Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 12, 2000 - Issue sup3: 7th International Symposium on Particle Toxicology
Submit an article Journal homepage
23
Views
16
CrossRef citations to date
0
Altmetric
Physical and Chemical Properties in Relation to Particle Toxicity

Ambient Particulate Matter Induces Oxidative Dna Damage in Lung Epithelial Cells

Ad M. KnaapenDepartment of Fiber and Particle Toxicology, Medical Institute of Environmental Hygiene, Dusseldorf, GermanyCorrespondence[email protected]
,
Roel P.F. SchinsDepartment of Fiber and Particle Toxicology, Medical Institute of Environmental Hygiene, Dusseldorf, Germany
,
Yvonne SteinfartzDepartment of Fiber and Particle Toxicology, Medical Institute of Environmental Hygiene, Dusseldorf, Germany
,
Höhr DorisDepartment of Fiber and Particle Toxicology, Medical Institute of Environmental Hygiene, Dusseldorf, Germany
,
Lothar DunemannDepartment of Analytical Chemistry, Medical Institute of Environmental Hygiene, Düsseldorf, Germany
&
Paul J.A. BormDepartment of Fiber and Particle Toxicology, Medical Institute of Environmental Hygiene, Düsseldorf, Germany
Pages 125-132 | Published online: 14 Sep 2015

References

  • Borm, P. J. A., Knaapen, A. M., Schins, R. P. F., Godschalk, R. W. L, and Van Schooten, F. J. 1997. Neutrophils amplify the formation of DNA-adducts by benzo[a]pyrene in lung target cells. Environ. Health Perspect. 105(suppl. 5)1089–1093.
  • Costa, D. L, and Dreher, K. L. 1997. Bioavailable transition metals in particulate matter mediate cardiopulmonary injury in healthy and compromised animal models. Environ. Health Perspect. 105(suppl 5) 1053–1060.
  • Donaldson, K., Brown, D. M., Mitchell, C., Dineva, M., Beswick, P. H., Cilmour, P., and MacNee, W. 1997. Free radical activity of PM10; Iron mediated generation of hydroxyl radicals. Environ. Health Perspect. 105(suppl. 5)1285–1289.
  • Donaldson, K., Li, X. Y., and MacNee, W. 1998. Ultrafine (nanometre) particle mediated lung injury. J. Aerosol Sci. 29:553–560.
  • Driscoll, K. E., Carter, J. M., lype, P. T., Kumari, H. L., Crosby, L. L., Aardema, M. J., Isfort, R. J., Cody, D., Chestnut, M. H., Burns, J. L., and Le Boeuf, R. A. 1995. Establishment of immortalized alveolar type II cell lines from adult rat lungs. In Vitro Cell. Dev. Biol. 30:516–527.
  • Gilmour, P. S., Brown, D. M., Lindsday, T. G., Beswick, P. H., MacNee, W., and Donaldson, K. 1996. Adverse health effects of PM 10 particles: Involvement of iron in generation of hydroxyl radical. Occup. Environ. Med. 53(12):81 7–822.
  • Halliwell, B., and Gutteridge, J. M. 1989. Free radicals in biology and medicine, 2nd ed. Oxford: Clarendon Press.
  • Knaapen, A. M., Seiler, F., Schilderman, P. A. E. L., Nehls, P., Bruch, J., Schins, R. P. F., and Borm, P. J. A. 1999. Neutrophils cause oxidative DNA damage in alveolar epithelial cells. Free Radical Biol. Med. 27:234–240.
  • Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65:516–527.
  • Pope, C. A., Bates, D. V., and Raizenne, M. E. 1995. Health effects of particulate air-pollution: Time for reassessment? Environ. Health Perspect. 103:472–480.
  • Seaton, A., MacNee, W., Donaldson, K., and Godden, D. 1995. Particulate air pollution and acute health effects. Lancet 345:1 76–1 78.
  • Smith, K. R., and Aust, A. E. 1997. Mobilization of iron from urban particulates leads to generation of reactive oxygen species in vitro and induction of ferritin synthesis in human lung epithelial cells. Chem. Res. Toxicol. 10(7):828–834.
  • Smith, K. R., Veranth, J. M., Lighty, J. S., and Aust, A. E. 1998. Mobilization of iron from coal fly ash was dependent upon the particle size and the source of coal. Chem. Res. Toxicol. 11(12):1494–1500.
  • Toyokuni, S., Tanaka, T., Hattori, Y., Nishiyama, Y., Yoshida, A., Uchida, K., Hiai, H., Ochi, H., and Osawa, T. 1997. Quantitative immunohistochemical determination of 8-hydroxy-2’-deoxyguanosine by a monoclonal antibody N45.1: Its application to ferric nitrolotriacetate-induced renal carcinogenesis model. Lab. Invest. 76:365–374.
  • van Maanen, J. M. S., Borm, P. J. A., Knaapen, A. M., van Herwijnen, M., Schilderman, P. A. E. L., Smith, K. R., Aust, A. E., Tomatis, M., and Fubini, B. 1999. In vitro effects of coal fly ashes: Hydroxyl radical generation, iron release, and DNA damage and toxicity in rat lung epithelial cells. Inhal. Toxicol. 11: 1123–1141.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.