Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 6-7
97
Views
19
CrossRef citations to date
0
Altmetric
Research Article

The Temporal Dynamics of Ozone-Induced FEV1 Changes in Humans: An Exposure-Response Model

, &
Pages 483-494 | Received 21 Nov 2006, Accepted 04 Jan 2007, Published online: 06 Oct 2008

REFERENCES

  • Adams W. C., Savin W. M., Christo A. E. Detection of ozone toxicity during continuous exercise via the effective dose concept. J. Appl. Physiol. Respir. Environ. Exercise Physiol. 1981; 51: 415–422
  • Adams W. C., Brookes K. A., Schelegle E. S. Effects of NO2 alone and in combination with O3 on young men and women. J. Appl. Physiol. 1987; 62: 1698–1704
  • Adams W. C. Relation of pulmonary responses induced by 6.6-h exposures to 0.08 ppm ozone and 2-h exposures to 0.30 ppm ozone via chamber and face-mask inhalation. Inhal. Toxicol. 2003; 15: 745–759
  • Adams W. C. Human pulmonary responses with 30-minute time intervals of exercise and rest when exposed for 8 hours to 0.12 ppm ozone via square-wave and acute triangular profiles. Inhal. Toxicol. 2006; 18: 413–422
  • Avol E. L., Linn W. S., Shamoo D. A., Valencia L. M., Anzar U. T., Venet T. G., Hackney J. D. Respiratory effects of photochemical oxidant air pollution in exercising adolescents. Am. Rev. Respir. Dis. 1985; 132: 619–622
  • Avol E. L., Linn W. S., Shamoo D. A., Spier C. E., Valencia L. M., Venet T. G., Trim S. C., Hackney J. D. Short-term respiratory effects of photochemical oxidant exposure in exercising children. J. Am. Pollut. Control Assoc. 1987; 37: 158–162
  • Balmes J. R., Chen L. L., Scannell C., Tager I., Christian D., Hearne P. Q., Kelly T., Aris R. M. Ozone-induced decrements in FEV1 do not correlate with measures of inflammation. Am. J. Respir. Crit. Care Med. 1996; 153: 904–909
  • Bush M. L., Asplund P. T., Miles K. A., Ben-Jebria A., Ultman J. S. Longitudinal distribution of O3 absorption in the lung: Gender differences and intersubject variability. J. Appl. Physiol. 1996; 81: 1651–1657
  • Drechsler-Parks D. M., Bedi J. F., Horvath S. M. Pulmonary function responses of older men and women to ozone exposure. Exp. Gerontol. 1987; 22: 91–101
  • Folinsbee L. J., Hazucha M. J. Time course of response to ozone exposure in healthy adult females. Inhal. Toxicol. 2000; 12: 151–167
  • Folinsbee L. J., Drinkwater B. L., Bedi J. F., Horvath S. M. The influence of exercise on the pulmonary function changes due to low concentrations of ozone. Environmental stress, L. J. Folinsbee, J. A. Wagner, J. F. Borgia, B. L. Drinkwater, J. A. Gliner, J. F. Bedi. Academic Press, New York 1978; 125–145
  • Folinsbee L. J., McDonnell W. F., Horstman D. H. Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone. J. Air Pollut. Control Assoc. 1988; 38: 28–35
  • Gliner J. A., Horvath S. M., Folinsbee L. J. Preexposure to low ozone concentrations does not diminish the pulmonary function response on exposure to higher ozone concentrations. Am. Rev. Respir. Dis. 1983; 127: 51–55
  • Hazucha M. J., Silverman F., Parent C., Field S., Bates D. V. Pulmonary function in man after short-term exposure to ozone. Arch. Environ. Health 1973; 27: 183–188
  • Hazucha M. J. Relationship between ozone exposure and pulmonary function changes. J. Appl. Physiol. 1987; 62: 1671–1680
  • Hazucha M. J., Folinsbee L. J., Seal E., Jr. Effects of steady-state and variable ozone concentration profiles on pulmonary function. Am. Rev. Respir. Dis. 1992; 146: 1487–1493
  • Hazucha M. J., Folinsbee L. J., Bromberg P. A. Distribution and reproducibility of spirometric response to ozone by gender and age. J. Appl. Physiol. 2003; 95: 1917–1925
  • Horstman D. H., Folinsbee L. J., Ives P. J., Abdul-Salaam S., McDonnell W. F. Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am. Rev. Respir. Dis. 1990; 142: 1158–1163
  • Horstman D. H., Ball B. A., Brown J., Gerrity T., Folinsbee L. J. Comparison of pulmonary responses of asthmatic and nonasthmatic subjects performing light exercise while exposed to a low level of ozone. Toxicol. Ind. Health 1995; 11: 369–385
  • Kehrl H. R., Vincent L. M., Kowalski R. J., Horstman D. H., O'Neil J. J., McCartney W. H., Bromberg P. A. Ozone exposure increases respiratory epithelial permeability in humans. Am. Rev. Respir. Dis. 1987; 135: 1124–1128
  • Koren H. S., Devlin R. B., Graham D. E., Mann R., McGee M. P., Horstman D. H., Kozumbo W. J., Becker S., House D. E., McDonnell W. F., Bromberg P. A. Ozone-induced inflammation in the lower airways of human subjects. Am. Rev. Respir. Dis. 1989; 139: 407–415
  • Kriebel D., Smith T. J. A nonlinear pharmacologic model of the acute effects of ozone on the human lungs. Environ. Res. 1990; 51: 120–146
  • Kulle T. J., Sauder L. R., Hebel J. R., Chatham M. D. Ozone response relationships in healthy nonsmokers. Am. Rev. Respir. Dis. 1985; 132: 36–41
  • Lauritzen S. K., Adams W. C. Ozone inhalation effects consequent to continuous exercise in females: Comparison to males. J. Appl. Physiol. 1985; 59: 1601–1606
  • Linn W. S., Avol E. L., Shamoo D. A., Peng R., Valencia L. M., Little D. L., Hackney J. D. Repeated laboratory ozone exposures of volunteer Los Angeles residents: An apparent seasonal variation in response. Toxicol. Ind. Health 1988; 4: 505–520
  • Linn W. S., Medway D. A., Anzar U. T., Valencia L. M., Spier C. E., Frank S.-D., Fischer A., Hackney J. D. Persistence of adaptation to ozone in volunteers exposed repeatedly for six weeks. Am. Rev. Respir. Dis. 1982; 125: 491–495
  • McDonnell W. F., Horstman D. H., Hazucha M. J., Seal E., Haak E. D., Salaam S., House D. E. Pulmonary effects of ozone exposure during exercise: Dose-response characteristics. J. Appl. Physiol. Respirat. Environ. Exercise Physiol. 1983; 54: 1345–1352
  • McDonnell W. F., Horstman D. H., Abdul-Salaam S., House D. E. Reproducibility of individual responses to ozone exposure. Am. Rev. Respir. Dis. 198; 131: 36–40
  • McDonnell W. F., Chapman R. S., Leigh M. W., Strope G. L., Collier A. M. Respiratory responses of vigorously exercising children to 0.12 ppm ozone exposure. Am. Rev. Respir. Dis. 1985; 132: 875–879
  • McDonnell W. F., Horstman D. H., Abdul-Salaam S., Raggio L. J., Green J. A. The respiratory responses of subjects with allergic rhinitis to ozone exposure and their relationship to nonspecific airway reactivity. Toxicol. Ind. Health 1987; 3: 507–517
  • McDonnell W. F. Individual variability in the magnitude of acute respiratory responses to ozone exposure. Susceptibility to inhaled pollutants, M. J. Utell, R. Frank. American Society for Testing and Materials, Philadelphia 1989; 75–88
  • McDonnell W. F., Kehrl H. R., Abdul-Salaam S., Ives P. J., Folinsbee L. J., Devlin R. B., O'Neil J. J., Horstman D. H. Respiratory responses of humans exposed to low levels of ozone for 6.6 hours. Arch. Environ. Health 1991; 46: 145–150
  • McDonnell W. F., Muller K. E., Bromberg P. A., Shy C. M. Predictors of individual differences in acute response to ozone exposure. Am. Rev. Respir. Dis. 1993; 147: 818–825
  • McDonnell W. F., Smith M. V. Description of acute ozone response as a function of exposure rate and total inhaled dose. J. Appl. Physiol. 1994; 76: 2776–2784
  • McDonnell W. F., Stewart P. W., Andreoni S., Smith M. V. Proportion of moderately exercising individuals responding to low-level, multi-hour ozone exposure. Am. J. Respir. Crit. Care Med. 1995; 152: 589–596
  • McDonnell W. F., Stewart P. W., Andreoni S., Seal E., Kehrl H. R., Horstman D. H., Folinsbee L. J., Smith M. V. Prediction of ozone-induced FEV1 changes:effects of concentration, duration and ventilation. Am. J. Respir. Crit. Care Med. 1997; 156: 715–722
  • McDonnell W. F., Stewart P. W., Smith M. V., Pan W. K., Pan J. Ozone-induced respiratory symptoms: Exposure-response models and association with lung function. Eur. Respir. J. 1999; 14: 845–853
  • McDonnell W. F. A method for identifying exposure—response models for the acute respiratory effects of inhaled irritants in humans: Effects of concentration, minute ventilation, and duration. Hum. Ecol. Risk Assess. 2001; 7: 1133–1144
  • Messineo T. D., Adams W. C. Ozone inhalation effects in females varying widely in lung size: Comparison with males. J. Appl. Physiol. 1990; 69: 96–1903
  • Miller F. J., Overton J. H., Jr., Jaskot R. H., Menzel D. B. A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol. Appl. Pharmacol. 1985; 79: 11–27
  • SAS Institute, Inc. SAS 9.1.3 help and documentation. SAS Institute, Inc., Cary, NC 2000–2004
  • Seal E., Jr., McDonnell W. F., House D. E., Salaam S. A., DeWitt P. J., Butler S. O., Green J., Raggio L. The pulmonary response of white and black adults to six concentrations of ozone. Am. Rev. Respir. Dis. 1993; 147: 804–810
  • Silverman F., Folinsbee L. J., Barnard J., Shephard R. J. Pulmonary function changes in ozone-interaction of concentration and ventilation. J. Appl. Physiol. 1976; 41: 859–864
  • Smith M. V., McDonnell W. F. A statistical model for FEV1 response to arbitrary dynamic ozone exposure conditions. J. Air Waste Manage. Assoc. 1999; 49: 289–298
  • Torres A., Utell M. J., Morrow P. E., Voter K. Z., Whitin J. C., Cox C., Looney R. J., Speers D. M., Tsai Y., Frampton M. W. Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am. J. Respir. Crit. Care Med. 1997; 156: 728–736
  • Weinmann G. G., Bowes S. M., Gerbase M. W., Kimball A. W., Frank R. Response to acute ozone exposure in healthy men: Results of a screening procedure. Am. J. Respir. Crit. Care Med. 1995; 151: 33–40

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.