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Inhalation Toxicology
International Forum for Respiratory Research
Volume 20, 2008 - Issue 12
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Research Article

Numerical Simulations Investigating the Regional and Overall Deposition Efficiency of the Human Nasal Cavity

Kevin T. Shanley Department of Mechanical and Aeronautical Engineering Clarkson University, , Potsdam, New York
,
Parsa Zamankhan Department of Mechanical and Aeronautical Engineering Clarkson University, , Potsdam, New York
,
Goodarz Ahmadi Department of Mechanical and Aeronautical Engineering Clarkson University, , Potsdam, New YorkCorrespondence[email protected]
,
Philip K. Hopke Department of Chemical and Biomolecular Engineering, Clarkson University, Potsdam, New York
&
Yung-Sung Cheng Lovelace Respiratory Research Laboratory, , Albuquerque, New Mexico, USA
Pages 1093-1100 | Received 04 Mar 2008, Accepted 15 Apr 2008, Published online: 24 Oct 2008

REFERENCES

  • Y. S. Cheng. (2003). Aerosol deposition in the extrathoracic region. Aerosol Sci. Technol. 37:659–671.
  • Y. S. Cheng, T. D. Holmes, J. Gao, R. A. Guilmette, S. Li, Y. Surakitbanharn, and C. Rowlings. (2001). Characterization of nasal spray pumps and deposition pattern in a replica of the human nasal airway. J. Aerosol Med. 14 (2):267–280.
  • Y. S. Cheng, H. C. Yeh, R. A. Guilmette, S. Q. Simpson, K. H. Cheng, and D. L. Swift. (2006). Nasal deposition of ultrafine particles in human volunteers and its relationship to airway geometry. Aerosol Sci. Technol. 25:274–291.
  • S. E. Churchill, L. L. Shackelford, J. N. Georgi, and M. T. Black. (2004). Morphological variation and airflow dynamics in the human nose. Am. J. Hum. Biol. 16 (6):625–638.
  • Y. T. Dai, Y. J. Juang, Y. Y. Wu, P. N. Breysse, and D. J. Hsu. (2006). In vivo measurements of inhalability of ultralarge aerosol particles in calm air by humans. J. Aerosol Sci. 37:967–973.
  • Fluent User's Manual, and . Fluent, Inc., LebanonNH, (2007) Version 6.3.26..
  • I. Hahn, P. W. Scherer, and M. M. Mozell. (1993). Velocity profiles measured for airflow through a large-scale model of the human nasal cavity. J. Appl. Physiol. 75:2273–2287.
  • W. C. Hinds. Aerosol technology: Properties, behavior, and measurement of airborne particles. John Wiley and Sons, New York, (1982) .
  • H. M. Janssens, J. C. De Jongste, W. J. Fokkens, S. G. F. Robben, K. Wouters, and H. A. W. M. Tiddens. (2001). The Sophia Anatomical Infant Nose Throat (SAINT) model: A valuable tool to study aerosol deposition in infants. J. Aerosol Med. 14 (4):433–441.
  • J. T. Kelly, B. Asgharian, J. S. Kimbell, and B. A. Wong. (2004). Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles. Aerosol Sci. Technol. 38:1063–1071.
  • J. T. Kelly, A. K. Prasad, and A. S. Wexler. (2000). Detailed flow patterns in the nasal cavity. J. Appl. Physiol. 89:323–337.
  • K. Keyhani, P. W. Scherer, and M. M. Mozell. (1995). Numerical simulation of airflow in the human nasal cavity. J. Biomech. Eng. 117:429–441.
  • S. K. Kim, and S. K. Chung. (2004). An investigation on airflow in disordered nasal cavity and its corrected models by tomographic PIV. Meas. Sci. Technol. 15:1090–1096.
  • Y. Liu, E. A. Matida, J. Gu, and M. R. Johnson. (2007). Numerical simulations of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES. J. Aerosol Sci. 38:693–700.
  • T. B. Martonen, and Z. Zhang. (1992). Comments on recent data for particle deposition in human nasal passages. J. Aerosol. Sci. 23 (6):667–674.
  • S. P. Newman, K. P. Steed, G. Hooper, and J. Brickwell. (1995). Scintographic assessment of the oropharyngeal and nasal depositions of fusafungine from a pressurized inhaler and from a novel pump spray device. J. Pharm. Pharmacol. 47:818–821.
  • S. Schreck, K. J. Sullivan, C. M. Ho, and H. K. Chang. (1993). Correlations between flow resistance and geometry in a model of the human nose. J. Appl. Physiol. 75:1767–1775.
  • H. Shi, C. Kleinstreuer, and Z. Zhang. (2007). Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness. J. Aerosol Sci. 38:398–409.
  • W. C. Su, and Y. S. Cheng. (2005). Deposition of fiber in the human nasal airway. Aerosol Sci. Technol. 39:888–901.
  • R. P. Subramanian, R. B. Richardson, K. T. Morgan, J. S. Kimbell, and R. A. Guilmette. (1998). Computational fluid dynamics simulations of inspiratory airflow in the human nose and nasopharynx. Inhal. Toxicol. 10:91–120.
  • D. L. Swift. (1991). Inspiratory inertial deposition of aerosols inhuman airway replicate casts: implication for the proposed NCRP lung model. Radiat. Prot. Dosim. 38:29–34.
  • D. L. Swift, and D. F. Proctor. Access of air to the respiratory tract Respiratory Defense mechanisms: Part IJ. D. Brian, D. F. Proctor, and L. M. Reid. Marcel Dekker, New York, (1977) 63–93.
  • L. Thorsson, S. P. Newman, A. Weisz, E. Trofast, and F. Mor'en. (1993). Nasal distribution of budesonide inhaled via a powder inhaler. Rhinology 31:7–10.
  • P. Zamankhan, G. Ahmadi, Z. Wang, P. K. Hopke, Y. S. Cheng, W. C. Su, and D. Leonard. (2006). Airflow and deposition of nano-particles in a human nasal cavity. Aerosol. Sci. Technol. 40:463–476.
  • G. J. Zwartz, and R. A. Guilmette. (2001). Effect of flow rate on particle deposition in a replica of a human nasal airway. Inhal. Toxicol. 13:109–127.

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