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Inhalation Toxicology
International Forum for Respiratory Research
Volume 20, 2008 - Issue 5
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Research Article

Disposition of Decamethylcyclopentasiloxane in Fischer 344 Rats Following Single or Repeated Inhalation Exposure to 14C-Decamethylcyclopentasiloxane (14C-D5)

Joseph M. Tobin Dow Corning Corporation, Midland, Michigan, USA
,
Debra A. McNett Dow Corning Corporation, Midland, Michigan, USA
,
Jeremy A. Durham Dow Corning Corporation, Midland, Michigan, USA
&
Kathleen P. Plotzke Dow Corning Corporation, Midland, Michigan, USA
Pages 513-531 | Received 26 Sep 2007, Accepted 03 Dec 2007, Published online: 06 Oct 2008

REFERENCES

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  • Burns-Naas L. A., Mast R. W., Meeks R. G., Mann P. C., Thevenaz P. Inhalation toxicology of Decamethylcyclopentasiloxane (D5) following a 3-month nose-only exposure in Fischer 344 rats. Toxicol. Sci. 1998b; 43: 230–240
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  • Jovanovic M. L., McNett D. A., Regan J. M., Plotzke K. P. Disposition of decamethylcyclopentasiloxane in F344 rats following a single oral dose. Toxicologis 2003; 72: 148
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  • Nedelman J. R., Gibiansky E., Lau D. T. W. Applying Bailer's Method for AUC confidence intervals to sparse sampling. Pharm. Res. 1995; 12: 124–128
  • Reddy M. B., Dobrev I. D., McNett D. A., Tobin J. M., Utell M. J., Morrow P. E., Plotzke K. P., Anderson M. E. Physiological modeling of the inhalation kinetics of decamethylcyclopentasiloxane (D5) in rats and humans, Submitted for publication
  • Varaprath S., Salyers K. L., Plotzke K. P., Nanavati S. Extraction of Octamethylcyclotetrasiloxane and its metabolites from biological matrices. Anal. Biochem. 1998; 256: 14–22

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