Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 17, 2005 - Issue 4-5
185
Views
30
CrossRef citations to date
0
Altmetric
Research Article

Effects of Subchronic Exposures to Concentrated Ambient Particles (CAPs) in Mice: I. Introduction, Objectives, and Experimental Plan

, &
Pages 177-187 | Received 06 Jul 2004, Accepted 07 Oct 2004, Published online: 06 Oct 2008

REFERENCES

  • Brook R. D., Brook J. R., Urch B., Vincent R., Rajagopalan S., Silverman F. Inhalation of fine particle air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002; 105: 1534–1536, [PUBMED], [INFOTRIEVE]
  • Brook R. D., Franklin B., Cascio W., Hong Y., Howard G., Lipsett M., Luepker R., Mittleman M., Samet J., Smith S. C., Tager I. Air pollution and cardiovascular disease: A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 2004; 109: 2655–2671, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Caligiuri G. B., Levy B., Pernow J., Thoren P., Hansson G. Myocardial infarction mediated by endothelium receptor signalling in hypocholesterolemic mice. Proc. Natl. Acad. Sci. 1999; 96: 6920–6924, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Chan C.-C., Chuang K. J., Shiao G. M., Lin L. Y. Personal exposure to submicrometer particles and heart rate variability in human subjects. Environ. Health Perspect. 2004; 112: 1063–1067, [PUBMED], [INFOTRIEVE], [CSA]
  • Chen L. C., Nadziejko C. Effects of subchronic exposures to CAPs in mice: V. Exacerbation of aortic plaque development in hyperlipidemic mice after subchronic exposure to CAPs. Inhal. Toxicol 2005; 17(4–5)217–224
  • Cheng T.-J., Hwang J.-S., Wang P.-Y., Tsai C.-F., Chen C.-Y., Lin S.-H., Chang C. C. Effects of concentrated ambient particles on heart rate and blood pressure in pulmonary hypertensive rats. Environ. Health Perspect. 2003; 111: 147–150, [PUBMED], [INFOTRIEVE], [CSA]
  • Clarke R. W., Coull B., Reinisch U., Catalano P., Killingsworth C. R., Koutrakis P., Kavouras I., Murthy G. G. K., Lawrence J., Lorett E., Wolfson J. M., Verrier R. L., Godleski J. J. Inhaled concentrated ambient particles are associated with hematological and bronchoalveolar lavage changes in canines. Environ. Health Perspect. 2000; 108: 1179–1187, [PUBMED], [INFOTRIEVE], [CSA]
  • Creason J., Neas L., Walsh D., Williams R., Sheldon L., Liao D., Shy C. Particulate matter and heart rate variability among elderly retirees in the Baltimore 1998 study. J. Expos. Anal. Environ. Epidemiol. 2001; 11: 116–122, [CSA], [CROSSREF]
  • Devlin R. B., Ghio A. J., Kehrl H., Sanders G., Cascio W. Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur. Respir. J. 2003; 40(suppl.)76s–80s, [CSA], [CROSSREF]
  • D'Ippoliti D., Forastiere F., Ancona C., Agabiti N., Fusco D., Michelozzi P., Perucci C. A. Air pollution and myocardial infarction in Rome. Epidemiology 2003; 14: 528–535, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Dockery D. W., Pope C. A., Xu X., Spengler J. D., Ware J. H., Fay M. E., Ferris B. G. Jr., Speizer F. E. An association between air pollution and mortality in six U.S. cities. N. Engl. J. Med. 1993; 329: 1753–1759, III[PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Gairola C. G., Drawdy M. I., Block A. E., Daugherty A. Sidestream cigarette smoke accelerates therogenesis in apolipoprotein E-/- mice. Atherosclerosis 2001; 156: 49–55, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Ghio A. J., Kim C., Devlin R. B. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am. J. Respir. Crit. Care Med. 2000; 162: 981–988, [PUBMED], [INFOTRIEVE], [CSA]
  • Ghio A. J., Huang Y. C. T. Exposure to concentrated ambient particles (CAPs): A review. Inhal. Toxicol. 2004; 16: 53–59, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Godleski J. J., Verrier R. L., Koutrakis P., Catalano P. Mechanisms of morbidity and mortality from exposure to ambient air particulate. Health Effects Institute, Cambridge, MA 2000; 91, Research Report
  • Gold D. R., Litonjua A., Schwartz J., Lovett E., Larson A., Nearing B., Allen G., Verrier M., Cherry R., Verrier R. Ambient pollution and heart rate variability. Circulation 2000; 101: 1267–1273, [PUBMED], [INFOTRIEVE]
  • Gong H. Jr., Sioutas C., Linn W. S., Clark K. W., Terrell S. L., Terrell L. L., Anderson K. R., Kim S., Chang M.-C. Controlled human exposures to concentrated ambient fine particles in metropolitan Los Angeles: Methodology and preliminary health-effect findings. In Proceedings of the Third Colloquium on Particulate Air Pollution and Human Health, R. F. Phalen. Inhal. Toxicol., Durham, NC June, 1999; 12: 107–119, first special issue suppl. 1
  • Gong H. Jr., Linn W. S., Sioutas C., Terrell S. L., Clark K. W., Anderson K. R., Terrell L. L. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhal. Toxicol. 2003; 15: 305–325, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Gong H. Jr., Linn W. S., Terrell S. L., Clark K. W., Geller M. D., Anderson K. R., Cascio W. E., Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhal. Toxicol. 2004; 16: 335–343, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Gordon T., Nadziejko C., Schlesinger R., Chen L. C. Pulmonary and cardiovascular effects of acute exposure to concentrated ambient particulate matter in rats. Toxicol. Lett. 1998a; 96–97: 285–288, [CROSSREF]
  • Gordon T., Gerber H., Fang C. P., Chen L. C. A centrifugal particle concentrator for use in inhalation toxicology. Inhal. Toxicol. 1998b; 11: 71–87, [CSA], [CROSSREF]
  • Gordon T., Nadziejko C., Chen L. C., Schlesinger R. Effects of concentrated ambient particles in rats and hamsters: An exploratory study. Health Effects Institute, Cambridge, MA 2000; 93, Research Report
  • Gunnison A., Chen L. C. Effects of subchronic exposures to CAPs in mice: VI. Genetic marker responses to subchronic exposure to CAPs. Inhal. Toxicol. 2005, [CSA]
  • Gurgueira S. A., Lawrence J., Coull B., Krishna Murthy G. G., Gonzalez-Flecha B. Rapid increases in the steady-state concentration of reactive oxygen species in the lungs and heart after particulate air pollution inhalation. Environ. Health Perspect. 2002; 110: 749–755, [PUBMED], [INFOTRIEVE], [CSA]
  • Gwynn R. C., Thurston G. D. The burden of air pollution among racial minorities. Environ. Health Perspect. 2001; 109(suppl. 4)501–506, [PUBMED], [INFOTRIEVE], [CSA]
  • Harder S. D., Soukup J. M., Ghio A. J., Devlin R. B., Becker S. Inhalation of PM2.5 does not modulate host defense or immune parameters in blood or lung of normal human subjects. Environ. Health Perspect. Suppl. 2001; 109(4)599–604
  • Holguin F., Tellez-Rojo M. M., Hernandez M., Cortez M., Chow J. C., Watson J. G., Mannino D., Romieu I. Air pollution and heart rate variability among the elderly in Mexico City. Epidemiology 2003; 14: 521–527, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Huang C., Mattjus P., Ma W. Y., Rincon M., Chen N. Y., Brown R. E., Dong Z. Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice. J. Biol. Chem 2000; 275: 9143–9149, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Hwang J.-S., Chen L. C. Effects of subchronic exposures to CAPs in mice: IV. Characterization of acute and chronic effects of ambient air fine particulate matter exposures on heart rate variability. Inhal. Toxicol. 2005; 17(4–5)209–216
  • Hwang J.-S., Nadziejko C., Chen L. C. Effects of subchronic exposures to CAPs in mice: III. Acute and chronic effects of CAPs on heart rate, heart rate variance, and body temperature. Inhal. Toxicol. 2005; 17(4–5)199–207
  • Irizarry R. A., Hobbs B., Collin F., Beazer-Barclay Y. D., Antonellis K. J., Scherf U., Speed T. P. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003; 4(2)249–264, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Kleeberger S. R., Reddy S., Zhang L. Y., Jedlicka A. E. Genetic susceptibility to ozone-induced lung hyperpermeability: Role of toll-like receptor 4. Am. J. Respir. Cell Mol. Biol. 2000; 22: 620–627, [PUBMED], [INFOTRIEVE], [CSA]
  • Koken P. J. M., Piver W. T., Ye F., Elixhauser A., Olsen L. M., Portier C. J. Temperature, air pollution, and hospitalization for cardiac diseases among elderly people in Denver. Environ. Health Perspect. 2003; 111: 1312–1317, [PUBMED], [INFOTRIEVE], [CSA]
  • Laden F., Neas L. M., Dockery D. W., Schwartz J. Association of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ. Health Perspect. 2000; 108: 941–947, [PUBMED], [INFOTRIEVE], [CSA]
  • Laden F., Schwartz J., Speizer F. E., Dockery D. W. Air pollution and mortality: A continued follow-up in the Harvard Six Cities Study. Epidemiology 2001; 12: S81, abst.
  • Li G., Tokuno S., Tahepold P., Vaage J., Lowbeer C., Valen G. Preconditioning protects the severely atherosclerotic mouse heart. Ann. Thorac. Surg. 2001; 71: 1296–1304, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Liao D., Creason J., Shy C., Williams R., Zweidinger R. Daily variation of particulate pollution and poor cardiac autonomic control in the elderly. Environ. Health Perspect. 1999; 107: 521–525, [PUBMED], [INFOTRIEVE], [CSA]
  • Lippmann M., Frampton M., Schwartz J., Dockery D., Schlesinger R., Koutrakis P., Froines J., Nel A., Finkelstein J., Godleski J., Kaufman J., Koenig J., Larson T., Luchtel D., Liu L. J. S., Oberdorster G., Peters A., Sarnat J., Sioutas C., Suh H., Sullivan J., Utell M., Wichmann E., Zelikoff J. The U.S. Environmental Protection Agency particulate matter health effects research centers program. Environ. Health Perspect. 2003; 111: 1074–1092, [PUBMED], [INFOTRIEVE], [CSA]
  • Lippmann M., Gordon T., Chen L. C. Effects of subchronic exposures to CAPs in mice: IX. Integral assessment and human health implications of subchronic exposures of mice to CAPs. Inhal. Toxicol. 2005; 17(4–5)255–261
  • Luchtel D. L., Fu C., Ghatpande P. A mouse model to study toxicity of particulate matter (PM). Am. J. Respir. Crit. Care Med. 2002; 165(8)A301, Labstr
  • Maciejczyk P., Chen L. C. Effects of subchronic exposures to CAPs in mice: VIII. Source-related daily variations in in vitro responses to CAPs. Inhal. Toxicol. 2005; 17(4–5)243–253
  • Maciejczyk P., Zhong M., Li Q., Xiong J., Nadziejko C., Chen L. C. Effects of subchronic exposures to CAPs in mice: II. The design of a CAPs exposure system for biometric telemetry monitoring. Inhal. Toxicol. 2005; 17(4–5)189–197
  • Mar T. F., Norris G. A., Koenig J. Q., Larson T. V. Association between air pollution and mortality in Phoenix. Environ.Health Perspect. 2000; 108: 347–353, [PUBMED], [INFOTRIEVE]
  • Metzger K. B., Tolbert P. E., Klein M., Peel J. L., Flanders W. D., Todd K., Mulholland J. A., Ryan P. B., Frumkin H. Ambient air pollution and cardiovascular emergency department visits. Epidemiology 2003; 15: 46–56
  • Morokata T., Ishikawa J., Ida K., Yamada T. C57BL/6 mice are more susceptible to antigen-induced pulmonary eosinophilia than BALBc mice irrespective of systemic T helper 1/T helper 2 responses. Immunology 1999; 98: 345–351, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Nadziejko C., Fang K., Nadziejko E., Narciso S. P., Zhing M., Chen L. C. Immediate effects of particulate air pollutants on heart rate and respiratory rate in hypertensive rats. Cardiovasc. Toxicol. 2003; 2: 245–252, [CSA], [CROSSREF]
  • Nadziejko C., Chen L. C., Nadas A., Hwang J. S. The “fishing license” method for analyzing the time course of effects in repeated measurements. Stat. Med. 2004; 23: 1399–1411, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Ogami A., Quinlan K., Chu F., Hards J., Vincent R. M., Van Eeden S., Hogg J. C. The effect of PM10 on atherosclerotic lesions in rabbits. Am. J. Respir. Crit. Care Med. 2000; 161: A240
  • Ohtsuka Y., Clarke R. W., Mitzner W., Brunson K., Jakab G. J., Kleeberger S. R. Interstrain variation in murine susceptibility to inhaled acid-coated particles. Am. J. Physiol. Lung Cell. Mol. Physiol. 2000; 278: L469–L476, [PUBMED], [INFOTRIEVE], [CSA]
  • Palinski W., Ord V. A., Plump A. S., Breslow J. L., Steinberg D., Witztum J. L. ApoE-deficient mice are a model of liproprotein oxidation in atherogenesis. Arterioscler. Thromb. 1994; 14: 605–616, [PUBMED], [INFOTRIEVE]
  • Peters A., Dockery D. W., Muller J. E., Mittleman M. A. Increased particulate air pollution and the triggering of myocardial infarction. Circulation 2001; 103(23)2810–2815, [PUBMED], [INFOTRIEVE]
  • Petrovic S., Urch B., Brook J., Datema J., Purdham J., Liu L., Lukic Z., Zimmerman B., Tofler G., Downar E., Corey P., Tarlo S., Broder I., Dales R., Silverman F. Cardiorespiratory effects of concentrated ambient PM2.5: A pilot study using controlled human exposures. In Proceedings of the Third Colloquium on Particulate Air Pollution and Human Health, R. F. Phalen. Inhal. Toxicol., Durham, NC June, 1999; 12: 173–188, first special issue suppl. 1
  • Pope C. A., Thun M. J., Namboodiri M. M., Dockery D. W., Evans J. S., Speizer F. E., Heath C. W. Jr. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med. 1995; 151: 669–674, III[PUBMED], [INFOTRIEVE], [CSA]
  • Pope C. A., Verrier R. I., Lovett E. G., Larson A. C., Raizenne M., Kanner M. E., Schwartz J., Villegas G. M., Gold D. R., Dockery D. W. Heart rate variability associated with particulate air pollution. Am. Heart J. 1999a; 138: 890–899, III[PUBMED], [INFOTRIEVE], [CSA]
  • Pope C. A., Dockery D. W., Kanner R. E., Vollegas G. M., Schwartx J. Oxygen saturation, pulse rate, and particulate air pollution: A daily time-series panel study. Am. J. Respir. Crit. Care Med. 1999b; 159: 365–372, III[CSA]
  • Pope C. A., Burnett R. T., Thun M. J., Calle E. E., Krewski D., Ito K., Thurston G. D. Lung cancer, cardiopulmonary mortality and long-term exposure to fine particulate air pollution. J. Am. Med. Assoc. 2002; 287: 1132–1147, III
  • Pope C. A., Burnett R. T., Thurston G. D., Thun M. J., Calle E. E., Krewski D., Godleski J. J. Cardiovascular mortality and long-term exposure to particulate matter. Circulation 2004; 109: 71–77, III[PUBMED], [INFOTRIEVE], [CROSSREF]
  • Saldiva P. H. N., Clarke R. W., Coull B. A., Stearns R. C., Lawrence J., Krishna-Murthy G. G., Diaz E., Koutrakis P., Suh H., Tsuda A., Godleski J. J. Lung inflammation induced by concentrated ambient air particles is related to particle composition. Am. J. Respir. Crit. Care Med. 2002; 165: 1610–1617, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Sioutas C., Kim S., Chang M. Development and evaluation of a prototype ultrafine particle collector. J. Aerosol Sci. 1999; 30: 1001–1012, [CSA], [CROSSREF]
  • Sioutas C., Koutrakis P., Godleski J., Ferguson S. T., Kim C. S., Burton R. M. Harvard/EPA ambient fine particle concentrators for human and animal exposures. J. Aerosol Sci. 1997; 28(6)1057–1071, [CSA], [CROSSREF]
  • Suwa T., Hogg J. C., Quinlan K. B., Ohgami A., Vincent R., van Eeden S. F. Particulate air pollution induces progression of atherosclerosis. J. Am. Coll. Cardiol. 2002; 39: 935–942, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Urch B., Brook J. R., Wasserstein D., Brook R. D., Rajagopalan S., Corey P., Silverman F. Relative contributions of PM2.5 chemical constituents to acute arterial vasoconstriction in humans. Inhal. Toxicol. 2004; 16: 345–352, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • 4th External review draft of air quality criteria for particulate matter. Report No. EPA/600/P-99/002aD (December 2003). U.S. Environmental Protection Agency., Research Triangle Park, NC: National Center for Environmental Assessment-RTP Office 2004
  • Veronesi B., Makwana O., Pooler M., Weir L., Chen L. C. Effects of subchronic exposures to CAPs in mice: VII. Degeneration of dopaminergic neurons in ApoE−/− mice. Inhal. Toxicol 2005; 17(4–5)235–241
  • Wadsworth M. P., Sobel B. E., Schneider D. J., Taatjes D. J. Delineation of the evolution of compositional changes in atheroma. Histochemi. Cell Biol. 2002; 118(1)59–68, [CSA]
  • Watkinson W. P., Campen M. J., Costa D. L. Cardiac arrhythmia induction after exposure to residual oil fly ash particles in a rodent model of pulmonary hypertension. Toxicol. Sci. 1998; 41: 209–216, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]
  • Wellenius G. A., Coull B. A., Godleski J. J., Koutrakis P., Okabe K., Savage S. T., Lawrence J. E., Krishna Murthy G. G., Verrier R. L. Inhalation of concentrated ambient air particles exacerbates myocardial ischemia in conscious dogs. Environ. Health Perspect. 2003; 111: 402–408, [PUBMED], [INFOTRIEVE], [CSA]
  • Zelikoff J. T., Chen L. C., Cohen M. D., Fang K., Gordon T., Li Y., Nadziejko C., Schlesinger R. B. Effects of inhaled ambient particulate matter on pulmonary antimicrobial immune defense. Inhal. Toxicol. 2003; 15: 131–150, [PUBMED], [INFOTRIEVE], [CSA], [CROSSREF]

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.