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Inhalation Toxicology
International Forum for Respiratory Research
Volume 20, 2008 - Issue 6
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Research Article

Exposures of Healthy and Asthmatic Volunteers to Concentrated Ambient Ultrafine Particles in Los Angeles

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Pages 533-545 | Received 19 Nov 2007, Accepted 12 Jan 2008, Published online: 06 Oct 2008

REFERENCES

  • American Thoracic Society. State of the art: Health effects of outdoor air pollution. Am. J. Respir. Crit. Care Med. 1996; 153(3–50)477–498
  • Beckett W. S., Chalupa D. F., Pauly-Brown A., Speers D. M., Stewart J. C., Frampton M. W., Utell M. J., Huang L. S., Cox C., Zareba W., Oberdorster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: A human inhalation study. Am. J. Respir. Crit. Care Med. 2005; 171: 1129–1135
  • Brook R. D., Brook J. R., Urch B., Vincent R., Rajagopalan S., Silverman F. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 2002; 105: 1534–1536
  • Cassee F. R., Boere A. J., Fokkens P. H., Leseman D. L., Sioutas C., Kooter I. M., Dormans J. A. Inhalation of concentrated particulate matter produces pulmonary inflammation and systemic biological effects in compromised rats. J. Toxicol. Environ. Health A 2005; 68: 773–796
  • Chalupa D. C., Morrow P. E., Oberdorster G., Utell M. J., Frampton M. W. Ultrafine particle deposition in subjects with asthma. Environ. Health Perspect. 2004; 112: 879–882
  • Delfino R. J., Sioutas C., Malik S. Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health. Environ. Health Perspect. 2005; 113: 934–946
  • Devlin R. B., Ghio A. J., Kehrl H., Sanders G., Cascio W. Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. Eur. Respir. J. 2003; 40: 76S–80S
  • Dockery D. W. Epidemiologic evidence of cardiovascular effects of particulate air pollution. Environ. Health Perspect 2001; 109(Suppl. 4)483–486
  • Donaldson K., Tran L., Jimenez L. A., Duffin R., Newby D. E., Mills N., MacNee W., Stone V. Combustion-derived nanoparticles: A review of their toxicology following inhalation exposure. Part. Fibre Toxicol. 2005; 2: 10
  • Englert N. Fine particles and human health—A review of epidemiological studies. Toxicol. Lett. 2004; 149: 235–242
  • Fahy J. V., Wong H. H., Liu J. T., Boushey H. A. Analysis of induced sputum after air and ozone exposures in healthy subjects. Environ. Res. 1995; 70: 77–83
  • Frampton M. W., Utell M. J., Zareba W., Oberdorster G., Cox C., Huang L. S., Morrow P. E., Lee F. E., Chalupa D., Frasier L. M., Speers D. M., Stewart J. Effects of exposure to ultrafine carbon particles in healthy subjects andsubjects with asthma. Res. Rep. Health Effects Inst. 2004; 126: 1–47
  • Frampton M. W., Stewart J. C., Oberdorster G., Morrow P. E., Chalupa D., Pietropaoli A. P., Frasier L. M., Speers D. M., Cox C., Huang L. S., Utell M. J. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ. Health Perspect 2006; 114: 51–58
  • Ghio A. J., Hall A., Bassett M. A., Cascio W. E., Devlin R. B. Exposure to concentrated ambient air particles alters hematologic indices in humans. Inhal. Toxicol. 2003; 15: 1465–1478
  • Green L. C., Armstrong S. R. Particulate matter in ambient air and mortality: Toxicologic perspectives. Regul. Toxicol. Pharmacol. 2003; 35: 327–337
  • Gong H., Linn W. S., Sioutas C., Terrell S. L., Clark K. W., Anderson K. R., Terrell L. L. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient fine particles in Los Angeles. Inhal. Toxicol. 2003a; 15: 305–325
  • Gong H., Sioutas C., Linn W. S. Controlled exposures of healthy and asthmatic volunteers to concentrated ambient particles in metropolitan Los Angeles. Res. Rep. Health Effects Inst. 2003b; 118: 1–36
  • Gong H., Linn W. S., Terrell S. L., Anderson K. R., Clark K. W., Sioutas C., Cascio W. E., Alexis N., Devlin R. B. Exposures of elderly volunteers with and without chronic obstructive pulmonary disease (COPD) to concentrated ambient fine particulate pollution. Inhal. Toxicol. 2004a; 16: 731–744
  • Gong H., Linn W. S., Terrell S. L., Clark K. W., Geller M. D., Anderson K. R., Cascio W. E., Sioutas C. Altered heart-rate variability in asthmatic and healthy volunteers exposed to concentrated ambient coarse particles. Inhal. Toxicol. 2004b; 16: 335–343
  • Hinds W. C. Aerosol technology: Properties, behavior, and measurement of airborne particles. J. Wiley & Sons, New York 1999
  • Kim S., Chang M.-C., Kim D., Sioutas C. A new generation of portable coarse, fine, and ultrafine particle concentrators for use in inhalation toxicology. Inhal. Toxicol. 2000; 12(Suppl. 1)121–137
  • Kleinman M. T., Hamade A., Meacher D., Oldham M., Sioutas C., Chakrabarti B., Stram D., Froines J. R., Cho A. K. Inhalation of concentrated ambient particulate matter near a heavily trafficked road stimulates antigen-induced airway responses in mice. J. Air Waste Manage. Assoc. 2005; 55: 1277–1288
  • Kongerud J., Crissman K., Hatch G., Alexis N. Ascorbic acid is decreased in induced sputum of mild asthmatics. Inhal Toxicol. 2003; 15: 101–109
  • Kooter I. M., Boere A. J., Fokkens P. H., Leseman D. L., Dormans J. A., Cassee F. R. Response of spontaneously hypertensive rats to inhalation of fine and ultrafine particles from traffic: Experimental controlled study. Part. Fibre Toxicol. 2006; 3: 7
  • Kreyling W. G., Semmler M., Moller W. Dosimetry and toxicology of ultrafine particles. J. Aerosol Med. 2004; 17: 140–152
  • Kuschner W. G., Wong H., D'Alessandro A., Quinlan P., Blanc P. D. Human pulmonary responses to experimental inhalation of high concentration fine and ultrafine magnesium oxide particles. Environ. Health Perspect. 1997; 105: 1234–1237
  • Misra C., Kim S., Shen S., Sioutas C. Design and evaluation of a high-flow rate, very low pressure drop impactor for separation and collection of fine from ultrafine particles. J. Aerosol Sci. 2002; 33(5)735–752
  • Misra S., Fine P. M., Singh M., Sioutas C. Development and evaluation of a compact facility for exposing humans to concentrated ambient ultrafine particles. Aerosol Sci. Technol. 2004; 38: 27–35
  • Morris J. F., Koski A., Johnson L. C. Spirometric standards for healthy nonsmoking adults. Am. Rev. Respir. Dis. 1971; 103: 57–67
  • Oberdorster G., Oberdorster E., Oberdorster J. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 2005; 113: 823–829
  • Pope C. A., Dockery D. Health effects of fine particulate air pollution: Lines that connect. J. Air Waste Manage. Assoc. 2006; 56: 709–742
  • Samet J. M., Graff D., Berntsen J., Ghio A. J., Huang Y. C. T., Devlin R. B. A comparison of studies on the effects of controlled exposure to fine, coarse, and ultrafine ambient particulate matter from a single location. Inhal. Toxicol. 2007; 19(Suppl. 1)29–32
  • Sardar S., Fine M., Mayo P. R., Sioutas C. Size fractionated chemical speciation measurements of ultrafine particles in Los Angeles using the NanoMOUDI. Environ. Sci. Technol. 2005; 39: 932–944
  • Schlesinger R. B., Kunzli N., Hidy G. M., Gotschi T., Jerrett M. The health relevance of ambient particulate matter characteristics: Coherence of toxicological and epidemiological inferences. Inhal. Toxicol. 2006; 18: 95–125
  • Schulz H., Harder V., Ibald-Mulli A., Khandoga A., Koenig W., Krombach F., Radykevicz R., Stampfl A., Thorand B., Peters A. Cardiovascular effects of fine and ultrafine particles. J. Aerosol Med. 2005; 18: 1–22
  • Sioutas C., Kim S., Chang M. Development and evaluation of a prototype ultrafine particle concentrator. J. Aerosol Sci. 1999; 30: 1001–1017
  • Sioutas C., Delfino R. J., Singh M. Exposure assessment for atmospheric ultrafine particles (UFPs) and implications in epidemiologic research. Environ. Health Perspect. 2005; 113: 947–955
  • Soriano J. B., Visick G. T., Muellerova H., Payvandi N., Hansell A. L. Patterns of comorbidities in newly diagnosed COPD and asthma in primary care. Chest 2005; 128: 2009–2107
  • Suissa S., Assimes T., Brassard P., Ernst P. Inhaled corticosteroid use in asthma and the prevention of myocardial infarction. Am. J. Med. 2003; 115: 377–381
  • Vedal S. Ambient particles and health: Lines that divide. J. Air Waste Manage. Assoc. 1997; 47: 551–581
  • Westerdahl D., Fruin S., Sax T., Fine P. M., Sioutas C. Mobile platform measurements of ultrafine particles and associated pollutant concentrations on freeways and residential streets in Los Angeles. Atmos. Environ. 2005; 39: 3597–3610
  • Yeatts K., Svendsen E., Creason J., Alexis N., Herbst M., Scott J., Kupper L., Williams R., Neas L., Cascio W., Devlin R. B., Peden D. B. Coarse particulate matter (PM2.5 - 10) affects heart rate variability, blood lipids, and circulating eosinophils in adults with asthma. Environ. Health Perspect. 2007; 115: 709–714
  • Zhu Y., Hinds W. C., Kim S., Sioutas C. Concentration and size distribution of ultrafine particles near a major highway. J. Air Waste Manage. Assoc. 2002a; 52: 1032–1042
  • Zhu Y., Hinds W. C., Kim S., Shen S., Sioutas C. Study of ultrafine particles near a major highway with heavy-duty diesel traffic. Atmos. Environ. 2002b; 36: 4323–4335

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