Acute Toxic Effects of Nerve Agent VX on Respiratory Dynamics and Functions Following Microinsillation Inhalation Exposure in Guinea Pigs

REFERENCES

• Anthony J. S., Haley M., Manthei J., Way R., Burnett D., Gaviola B., Sommerville D., Crosier R., Mioduszewski R., Thomson S., Crouse C., Matson K. Inhalation toxicity of Cyclosarin (GF) vapor in rats as a function of exposure concentration and duration: potency comparison to sarin (GB). Inhal. Toxicol 2004; 16: 103–111
   PubMed Web of Science ®Google Scholar
• Anzueto A., Berdine G. G., Moore G. T., Gleiser C., Johnson D., White C. D., Johanson W. G., Jr. Pathophysiology of soman intoxication in primates. Toxicol. Appl. Pharmacol. 1986; 86: 56–68
   PubMed Web of Science ®Google Scholar
• Anzueto A., deLemos R. A., Seidenfeld J., Moore G., Hamil H., Johnson D., Jenkinson S. G. Acute inhalation toxicity of soman and sarin in baboons. Fundam. Appl. Toxicol. 1990; 14: 676–687
   PubMedGoogle Scholar
• Bajgar J., Sevelova L., Krejcova G., Fusek J., Vachek J., Kassa J., Herink J., de Jong L. P., Benschop H. P. Biochemical and behavioral effects of soman vapors in low concentrations. Inhal. Toxicol. 2004; 16: 497–507
   PubMed Web of Science ®Google Scholar
• Bargeton D., Barres G., Gauge P. [Pressure–volume relationship in air plethysmography.]. J. Physiol (Paris) 1964; 56: 282–283
   PubMedGoogle Scholar
• Bates J., Irvin C., Brusasco V., Drazen J., Fredberg J., Loring S., Eidelman D., Ludwig M., Macklem P., Martin J., Milic-Emili J., Hantos Z., Hyatt R., Lai-Fook S., Leff A., Solway J., Lutchen K., Suki B., Mitzner W., Pare P., Pride N., Sly P. The use and misuse of Penh in animal models of lung disease. Am. J. Respir. Cell Mol. Biol. 2004; 31: 373–374
   PubMed Web of Science ®Google Scholar
• Benschop H. P., Trap H. C., Spruit H. E., van der Wiel H. J., Langenberg J. P., de Jong L. P. Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs. Toxicol. Appl. Pharmacol. 1998; 153: 179–185
   PubMed Web of Science ®Google Scholar
• Bice D. E., Seagrave J., Green F. H. Animal models of asthma: Potential usefulness for studying health effects of inhaled particles. Inhal. Toxicol. 2000; 12: 829–862
   PubMed Web of Science ®Google Scholar
• Bide R. W., Risk D. J. Inhalation toxicity in mice exposed to sarin (GB) for 20–720 min. J. Appl. Toxicol. 2004; 24: 459–467
   PubMed Web of Science ®Google Scholar
• Buchanan K. C., Burge R. R., Ruble G. R. Evaluation of injectable anesthetics for major surgical procedures in guinea pigs. Contemp. Top. Lab. Anim. Sci. 1998; 37: 58–63
   PubMedGoogle Scholar
• Caranto G. R., Waibel K. H., Asher J. M., Larrison R. W., Brecht K. M., Schutz M. B., Raveh L., Ashani Y., Wolfe A. D., Maxwell D. M. Amplification of the effectiveness of acetylcholinesterase for detoxification of organophosphorus compounds by bis-quaternary oximes. Biochem. Pharmacol. 1994; 47: 347–357
   PubMed Web of Science ®Google Scholar
• Chand N., Nolan K., Pillar J., Lomask M., Diamantis W., Sofia R. D. Aeroallergen-induced dyspnea in freely moving guinea pigs: Quantitative measurement by bias flow ventilated whole body plethysmography. Allergy 1993; 48: 230–235
   PubMed Web of Science ®Google Scholar
• Chong B. T., Agrawal D. K., Romero F. A., Townley R. G. Measurement of bronchoconstriction using whole-body plethysmograph: Comparison of freely moving versus restrained guinea pigs. J. Pharmacol. Toxicol. Methods 1998; 39: 163–168
   PubMed Web of Science ®Google Scholar
• DeLorenzo R. A. Exposed. Signs, symptoms & EMS management of nerve-agent poisoning. JEMS 2001; 26: 48–57
   PubMedGoogle Scholar
• Drorbaugh J. E., Fenn W. O. A barometric method for measuring ventilation in newborn infants. Pediatrics 1955; 16: 81–87
   PubMed Web of Science ®Google Scholar
• Ghanei M., Fathi H., Mohammad M. M., Aslani J., Nematizadeh F. Long-term respiratory disorders of claimers with subclinical exposure to chemical warfare agents. Inhal. Toxicol. 2004; 16: 491–495
   PubMed Web of Science ®Google Scholar
• Graham J. R., Wright B. S., Rezk P. E., Gordon R. K., Sciuto A. M., Nambiar M. P. Butyrylcholinesterase in guinea pig lung lavage: A novel biomarker to assess lung injury following inhalation exposure to nerve agent VX. Inhal. Toxicol. 2006; 18: 493–500
   PubMed Web of Science ®Google Scholar
• Hartmann H. M. Evaluation of risk assessment guideline levels for the chemical warfare agents mustard, GB, and VX. Regul. Toxicol. Pharmacol. 2002; 35: 347–356
   PubMed Web of Science ®Google Scholar
• Holroyde M. C., Smith S. Y., Holme G. Evaluation of pulmonary mechanics in guinea pigs during respiratory anaphylaxis. J. Pharmacol. Exp. Ther. 1980; 212: 162–166
   PubMed Web of Science ®Google Scholar
• Hyams K. C., Murphy F. M., Wessely S. Responding to chemical, biological, or nuclear terrorism: the indirect and long-term health effects may present the greatest challenge. J. Health Polit. Policy Law 2002; 27: 273–291
   PubMed Web of Science ®Google Scholar
• Inoue N. [Neurological effects of chemical and biological weapons]. Rinsho Shinkeigaku 2003; 43: 880–882
   PubMedGoogle Scholar
• Jamal G. A. Long term neurotoxic effects of chemical warfare organophosphate compounds (Sarin). Adverse Drug React. Toxicol. Rev. 1995; 14: 83–84
   PubMedGoogle Scholar
• Jimmerson V. R., Shih T. M., Maxwell D. M., Kaminskis A., Mailman R. B. The effect of 2-(o-cresyl)-4H-1:3:2-benzodioxaphosphorin-2-oxide on tissue cholinesterase and carboxylesterase activities of the rat. Fundam. Appl. Toxicol. 1989a; 13: 568–575
   PubMedGoogle Scholar
• Jimmerson V. R., Shih T. M., Maxwell D. M., Mailman R. B. Cresylbenzodioxaphosphorin oxide pretreatment alters soman-induced toxicity and inhibition of tissue cholinesterase activity of the rat. Toxicol. Lett. 1989b; 48: 93–103
   PubMed Web of Science ®Google Scholar
• Kadivar H., Adams S. C. Treatment of chemical and biological warfare injuries: insights derived from the 1984 Iraqi attack on Majnoon Island. Mil. Med. 1991; 156: 171–177
   PubMed Web of Science ®Google Scholar
• Karalliedde L., Gauci C. A., Carter M. Chemical weapons. BMJ 1991; 302: 474
   PubMed Web of Science ®Google Scholar
• Karalliedde L., Wheeler H., Maclehose R., Murray V. Possible immediate and long-term health effects following exposure to chemical warfare agents. Public Health 2000; 114: 238–248
   PubMed Web of Science ®Google Scholar
• Kass R., Kochar G., Lippman M. Adult respiratory distress syndrome from organophosphate poisoning. Am. J. Emerg. Med. 1991; 9: 32–33
   PubMed Web of Science ®Google Scholar
• Kubin L., Fenik V. Pontine cholinergic mechanisms and their impact on respiratory regulation. Respir. Physiol. Neurobiol. 2004; 143: 235–249
   PubMed Web of Science ®Google Scholar
• Kuna S. T., Smickley J. S., Murchison L. C. Hypercarbic periodic breathing during sleep in a child with a central nervous system tumor. Am. Rev. Respir. Dis. 1990; 142: 880–883
   PubMed Web of Science ®Google Scholar
• Lainee P., Robineau P., Guittin P., Coq H., Benchetrit G. Mechanisms of pulmonary edema induced by an organophosphorus compound in anesthetized dogs. Fundam. Appl. Toxicol 1991; 17: 177–185
   PubMedGoogle Scholar
• Langenberg J. P., van der Schans G. P., Spruit H. E., Kuijpers W. C., Mars-Groenendijk R. H., Dijk-Knijnenburg H. C., Trap H. C., van Hel den H. P., Benschop H. P. Toxicokinetics of sulfur mustard and its DNA-adducts in the hairless guinea pig. Drug Chem. Toxicol 1998; 21(suppl. 1): 131–147
   PubMed Web of Science ®Google Scholar
• Little P. J., Reynolds M. L., Bowman E. R., Martin B. R. Tissue disposition of [3H]sarin and its metabolites in mice. Toxicol. Appl. Pharmacol. 1986; 83: 412–419
   PubMed Web of Science ®Google Scholar
• Little P. J., Scimeca J. A., Martin B. R. Distribution of [3H]diisopropylfluorophosphate, [3H]soman, [3H]sarin, and their metabolites in mouse brain. Drug Metab, Dispos. 1988; 16: 515–520
   PubMed Web of Science ®Google Scholar
• Martin T., Lobert S. Chemical warfare. Toxicity of nerve agents. Crit. Care Nurse 2003; 23: 15–20
   PubMedGoogle Scholar
• Masuda N., Takatsu M., Morinari H., Ozawa T. Sarin poisoning in Tokyo subway. Lancet 1995; 345: 1446
   PubMed Web of Science ®Google Scholar
• Maxwell D. M., Brecht K. M. The role of carboxylesterase in species variation of oxime protection against soman. Neurosci. Biobehav. Rev. 1991; 15: 135–139
   PubMed Web of Science ®Google Scholar
• Maxwell D. M., Brecht K. M., O'Neill B. L. The effect of carboxylesterase inhibition on interspecies differences in soman toxicity. Toxicol. Lett. 1987; 39: 35–42
   PubMed Web of Science ®Google Scholar
• Mergoni M., Rossi A. [Physiopathology of acute respiratory failure in COPD and asthma]. Minerva Anestesiol. 2001; 67: 198–205
   PubMedGoogle Scholar
• Mitzner W., Tankersley C. Interpreting Penh in mice. J. Appl. Physiol 2003; 94: 828–831
   PubMed Web of Science ®Google Scholar
• Munro N. Toxicity of the organophosphate chemical warfare agents GA, GB, and VX: Implications for public protection. Environ. Health Perspect. 1994; 102: 18–37
   PubMed Web of Science ®Google Scholar
• Nambiar M. P., Wright B. S., Smith K. B., Moran S. T., Richards S. M., Gordon R. K., Sciuto A. M. Development of a microinstillation model of inhalation exposure to assess lung injury following exposure to toxic chemicals and nerve agents. J. Toxicol. Mech. Methods 2006; 16: 295–307
   PubMed Web of Science ®Google Scholar
• Niven A. S., Roop S. A. Inhalational exposure to nerve agents. Respir. Care Clin. N. Am. 2004; 10: 59–74
   PubMedGoogle Scholar
• Nogues M. A., Roncoroni A. J., Benarroch E. Breathing control in neurological diseases. Clin. Auton. Res. 2002; 12: 440–449
   PubMed Web of Science ®Google Scholar
• Okumura T., Suzuki K., Fukuda A., Kohama A., Takasu N., Ishimatsu S., Hinohara S. The Tokyo subway sarin attack: Disaster management, Part 1: Community emergency response. Acad. Emerg. Med. 1998a; 5: 613–617
   PubMed Web of Science ®Google Scholar
• Okumura T., Suzuki K., Fukuda A., Kohama A., Takasu N., Ishimatsu S., Hinohara S. The Tokyo subway sarin attack: Disaster management, Part 2: Hospital response. Acad. Emerg. Med. 1998b; 5: 618–624
   PubMed Web of Science ®Google Scholar
• Okumura T., Takasu N., Ishimatsu S., Miyanoki S., Mitsuhashi A., Kumada K., Tanaka K., Hinohara S. Report on 640 victims of the Tokyo subway sarin attack. Ann. Emerg. Med. 1996; 28: 129–135
   PubMed Web of Science ®Google Scholar
• Roberts A. M., Bhattacharya J., Schultz H. D., Coleridge H. M., Coleridge J. C. Stimulation of pulmonary vagal afferent C-fibers by lung edema in dogs. Circ. Res. 1986; 58: 512–522
   PubMed Web of Science ®Google Scholar
• Sciuto A. M., Lee R. B., Forster J. S., Cascio M. B., Clapp D. L., Moran T. S. Temporal changes in respiratory dynamics in mice exposed to phosgene. Inhal. Toxicol 2002; 14: 487–501
   PubMed Web of Science ®Google Scholar
• Segura P., Chavez J., Montano L. M., Vargas M. H., Delaunois A., Carbajal V., Gustin P. Identification of mechanisms involved in the acute airway toxicity induced by parathion. Naunyn Schmiedebergs Arch. Pharmacol. 1999; 360: 699–710
   PubMed Web of Science ®Google Scholar
• Thorne P. S., Karol M. H. Assessment of airway reactivity in guinea pigs: Comparison of methods employing whole body plethysmography. Toxicology 1988; 52: 141–163
   PubMed Web of Science ®Google Scholar
• Vale A. What lessons can we learn from the Japanese sarin attacks?. Przegl. Lek. 2005; 62: 528–532
   PubMedGoogle Scholar
• van d er, Schans M. J., Lander B. J., van der W. H., Langenberg J. P., Benschop H. P. Toxicokinetics of the nerve agent (+/−)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration. Toxicol. Appl. Pharmacol. 2003; 191: 48–62
   PubMed Web of Science ®Google Scholar
• van Hel den H. P., Trap H. C., Kuijpers W. C., Oostdijk J. P., Benschop H. P., Langenberg J. P. Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis. J. Appl. Toxicol 2004; 24: 59–68
   PubMed Web of Science ®Google Scholar
• Vieillard-Baron A., Jardin F. The issue of dynamic hyperinflation in acute respiratory distress syndrome patients. Eur. Respir. J. Suppl 2003; 42: 43s–47s
   Google Scholar
• Vieillard-Baron A., Prin S., Schmitt J. M., Augarde R., Page B., Beauchet A., Jardin F. Pressure–volume curves in acute respiratory distress syndrome: Clinical demonstration of the influence of expiratory flow limitation on the initial slope. Am. J. Respir. Crit. Care Med. 2002; 165: 1107–1112
   PubMed Web of Science ®Google Scholar
• Volans G. N., Karalliedde L. Long-term effects of chemical weapons. Lancet 2002; 360 Suppl: s35–s36
   Web of Science ®Google Scholar
• Widdicombe J. Airway receptors. Respir. Physiol 2001; 125: 3–15
   PubMedGoogle Scholar
• Widdicombe J. Reflexes from the lungs and airways: Historical perspective. J. Appl. Physiol. 2006; 101: 628–634
   PubMed Web of Science ®Google Scholar
• Wright B. S., Rezk P. E., Graham J. R., Steele K. E., Gordon R. K., Sciuto A. M., Nambiar M. P. Acute lung injury following inhalation exposure to nerve agent VX in guinea pigs. Inhal. Toxicol. 2006; 18: 437–448
   PubMed Web of Science ®Google Scholar