Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 6-7
42
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Smokers Have Reduced Nitric Oxide Production by Conducting Airways but Normal Levels in the Alveoli

, , , , , , & show all
Pages 533-541 | Received 19 Sep 2006, Accepted 17 Jan 2007, Published online: 06 Oct 2008

REFERENCES

  • Adesina A. M., Vallyathan V., McQuillen E. N., Weaver S. O., Craighead J. C. Bronchiolar inflammation and fibrosis associated with smoking. Am. Rev. Respir. Dis. 1990; 143: 144–149
  • American Thoracic Society. Recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide in adults and children. Am. J. Respir. Crit. Care Med. 1999; 160: 2104–2117
  • Archie P. A. Mathematical coupling of data: a common source of error. Ann. Surg. 1981; 193: 296–303
  • Assrevy J., Cunha F. Q., Liew F. Y., Moncado S. Feedback inhibition of nitric oxide synthase by nitric oxide. Br. J. Pharmacol. 1993; 108: 833–837
  • Barberà J. A., Peinado V. I., Santo S., Ramirez J., Roca J., Rodriguez-Roisin R. Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. Am. J. Respir. Crit. Care Med. 2001; 164: 709–713
  • Borland C., Higenbottam T. Nitric oxide yields of contemporary UK, US and French cigarettes. Int. J. Epidemiol. 1987; 16: 31–34
  • Brindicci C., Ito K., Regto O., Pride N. B., Barnes P. J., Kharitonov S. A. Exhaled nitric oxide from lung periphery is increased in COPD. Eur. Respir. J. 2005; 26: 52–59
  • Buga G. M., Griscavage J. M., Rogers N. E., Ignarro L. J. Negative feedback regulations of endothelial cell function by nitric oxide. Circ. Res. 1993; 78: 808–812
  • Cosio M. G., Hale K. A., Niewoehrer D. E. Morphologic and morphometric effects of prolonged cigarette smoking on the small airways. Am. Rev. Respir. Dis. 1980; 122: 265–271
  • Girgis R. E., Gugnani M. K., Abrams J., Mayes M. D. Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease. Am. Rev. Respir. Crit. Care Med. 2002; 165: 1587–1591
  • George S. C., Högman M., Permutt S., Silkoff F. E. Modeling pulmonary nitric oxide exchange. J. Appl. Physiol. 2004; 96: 831–839
  • Guo F. H., DeRaeve H., Rise T. W., Stuehr D. J., Thunnissen F. B., Erzurum S. C. Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc. Natl. Acad. Sci. USA 1995; 93: 7809–7813
  • Högman M., Holmkuist T., Walinder R., Meriläinen P., Ludviksdottir D., Kakansson L., Hedenström H. Increased nitric oxide elimination from the airways after smoking cessation. Clin. Sci. 2002a; 103: 15–19
  • Högman M., Holmkuist T., Wegener T., Emtner M., Andersson M., Hedenström H., Meriläinen P. Extended NO analysis applied to patients with COPD, allergic asthma and allergic rhinitis. Respir. Med. 2002b; 96: 24–30
  • Högman M., Stromberg S., Schedin U., Frostell C., Hedenstierna G., Gustafsson L. E. Nitric oxide from the respiratory tract efficiently quantified by standardized single breath measurements. Acta Physiol. Scand. 1997; 159: 345–346
  • Hyde R. W., Geigel E. J., Olszowka A. J., Krasney J. A., Forster R. E., Utell M. J., Frampton M. W. Determination of production of nitric oxide by lower airways of humans—Theory. J. Appl. Physiol. 1997; 82: 1290–1296
  • Jarvis M. J., Tunstall-Pedoe H., Feyerabend C., Vesey C., Yussuf S. Comparison of tests used to distinguish smokers from nonsmokers. Am. J. Public Health 1987; 77: 1435–1438
  • Jorres R. A. Modelling the production of nitric oxide within the human airways. Eur. Respir. J. 2000; 16: 555–560
  • Kharitonov S., Alving K., Barnes P. T. Exhaled and nasal nitric oxide measurements. Eur. Respir. J. 1997; 10: 1683–1693
  • Kharitonov S. A., Robbins G. A., Yates D., Keatings V., Barnes P. J. Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am. J. Resp. Crit. Care Med. 1995; 152: 609–612
  • Lowenstein C. J., Snyder S. H. Nitric oxide, a novel biologic messenger. Cell 1992; 70: 705–707
  • Ludwig P. W., Hoidal J. R. Alterations in leukocyte oxidative metabolism in cigarette smokers. Am. Rev. Respir. Dis. 1982; 126: 977–980
  • Lehtimäki L., Kankaanranta H., Saarelainen S., Hahtola P., Järvenpää R., Koivula T., Turjanmaa V., Moilanen E. Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation. Am. J. Respir. Crit. Care Med. 2001; 163: 1557–1561
  • Meyer M., Schuster K. D., Schulz H., Mohr M., Piiper J. Pulmonary diffusing capacities for nitric oxide and carbon monoxide determined by rebreathing in dogs. J. Appl. Physiol. 1990; 68: 2344–2357
  • Morrow J. D., Frei B., Longmire A. W., Gaziano M., Lynch S. M., Shyr Y., Strauss W. E., Oates J. A., Roberts L. J. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. N. Engl. J. Med. 1995; 32: 1198–1203
  • Perillo I. B., Hyde R. W., Olszowka A., Pietropaoli A. P., Frasier L. M., Torres A., Perkins P. T., Forster R. E., Utell M. J., Frampton M. W. Chemiluminescent measurements of nitric oxide pulmonary diffusing capacity and alveolar production in humans. J. Appl. Physiol. 2001; 91: 1931–1940
  • Persson M. G., Zetterström O., Agrenius V., Ihre E., Gustafsson L. E. Single breath nitric oxide measurements in asthmatic patients and smokers. Lancet 1994; 343: 146–147
  • Pietropaoli A. P., Perillo I. B., Torres A., Perkins P. T., Frasier L. M., Utell M. J., Frampton M. W., Hyde R. W. Simultaeous measurement of nitric oxide production by conducting and alveolar airways of humans. J. Appl. Physiol. 1999; 87: 1532–1543
  • Pitt B. R., St. Croix C. M. Complex regulation of iNOS in lung. Am. J. Respir. Cell. Mol. Biol. 2002; 26: 6–9
  • Rengassamy A., Xue A. C., Johns R. A. Regulation of nitric oxide synthase by nitric oxide. Mol. Pharmacol. 1994; 44: 124–128
  • Ronco J. J., Phang P. T., Walley K. R., Wiggs B., Fenwick J. C., Russell J. A. Oxygen consumption is independent of changes in oxygen delivery in severe adult respiratory distress syndrome. Am. Rev. Respir. Dis. 1991; 143: 1267–1273
  • Roughton F. J. W. Transport of oxygen and carbon dioxide. Handbook of physiology, Section 3: Respiration. American Physiological Society, Washington, DC 1964; vol. I: 767–825
  • Silkoff P. E., McClean P. A., Caramori M., Slutsky A. S., Zamel N. A significant proportion of exhaled nitric oxide arises in large airways in normal subjects. Respir. Physiol. 1998; 113: 33–38
  • Silkoff P. E., Sylvester J. T., Zamel N., Permutt S. Aiway nitric oxide diffusion in asthma. Am. J. Respir. Crit. Care Med. 2000; 161: 1218–1228
  • Shin H.-W., Condorelli P., George S. C. A new and more accurate technique to characterize airway nitric oxide using different breath-hold times. J. Appl. Physiol. 2005; 98: 1869–1877
  • Shin H.-W., Condorelli P., Rose-Gottron C. M., Cooper D. M., George S. C. Probing the impact of axial diffusion on nitric oxide exchange dynamic with heliox. J. Appl. Physiol. 2004; 97: 874–882
  • Shin H.-W., George S. C. Impact of axial diffusion on nitric oxide exchange in the lungs. J. Appl. Physiol. 2002; 93: 2070–2080
  • Smith T. C., Rankin J. Pulmonary diffusing capacity and the capillary bed during Valsalva and Müller maneuvers. J. Appl. Physiol. 1969; 27: 826–833
  • Tockman M., Menkes H., Cohen B., Permutt S., Bengamiiv J., Ball W. C., Tomascia J. A comparison of pulmonary function in male smokers and non-smokers. Am. Rev. Respir. Dis. 1976; 114: 711–722
  • Tsoukias N. M., George S. C. A two compartment model of pulmonary nitric oxide exchange dynamics. J. Appl. Physiol. 1998; 85: 653–666
  • Van Muylem A., Nol C., Paiva M. Modeling of impact of gas molecular diffusion on nitric oxide expired profile. J. Appl. Phyiol. 2002; 94: 119–127
  • Weibel E. R. Morphometrics of the human lung. Academic Press, New York 1963
  • White K. A., Marletta M. A. Nitric oxide synthase is a cytochrome P-450 type hemoprotein. Biochemistry 1992; 31: 6627–6631

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.