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Inhalation Toxicology
International Forum for Respiratory Research
Volume 19, 2007 - Issue 11
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Research Article

Pulmonary Toxicity Screening Studies in Male Rats with M5 Respirable Fibers and Particulates

David B. Warheit DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
,
Thomas R. Webb DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
&
Kenneth L. Reed DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware, USA
Pages 951-963 | Received 09 Apr 2007, Accepted 14 May 2007, Published online: 06 Oct 2008

REFERENCES

  • Hesterberg T. W., McConnell E. E., Miiller W. C., Hamilton R., Bunn W. B. Pulmonary toxicity of inhaled polypropylene fibers in rats. Fundam. Appl. Toxicol. 1992; 19: 358–366
  • Lee K. P., Kelly D. P., O'Neal F. O., Stadler J. C., Kennedy G. L., Jr. Lung response to ultrafine Kevlar aramid synthetic fibrils following 2-year inhalation exposure in rats. Fundam. Appl. Toxicol. 1988; 11: 1–20
  • Warheit D. B., Carakostas M. C., Hartsky M. A., Hansen J. F. Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: Comparisons of pulmonary responses to carbonyl iron and silica. Toxicol. Appl. Pharmacol. 1991; 107: 350–368
  • Warheit D. B., Kellar K. A., Hartsky M. A. Pulmonary cellular effects in rats following aerosol exposures to ultrafine Kevlar® aramid fibrils: Evidence for biodegradability of inhaled fibrils. Toxicol. Appl. Pharmacol. 1992; 116: 225–239
  • Warheit D. B., Hansen J. F., Yuen I. S., Kelly D. P., Snajdr S., Hartsky M. A. Inhalation of high concentrations of low toxicity dusts in rats results in pulmonary and macrophage clearance impairments. Toxicol. Appl. Pharmacol. 1997a; 145: 10–22
  • Warheit D. B., Snajdr S. I., Hartsky M. A., Frame S. R. Rapid communication—Pulmonary responses to inhaled para-aramid fibrils in hamsters: Evidence of biodegradability in the lungs of a second rodent species. Inhal. Toxicol. 1997b; 9: 181–187
  • Warheit D. B., Hart G. A., Hesterberg T. W., Collins J. J., Dyer W. M., Swaen G. M. H., Castranova V., Soiefer A. I., Kennedy G. L., Jr. Potential pulmonary effects of man-made organic fiber dusts. Crit. Rev. Toxicol. 2001a; 31: 697–736
  • Warheit D. B., Hartsky M. A., Reed K. L., Webb T. R. Biodegradability of inhaled para-aramid RFP: Mechanistic in vivo and in vitro studies. Toxicol. Appl. Pharmacol. 2001b; 174: 78–88
  • Warheit D. B., Reed K. L., Webb T. R., Reed K. L., Hansen J. F., Kennedy G. L., Jr. Four-week inhalation toxicity study in rats with nylon respirable fibers: Rapid lung clearance. Toxicology 2003; 192: 189–210
  • Warheit D. B., Reed K. L., Stonehuerner J. D., Ghio A. J., Webb T. R. Biodegradability of para-aramid respirable-sized fiber-shaped particulates (RFP) in human lung cells. Toxicol. Sci. 2006; 89: 296–303

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