesel engine exhaust. In Man and his ecosystem: World Class Air Congress 1989: Hague, Netherland, eds. L. J. Brasser and W. C. Mulder, vol. 2, pp. 149-154. Amsterdam: Elsevier.
  • Maron, D. M., and Ames, B. N. 1983. Revised methods for the Salmonella mutagenicity test. Mutt. Res. 113:173-215.
  • Mauderly, J. L 1998. Health issues concerning inhalation of petroleum diesel and biodiesel exhaust. In Plant oils as fuels-Present state of science and future developments, eds. N. Martini and J. Schell, pp. 92-103. Berlin: Springer.
  • Mauderly, J. L. 1999. Diesel exhaust. In Environmental toxicants: Human exposures and their health effects, ed. M. Lippmann, 2nd ed., pp. 193-241. New York: Wiley.
  • Mauderly, J. L., Bice, D. E., Carpenter, R. L., Gillett, N. A., Hahn, F. F., Henderson, R. F., Pickrell, J. A., and Wolff, R. K. 1987. Effect of inhaled NO2 and diesel exhaust on developing lung. Research Report No. 8. Cambridge, MA: Health Effects Institute.
  • Mauderly, J. L., Gillett, N. A., Henderson, R. F., Jones, R. K., and McClellan, R. 0.1988. Relationships of lung structural and functional changes to accumulation of diesel exhaust particles. Ann. Occup. Hyg. 32(suppl. 1):659-669.
  • McCormick, R. L., Graboski, M. S., Alleman, T. L., Herring, A. M., and Tyson, K. S. 2001. Impact of biodiesel source material and chemical structure on emissions of criteria pollutants from a heavyduty engine. Environ. Sei. Technol. 35(9):1742-1747.
  • Miller, F. J. 2000a. Dosimetry of particles in laboratory animals and humans in relationship to issues surrounding lung overload and human health risk assessment: A critical review, lnhal. Toxicol. 12: 19-57.
  • Miller, F. J. 2000b. Errata, lnhal. Toxicol. 12:1257-1259.
  • Miller, F. J., Overton, Jr., J. H., Smolko, E. D., Graham, R. C, and Menzel, D. B. 1987. Hazard assessment using an integrated physiologically-based dosimetry modeling approach: Ozone. In Pharmacokinetics in risk assessment/drinking water and health, vol. 8, pp. 353-368. Washington, DC: National Academy Press.
  • Mokler, B. V., Archibeque, F. A., Beethe, R. L., Kelley, C. P. J., Lopez, J. A., Mauderly, J. L., and Stafford, D. L 1984. Diesel exhaust exposure system for animal studies. Fundam. Appl. Toxicol. 4: 270-277.
  • Newton, G. J., Raabe, O. G., and Mokler, B. V. 1977. Cascade impactor design and performance. J. Aerosol Sci. 8:339-347.
  • Nikula, K. J., Snipes, M. B., Barr, E. B., Griffith, W. C, Henderson, R. F., and Mauderly, J. L. 1995. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. Appl. Toxicol. 25:80-94.
  • Peterson, C. L, Taberski, J. S., Thompson, J. C, and Chase, C. L. 2000. The effect of biodiesel feedstock on regulated emissions in chassis dynamometer tests of a pickup truck. Trans. Am. Soc. Agric. Eng. 43(6):1371-1381.
  • Reece, D. L, Zhang, X., and Peterson, C. L. 1998. Environmental and health effects of biodiesel. In Liquid fuel and industrial products from renewable resources, eds. J. S. Cundiff, E. E. Gavett, C. Hansen, C. Peterson, M. A. Sanderson, H. Shapouri, and D. L. VanDyne, pp. 166-176. St. Joseph, Ml: American Society of Agricultural Engineers.
  • Renner, R. 2001. Catalyzing pollution. Environ. Sd. Technol. 35(7):138A-139A.
  • Schröder, O., Bünger, J., and Munack, A. 1999. Environmental and health effects caused by the use of biodiesel, SAE Technical Paper Series 1999-01-3561, pp. 89-99. Warrendale, PA: Society of Automotive Engineers, Inc.
  • Schumacher, L, Borgelt, S. C, Hires, W. G., Wetherell, W., and Nevils, A. 1996. 100,000 Miles of fueling 5.9L Cummins engines with 100% biodiesel. SAE Technical Paper Series 96223. Warrendale, PA: Society of Automotive Engineers, Inc.
  • Senthil Kumar, M., Ramesh, A., and Nagalingam, B. 2001. Investigations on the use of Jatropha oil and its methyl ester as a fuel in a compression ignition engine. J. lnst. Energy 74(498):24-28.
  • Snee, R. D., and Irr, J. D. 1981. Design of a statistical method for the analysis of mutagenesis at the hypoxanthine guanine phosphoribosyl transferase locus of cultured Chinese hamster ovary cells. Mutat. Res. 85:77-93.
  • Snipes, M. B. 1989. Long-term retention and clearance of particles inhaled by mammalian species. Crit. Rev. Toxicol. 20:175-211.
  • U.S. Environmental Protection Agency. 2001. Health assessment document for diesel exhaust (EPA 600/8-90/05 7F). Washington, DC: National Center for Environmental Assessment, U.S. EPA.
  • Wang. W. G., Lyons, D. W., Clark, N. N., Gautam, M., and Norton, P. M. 2000. Emissions from nine heavy trucks fueled by diesel and biodiesel blend without engine modification. Environ. Sd. Technol. 34:933-939.
  • Watanabe, N., and Nakamura, T. 1996. Inhalation of diesel engine exhaust increases bone mineral concentrations in growing rats. Arch. Environ. Contam. Toxicol. 30(3):407-411.
  • White, H. J., and Garg, B. D. 1981. Early pulmonary response of the rat lung to inhalation of high concentration of diesel particles. J. Appl. Toxicol. 1:104-110.
  • Wilson, J. G. 1965. Methods for administering drugs and detecting malformations in experimental animals. In Teratology principles and techniques, eds. J. G. Wilson and J. Warkany, pp. 262-277. Chicago: University of Chicago Press.
  • Wolford, S. T., Schroer, R. A., GaIIo, P. P., Gohs, F. X., Brodeck, M., FaIk, H. B., and Ruhren, R. 1987. Age-related changes in serum chemistry and hematology values in normal Sprague-Dawley rats. Fundam. Appl. Toxicol. 8:80-88.
  • Womac, A. R., Strange, R. J., Crouch, J. A., and Easterly, C. 1996. Power, emissions, and bioresponse of biodiesel in a marine environment. In Liquid fuel and industrial products from renewable resources, eds. J. S. Cundiff, E. E. Gavett, C. Hansen, C. Peterson, M. A. Sanderson, H. Shapouri, and D. L VanDyne, pp. 177-190. St. Joseph, Ml: American Society of Agricultural Engineers.
  • Xu, G. B., and Yu, C. P. 1987. Deposition of diesel exhaust particles in mammalian lungs. A comparison between rodents and man. Aerosol Sci. Technol. 7:117-123.

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