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Inhalation Toxicology
International Forum for Respiratory Research
Volume 14, 2002 - Issue 11
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Research Article

TOXICOLOGIC EVALUATION OF HUMECTANTS ADDED TO CIGARETTE TOBACCO: 13-WEEK SMOKE INHALATION STUDY OF GLYCERIN AND PROPYLENE GLYCOL IN FISCHER 344 RATS

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Pages 1135-1152 | Published online: 01 Oct 2008

  • Baumgartner, H., and Coggins, C. R. E. 1980. Description of a continuous-smoking inhalation machine for exposing small animals to tobacco smoke. Belt. Tabakforsch. 10(3):169-174.
  • Carmines, E. L. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 1: Cigarette design, testing approach, and review of results. Food Chem. Toxicol. 40:77-91.
  • Coggins, C. R. E. 1998. A review of chronic inhalation studies with mainstream cigarette smoke in rats and mice. Toxicol. Pathol. 26(3):307-314.
  • Coggins, C. R. E., Duchosal, F., Musy, C., and Ventrone, R. 1981. Measurement of respiratory patterns in rodents using whole-body plethysmography and a pneumotachograph. Lab. Anim. 15:137-140.
  • Coggins, C. R. E., Lam, R., and Morgan, K. T. 1982. Chronic inhalation study in rats using cigarettes containing different amounts of Cytrel tobacco supplement. Toxicology 22(4):287-296.
  • Dalbey, W. E., Nettesheim, P., Griesmer, R., Caton, J. E., and Guerin, M. R. 1980. Chronic inhalation of cigarette smoke by F344 rats. JNCI 64(2):383-390.
  • Doihara, T., Kobashi, U., Sugawara, S., and Kaburaki, Y. 1964. Studies of flavoring effect (IV). Pyrolysis of polyhydric alcohols. Nippon Senbai Kosha Chua Kenkyusho Kenkyn Hokuku 106:129-135.
  • Dungworth, D. L., Schwartz, L. W., and Tyler, W. S. 1976. Morphological methods for evaluation of pulmonary toxicity in animals. Ann. Rev. Pharmacol. Toxicol. 16:381-399.
  • Gaworski, C. L, Dozier, M. M., Gerhart, J. M., Rajendran, N., Brennecke, L. H., Aranyi, C., and Heck, J. D. 1997.13-Week inhalation study of menthol cigarette smoke. Food Chem. Toxicol. 35:683-692.
  • Gaworski, C. L., Dozier, M. M., Heck, J. D., Gerhart, J. M., Rajendran, N., David, R. M., Brennecke, L. H., and Morrissey, R. 1998. Toxicologie evaluation of flavor ingredients added to cigarette tobacco: 13-Week inhalation exposures in rats, lnhal. Toxicol. 10(4):357-381.
  • Gaworski, C. L, Heck, J. D., Bennett, M. B., and Wenk, M. L. 1999. Toxicologie evaluation of flavor ingredients added to cigarette tobacco: skin painting bioassay of cigarette smoke condensate in SENCAR mice. Toxicology 139:1-17.
  • Hoffmann, D., and Hoffmann, I. 1997. The changing cigarette 1950-1995.J. Toxicol. Environ. Health 50:307-364.
  • Kane, L. E., and Alarie, Y. 1977. Sensory irritation to formaldehyde and acrolein during single and repeated exposures in mice. Am. Ind. Hyg. Assoc.j. 38(10):509-522.
  • Kobashi, U., Doihara, T., Sugawara, S., and Kaburaki, Y. 1966. Changes in the chemical composition of smoke imparted with several polyols. Res. Inst.Jpn. Monopoly Corp. 107:319-323.
  • Laurene, A. H., Cundiff, R. H., and Greene, G. H. 1965. Determination of glycerol and propylene glycol in cigarette smoke. Tobacco Sd. 9:1-4.
  • National Cancer Institute. 1977. Toward less hazardous cigarettes: Report no. 3, The third set of experimental cigarettes. Washington, DC: National Cancer Institute Smoking and Health Program.
  • Penney, D. G. 1993. Acute carbon monoxide poisoning in an animal model: the effects of altered glucose on morbidity and mortality. Toxicology 80:85-101.
  • Rustemeier, K., Sabbert R., Haussmann, H.-J., Roemer, E., and Carmines, E. L 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food Chem. Toxicol. 40:93-104.
  • Sagartz, J. W., Madarasz, A. J., Forsell, M. A., Burger, G. T., Ayres, P. H., and Coggins, C. R. E. 1992. Histological sectioning of the rodent larynx for inhalation toxicity testing. Toxicol. Pathol. 20(1): 118-121.
  • Stein, Y. S., and Antal, M. J. 1983. A study of the gas-phase pyrolysis of glycerol. J. Anal. Appl. Pyrol. 4(4):283-296.
  • Vanscheeuwijck, P. M., Teredesai, A., Terpstra, P. M., Verbeeck, J., Kuhl, P., Gerstenberg, B., Gebel, S., and Carmines, E. L 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 4: Subchronic inhalation toxicity. Food Chem. Toxicol. 40:113-131.
  • Van Vunakis, H., Gjika, H. B., and Langone, J. J. 1987. Environmental carcinogens. Methods of analysis and exposure measurement, vol. 9, Passive smoking. Lyon: IARC.
  • Wehner, A. P., Dagle, G. E., Millman, E. M., Phelps, D. W., Carr, D. B., Decker, J. R., and Filipy, R. E. 1981. Inhalation bioassay of cigarette smoke in rats. Toxicol. Appl. Pharmacol. 61 (1) :1-17.
  • Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. Appl. Toxicol. 61(1): 309-312.

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