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Inhalation Toxicology
International Forum for Respiratory Research
Volume 29, 2017 - Issue 8
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Research Article

Nonclinical safety assessment of SPX-101, a novel peptide promoter of epithelial sodium channel internalization for the treatment of cystic fibrosis

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Pages 356-365 | Received 02 May 2017, Accepted 03 Aug 2017, Published online: 06 Oct 2017

References

  • Alexander DJ, Collins CJ, Coombs DW, et al. (2008). Association of Inhalation Toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in non-clinical aerosol inhalation toxicology studies with pharmaceuticals. Inhal Toxicol 20:1179–89.
  • Astrand AB, Hemmerling M, Root J, et al. (2015). Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition. Am J Physiol Lung Cell Mol Physiol 308:L22–32.
  • Elkins MR, Robinson M, Rose BR, et al. (2006). A controlled trial of long-term inhaled hypertonic saline in patients with cystic fibrosis. N Engl J Med 354:229–40.
  • Hirsh AJ, Sabater JR, Zamurs A, et al. (2004). Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. J Pharmacol Exp Ther 311:929–38.
  • Hobbs CA, Blanchard MG, Alijevic O, et al. (2013). Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Am J Physiol Lung Cell Mol Physiol 305:L990–1001.
  • Knowles MR, Church NL, Waltner WE, et al. (1990). A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. N Engl J Med 322:1189–94.
  • O’Riordan TG, Donn KH, Hodsman P, et al. (2014). Acute hyperkalemia associated with inhalation of a potent ENaC antagonist: Phase 1 trial of GS-9411. J Aerosol Med Pulm Drug Deliv 27:200–8.
  • Rollins BM, Garcia-Caballero A, Stutts MJ, Tarran R. (2010). SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Channels (Austin) 4:255–9.
  • Scott DW, Walker MP, Sesma J, et al. (2017). SPX-101 is a novel ENaC-targeted therapeutic for cystic fibrosis that restores mucus transport. Am J Respir Crit Care Med. [Epub ahead of print]. doi: 10.1164/rccm.201612-2445OC
  • Tepper JS, Kuehl PJ, Cracknell S, et al. (2016). Symposium Summary: “Breathe In, Breathe Out, Its Easy: What You Need to Know About Developing Inhaled Drugs”. Int J Toxicol 35:376–92.
  • Wolff RK, Dorato MA. (1993). Toxicologic testing of inhaled pharmaceutical aerosols. Crit Rev Toxicol 23:343–69.

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