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Inhalation Toxicology
International Forum for Respiratory Research
Volume 17, 2005 - Issue 11
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Research Article

Chronic Nose-only Inhalation Study in Rats, comparing Room-aged Sidestream Cigarette Smoke and Diesel Engine Exhaust

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Pages 549-576 | Received 31 Jan 2005, Accepted 23 Mar 2005, Published online: 06 Oct 2008

REFERENCES

  • AALAS 1991. American Association for Laboratory Animals Science Policy on the Humane Care and Use of Laboratory Animals. Lab. Anim. Sci., 41: 91
  • Armitage P. The comparison of survival curves. J. Royal Statistical Soc. A 1959; 122: 279–292
  • Ayres P. H., McKarns S. C., Coggins C. R. E., Doolittle D. J., Sagartz J. E., Payne V. M., Mosberg A. T. Replicative DNA synthesis in tissues of the rat exposed to aged and diluted sidestream smoke. Inhal. Toxicol. 1995; 7: 1225–1246
  • Baker R. R., Proctor C. J. The origins and properties of environmental tobacco smoke. Environ. Intl. 1990; 16: 231–245, [CROSSREF]
  • Balansky R., D'Agostini F., Zannacchi P., De Flora S. Protection by N-acetylcysteine of the histopathological and cytogenetical damage produced by exposure of rats to cigarette smoke. Cancer Lett. 1992; 64: 123–131, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Beach A. C., Gupta R. C. Human biomonitoring and the 32P-postlabelling assay. Carcinogenesis 1992; 13: 1053–1074, [PUBMED], [INFOTRIEVE], [CSA]
  • Bermudez E., Mangum J. B., Wong B. A., Asgharian B., Hext P. M., Warheit D. B., Everitt J. I. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol. Sci. 2004; 77: 347–357, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Bonham A. C., Chen C. -Y., Mutoh T., Joad J. P. Lung C-fiber CNS reflex: role in the respiratory consequences of extended environmental tobacco smoke exposure in young guinea pigs. Environ. Health Perspect. 2001; 109: 573–578, [PUBMED], [INFOTRIEVE], [CSA]
  • Borm P. J. A., Schins R. P. F., Albrecht C. Inhaled particles and lung cancer, Part B: paradigms and risk assessment. Int. J. Cancer 2004; 110: 3–14, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Brightwell J., Fouillet X. L. M., Cassano-Zoppi A. L., Bernstein D., Crawley F., Duchosal F., Gatz R., Perczel S., Pfeifer H. Tumours of the respiratory tract in rats and hamsters following chronic inhalation of engine exhaust emissions. J. Appl. Toxicol. 1989; 9: 23–31, [PUBMED], [INFOTRIEVE]
  • Bundesgesetzblatt 1 (47) 1994. Grundsaetze der Guten Laborpraxis (GLP). In Anhang 1 (zu 19a Abs.1) der Neufassung des Chemikaliengesetzes vom 25 Juli 1993 1703–1734
  • Burger G. T., Renne R. A., Sagartz J. W., Ayres P. H., Coggins C. R. E., Mosberg A. T., Hayes A. W. Histologic changes in the respiratory tract induced by inhalation of xenobiotics: physiologic adaptation or toxicity?. Toxicol. Appl. Pharmacol. 1989; 101: 521–542, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Coggins C. R. E. A minireview of chronic animal inhalation studies with mainstream cigarette smoke. Inhal. Toxicol. 2002; 14: 991–1002, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Coggins C. R. E., Ayres P. H., Mosberg A. T., Ogden M. W., Hayes A. W., Sagartz J. W. Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. I. Inhalation toxicology; histopathology. Fundam. Appl. Toxicol. 1992; 19: 133–140, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Coggins C. R. E., Ayres P. H., Mosberg A. T., Sagartz J. W., Hayes A. W. Subchronic inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. Inhal. Toxicol. 1993; 5: 77–96, [CSA]
  • Coggins C. R. E., Duchosal F., Musy C., Ventrone R. Measurement of respiratory patterns in rodents, using whole-body plethysmography and a pneumotachograph. Lab. Anim. 1981; 15: 137–140, [PUBMED], [INFOTRIEVE]
  • Coggins C. R. E., Musy C., Ventrone R. Changes in the minute ventilation of rats exposed to different concentrations of tobacco smoke. Toxicol. Lett. 1982; 11: 181–185, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Cox L. A. Does diesel exhaust cause human lung cancer?. Risk Anal. 1997; 17: 807–829, [PUBMED], [INFOTRIEVE], [CSA]
  • Creutzenberg O., Bellmann B., Muhle H., Dasenbrock C., Morrow P., Mermelstein R. Lung clearance and retention of toner, TiO2, and crystalline silica, utilizing a tracer technique during chronic inhalation exposure in Syrian golden hamsters. Inhal. Toxicol. 1998; 10: 731–751, [CROSSREF]
  • Curtin G. M., Higuchi M. A., Ayres P. H., Swauger J. E., Mosberg A. T. Lung tumorigenicity in A/J and ras-H2 Tg mice following mainstream tobacco smoke inhalation. Toxicol. Sci. 2004; 81: 26–34, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • DeMarini D. M., Brooks L. R., Warren S. H., Kobayashi T., Gilmour M. I., Singh P. Bioassay-directed fractionation and Salmonella mutagenicity of automobile and forklift diesel exhaust particulates. Environ. Health Perspect. 2004; 112: 814–819, [PUBMED], [INFOTRIEVE], [CSA]
  • Diana J. N., Vaught A. Research Cigarettes. University of Kentucky Printing Services, Lexington, KY 1990
  • Driscoll K. E. Role of inflammation in the development of rat lung tumors in response to chronic particle exposure. Inhal. Toxicol. 1996; 8: 139–153
  • Dunnett C. W. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 1955; 50: 1096–1121
  • Eiben R., Bomhard E. M. Trends in mortality, body weights and tumor incidences of Wistar rats over 20 years. Exp. Toxicol. Pathol. 1999; 51: 523–536, [PUBMED], [INFOTRIEVE], [CSA]
  • Feron V. J., Bruyntjes J. P., Woutersen R. A., Immel H. R., Appelman L. M. Nasal tumors in rats after short-term exposure to a cytotoxic concentration of formaldehyde. Cancer Letters 1988; 39: 101–111, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Gallagher J., Heinrich U., George M., Hendee L., Phillips D. H., Lewtas J. Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles. Carcinogenesis 1994; 15: 1291–1299, [PUBMED], [INFOTRIEVE], [CSA]
  • Gerde P., Muggenburg B. A., Lundborg M., Dahl A. R. The rapid alveolar absorption of diesel soot-adsorbed benzo[a]pyrene: bioavailability, metabolism and dosimetry of an inhaled particle-borne carcinogen. Carcinogenesis 2001; 22: 741–749, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Greim H., Borm P., Schins R., Donaldson K., Driscoll K., Hartwig A., Kuempel E., Oberdörster G., Speit G. Toxicity of fibers and particles-report of the workshop held in Munich, Germany, 26-27 October 2000. Inhal. Toxicol. 2001; 13: 737–754, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Gupta R. C. Enhanced sensitivity of 32P-postlabelling analysis of aromatic carcinogens: DNA adducts. Cancer Res. 1985; 45: 5656–5662, [PUBMED], [INFOTRIEVE]
  • Gupta R. C. 32P-postlabelling for detection of DNA adducts. Technologies for detection of DNA damage and mutations, G. P. Pfeiffer. Plenum Press, New York 1996; 45–61
  • Gupta R. C., Arif J. M., Gairola C. G. Enhancement of pre-existing DNA adducts in rodents exposed to cigarette smoke. Mutat. Res. 1999; 424: 195–205, [PUBMED], [INFOTRIEVE]
  • Guyton A. C. Measurement of the respiratory volumes of laboratory animals. Am. J. Physiol. 1947; 150: 70–77
  • Hammond W. G., Teplitz R. L., Benfield J. R. A step section method for full histopathological assessment of carcinogen-affected target tissue during respiratory carcinogenesis. Microsc. Res. Tech. 1993; 26: 466–471, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Harrison P. T. An ethanol-acetic acid-formol saline fixative for routine use with special application to the fixation of non-perfused rat lung. Lab. Anim. 1984; 18: 325–331, [PUBMED], [INFOTRIEVE]
  • Haussmann H. -J., Anskeit E., Becker D., Kuhl P., Stinn W., Teredesai A., Voncken P., Walk R. -A. Comparison of fresh and room-aged cigarette sidestream smoke in a subchronic inhalation study on rats. Toxicol. Sci. 1998a; 41: 100–116, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Haussmann H. -J., Anskeit E., Kuhl P., Rustemeier K., Schepers G., Schnell P., Terpstra P. M. The influence of diesel engine exhaust age on lung soot burden and related responses in rats. Relationship between respiratory disease and exposure to air pollution, U. Mohr. ILSI Press, Washington, DC 1998b; 338–342
  • Haussmann H. -J., Gerstenberg B., Goecke W., Kuhl P., Schepers G., Stabbert R., Stinn W., Teredesai A., Tewes F., Anskeit E., Terpstra P. 12-Month inhalation study on room-aged cigarette sidestream smoke in rats. Inhal. Toxicol. 1998c; 10: 663–697, [CROSSREF]
  • Heinrich U., Fuhst R., Rittinghausen S., Creutzenberg O., Bellmann B., Koch W., Levsen K. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal. Toxicol. 1995; 7: 533–556
  • Heinrich U., Muhle H., Takenaka S., Ernst H., Fuhst R., Mohr U., Pott F., Stöber W. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions. J. Appl. Toxicol. 1986; 6: 383–395, [PUBMED], [INFOTRIEVE]
  • Henderson R. F., Pickrell J. A., Jones R. K., Sun J. M., Benson J. M., Mauderly J. L., McClellan R. O. Response of rodents to inhaled diluted diesel exhaust: biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue. Fund. Appl. Toxicol. 1988; 11: 546–567, [CROSSREF], [CSA]
  • Ichinose T., Yamanushi T., Seto H., Sagai M. Oxygen radicals in lung carcinogenesis accompanying phagocytosis of diesel exhaust particles. Int. J. Oncol. 1997; 11: 571–575
  • International Agency for Research on Cancer. Tobacco smoke and involuntary smoking. IARC Monogr. Eval. Carcinog. Risks Hum. IARC, LyonFrance 2004; vol. 83: 1191–1413
  • International Organization for Standardization. Routine analytical cigarette-smoking machine. Definitions and standard conditions. Third edition. International Standard ISO 3308, GenevaSwitzerland 1991a
  • International Organization for Standardization. Tobacco and tobacco products. Atmosphere for conditioning and testing. Third edition. International Standard ISO 3402, GenevaSwitzerland 1991b
  • Ishihara Y., Kagawa J. Dose-response assessment and effect of particles in guinea pigs exposed chronically to diesel exhaust: analysis of various biological markers in pulmonary alveolar lavage fluid and circulating blood. Inhal. Toxicol. 2002; 14: 1049–1067, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Ishihara Y., Kagawa J. Chronic diesel exhaust exposures of rats demonstrate concentration and time-dependent effects on pulmonary inflammation. Inhal. Toxicol. 2003; 15: 473–492, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Iwai K., Adachi S., Takahashi M., Moller L., Udagawa T., Mizuno S., Sugawara I. Early oxidative DNA damages and late development of lung cancer in diesel exhaust-exposed rats. Environ. Res. 2000; 84: 255–264, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Iwai K., Higuchi K., Udagawa T., Ohtomo K., Kawabata Y. Lung tumor induced by long-term inhalation or intratracheal instillation of diesel exhaust particles. Exp. Toxicol. Pathol. 1997; 49: 393–401, [PUBMED], [INFOTRIEVE], [CSA]
  • Jenkins R. A., Guerin M. R., Tomkins B. A. The chemistry of environmental tobacco smoke: composition and measurement. Second edition. Lewis Publishers, Boca Raton, FL 2000
  • Kalbfleisch H. J., Prentice R. L. The Statistical Analysis of Failure Time Data. Second edition. John Wiley & Sons., Inc., Hoboken, NJ 2002
  • Kato A., Nagai A., Kagawa J. Morphological changes in rat lung after long-term exposure to diesel emissions. Inhal. Toxicol. 2000; 12: 469–490, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Kerényi T., Voss B. Cellular autofluorescent pigment and interstitial fibrosis in smoker's lung. Path. Res. Pract. 1992; 188: 925–930
  • Kittelson D. B. Engines and nanoparticles: A Review. J. Aerosol Sci. 1998; 29: 575–588, [CROSSREF], [CSA]
  • Klimisch H. J., Meißner K., Wernicke H. Quantitative determination of carbon monoxide in blood by gaschromatography. Chem. Klin. Biochem. 1974; 12: 535–538, [CSA]
  • Knaapen A. M., Borm P. J. A., Albrecht C., Schins R. P. F. Inhaled particles and lung cancer. Part A: Mechanisms. Int. J. Cancer 2004; 109: 799–809, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Koch C. G., Edwards E. Clinical efficiency trials with categorical data. Biopharmaceutical Statistics for Drug Development, K. E. Pearce. Marcel Dekker, New York 1988; 403–457
  • Lee C. K., Brown B. G., Reed B. A., Rahn C. A., Coggins C. R. E., Doolittle D. J., Hayes A. W. Fourteen-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette. Fundam. Appl. Toxicol. 1992; 19: 141–146, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Lee C. K., Brown B. G., Reed E. A., Coggins C. R. E., Doolittle D. J., Hayes A. W. Ninety-day inhalation study in rats, using aged and diluted sidestream smoke from a reference cigarette: DNA adducts and alveolar macrophage cytogenetics. Fundam. Appl. Toxicol. 1993; 20: 393–401, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Lewis D. J. Factors affecting the distribution of tobacco smoke-induced lesions in the rodent larynx. Toxicol. Lett. 1981; 9: 189–194, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Lewis D. J. Morphological assessment of pathological changes within the rat larynx. Toxicol. Pathol. 1991; 19: 352–357, [PUBMED], [INFOTRIEVE]
  • Lipsett M., Campleman S. Occupational exposure to diesel exhaust and lung cancer: A meta-analysis. Am. J. Public Health 1999; 89: 1009–1017, [PUBMED], [INFOTRIEVE], [CSA]
  • Mantel N., Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J. Natl. Cancer. Inst. 1959; 22: 719–748, [PUBMED], [INFOTRIEVE]
  • Mauderly J. L., Jones R. K., Griffith W. C., Henderson R. F., McClellan R. O. Diesel exhaust is a pulmonary carcinogen in rats exposed chronically by inhalation. Fundam. Appl. Toxicol. 1987; 9: 208–221, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Mauderly J. L., Banas D. A., Griffith W. C., Hahn F. F., Henderson R. F., McClellan R. O. Diesel exhaust is not a pulmonary carcinogen in CD-1 mice exposed under conditions carcinogenic to F344 rats. Fundam. Appl. Toxicol. 1996; 30: 233–242, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Mauderly J. L. Diesel exhaust. Environmental toxicants - Human exposures and their health effects, M. Lippmann. Wiley, New York 2000; 193–241
  • Mauderly J. L., Gigliotti A. P., Barr E. B., Bechtold W. E., Belinsky S. A., Hahn F. F., Hobbs C. A., March T. H., Seilkop S. K., Finch G. L. Chronic inhalation exposure to mainstream cigarette smoke increases lung and nasal tumor incidence in rats. Toxicol. Sci. 2004; 81: 280–292, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Miller F. J. Dosimetry of inhaled gases. Respiratory toxicology and risk assessment, E. M. Smith, D. Kayser, H. Muhle. WVG, Stuttgart 1994; 111–144
  • Miller F. J. Dosimetry of particles in laboratory animals and humans in relationship to issues surrounding lung overload and human health risk assessment: a critical review. Inhal. Toxicol. 2000; 12(1-2)19–57, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Mohr U., Rittinghausen S., Takenaka S., Ernst H., Dungworth D. L., Pylev L. N. Tumours of the lower respiratory tract and pleura of the rat. Pathology of Tumours in Laboratory Animals, V. Turusov, U. Mohr. IARC, Lyon 1990; vol 1
  • Mohtashamipur E., Mohtashamipur A., Germann P. G., Ernst H., Norpoth K., Mohr U. Comparative carcinogenicity of cigarette mainstream and sidestream smoke condensates on the mouse skin. J. Cancer Res. Clin. Oncol. 1990; 116: 604–608, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Morrow P. E., Haseman J. K., Hobbs C. H., Driscoll K. E., Vu V., Oberdörster G. The maximum tolerated dose for inhalation bioassays: Toxicity vs. overload. Fundam. Appl. Toxicol. 1996; 29: 155–167, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Muhle H., Bellmann B., Creutzenberg O., Fuhst R., Koch W., Mohr U., Takenaka S., Morrow P., Kilpper R., MacKenzie J., Mermelstein R. Subchronic inhalation study of toner in rats. Inhal. Toxicol. 1990; 2: 341–360, [CSA]
  • Muscat J. E. Carcinogenic effects of diesel emissions and lung cancer: The epidemiologic evidence is not causal. J. Clin. Epidemiol. 1996; 49: 891–892, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • National Cancer Institute. Health effects of exposure to environmental tobacco smoke: The report of the California Environmental Protection Agency. Smoking and Tobacco Control Monograph, U.S. Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda, MD 1999, NIH Pub. No. 99-4645. no. 10
  • National Toxicology Program. Specifications for the conduct of studies to evaluate the toxic and carcinogenic potential of chemical, biological and physical agents in laboratory animals for the National Toxicology Program. Research Triangle Park, NC 1991
  • Nikula K. J., Avila K. J., Griffith W. C., Mauderly J. L. Lung tissue responses and sites of particle retention differ between rats and cynomolgus monkeys exposed chronically to diesel exhaust and coal dust. Fundam. Appl. Toxicol. 1997; 37: 37–53, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Nikula K. J., Snipes M. B., Barr E. B., Griffith W. C., Henderson R. F., Mauderly J. L. Comparative pulmonary toxicities and carcinogenicities of chronically inhaled diesel exhaust and carbon black in F344 rats. Fundam. Appl. Toxicol. 1995; 25: 80–94, [CROSSREF], [CSA]
  • Nikula K. J., Vallyathan V., Green F. H. Y., Hahn F. F. Influence of exposure concentration or dose on the distribution of particulate material in rat and human lungs. Environ. Health Perspect. 2001; 109: 311–318, [PUBMED], [INFOTRIEVE], [CSA]
  • Ning Z., Cheung C. S., Liu S. X. Experimental investigation on the effect of exhaust gas cooling on diesel particulate. J. Aerosol Sci. 2004; 35: 333–345, [CROSSREF]
  • Oberdörster G. Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose. Environ. Health Perspect. 1997; 105: 1347–1355, [CSA]
  • OECD. Carcinogenicity studies. OECD Guideline for the testing of chemicals. Organization for Economic Cooperation and Development, Paris 1981, No. 451
  • Pepelko W. E., Peirano W. B. Health effects of exposure to diesel engine emissions. A summary of animal studies conducted by the U.S. Environmental Protection Agency's research laboratories at Cincinnati, Ohio. J. Am. Coll. Toxicol. 1983; 2: 253–306
  • Peto R., Pike M. C., Day N. E., Gray R. G., Lee P. N., Parish S., Peto J., Richards S., Wahrendorf J. Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. Long-term and short-term screening assays for carcinogens: a critical appraisal. IARC, LyonFrance 1980; 311–426
  • Pottenger L. H., Penman M., Moore N. P., Priston R. A. J., Thomas M. Biological significance of DNA adducts: summary of discussion of expert panel. Regul. Toxicol. Pharmacol. 2004; 39: 403–408, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Randerath K., Putman K. L., Mauderly J. L., Williams P., Randerath E. Pulmonary toxicity of inhaled diesel exhaust and carbon black in chronically exposed rats. Part II: DNA damage. Health Effects Institute, Boston, MA 1995
  • Rausch L. J., Bisinger E. C., Sharma A. Carbon black should not be classified as a human carcinogen based on rodent bioassay data. Regul. Toxicol. Pharmacol. 2004; 40: 28–41, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Reddy M. V., Randerath K. Nuclease P1-mediated enhancement of sensitivity of 32P-postlabelling for structurally diverse DNA adducts. Carcinogenesis 1986; 7: 1543–1551, [PUBMED], [INFOTRIEVE], [CSA]
  • Reddy M. V., Randerath K. Nuclease P1-enhanced 32P-postlabelling assay for aromatic carcinogen-DNA adducts. Methods Toxicol. 1994; 1B: 201–215
  • Reed M. D., Gigliotti A. P., McDonald J. D., Seagrave J. C., Seilkop S. K., Mauderly J. L. Health effects of subchronic exposure to environmental levels of diesel exhaust. Inhal. Toxicol. 2004; 16: 177–193
  • Rehm S., Ward J. M. Quantitative analysis of alveolar type II cell tumors in mice by whole lung serial and step sections. Toxicol. Pathol. 1989; 17: 737–742, [PUBMED], [INFOTRIEVE]
  • Roemer E., Stabbert R., Rustemeier K., Veltel D. J., Meisgen T. J., Reininghaus W., Carchman R. A., Gaworski C. L., Podraza K. F. Chemical composition, cytotoxicity and mutagenicity of smoke from US commercial and reference cigarettes smoked under two sets of machine smoking conditions. Toxicology 2004; 195: 31–52, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Rustemeier K., Demetriou D., Schepers G., Voncken P. High-performance liquid chromatographic determination of nicotine and its urinary metabolites via their 1,3-diethyl-12-thiobarbituric acid derivatives. J. Chromatogr. 1993; 613: 95–103, [PUBMED], [INFOTRIEVE]
  • Schauer J. J. Evaluation of elemental carbon as a marker for diesel particulate matter. J. Expo. Anal. Environ. Epidemiol. 2003; 13: 443–453, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Schepers G., Rustemeier K., Walk R. -A., Hackenberg U. Metabolism of S-nicotine in noninduced and Aroclor-induced rats. Eur. J. Drug Metab. Pharmacokinet 1993; 18(2)187–197, [PUBMED], [INFOTRIEVE]
  • Schilhabel J., Levsen K. Identification of nitrated polycyclic hydrocarbons by negative ion chemical ionization and tandem mass spectrometry. Fres. J. Anal. Chem. 1989; 333: 800–805, [CROSSREF]
  • Sharma O. P., Lamb C. Cancer in interstitial pulmonary fibrosis and sarcoidosis. Curr. Opin. Pulm. Med. 2003; 9: 398–401, [PUBMED], [INFOTRIEVE], [CROSSREF]
  • Sköld C. M., Eklund A., Hed J., Hambrand R. Endocytosis of cigarette smoke condensate by rabbit alveolar macrophages in vitro measured as fluorescence intensity. Eur. Respir. J. 1992; 5: 53–58
  • Singh P., DeMarini D. M., Dick C. A. J., Tabor D. G., Ryan J. V., Linak W. P., Kobayashi T., Gilmour M. I. Sample characterization of automobile and forklift diesel exhaust particles and comparative pulmonary toxicity in mice. Environ. Health Perspect. 2004; 112: 820–825, [PUBMED], [INFOTRIEVE], [CSA]
  • Stabbert R., Schepers G., Stinn W., Haussmann H. -J. Hemoglobin adducts in rats chronically exposed to room-aged cigarette sidestream smoke and diesel engine exhaust. Adv. Exp. Med. Biol. 2001; 500: 153–156, [PUBMED], [INFOTRIEVE], [CSA]
  • Stinn W., Teredesai A., Kuhl P., Knörr-Wittman C., Kindt R., Coggins C. R. E., Haussmann H. -J. Mechanisms involved in A/J mouse lung tumorigenesis induced by inhalation of an environmental tobacco smoke surrogate. Inhal. Toxicol. 2005, Accepted[CSA]
  • Stöber W., Abel U. R., McClellan R. O. Revisiting epidemiological key studies on occupational diesel exhaust exposure and lung cancer in truck drivers. Inhal. Toxicol. 1998; 10: 1045–1078, [CROSSREF]
  • Stöber W., Flachsbart H. Size-separating precipitation of aerosols in a spinning spiral duct. J. Environ. Sci. Tech. 1969; 3: 1280–1296, [CROSSREF]
  • Stöber W., Mauderly J. L. Model-inferred hypothesis of a critical dose for overload tumor induction by diesel soot and carbon black. Inhal. Toxicol. 1994; 6: 427–457, [CSA]
  • Stöber W., McClellan R. O. Pulmonary retention and clearance of inhaled biopersistent aerosol particles: Data-reducing interpolation models and models of physiologically based systems - A review of recent progress and remaining problems. Crit. Rev. Toxicol. 1997; 27: 539–598, [CSA]
  • Stöber W., Morrow P. E., Oberdörster G. Pulmonary retention of inhaled anatase (TiO2) aerosols and lung tumor induction in rats simulated by a physiology-oriented model. Inhal. Toxicol. 1995; 7: 1059–1074
  • Teredesai A., Prühs D. Histopathological findings in the rat and hamster respiratory tract in a 90-day inhalation study using fresh sidestream smoke of the standard reference cigarette 2R1. Toxic and carcinogenic effects of solid particles in the respiratory tract, U. Mohr, D. L. Dungworth, J. Mauderly, G. Oberdörster. ILSI Press, Washington, DC 1994; 629–635
  • Thun M. J., Henley S. J., Gansler T. Inflammation and cancer: an epidemiological perspective. Novartis. Found. Symp. 2004; 256: 6–21
  • Tyuma I., Ueda Y., Imaizumi K. Prediction of the carbonmonoxyhemoglobin levels during and after carbon monoxid exposure in various animal species. Jpn. J. Physiol. 1981; 31: 131–143, [PUBMED], [INFOTRIEVE], [CSA]
  • U.S. Department of Health and Human Services. Tenth Report on carcinogens. Public Health Service, National Toxicology Program, Research Triangle Park, NC 2002
  • U.S. Environmental Protection Agency. Respiratory health effects of passive smoking: lung cancer and other disorders. USEPA/600/6-90-006F, Washington, DC 1992
  • Valberg P. A., Crouch E. A. C. Meta-analysis of rat lung tumors from lifetime inhalation of diesel exhaust. Environ. Health Perspect. 1999; 107: 693–699, [PUBMED], [INFOTRIEVE], [CSA]
  • von Meyerinck L., Scherer G., Adlkofer F., Wenzel-Hartung R., Brune H., Thomas C. Exposure of rats and hamsters to sidestream smoke from cigarettes in a subchronic inhalation study. Exp. Pathol. 1989; 37: 186–189, [PUBMED], [INFOTRIEVE]
  • Voncken P., Stinn W., Haussmann H. -J., Anskeit E. Influence of aging and surface contact on the composition of cigarette sidestream smoke - models for environmental tobacco smoke. Toxic and carcinogenic effects of solid particles in the respiratory tract, U. Mohr, D. L. Dungworth, J. L. Mauderly, G. Oberdörster. ILSI, Washington, DC 1994; 637–641
  • Wiencke J. K. DNA adduct burden and tobacco carcinogenesis. Oncogene 2002; 21: 7376–7391, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Witschi H. Successful and not so successful chemoprevention of tobacco smoke-induced lung tumors. Exp. Lung Res. 2000; 26: 743–755, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Witschi H., Espiritu I., Maronpot R. R., Pinkerton K. E., Jones A. D. The carcinogenic potential of the gas phase of environmental tobacco smoke. Carcinogenesis 1997; 18: 2035–2042, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Witschi H., Espiritu I., Uyeminami D., Suffia M., Pinkerton K. E. Lung tumor response in strain-A mice exposed to tobacco smoke: some dose-effect relationships. Inhal. Toxicol. 2004; 16: 27–32, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Witschi H., Oreffo V. I. C., Pinkerton K. E. Six-month exposure of strain A/J mice to cigarette sidestream smoke: cell kinetics and lung tumor data. Fundam. Appl. Toxicol. 1995; 26: 32–40, [PUBMED], [INFOTRIEVE], [CROSSREF], [CSA]
  • Young J. T. Histopathological examination of the rat nasal cavity. Fundam. Appl. Toxicol. 1981; 1: 309–312, [PUBMED], [INFOTRIEVE]
  • Zaebst D. D., Clapp D. E., Blade L. M., Marlow D. A., Steenland K., Hornung R. W., Scheutzle D., Butler J. P. Quantitative determination of trucking industry workers' exposure to diesel exhaust particles. Am. Ind. Hyg. Assoc. J. 1991; 52: 529–541, [PUBMED], [INFOTRIEVE], [CSA]

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