Pulmonary Function, Diffusing Capacity, and Inflammation in Healthy and Asthmatic Subjects Exposed to Ultrafine Particles

REFERENCES

• American Thoracic Society, 1999. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children. Am. J. Respir. Crit. Care Med.. 160: 2104–2117
   PubMed Web of Science ®Google Scholar
• American Thoracic Society, 2000. Guideines for methacholine and exercise challenge testing—1999. Am. J. Respir. Crit. Care Med.. 161: 309–329
   PubMed Web of Science ®Google Scholar
• Atkinson R. W., Anderson H. R., Sunyer J., Ayres J., Baccini M., Vonk J. M., Boumghar A., Forastiere F., Forsberg B., Touloumi G., Schwartz J., Katsouyanni K.. 2001. Acute Effects of Particulate Air Pollution on Respiratory Admissions. Results from APHEA 2 Project. Am. J. Respir. Crit. Care Med.. 164: 1860–1866. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Batalha J. R., Saldiva P. H., Clarke R. W., Coull B. A., Stearns R. C., Lawrence J., Murthy G. G., Koutrakis P., Goldleski J. J.. 2002. Concentrated ambient air particles induce vasoconstriction of small pulmonary arteries in rats. Environ. Health Perspect. 110(12)1191–1197. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Brand P., Gebhart J., Below M., Georgi B., Heyder J.. 1991. Characterization of environmental aerosols on Heligoland Island. Atmos. Environ.. 25A: 581–585
   Web of Science ®Google Scholar
• Brand P., Ruob K., Gebhart J.. 1992. Performance of a mobile aerosol spectrometer for an in situ characterization of environmental aerosols in Frankfurt City. Atmos. Environ.. 26A: 2451–2457
   Web of Science ®Google Scholar
• Brook R. D., Brook J. R., Urch B., Vincent R., Rajagopalan S., Silverman F.. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation. 105: 1534–1536. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K.. 2001. Size dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol.. 175: 191–199. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Chalupa D. C., Gibb F. R., Morrow P. E., Oberdörster G., Riesenfeld E., Gelein R., Utell M. J., Frampton M. W.. 2002. A facility for controlled human exposures to ultrafine particles. Crucial issues in inhalation research—Mechanistic, clinical and epidemiologic: INIS monographs. 8th international symposium, U., Heinrich, U., Mohr, pp. 242–253, Washington, DC, ILSI Press
   Google Scholar
• Elder A. C. P., Gelein R., Finkelstein J. N., Cox C., Oberdörster G.. 2000. Endotoxin priming affects the lung response to ultrafine particles and ozone in young and old rats. Inhal. Toxicol.. 12(s1)85–98. [CROSSREF]
   Google Scholar
• Ghio A. J., Stoneheurner J., Dailey L. A., Carter J. D.. 1999. Metals associated with both the water-soluble and insoluble fractions of an ambient air pollution particle catalyze an oxidative stress. Inhal. Toxicol.. 11: 37–49. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Ghio A. J., Kim C., Devlin R. B.. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med.. 162: 981–988. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Girgis R. E., Gugnani M. K., Abrams J., Mayes M. D.. 2002. Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease. Am. J. Respir. Crit. Care Med.. 165: 1587–1591. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Gong H., Jr., Linn W. S., Sioutas C., Terrell S. L., Clark K. W., Anderson K. R., Terrell L. L.. 2003. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhal. Toxicol.. 15: 305–325. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hiltermann T. J., Stolk J., van der, Zee S. C., Brunekreef B., de, Bruijne C. R., Fischer P. H., Ameling C. B., Sterk P. J., Hiemstra P. S., van, Bree L.. 1998. Asthma severity and susceptibility to air pollution. Eur. Respir. J.. 11: 686–693. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Holz O., Richter K., Jorres R. A., Speckin P., Mucke M., Magnussen H.. 1997. Changes in sputum composition between two inductions performed on consecutive days. Thorax. 53: 83–86
   Google Scholar
• Huang Y.-C. T., Ghio A. J., Stonehuerner J., McGee J., Carter J. D.. 2003. The role of soluble components in ambient fine particles-induced changes in human lungs and blood. Inhal. Toxicol.. 15: 327–342. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Hyde R. W., Geigel E. J., Olszowka A. J., Forster R. E., II., Utell M. J., Frampton M. W.. 1997. Determination of production of nitric oxide by the lower airways of humans—Theory. J. Appl. Physiol.. 82: 1290–1296. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• International Commission on Radiological Protection (ICRP), 1994. Human respiratory tract model for radiological protection. Annals of the ICRP.. 24: 1–3
   Google Scholar
• Jones B., Kenward M. G.. 1989; Design and analysis of cross-over trials. New York, Chapman and Hall
   Google Scholar
• Jörres R. A.. 2000. Modelling the production of nitric oxide within the human airways. Eur. Respir. J. 16: 555–560. [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Kittelson D. B., Watts W. F., Johnson J. P.. 2001; Fine particle (nanoparticle) emissions on Minnesota highways, Mn/DOT report no. 2001–12. St. Paul, Minnesota Department of Transportation
   Google Scholar
• Kharitonov S., Alving K., Barnes P. J.. 1997. Exhaled and nasal nitric oxide measurements: Recommendations. Eur. Respir. J.. 10: 1683–1693. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lee Y. C., Cheon K. T., Rhee Y. K.. 1997. Changes of soluble ICAM-1 levels in serum and bronchoalveolar lavage fluid from patients with atopic bronchial asthma after allergen challenge. J. Asthma. 34: 405–412. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Li N., Venkatesan M. I., Miguel A., Kaplan R., Gujuluva C., Alam J., Nel A.. 2000. Induction of heme oxygenase-1 expression in macrophages by diesel exhaust particle chemicals and quinones via the antioxidant-responsive element. J. Immunol.. 165: 3393–3401. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Li N., Sioutas C., Cho A., Schmitz D., Misra C., Sempf J., Wang M., Oberley T., Froines J., Nel A.. 2003. Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. Environ. Health Perspect.. 111: 455–460. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Li X. Y., Brown D., Smith S., MacNee W., Donaldson K.. 1999. Short-term inflammatory responses following intratracheal instillation of fine and ultrafine carbon black in rats. Inhal. Toxicol.. 11: 709–731. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Lipsett M., Hurley S., Ostro B.. 1997. Air pollution and emergency room visits for asthma in Santa Clara County, California. Environ. Health Perspect.. 105: 216–222. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Montefort S., Lai C. K. W., Kapahi P., Leung J., Lai K. N., Chan H. S., Haskard D. O., Howarth P. H., Holgate S. T.. 1994. Circulating adhesion molecules in asthma. Am. J, Respir. Crit. Care Med.. 149: 1149–1152
   Google Scholar
• Morris J., Koski A., Johnson L.. 1971. Spirometric standards for healthy nonsmoking adults. Am. Rev. Respir. Dis.. 103: 57–61. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Morris R. J., Gibson Q. H.. 1980. The role of diffusion in limiting the rate of ligand binding to hemoglobin. J. Biol. Chem. 255: 8050–8053. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• National Institutes of Health, 1997; Expert panel report 2: Guidelines for the diagnosis and management of asthma, NIH publication no. 97–4051. Bethesda, MD, NIH
   Google Scholar
• National Research Council, 1998; Research priorities for airborne particulate matter: I. Immediate priorities and a long-range research portfolio, Commission on Life Sciences, Commission on Geosciences, Environment, and Resources, National Research Council. Washington, DC, National Academy Press
   Google Scholar
• Nel A. E., Diaz-Sanchez D., Li N.. 2001. The role of particulate pollutants in pulmonary inflammation and asthma: Evidence for the involvement of organic chemicals and oxidative stress. Curr. Opin. Pulm. Med.. 7: 20–26. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMedGoogle Scholar
• Nightingale J. A., Rogers D. F., Barnes P. J.. 1998. Effect of repeated sputum induction on cell counts in normal volunteers. Thorax. 53: 87–90. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Oberdörster G., Gelein R. M., Ferin J., Weiss B.. 1995. Association of particulate air pollution and acute mortality: Involvement of ultrafine particles?. Inhal. Toxicol.. 7: 111–124
   PubMed Web of Science ®Google Scholar
• Oberdörster G., Finkelstein J. N., Johnston C., Gelein R., Cox C., Baggs R., Elder A. C.. 2000; HEI research report: Acute pulmonary effects of ultrafine particles in rats and mice, Research report no. 96. Cambridge, MA, Health Effects Institute
   Google Scholar
• Ohkawara Y., Yamauchi K., Maruyama N., Hoshi H., Ohno I., Honma M., Tanno Y., Tamura G., Shirato K., Ohtani H.. 1995. In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: In vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration. Am. J. Respir. Cell Mol., Biol.. 12: 4–12
   Google Scholar
• Perillo I. B., Hyde R. W., Olszowka A. J., Pietropaoli A. P., Frasier L. M., Torres A., Perkins P. T., Forster R. E., II, Utell M. J., Frampton M. W.. 2001. Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans. J. Appl. Physiol. 91: 1931–1940. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Peters A., Wichmann H. E., Tuch T., Heinrich J., Heyder J.. 1997. Respiratory effects are associated with the number of ultrafine particles. Am. J. Respir. Crit. Care Med. 155: 1376–1383. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pietropaoli A. P., Perillo I. B., Torres A., Perkins P. T., Frasier L. M., Utell M. J., Frampton M. W., Hyde R. W.. 1999. Simultaneous measurement of nitric oxide production by conducting and alveolar airways of humans. J. Appl. Physiol.. 87: 1532–1542. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Pizzichini E., Pizzichini M. M. M., Efthimiadis A., Hargreave F. E., Dolovich J.. 1996. Measurement of inflammatory indices in induced sputum: Effects of selection of sputum to minimize salivary contamination. Eur. Respir. J.. 9: 1174–1180. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Pope C. A. I., Burnett R. T., Thun M. J., Calle E. E., Krewski D., Ito K., Thurston G. D.. 2002. Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc.. 287: 1132–1141. [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Roughton F. J. W., Forster R. E.. 1957. Relative importance of diffusion and chemical reaction rates in determining rate of exchange of gases in the human lung, with special reference to the true diffusing capacity of pulmonary membrane and volume of blood in the lung capillaries. J. Appl. Physiol.. 11: 290–302. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Salvi S., Blomberg A., Rudell B., Kelly F., Sandstrom T., Holgate S. T., Frew A.. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am. J. Respir. Crit. Care Med.. 159: 702–709. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Samet J. M., Dominici F., Curriero F. C., Coursac I., Zeger S. L.. 2000. Fine particulate air pollution and mortality in 20 U.S. cities, 1987–1994. N. Engl. J. Med.. 343: 1742–1749. [PUBMED], [INFOTRIEVE], [CROSSREF]
   PubMed Web of Science ®Google Scholar
• Searle S. R., Casella G., McCulloch C. E.. 1992; Variance components. New York, John Wiley & Sons
   Google Scholar
• Shin H. W., Rose-Gottron C. M., Sufi R. S., Perez F., Cooper D. M., Wilson A. F., George S. C.. 2002. Flow-independent nitric oxide exchange parameters in cystic fibrosis. Am. J. Respir. Crit. Care Med.. 165: 349–357. [PUBMED], [INFOTRIEVE]
   PubMedGoogle Scholar
• Silkoff P. E., Sylvester J. T., Zamel N., Permutt S.. 2000. Airway nitric oxide diffusion in asthma: Role in pulmonary function and bronchial responsiveness. Am. J. Respir. Crit. Care Med. 161: 1218–1228. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Stearns R. C., Murthy G. G. K., Skornik W., Hatch V., Katler M., Godleski J. J.. 1994. Detection of ultrafine copper oxide particles in the lungs of hamsters by electron spectroscopic imaging. ICEM 13-Paris, 17–22 July. pp. 763–764
   Google Scholar
• Tolbert P. E., Mulholland J. A., MacIntosh D. L., Xu F., Daniels D., Devine O. J., Carlin B. P., Klein M., Dorley J., Butler A. J., Nordenberg D. F., Frumkin H., Ryan P. B., White M. C.. 2000. Air quality and pediatric emergency room visits for asthma in Atlanta, Georgia, USA. Am. J. Epidemiol.. 151: 798–810. [PUBMED], [INFOTRIEVE]
   PubMed Web of Science ®Google Scholar
• Tsoukias N. M., George S. C.. 1998. A two-compartment model of pulmonary nitric oxide exchange dynamics. J. Appl. Physiol. 85(2)658–666
   Google Scholar
• U.S. Environmental Protection Agency, 1996; Air quality criteria for particulate matter. Washington, DCU.S., EPA
   Google Scholar
• U.S. Environmental Protection Agency, 1998; Executive summary. Particulate matter research needs for human health risk assessment to support future reviews of the National Ambient Air Quality Standards for Particulate Matter. Research Triangle Park, NC, National Center for Environmental Assessment
   Google Scholar
• Utell M. J., Drew R.. 1998. Summary of the workshop on clinical studies and particulate matter. Inhal. Toxicol.. 10: 625–638. [CROSSREF]
   Google Scholar
• Wallenstein S., Fisher A. C.. 1977. Analysis of the two-period repeated measurements crossover design with application to clinical trials. Biometrics. 30: 261–269
   Google Scholar
• Zhu Y., Hinds W. C., Kim S., Sioutas C.. 2002. Concentration and size distribution of ultrafine particles near a major highway. J. Air Waste Manage. Assoc.. 52: 1032–1042
   Web of Science ®Google Scholar