Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 29, 2017 - Issue 7
466
Views
10
CrossRef citations to date
0
Altmetric
Research Article

Airway injury in an in vitro human epithelium-fibroblast model of diacetyl vapor exposure: diacetyl-induced basal/suprabasal spongiosis

, , , &
Pages 310-321 | Received 07 Jun 2017, Accepted 15 Aug 2017, Published online: 06 Oct 2017

References

  • Akpinar-Elci M, Stemple KJ, Enright PL, et al. (2005). Induced sputum evaluation in microwave popcorn production workers. Chest 128:991–7.
  • Akpinar-Elci M, Travis WD, Lynch DA, Kreiss K. (2004). Bronchiolitis obliterans syndrome in popcorn production plant workers. Eur Respir J 24:298–302.
  • Babu AN, Murakawa T, Thurman JM, et al. (2007). Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. J Clin Invest 117:3774–85.
  • Babu AN, Nicolls MR. (2006). Critical pathways leading to obliterative bronchiolitis in lung allografts. Curr Opin Organ Tran 11:483–9.
  • Brass DM, Gwinn WM, Valente AM, et al. (2017). The diacetyl-exposed human airway epithelial secretome: new insights into flavoring induced airways disease. Am J Respir Cell Mol Biol 56:784–95.
  • Bylaite E, Ilgunaite Z, Meyer AS, Adler-Nissen J. (2004). Influence of lambda-carrageenan on the release of systematic series of volatile flavor compounds from viscous food model systems. J Agric Food Chem 52:3542–9.
  • Foster MW, Gwinn WM, Kelly FL, et al. (2017). Proteomic analysis of primary human airway epithelial cells exposed to the respiratory toxicant diacetyl. J Proteome Res 16:538–49.
  • Gueders MM, Foidart JM, Noel A, Cataldo DD. (2006). Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. Eur J Pharmacol 533:133–44.
  • Gwinn WM, Qu W, Shines CJ, et al. (2013). Macrophage solubilization and cytotoxicity of indium-containing particles in vitro. Toxicol Sci 135:414–24.
  • Hubbs AF, Battelli LA, Goldsmith WT, et al. (2002). Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring. Toxicol Appl Pharmacol 185:128–35.
  • Hubbs AF, Cumpston AM, Goldsmith WT, et al. (2012). Respiratory and olfactory cytotoxicity of inhaled 2,3-pentanedione in Sprague-Dawley rats. Am J Pathol 181:829–44.
  • Hubbs AF, Goldsmith WT, Kashon ML, et al. (2008). Respiratory toxicologic pathology of inhaled diacetyl in sprague-dawley rats. Toxicol Pathol 36:330–44.
  • Jonigk D, Izykowski N, Rische J, et al. (2015). Molecular profiling in lung biopsies of human pulmonary allografts to predict chronic lung allograft dysfunction. Am J Pathol 185:3178–88.
  • Kanwal R, Kullman G, Fedan KB, Kreiss K. (2011). Occupational lung disease risk and exposure to butter-flavoring chemicals after implementation of controls at a microwave popcorn plant. Public Health Rep 126:480–94.
  • Kanwal R, Kullman G, Piacitelli C, et al. (2006). Evaluation of flavorings-related lung disease risk at six microwave popcorn plants. J Occup Environ Med 48:149–57.
  • Kelly FL, Sun J, Fischer BM, et al. (2014). Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans. Am J Respir Cell Mol Biol 51:568–74.
  • Kennedy VE, Todd JL, Palmer SM. (2013). Bronchoalveolar lavage as a tool to predict, diagnose and understand bronchiolitis obliterans syndrome. Am J Transplant 13:552–61.
  • King TE. Jr. (2003). Miscellaneous causes of bronchiolitis: inhalational, infectious, drug-induced, and idiopathic. Semin Respir Crit Care Med 24:567–76.
  • Kreiss K, Gomaa A, Kullman G, et al. (2002). Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med 347:330–8.
  • Kuhlmann UC, Chwieralski CE, Reinhold D, et al. (2009). Radiation-induced matrix production of lung fibroblasts is regulated by interleukin-8. Int J Radiat Biol 85:138–43.
  • Le TT, Karmouty-Quintana H, Melicoff E, et al. (2014). Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis. J Immunol 193:3755–68.
  • Lee J, Nakagiri T, Kamimura D, et al. (2013). IL-6 amplifier activation in epithelial regions of bronchi after allogeneic lung transplantation. Int Immunol 25:319–32.
  • Madala SK, Edukulla R, Schmidt S, et al. (2014). Bone marrow-derived stromal cells are invasive and hyperproliferative and alter transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 50:777–86.
  • McQuibban GA, Gong JH, Tam EM, et al. (2000). Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3. Science 289:1202–6.
  • Morgan DL, Flake GP, Kirby PJ, Palmer SM. (2008). Respiratory toxicity of diacetyl in C57BL/6 mice. Toxicol Sci 103:169–80.
  • Morgan DL, Jokinen MP, Johnson CL, et al. (2016). Chemical reactivity and respiratory toxicity of the alpha-diketone flavoring agents: 2,3-butanedione, 2,3-pentanedione, and 2,3-hexanedione. Toxicol Pathol 44:763–83.
  • Morgan DL, Jokinen MP, Price HC, et al. (2012). Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. Toxicol Pathol 40:448–65.
  • Morgan DL, Merrick BA, Gerrish KE, et al. (2015). Gene expression in obliterative bronchiolitis-like lesions in 2,3-pentanedione-exposed rats. PLoS One 10:e0118459.
  • Morris JB, Hubbs AF. (2009). Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors. Toxicol Sci 108:173–83.
  • O’Koren EG, Hogan BL, Gunn MD. (2013). Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. Am J Respir Cell Mol Biol 49:788–97.
  • Otsuka M, Mine T, Ohuchi K, Ohmori S. (1996). A detoxication route for acetaldehyde: metabolism of diacetyl, acetoin, and 2,3-butanediol in liver homogenate and perfused liver of rats. J Biochem 119:246–51.
  • Palmer SM, Flake GP, Kelly FL, et al. (2011). Severe airway epithelial injury, aberrant repair and bronchiolitis obliterans develops after diacetyl instillation in rats. PLoS One 6:e17644.
  • Pedroza M, Schneider DJ, Karmouty-Quintana H, et al. (2011). Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. PLoS One 6:e22667–10.
  • Qazi BS, Tang K, Qazi A. (2011). Recent advances in underlying pathologies provide insight into interleukin-8 expression-mediated inflammation and angiogenesis. Int J Inflam 2011:908468.
  • Rincon M, Irvin CG. (2012). Role of IL-6 in asthma and other inflammatory pulmonary diseases. Int J Biol Sci 8:1281–90.
  • Saito F, Tasaka S, Inoue K, et al. (2008). Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice. Am J Respir Cell Mol Biol 38:566–71.
  • Sharples LD, McNeil K, Stewart S, Wallwork J. (2002). Risk factors for bronchiolitis obliterans: a systematic review of recent publications. J Heart Lung Transplant 21:271–81.
  • Sun Y, Oliver JD. (1994). Antimicrobial action of some GRAS compounds against Vibrio vulnificus. Food Addit Contam 11:549–58.
  • Taghavi S, Krenn K, Jaksch P, et al. (2005). Broncho-alveolar lavage matrix metalloproteases as a sensitive measure of bronchiolitis obliterans. Am J Transplant 5:1548–52.
  • Todd JL, Palmer SM. (2011). Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. Chest 140:502–8.
  • Verleden SE, Sacreas A, Vos R, et al. (2016). Advances in understanding bronchiolitis obliterans after lung transplantation. Chest 150:219–25.
  • Willis BC, Borok Z. (2007). TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease. Am J Physiol Lung Cell Mol Physiol 293:L525–34.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.