Concordance Between InVitro and InVivo Dosimetry in the Proinflammatory Effects of Low-Toxicity, Low-Solubility Particles: The Key Role of the Proximal Alveolar Region

REFERENCES

• Albrecht C., Adolf B., Weishaupt C., Hohr D., Zeittrager I., Friemann J., Borm P. J. Clara-cell hyperplasia after quartz and coal-dust instillation in rat lung. Inhal. Toxicol. 2001; 13(3)191–205
   PubMed Web of Science ®Google Scholar
• Aust A. E., Ball J. C., Hu A. A., Lighty J. S., Smith K. R., Straccia A. M., Veranth J. M., Young W. C. Particle characteristics responsible for effects on human lung epithelial cells. Res. Rep. Health Effects Inst. 2002; 110: 1–65
   PubMedGoogle Scholar
• Balashazy I., Hofmann W., Heistracher T. Local particle deposition patterns may play a key role in the development of lung cancer. J Appl. Physiol 2003; 94(5)1719–1725
   PubMed Web of Science ®Google Scholar
• Brown D. M., Wilson M. R., MacNee W., Stone V., Donaldson K. Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines. Toxicol. Appl. Pharmacol. 2001; 175(3)191–199
   PubMed Web of Science ®Google Scholar
• Chang L. Y., Huang Y., Stockstill B. L., Graham J. A., Grose E. C., Menache M. G., Miller F. J., Costa D. L., Crapo J. D. Epithelial injury and interstitial fibrosis in the proximal alveolar regions of rats chronically exposed to a simulated pattern of urban ambient ozone. Toxicol. Appl. Pharmacol. 1992; 115(2)241–252
   PubMed Web of Science ®Google Scholar
• Churg A., Colby T. V. Diseases caused by metals and related compounds. Pathology of occupational lung disease, 2nd ed., A. Churg, F. H. Y. Green. Williams & Wilkins, Baltimore, MD 1998; 77–128
   Google Scholar
• Churg A., Green F. Pathology of occupational lung disease, 2nd ed. Williams & Wilkins, Baltimore 1999
   Google Scholar
• Cullen R. T., Tran C. L., Buchanan D., Davis J. M., Searl A., Jones A. D., Donaldson K. Inhalation of poorly soluble particles. I. Differences in inflammatory response and clearance during exposure. Inhal. Toxicol. 2000; 12(12)1089–1111
   PubMedGoogle Scholar
• Donaldson K., Jimenez L. A., Rahman I., Faux S. P., MacNee W., Gilmour P. S., Borm P. J., Schins R. P. F., Shi T., Stone V. Respiratory health effects of ambient air pollution particles: Role of reactive species. Oxygen/nitrogen radicals: Lung injury and disease, V. Vallyathan, X. Shi, V. Castranova. Marcel Dekker, New York 2004, Vol. 187 in Lung Biology in Health and Disease
   Google Scholar
• Donaldson K., Stone V., Borm P. J., Jimenez L. A., Gilmour P. S., Schins R. P., Knaapen A. M., Rahman I., Faux S. P., Brown D. M., MacNee W. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radical Biol. Med 2003; 34(11)1369–1382
   PubMed Web of Science ®Google Scholar
• Donaldson K., Tran C. L. Inflammation caused by particles and fibers. Inhal. Toxicol. 2002; 14(1)5–27
   PubMed Web of Science ®Google Scholar
• Driscoll K. E. Macrophage inflammatory proteins—Biology and role in pulmonary inflammation. Exp. Lung Res. 1994; 20: 473–490
   PubMed Web of Science ®Google Scholar
• Driscoll K. E. TNFalpha and MIP-2: Role in particle-induced inflammation and regulation by oxidative stress. Toxicol. Lett. 2000; 112–113: 177–183
   PubMed Web of Science ®Google Scholar
• Driscoll K. E., Carter J. M., Hassenbein D. G., Howard B. Cytokines and particle-induced inflammatory cell recruitment. Environ. Health Perspect. 1997; 105: 1159–1164
   PubMed Web of Science ®Google Scholar
• Driscoll K. E., Hassenbein D. G., Carter J., Poynter J., Asquith T. N., Grant R. A., Whitten J., Purdon M. P., Takigiku R. Macrophage inflammatory proteins 1 and 2: expression by rat alveolar macrophages, fibroblasts, and epithelial cells and in rat lung after mineral dust exposure. Am. J. Respir. Cell Mol. Biol. 1993; 8(3)311–318
   PubMedGoogle Scholar
• Driscoll K. E., Hassenbein D. G., Howard B. W., Isfort R. J., Cody D., Tindal M. H., Suchanek M., Carter J. M. Cloning, expression, and functional-characterization of rat mip-2—A neutrophil chemoattractant and epithelial-cell mitogen. J. Leukocyte Biol. 1995; 58: 359–364
   PubMed Web of Science ®Google Scholar
• Duffin R., Clouter A., Brown D., Tran C. L., MacNee W., Stone V., Donaldson K. The importance of surface area and specific reactivity in the acute pulmonary inflammatory response to particles. Ann. Occup. Hyg. 2002; 46: 242–245, (Suppl. 1)
   Google Scholar
• Duffin R., Tran C. L., Brown D. M., Stone V., Donaldson K. Proinflammogenic effects of of nanoparticles in vivo in vitro: highlighting the role of particle surface area and surface reactivity. Inhal. Toxicol 2007; 19: 849–856
   PubMed Web of Science ®Google Scholar
• Gehr P., Mwangi D. K., Ammann A., Maloiy G. M., Taylor C. R., Weibel E. R. Design of the mammalian respiratory system. V. Scaling morphometric pulmonary diffusing capacity to body mass: Wild and domestic mammals. Respir. Physiol. 1981; 44(1)61–86
   PubMedGoogle Scholar
• Gibbs A. R. Pathological reactions of the lung to dust. Occupational lung diseases, W. K. C. Morgan, A. Seaton. W. B. Saunders, Philadelphia 1995; 127–157
   Google Scholar
• Gilmour P. S., Rahman I., Donaldson K., MacNee W. Histone acetylation regulates epithelial IL-8 release mediated by oxidative stress from environmental particles. Am. J. Physiol. Lung Cell Mol. Physiol. 2003; 284(3)L533–L540
   PubMed Web of Science ®Google Scholar
• Gilmour P. S., Ziesenis A., Morrison E. R., Vickers M. A., Drost E. M., Ford I., Karg E., Mossa C., Schroeppel A., Ferron G. A., Heyder J., Greaves M., MacNee W., Donaldson K. Pulmonary and systemic effects of short-term inhalation exposure to ultrafine carbon black particles. Toxicol. Appl. Pharmacol. 2004; 195(1)35–44
   PubMed Web of Science ®Google Scholar
• Girod C. E., King T. E., Jr. COPD: A dust-induced disease?. Chest 2005; 128(4)3055–3064
   PubMed Web of Science ®Google Scholar
• Green F. H. Y., Vallyathan V. Coal workers' pneumoconiosis and pneumoconiosis due to other carbonaceous dusts. Pathology of occupational lung disease, 2nd ed., A. Churg, F. H. Y. Green. Williams & Wilkins, Baltimore, MD 1998; 129–207
   Google Scholar
• Hetland R. B., Refsnes M., Myran T., Johansen B. V., Uthus N., Schwarze P. E. Mineral and/or metal content as critical determinants of particle-induced release of IL-6 and IL-8 from A549 cells. J. Toxicol. Environ. Health A 2000; 60(1)47–65
   PubMed Web of Science ®Google Scholar
• ILSI Workshop. The relevance of the rat lung response to particle overload for human risk assessment. Inhal. Toxicol. 2000; 12(1–2)
   Google Scholar
• Kim H., Liu X., Kobayashi T., Kohyama T., Wen F. Q., Romberger D. J., Conner H., Gilmour P. S., Donaldson K., MacNee W., Rennard S. I. Ultrafine carbon black particles inhibit human lung fibroblast-mediated collagen gel contraction. Am. J. Respir. Cell Mol. Biol. 2003; 28(1)111–121
   PubMedGoogle Scholar
• Mercer R. R., Anjilvel S., Miller F. J., Crapo J. D. Inhomogeneity of ventilatory unit volume and its effects on reactive gas uptake. J. Appl. Physiol. 1991; 70(5)2193–2205
   PubMedGoogle Scholar
• Mercer R. R., Crapo J. D. Three-dimensional reconstruction of the rat acinus. J. Appl. Physiol. 1987; 63(2)785–794
   PubMedGoogle Scholar
• Miller F. J. Dosimetry of particles in laboratory animals and humans in relationship to issues surrounding lung overload and human health risk assessment: a critical review. Inhal. Toxicol. 2000; 12(1–2)19–57
   PubMed Web of Science ®Google Scholar
• Monteiller C., Tran L., MacNee W., Faux S., Jones A., Miller B., Donaldson K. The proinflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area. Occup. Environ. Med. 2007a; 64(9)609–615
   PubMed Web of Science ®Google Scholar
• Nikula K. J., Avila K. J., Griffith W. C., Mauderly J. L. Lung tissue responses and sites of particle retention differ between rats and cynomolgus monkeys exposed chronically to diesel exhaust and coal dust. Fundam. Appl. Toxicol. 1997; 37: 37–53
   PubMedGoogle Scholar
• Oberdorster G., Ferin J., Gelein R., Soderholm S. C., Finkelstein J. Role of the alveolar macrophage in lung injury: Studies with ultrafine particles 23. Environ Health Perspect. 1992; 97: 193–199
   PubMed Web of Science ®Google Scholar
• Oberdorster G., Ferin J., Lehnert B. E. Correlation between particle size, in vivo particle persistence, and lung injury. Environ. Health Perspect. 1994a; 102: 173–179, (Suppl. 5)
   PubMed Web of Science ®Google Scholar
• Oberdorster G., Ferin J., Soderholm S. C., Gelein R., Cox C., Baggs R., Morrow P. E. Increased pulmonary toxicity of ultrafine particles: Due to lung overload alone?. Ann. Occup. Hyg 1994b; 38: 295–302, (Suppl. 1)
   Web of Science ®Google Scholar
• Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005; 113(7)823–839
   PubMed Web of Science ®Google Scholar
• Ovrevik J., Myran T., Refsnes M., Lag M., Becher R., Hetland R. B., Schwarze P. E. Mineral particles of varying composition induce differential chemokine release from epithelial lung cells: Importance of physico-chemical characteristics. Ann. Occup. Hyg. 2005; 49(3)219–231
   PubMedGoogle Scholar
• Pinkerton K. E., Plopper C. G., Hyde D. M., Harkema J. R., Tyler W. S., Morgan K. T., St. George J. A., Kay M., Mariassy A. Structure and function of the respiratory tract. Handbook of human toxicology, J. Massaro. CRC Press, Boca Raton, FL 1997; 469
   Google Scholar
• Pinkerton K. E., Zhou Y. M., Teague S. V., Peake J. L., Walther R. C., Kennedy I. M., Leppert V. J., Aust A. E. Reduced lung cell proliferation following short-term exposure to ultrafine soot and iron particles in neonatal rats: Key to impaired lung growth?. Inhal. Toxicol. 2004; 16: 73–81, (Suppl. 1)
   PubMed Web of Science ®Google Scholar
• Renwick L. C., Brown D., Clouter A., Donaldson K. Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup. Environ. Med. 2004; 61(5)442–447
   PubMed Web of Science ®Google Scholar
• Schins R. P., McAlinden A., MacNee W., Jimenez L. A., Ross J. A., Guy K., Faux S. P., Donaldson K. Persistent depletion of I kappa B alpha and interleukin-8 expression in human pulmonary epithelial cells exposed to quartz particles. Toxicol. Appl. Pharmacol. 2000; 167(2)107–117
   PubMedGoogle Scholar
• Schlesinger R. B., Ben-Jebria A., Dahl A. R., Snipes M. B., Ultman J. Disposition of inhaled toxicicants. Handbook of human toxicology, E. J. Massaro. CRC Press, Boca Raton, FL 1997; 493–550
   Google Scholar
• Shukla A., Timblin C., BeruBe K., Gordon T., McKinney W., Driscoll K., Vacek P., Mossman B. T. Inhaled particulate matter causes expression of nuclear factor (NF)-kappaB-related genes and oxidant-dependent NF-kappaB activation in vitro. Am. J. Respir. Cell Mol. Biol. 2000; 23(2)182–187
   PubMed Web of Science ®Google Scholar
• Smith K. R., Veranth J. M., Kodavanti U. P., Aust A. E., Pinkerton K. E. Acute pulmonary and systemic effects of inhaled coal fly ash in rats: Comparison to ambient environmental particles. Toxicol. Sci. 2006; 93: 390–399
   PubMed Web of Science ®Google Scholar
• Snipes M. B., Olson T. R., Yeh H. C. Deposition and retention patterns for 3-, 9-, and 15-micron latex microspheres inhaled by rats and guinea pigs. Exp. Lung Res. 1998; 14: 37–50
   Google Scholar
• Stone V., Brown D. M., Watt N., Wilson M., Donaldson K., Ritchie H., MacNee W. Ultrafine particle-mediated activation of macrophages: Intracellular caclium signalling and oxidative stress. Inhal. Toxicol. 2001; 12: 345–351, (Suppl. 3)
   Google Scholar
• Stringer B., Kobzik L. Environmental particulate-mediated cytokine production in lung epithelial cells (A549): Role of preexisting inflammation and oxidant stress. J. Toxicol. Environ. Health A 1998; 55(1)31–44
   PubMedGoogle Scholar
• Tran C. L., Buchanan D., Cullen R. T., Searl A., Jones A. D., Donaldson K. Inhalation of poorly soluble particles. II. Influence of particle surface area on inflammation and clearance. Inhal. Toxicol. 2000; 12(12)1113–1126
   PubMed Web of Science ®Google Scholar
• Warheit D. B., Chang L. Y., Hill L. H., Hook G. R., Crapo J. D., Brody A. R. Pulmonary macrophage accumulation and asbestos-induced lesions at sites of fiber deposition. Am. Rev. Respir. Dis. 1984; 129: 301–310
   PubMed Web of Science ®Google Scholar
• Wilson M. R., Lightbody J. H., Donaldson K., Sales J., Stone V. Interactions between ultrafine particles and transition metals in vivo in vitro. Toxicol. Appl. Pharmacol. 2002; 184(3)172–179
   PubMed Web of Science ®Google Scholar
• Yeh H. C., Cuddihy R. G., Phalen R. F., Chang I. Y. Comparisons of calculated respiratory-tract deposition of particles based on the proposed NCRP model and the new ICRP66 model. Aerosol Sci. Technol. 1996; 25: 134–140
   Web of Science ®Google Scholar