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Inhalation Toxicology
International Forum for Respiratory Research
Volume 15, 2003 - Issue 10
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Research Article

Evaluation of the Potential Impact of Age- and Gender-Specific Lung Morphology and Ventilation Rate on the Dosimetry of Vapors

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Pages 987-1016 | Published online: 01 Oct 2008

  • Andersen, M., Clewell, H., Gargas, M., Smith, F., and Reitz, R. 1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87(2): 185-205.
  • Andersen, M. 1981. A physiologically based toxicokinetic description of the metabolism of inhaled gases and vapors: Analysis at steady state. Toxicol. Appl. Pharmacol. 60:509-526.
  • Astrand, 1.1983. Effect of physical exercise on uptake, distribution and elimination of vapors in man. In Modeling of inhalation exposure to vapors: Uptake, distribution, and elimination, vol. 2, ed. V. Fiserova-Bergerova, pp. 107-130. Boca Raton, FL: CRC Press.
  • Bearer, C. F. 1995. How are children different from adults? Environ. Health Perspect. 103:7-12.
  • Bennett, W. D., Zeman, K. L., and Kim, C. 1996. Variability of fine particle deposition in healthy adults: Effect of age and gender. Am. J. Respir. Crit. Care Med. 153:1641 -1647.
  • Bogdanffy, M., Sarangapani, R., Kimbell, J., Frame, S., and Plowchalk, D. 1998. Analysis of vinyl acetate metabolism in rat and human nasal tissues by an in vitro gas uptake technique. Toxicol. Sd. 46:235-246.
  • Braunlich, H. 1977. Kidney development: Drug elimination mechanisms. In Drug disposition during development, ed. P. MorselIi, pp. 89-101. New York: Spectrum Publications, Inc.
  • Brown, R., DeIp, M., Lindstedt, S., Rhomberg, L., and Beliles, R. 1997. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13:407-484.
  • Clewell, H. J., and Andersen, M. E. 1996. Use of physiologically-based pharmacokinetic modeling to investigate individual versus population risk. Toxicology 111:315-329.
  • Clewell, H. J., Gentry, P. R., Gearhart, J. M., Covington, T. R., Banton, M. I., and Andersen, M. E. 2001 a. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol. Sci. 63:160-172.
  • Clewell, H. J., Gentry, P. R., Gearhart, J. M., Alien, B. C., and Andersen, M. E. 2001b. Comparison of cancer risk estimates for vinyl chloride using animal and human data with a PBPK model. Sci. Total Environ. 274(1 -3):37-66.
  • Clewell, H., Teeguarden, J., McDonald, T., Sarangapani, R., Lawrence, G., Covington, T., Gentry, R., and Shipp, A. 2002. Review and evaluation of the potential impact of age and gender-specific pharmacokinetic differences on tissue dosimetry. Crit. Rev. Toxicol. 32(5):329-389.
  • Crapo, R. 1994. Pulmonary-function testing. N. Engl. J. Med. 331:25-30.
  • Dunnill, M. 1982. The problem of lung growth [editorial]. Thorax 37:561-563.
  • Frederick, C. B., Bush, M. L, Lomax, L. G., Black, K. A., Finch, L, Kimbell, J. S., Morgan, K. T., Subramaniam, R. P., Morris, J. B., and Ultman, J. S. 1998. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol. Appl. Pharmacol. 152:211-231.
  • Gearhart, J. M., Mahle, D. A., Greene, R. J., Seckel, C. S., Flemming, C. D., Fisher, J. W., and Clewell, H. J. 1993. Variability of physiologically-based pharmacokinetic (PB-PK) model parameters and their effects on PB-PK model predictions in a risk assessment for perchloroethylene. Toxicol. Lett. 68:131-144.
  • Gillooly, M., and Lamb, D. 1993. Airspace size in lungs of lifelong non-smokers: Effect of age and sex. Thorax 48:39-43.
  • Guilmette, R., Wicks, J., and Wolff, R. 1989. Morphometry of human nasal airways in vivo using magnetic resonance imaging. /. Aerosol. Med. 2:365-377.
  • Hattis, D., Russ, A., Banati, P., Kozlak, M., Coble, R., and Ginsberg, G. 2000. Development of a comparative child/adult pharmacokinetic database based upon the therapeutic drug literature. Draft report. Developed for NCEA/ORD, Washington, DC
  • Hofmann, W. 1982. Mathematical model for the postnatal growth of the human lung. Respir. Physiol. 49:115-129.
  • International Commission on Radiological Protection. 1994. Human respiratory tract model for radiological protection: A report of a task group of the International Commission on Radiological Protection. Elsevier Sciences, Ltd., Oxford, UK.
  • International Commission on Radiological Protection. 1975. Report of the Task Croup on Reference Man. ICRP Publication 23. Oxford: Pergamon Press.
  • Jaques, P. A., and Kim, C. S. 2000. Measurement of total lung deposition of inhaled ultrafine particles in healthy men and women, lnhal. Toxicol. 12:715-731.
  • Kim, C. S., and Hu, S. C. 1998. Regional deposition of inhaled particles in human lungs: Comparison between men and women. J. Appl. Physiol. 84:1834-1844.
  • Menache, M., Hanna, L., Gross, E., Lou, S., Zinreich, S., Leopold, D., Jarabek, A., and Miller, F. 1997. Upper respiratory tract surface areas and volumes of laboratory animals and humans: Considerations for dosimetry models. J. Toxicol. Environ. Health 50:475-506.
  • Miller, F., Overton, J., Jaskot, R., and Menzel, D. 1985. A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol. Appl. Pharmacol. 79(1) :11-27.
  • Milsap, R. L., and Jusko, W. J. 1994. Pharmacokinetics in the infant. Environ. Health Perspect. 102(suppl. 11):107-110.
  • Moolgavkar, S. H., Day, N. E., and Stevens, R. G. 1980. Two-stage model for carcinogenesis: Epidemiology of breast cancer in females. JNCI 65(3):559-569.
  • Morris, J. B., Hassett, D. N., and Blanchard, K. T. 1993. A physiologically based pharmacokinetic model for nasal uptake and metabolism of nonreactive vapors. Toxicol. Appl. Pharmacol. 123:120-129.
  • Musante, C., and Martonen, T. 2000. Computer simulations of particle deposition in the developing human lung. J. Air Waste Manage. Assoc. 50(8):1426-1432.
  • National Health and Nutrition Examination Survey (NHANES). 1995. Third National Health and Nutrition Examination Survey, 1988-1991. Selected laboratory and mobile examination center data. Ver. 1. September.
  • Ogiu, N., Nakamura, Y., Ijiri, I., Hiraiwa, K., and Ogiu, T. 1997. A statistical analysis of the internal organ weights of normal Japanese people. Health Phys. 72:368-383.
  • Oldham, M., Mannix, R., and Phalen, R. 1997. Deposition of monodisperse particles in hollow models representing adult and child-size tracheobronchial airways. Health Phys. 72(6):827-834.
  • Paulsson, B., Bende, M., and Ohlin, P. 1985. Nasal mucosal blood flow at rest and during exercise. Acta Otalaryngol. 99:140-143.
  • Pelekis, M., Gephart, L., and Lerman, S. 2001. Physiological-model-based derivation of the adult and child pharmacokinetic intraspecies uncertainty factors for volatile organic compounds. Regul. Toxicol. Pharmacol. 33:12-20.
  • Phalen, R. F., Oldham, M. J., Beaucage, C. B., Cracker, T. T., and Mortensen J. D. 1985. Postnatal enlargement of human tracheobronchial airways and implications for particle deposition. Anat. Rec. 212:368-380.
  • Pikkaralnen, P. H., and Räihä, N. C. R. 1967. Development of alcohol dehydrogenase activity in the human liver. Pediatric Res. 1:165-168.
  • Plunkett, L. M., et al. 1992. Differences between adults and children affecting exposure assessment. In Similarities and differences between children and adults: Implications for risk assessment, eds. P. Guzelian, C. Henry, and S. Olin, pp. 79-94. Washington, DC: ILSI Press.
  • Renwick, A., Dorne, J., and Walton, K. 2000. An analysis of the need for an additional uncertainty factor for infants and children. Regul. Toxicol. Pharmacol. 31:286-296.
  • Sarangapani, R., Teeguarden, J., Cruzan, G., Clewell, H., and Andersen, M. 2002. Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans, lnhal. Toxicol. 14(8):789-834.
  • Swift, D. L. 1989. Age-related scaling for aerosol and vapor deposition in the upper airways of humans. Health Phys. 57(suppl. 1):293-297.
  • U.S. Environmental Protection Agency. 1992. Draft report: A cross-species scaling factor for carcinogen risk assessment based on equivalence of mg/kg3/4/day; Notice. Fed. Reg. 57(109):24152-24173.
  • U.S. Environmental Protection Agency. 1994. Methods for derivation of inhalation reference concentrations and application of inhalation dosimetry. Washington, DC: Office of Health and Environmental Assessment.
  • U.S. Environmental Protection Agency. 1997. Exposure factors handbook: Volume I. General factors. Washington, DC: Office of Research and Development. EPA/600/95/002Fa.
  • Vieira, I., Sonnier, M., and Cresteil, T. 1996. Developmental expression of CYP2E1 in the human liver. Hypermethylation control of gene expression during the neonatal period, fur. J. Biochem. 238:476483.
  • Yu, C., and Xu, G. 1987. Predictive models for deposition of inhaled diesel exhaust particles in humans and laboratory species. Res. Rep. Health Effects lnst. 10:3-22.

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