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Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 3
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Research Article

Heterogeneities in Inflammatory and Cytotoxic Responses of RAW 264.7 Macrophage Cell Line to Urban Air Coarse, Fine, and Ultrafine Particles From Six European Sampling Campaigns

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Pages 213-225 | Received 31 Jul 2006, Accepted 28 Sep 2006, Published online: 06 Oct 2008

REFERENCES

  • Anderson H. R., Atkinson R. W., Peacock J. L., Marston L., Konstantinou K. Meta-analysis of time-series studies and panel studies of particulate matter (PM) and ozone (O3). Report EUR/04/5042688 of a WHO task group. WHO Regional Office for Europe, Copenhagen, Denmark 2004
  • Atkinson R. W., Anderson H. R., Sunyer J., Ayres J., Baccini M., Vonk J. M., Boumghar A., Forastiere F., Forsberg B., Touloumi G., Schwartz J., Katsouyanni K. Acute effects of particulate air pollution on respiratory admissions: Results from APHEA 2 project. Am. J. Respir. Crit. Care Med. 2001; 164: 1860–1866
  • Baird W. M., Kaspin C., Kudla K., Seidel A., Greim H., Luch A. Relationship of dibenzo[a,l]pyrene–DNA binding to the induction of p53, p21(WAF1) and cell cycle arrest in human cells in culture. Polycycl. Aromat. Comp. 1999; 16: 119–129
  • Becker S., Soukup J. M. Coarse (PM2.5−10), fine (PM2.5) and ultrafine air pollution particles induce/increase immune costimulatory receptors on human blood-derived monocytes but not on alveolar macrophages. J. Toxicol. Environ. Health A 2003; 66: 847–859
  • Becker S., Soukup J. M., Gallagher J. E. Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages. Toxicol. In Vitro 2002; 16: 209–218
  • Becker S., Soukup J. M., Sioutas C., Cassee F. Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles. Exp. Lung Res. 2003; 29: 29–44
  • Becker S., Dailey L. A., Soukup J. M., Grambow S. C., Devlin R. B., Huang Y.-C. Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. Environ. Health Perspect. 2005; 113: 1032–1038
  • Binková B., Giguère Y., Rössner P., Dostál M., Šram R. J. The effect of dibenzo[a,l]pyrene and benzo[a]pyrene on human diploid lung fibroblasts: The induction of DNA adducts, expression of p53 and p21WAF1 proteins and cell cycle distribution. Mutat. Res 2000; 471: 57–70
  • Binková B., Černá M., Pastorovká A., Jel R., Beneš I., Novák J., Šrám R. J. Biological activities of organic compounds absorbed onto ambient air particles: Comparison between the cities of Teplice and Prague during the summer and winter seasons 2000–2001. Mutat. Res. 2003; 525: 43–59
  • Brook R. D., Franklin B., Cascio W., Hong Y., Howard G., Lipsett M., Luepker R., Mittleman M., Samet J., Smith S. C., Tager I. Air pollution and cardiovascular disease: A statement for healthcare professionals from the expert panel on population and prevention science of the American Heart Association. Circulation 2004; 109: 2655–2671
  • Brunekreef B., Forsberg B. Epidemiological evidence of effects of coarse airborne particles on health. Eur. Respir. J. 2005; 26(2)309–318
  • Brunekreef B., Holgate S. T. Air pollution and health. Lancet 2002; 360: 1233–1244
  • Clancy L., Goodman P., Sinclair H., Dockery D. W. Effect of air-pollution control on death rates in Dublin, Ireland: An intervention study. Lancet 2002; 360: 1210–1214
  • Dybing E., Lovdal T., Hetland R. B., Lovik M., Schwarze P. E. Respiratory allergy adjuvant and inflammatory effects of urban ambient particles. Toxicology 2004; 198: 307–314
  • Farmer P. B., Singh R., Kaur B., Sram R. J., Binkova B., Kalina I., Popov T. A., Garte S., Taioli E., Gabelova A., Cebulska-Wasilewska A. Molecular epidemiology studies of carcinogenic environmental pollutants: Effects of polycyclic aromatic hydrocarbons (PAHs) in environmental pollution on exogenous and oxidative DNA damage. Mutat. Res. 2003; 544: 397–402
  • Green L. C., Wagner D. A., Glogowski J., Skipper P. L., Wishnok J. S., Tannebaum S. R. Analysis of nitrate, nitrite and [15N] nitrate in biological fluids. Anal. Biochem 1982; 126: 131–138
  • Hetland R. B., Cassee F. R., Låg M., Refsnes M., Dybing E., Schwarze P. E. Cytokine release from alveolar macrophages exposed to ambient particulate matter: Heterogeneity in relation to size, city and season. Part. Fibre Toxicol 2005; 2: 4
  • Hetland R. B., Cassee F. R., Refsnes M., Schwarze P. E., Låg M., Boere A. J. F., Dybing E. Release of inflammatory cytokines, cell toxicity and apoptosis in epithelial lung cells after exposure to ambient air particles of different size fractions. Toxicol. In Vitro 2004; 18: 203–212
  • Hoek G., Brunekreef B., Goldbohm S., Fischer P., van den Brandt P. A. Association between mortality and indicators of traffic-related air pollution in the Netherlands: A cohort study. Lancet 2002; 360: 1203–1209
  • Imrich A., Ning Y. Y., Kobzik L. Insoluble components of concentrated air particles mediate alveolar macrophage responses in vitro. Toxicol. Appl. Pharmacol 2000; 167: 140–150
  • Jalava P., Salonen R. O., Hälinen A. I., Sillanpää M., Sandell E., Hirvonen M.-R. Effects of sample preparation on chemistry, cytotoxicity and inflammatory responses induced by air particulate matter. Inhal. Toxicol. 2005; 17: 107–117
  • Jalava P. I., Salonen R. O., Hälinen A. I., Pennanen A. S., Sillanpää M., Hillamo R., Hirvonen M.-R. In-vitro inflammatory and cytotoxic effects of size-segregated particulate samples collected during long-range transport of wildfire smoke to Helsinki. Toxicol. Appl. Pharmacol 2006; 215: 341–353
  • Janssen N. A. H., Brunekreef B., van Vliet P., Aarts F., Meliefste K., Harssema H., Fischer P. The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ. Health Perspect. 2003; 111: 1512–1518
  • Laden F., Neas L. M., Dockery D. W., Schwartz J. Associations of fine particulate matter from different sources with daily mortality in six U.S. cities. Environ. Health Perspect 2000; 108: 941–947
  • Lanki T., de Hartog J. J., Heinrich J., Hoek G., Janssen N. A. H., Peters A., Stölzel M., Timonen K. L., Vallius M., Vanninen E., Pekkanen J. Can we identify sources of fine particles responsible for exercise-induced ischemia on days with elevated air pollution? The ULTRA study. Environ. Health Perspect. 2006; 114: 655–660
  • Molinelli A. R., Madden M. C., McGee J. K., Stonehuerner J. G., Ghio A. J. Effect of metal removal on the toxicity of airborne particulate matter from Utah Valley. Inhal. Toxicol 2002; 14: 1069–1086
  • Monn C., Becker S. Cytotoxicity and induction of proinflammatory cytokines from human monocytes exposed to fine (PM2.5) and coarse particles (PM10−2.5) in outdoor and indoor air. Toxicol. Appl. Pharmacol 2002; 155: 245–252
  • Monn C., Naef R., Koller T. Reactions of macrophages exposed to particles < 10 μ m. Environ. Res. 2003; 91: 35–44
  • Osornio-Vargas Á.R., Bonner J. C., Alfaro-Moreno E., Martinez L., Garcia-Cuellar C., Ponce-de-León Rosales S., Miranda J., Rosas I. Proinflammatory and cytotoxic effects of Mexico City air pollution particulate matter in vitro are dependent on particle size and composition. Environ. Health Perspect 2003; 111: 1289–1293
  • Penttinen P., Pelkonen J., Huttunen K., Toivola M., Hirvonen M.-R. Interactions between Streptomyces californicus and Stachybotrys chartarum can induce apoptosis and cell cycle arrest in mouse RAW264.7 macrophages. Toxicol. Appl. Pharmacol 2005; 202: 278–288
  • Phalen R. F., Oldham M. J., Nel A. E. Tracheobronchial particle dose considerations for in vitro toxicology studies. Toxicol. Sci. 2006; 92: 126–132
  • Pope C. A., III, Dockery D. W., Spengler J. D., Raizenne M. E. Respiratory health and PM10 pollution: A daily time series analysis. Am. Rev. Respir. Dis 1991; 144: 668–674
  • Pope C. A., III, Burnett R. T., Thurston G. D., Thun M. J., Calle E. E., Krewski D., Godleski J. J. Cardiovascular mortality and long-term exposure to air pollution particles—Epidemiological evidence of pathophysiological pathways of disease. Circulation 2004; 109: 71–77
  • Pozzi R., De Berardis B., Paoletti L., Guastadisegni C. Inflammatory mediators induced by coarse (PM2.5−10) and fine (PM2.5) urban air particles in RAW 264.7 cells. Toxicology 2003; 183: 243–254
  • Salonen R. O., Hälinen A. I., Pennanen A. S., Hirvonen M.-R., Sillanpää M., Hillamo R., Shi T., Borm P., Sandell E., Koskentalo T., Aarnio P. Chemical and in vitro toxicological characterization of wintertime and springtime urban-air particles with an aerodynamic diameter below 10 μm in Helsinki. Scand. J. Work Environ. Health 2004; 30(suppl. 2): 80–90
  • Samoli E., Analitis A., Touloumi G., Schwartz J., Anderson H. R., Sunyer J., Bisanti L., Zmirou D., Vonk J. M., Pekkanen J., Goodman P., Paldy A., Schindler C., Katsouyanni K. Estimating the exposure-response relationships between particulate matter and mortality within the APHEA multicity project. Environ. Health Perspect. 2005; 113: 88–95
  • Sillanpää M., Hillamo R., Mäkelä T., Pennanen A. S., Salonen R. O. Field and laboratory tests of a high volume cascade impactor. J. Aerosol Sci. 2003; 34: 485–500
  • Sillanpää M., Frey A., Hillamo R., Makkonen U., Sandell E., Pennanen A. S., Salonen R. O. The PM10 mass concentrations of benzo[a]pyrene and carcinogenic heavy metals during contrasting air pollution situations in Europe (PAMCHAR). J. Aerosol Sci. 2004; 35(suppl. 1): S461–S462
  • Sillanpää M., Frey A., Hillamo R., Pennanen A. S., Salonen R. O. Organic, elemental and inorganic carbon in particulate matter of six urban environments in Europe. Atmos. Chem. Phys. 2005; 5: 2869–2879
  • Sillanpää M., Hillamo R., Saarikoski S., Frey A., Pennanen A. S., Makkonen U., Spolnik Z., van Grieken R., Branis M., Brunekreef B., Chalbot M.-C., Kuhlbusch T., Sunyer J., Kerminen V.-M., Kulmala M., Salonen R. O. Chemical composition and mass closure of particulate matter at six urban sites in Europe. Atmos. Environ 2006; 40: S212–S223
  • Upadhyay D., Vijayalakshmi P., Ghio A., Kamp D. W. Particulate matter induces epithelial cell DNA damage and apoptosis: Role of free radicals and mitochondria. Am. J. Respir. Cell Mol. Biol. 2003; 29: 180–187
  • U.S. Environmental Protection Agency. Air quality criteria for particulate matter. National Center for Environmental Assessment–RTP Office. U.S. EPA Office of Research and Development, Publication EPA/600/P-99/002aF., Research Triangle Park, NC 2004
  • World Health Organization. Selected non-heterocyclic polycyclic aromatic hydrocarbons. Environmental Health Criteria 202. WHO International Program of Chemical Safety (IPCS), Geneva, Switzerland 1998
  • World Health Organization. Health aspects of air pollution with particulate matter, ozone and nitrogen dioxide. Report EUR/03/5042688 of working group, Bonn, Germany, 13–15 January 2003. WHO Regional Office for Europe, Copenhagen, Denmark 2003
  • Xia T., Korge P., Weiss J. N., Li N., Venkatesen M. I., Sioutas C., Nel A. Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: Implications for ultrafine particulate toxicology. Environ. Health Perspect. 2004; 112: 1347–1358

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