Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 5
Submit an article Journal homepage
81
Views
22
CrossRef citations to date
0
Altmetric
Research Article

Chronic Diesel Exhaust Exposures of Rats Demonstrate Concentration and Time-Dependent Effects on Pulmonary Inflammation

Yoko Ishihara Department of Hygiene and Public Health (I), School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
&
Jun Kagawa Department of Hygiene and Public Health (I), School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
Pages 473-492 | Published online: 01 Oct 2008

  • Bascom, R., Bromberg, P. A., and Costa, D. L. 1996. Health effects of outdoor air pollution: State of the art. Am. J. Respir. Crit. Care Med. 153:3-50, 477-498.
  • Bice, D. E., Mauderly, J. L., Jones, R. K., and McClellan, R. 0.1985. Effects of inhaled diesel exhaust on immune responses after lung immunization. Fundam. Appl. Toxicol. 5:1074-1086.
  • Chang, J. C. F., Steinhagen, W. H., and Barrow, C. S. 1981. Effect of single or repeated formaldehyde exposure on minute volume of B6C3F1 mice and F344 rats. Toxicol. Appl. Pharmacol. 61:451-459.
  • Churg, A. 2000. Particle uptake by epithelial cells. In Particle-lung interactions, eds. P. Gehr and J. Hyder, Lung biology in health and disease, vol. 143, pp. 401-435. New York: Marcel Dekker.
  • Costa, D. L., and Schelegle, E. S. 1999. Irritant air pollutants. In Air pollutants and the respiratory tract, eds. D. L. Swift and W. M. Foster, pp. 119-145. New York: Marcel Dekker.
  • Djurdjic, V., and Mandic, L. 1990. A spectrophotometric method for simultaneous determination of protein-bound hexoses and fucose with a mixture of l-cysteine and phenol. Anal. Biochem. 188:222227.
  • Dockery, D. W., Schwartz, J., and Spengler, J. D. 1992. Air pollution and daily mortality association with particulates and acid aerosols. Environ. Res. 5:362-373.
  • Finkelstein, J. N., and Barrett, E. G. 2000. Alteration in gene expression in pulmonary cells following particle interactions. In Particle-lung interactions, eds. P. Gehr and J. Hyder, vol. 143, pp. 379399. New York: Marcel Dekker.
  • Freeman, G., Stephens, R. J., Crane, S. C., and Furiosi, N. J. 1968. Lesion of the lung in rats continuously exposed to two ppm of nitrogen dioxide. Arch. Environ. Health 17:181 -192.
  • Giddens, W. E., and Fairchild, G. A. 1972. Effects of sulfur dioxide on the nasal mucous of mice. Arch. Environ. Health 25:166-173.
  • Hara, S., Takemori, Y., Yamaguchi, M., Nakamura, M., and Ohkura, Y. 1987. Fliorometric high performance liquid chromatography of N-acetyl- and N-glucolyneuraminic acids and its application to their microdetermination in human and animal sera, glycoproteins, and glycolipids. Anal. Biochem. 164:138-145.
  • Ishihara, Y., and Kagawa, J. 2002. Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust: Analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood, lnhal. Toxicol. 14:1049-1067.
  • Kato, A., Nagai, A., and Kagawa, J. 2000. Morphological changes in rat lung after long-term exposure to diesel emissions, lnhal. Toxicol. 12:469-490.
  • Lamb, D., and Reid, L. 1968. Mitotic rates, goblet cell increase, and histochemical changes in mucus in rat bronchial epithelium during exposure to sulphur dioxide. J. Pathol. Bacteriol. 96:97-111.
  • Lewkowski, J. P., Malanchuk, M., Hastings, L., Vinegar, A., and Cooper, G. P. 1979. Effects of chronic exposure of rats to automobile exhaust, H2SO4, SO2, AI2(SO4), and CO. In Assessing toxic effects of environmental pollutants, eds. S. D. Lee and J. B. Nudd, pp. 187-217. Ann Arbor, Ml: Ann Arbor Science.
  • Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the FoMn phenol reagents. J. Biol. Chem. 193:265-275.
  • Mauderly, J. L., Snipes, M. B., Barr, E. B., Belinsky, S. A., Bond, J. A., Brooks, A. L., Chang, I. Y., Cheng, Y. S., Gillett, N. A., Griffith, W. C., Henderson, R. F., Mitchell, C. E., Nikula, K. J., and Thomassen, D. G. 1994. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. HEI Research Report 68. Cambridge, MA: Health Effects Institute.
  • Mentnech, M. S., Lewis, D. M., Olenchock, S. A., Mull, J. C., Koller, W. A., and Lewis, T. R. 1984. Effects of coal dust and diesel exhaust on immune competence in rats. J. Toxicol. Environ. Health 13:31-41.
  • Miyabu, Y., Takano, H., Ichinose, T., Lim, H. B., and Sagai, M. 1998. Diesel exhaust enhances allergie airway inflammation and hyperresponsiveness in mice. Am. J. Respir. Crit. Care Med. 157:11381144.
  • Mizohata, A. 2001. Background and problem of the PM2.5. J. Aerosol Res.] pn. 16:34-36 (in Japanese).
  • Nakajima, T., Morooka, A., and Sakamoto, K. 1999. Quantification of diesel exhaust particles deposited in the lungs after long term inhalation. J. Aerosol Res.] pn. 14:329-337.
  • Pavord, I. D., and Tattersfield, A. E. 1995. Bronchoprotective role for endogenous prostaglandin. Lancet 345:436-438.
  • Pope, C. A. Ill, and Dockery, D. W. 1999. Epidemiology of particle effects. In Air pollution and health, eds. S. T. Holgate, J. M. Samet, H. S. Koren, and R. L. Maynard, pp. 673-705. San Diego: Academic Press.
  • Pope, C. A. Ill, Thun, M. J., Namboodiri, M. M., Dockery, D. W., Evans, J. S., Speizer, F. E., and Heath, C. W., Jr. 1995. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med. 151:669-674.
  • Pope, C. A. Ill, Burnett, R. T., Thun, M. J., CaIIe, E. E., Krewski, D., lto, K., and Thurston, G. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine participate air pollution. J. Am. Med. Assoc. 287:1132-1141.
  • Samet, J. M., and Cheng, P. W. 1994. The role of airway mucus in pulmonary toxicology. Environ. Health Perspect. 102(suppl. 2):89-103.
  • Snipes, M. B. 1989. Species comparisons for pulmonary retention of inhaled particles. In Concepts in inhalation toxicology, eds. R. O. McClellan and R. F. Henderson, pp. 133-229. Washington, DC: Hemisphere.
  • Sugiura, M., Oikawa, T., and Hirano, K. 1978. An enzymic determination for serum phospholipid. Clin. Chem. Acta 89:447-453.
  • Ye, F., Piver, W. T., Portier, C. J., and Ando, M. 2001. Effects of temperature and air pollutants on cardiovascular and respiratory diseases for males and females older than 65 years of age in Tokyo in July and August 1980-1995. Environ. Health Perspect. 109:355-359.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.