Characterization of an aerosol generation system to assess inhalation risks of aerosolized nano-enabled consumer products

References

• Adeleye AS, Conway JR, Garner K, Huang Y, Su Y, Keller AA. 2016. Engineered nanomaterials for water treatment and remediation: costs, benefits, and applicability. Chem Eng J. 286:640–662.
   Web of Science ®Google Scholar
• Bantz C, Koshkina O, Lang T, Galla H-J, Kirkpatrick CJ, Stauber RH, Maskos M. 2014. The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions. Beilstein J Nanotechnol. 5:1774–1786.
   PubMed Web of Science ®Google Scholar
• Bekker C, Brouwer DH, van Duuren-Stuurman B, Tuinman IL, Tromp P, Fransman W. 2014. Airborne manufactured nano-objects released from commercially available spray products: temporal and spatial influences. J Expo Sci Environ Epidemiol. 24(1):74–81.
   PubMed Web of Science ®Google Scholar
• Bello D, Martin J, Santeufemio C, Sun Q, Lee Bunker K, Shafer M, Demokritou P. 2013. Physicochemical and morphological characterisation of nanoparticles from photocopiers: implications for environmental health. Nanotoxicology. 7(5):989–1003.
   PubMed Web of Science ®Google Scholar
• Borowska S, Brzóska MM. 2015. Metals in cosmetics: implications for human health. J Appl Toxicol. 35(6):551–572.
   PubMed Web of Science ®Google Scholar
• Boverhof DR, Bramante CM, Butala JH, Clancy SF, Lafranconi M, West J, Gordon SC. 2015. Comparative assessment of nanomaterial definitions and safety evaluation considerations. Regul Toxicol Pharmacol. 73(1):137–150.
   PubMed Web of Science ®Google Scholar
• Boxall A, Tiede K, Chaudhry Q, Aitken R, Jones A, Jefferson B, Lewis J. 2007. Current and future predicted exposure to engineered nanoparticles. Health Environ Res. [accessed 2018 Jun 16]. http://randd.defra.gov.uk/Document.aspx?Document=CB01098_6270_FRP.pdf
   Google Scholar
• Bremmer H, Prud’homme de Lodder L, van Engelen J. Sir. 2006. Cosmetics fact sheet. To assess the risks for the consumer. Updated Version for ConsExpo 4. RIVM report 320104001/2006. [accessed 2018 Jun 16]. https://www.rivm.nl/bibliotheek/rapporten/320104001.pdf
   Google Scholar
• Calderón L, Yang L, Lee K-B, Mainelis G. 2018. Characterization of airborne particle release from nanotechnology-enabled clothing products. J Nanoparticle Res. 20(12):330.
   Web of Science ®Google Scholar
• Chalbot MCG, Pirela SV, Schifman L, Kasaraneni V, Oyanedel-Craver V, Bello D, Castranova V, Qian Y, Thomas T, Kavouras IG, et al. 2017. Synergistic effects of engineered nanoparticles and organics released from laser printers using nano-enabled toners: potential health implications from exposures to the emitted organic aerosol. Environ Sci: Nano. 4(11):2144–2156.
   PubMed Web of Science ®Google Scholar
• Chen BT, Afshari A, Stone S, Jackson M, Schwegler-Berry D, Frazer DG, Castranova V, Thomas TA. 2010. Nanoparticles-containing spray can aerosol: characterization, exposure assessment, and generator design. Inhal Toxicol. 22(13):1072–1082.
   PubMed Web of Science ®Google Scholar
• Chen LC, Lippmann M. 2015. Inhalation toxicology methods: the generation and characterization of exposure atmospheres and inhalational exposures. Curr Protoc Toxicol. 63:24.4.1–24.4.23.
   Google Scholar
• Cheng YS, Bowen L, Rando RJ, Postlethwait EM, Squadrito GL, Matalon S. 2010. Exposing animals to oxidant gases. Proc Am Thorac Soc. 7(4):264–268.
   PubMedGoogle Scholar
• Cheng YS, Moss OR. 1995. Inhalation exposure systems. Toxicol Methods. 5(3):161–197.
   Web of Science ®Google Scholar
• Choudhury T, Chatsworth C. 2008. The physical chemistry of cosmetic formulations. [accessed 2018 Jun 16]. https://www.happi.com/contents/view_features/2008-02-29/the-physical-chemistry-of-cosmetic-formulatio/
   Google Scholar
• Drew R, Hagen T. 2015. Jan. Engineered Nanomaterials: An Update on the Toxicology and Work Health Hazards. Safe Work Aust.:241. [accessed 2018 Jun 16]. https://www.safeworkaustralia.gov.au/system/files/documents/1702/engineered-nanomaterials-update-toxicology.pdf.
   Google Scholar
• Ferin J, Oberdörster G, Penney DP, Soderholm SC, Gelein R, Piper HC. 1990. Increased pulmonary toxicity of ultrafine particles? I. Particle clearance, translocation, morphology. J Aerosol Sci. 21(3):381–384.
   Web of Science ®Google Scholar
• Forestier S, Hansenne I, inventors; Korea Research Institute of Bioscience and Biotechnology KRIBB, assignee. 1997. Cosmetic composition containing a mixture of metal oxde nanopigments and melanne pigments. European Patent Office EP1909745A1.
   Google Scholar
• Fröhlich E, Salar-Behzadi S. 2014. Toxicological assessment of inhaled nanoparticles: role of in vivo, ex vivo, in vitro, and in silico studies. IJMS. 15(3):4795–4822.
   Google Scholar
• Heinrich U, Fuhst R, Rittinghausen S, Creutzenberg O, Bellmann B, Koch W, Levsen K. 1995. Chronic inhalation exposure of wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. Inhal Toxicol. 7(4):533–556.
   Web of Science ®Google Scholar
• Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Stone V. 2009. Identification of the mechanisms that drive the toxicity of TiO(2) particulates: the contribution of physicochemical characteristics. Part Fibre Toxicol. 6(1):33.
   PubMedGoogle Scholar
• Kamiya H, Iijima M. 2010. Surface modification and characterization for dispersion stability of inorganic nanometer-scaled particles in liquid media. Sci Technol Adv Mater. 11(4):044304.
   PubMed Web of Science ®Google Scholar
• Kessler R. 2011. Engineered nanoparticles in consumer products: understanding a new ingredient. Environ Health Perspect. 119(3):A120–A125.
   PubMed Web of Science ®Google Scholar
• Kim YS, Lim CH, Shin SH, Kim JC 2017. Twenty-eight-day repeated inhalation toxicity study of nano-sized neodymium oxide in male sprague-dawley rats. Toxicol Res. 33(3):239–253.
   PubMed Web of Science ®Google Scholar
• Lioy PJ, Nazarenko Y, Han TW, Lioy MJ, Mainelis G. 2010. Nanotechnology and exposure science: what is needed to fill the research and data gaps for consumer products. Int J Occup Environ Health. 16(4):378–387.
   PubMed Web of Science ®Google Scholar
• Lohani A, Verma A, Joshi H, Yadav N, Karki N. 2014. Nanotechnology-based cosmeceuticals. Int Sch Res Not. 2014:843687.
   Google Scholar
• Losert S, von Goetz N, Bekker C, Fransman W, Wijnhoven SWP, Delmaar C, Hungerbuhler K, Ulrich A. 2014. Human exposure to conventional and nanoparticle–containing sprays-a critical review. Environ Sci Technol. 48(10):5366–5378.
   PubMed Web of Science ®Google Scholar
• Lu PJ, Huang SC, Chen YP, Chiueh LC, Shih DC. 2015. Analysis of titanium dioxide and zinc oxide nanoparticles in cosmetics. J Food Drug Anal. 23(3):587–594.
   PubMed Web of Science ®Google Scholar
• Lux Research 2014. Feb 17. Nanotechnology Update: Corporations Up Their Spending as Revenues for Nano-enabled Products Increase. [accessed 2018 Feb 19]. https://members.luxresearchinc.com/research/report/13748.
   Google Scholar
• McKinney W, Chen B, Frazer D. 2009. Computer controlled multi-walled carbon nanotube inhalation exposure system. Inhal Toxicol. 21(12):1053.
   PubMed Web of Science ®Google Scholar
• Mitrano DM, Motellier S, Clavaguera S, Nowack B. 2015. Review of nanomaterial aging and transformations through the life cycle of nano-enhanced products. Environ Int. 77:132–147.
   PubMed Web of Science ®Google Scholar
• Myers TR. 2013. The science guiding selection of an aerosol delivery device. Respir Care. 58(11):1963–1973.
   PubMed Web of Science ®Google Scholar
• Nazarenko Y, Han TW, Lioy PJ, Mainelis G. 2011. Potential for exposure to engineered nanoparticles from nanotechnology-based consumer spray products. J Expo Sci Environ Epidemiol. 21(5):515–528.
   PubMed Web of Science ®Google Scholar
• Nazarenko Y, Lioy PJ, Mainelis G. 2014. Quantitative assessment of inhalation exposure and deposited dose of aerosol from nanotechnology-based consumer sprays. Environ Sci: Nano. 1(2):161–171.
   PubMed Web of Science ®Google Scholar
• Nazarenko Y, Zhen H, Han T, Lioy PJ, Mainelis G. 2012a. Potential for inhalation exposure to engineered nanoparticles from nanotechnology-based cosmetic powders. Environ Health Perspect. 120(6):885–892.
   PubMed Web of Science ®Google Scholar
• Nazarenko Y, Zhen H, Han T, Lioy PJ, Mainelis G. 2012b. Nanomaterial inhalation exposure from nanotechnology-based cosmetic powders: a quantitative assessment. J Nanoparticle Res Interdiscip Forum Nanoscale Sci Technol. 14(11):1229.
   PubMed Web of Science ®Google Scholar
• Nel AE, Mädler L, Velegol D, Xia T, Hoek EMV, Somasundaran P, Klaessig F, Castranova V, Thompson M. 2009. Understanding biophysicochemical interactions at the nano–bio interface. Nature Mater. 8(7):543–557.
   PubMed Web of Science ®Google Scholar
• Newman MD, Stotland M, Ellis JI. 2009. The safety of nanosized particles in titanium dioxide- and zinc oxide-based sunscreens. J Am Acad Dermatol. 61(4):685–692.
   PubMed Web of Science ®Google Scholar
• NSF 2014. Market report on emerging nanotechnology now available | NSF - National Science Foundation. Natl Sci Found. [accessed 2017 Aug 13]. https://www.nsf.gov/news/news_summ.jsp?cntn_id=130586.
   Google Scholar
• OECD 2018. Series on Testing and Assessment: Testing for Human Health. [accessed 2019 Jul 11]. http://www.oecd.org/chemicalsafety/testing/seriesontestingandassessmenttestingforhumanhealth.htm.
   Google Scholar
• Osmond-McLeod MJ, Oytam Y, Rowe A, Sobhanmanesh F, Greenoak G, Kirby J, McInnes EF, McCall MJ. 2015. Long-term exposure to commercially available sunscreens containing nanoparticles of TiO2 and ZnO revealed no biological impact in a hairless mouse model. Part Fibre Toxicol. 13(1):44–56.
   Google Scholar
• Oyabu T, Morimoto Y, Izumi H, Yoshiura Y, Tomonaga T, Lee B-W, Okada T, Myojo T, Shimada M, Kubo M, et al. 2016. Comparison between whole-body inhalation and nose-only inhalation on the deposition and health effects of nanoparticles. Environ Health Prev Med. 21(1):42–48.
   PubMed Web of Science ®Google Scholar
• Pal A, Watson CY, Pirela SV, Singh D, Chalbot MSG, Kavouras I, and Demokritou P. 2015. Linking exposures of particles released from nano-enabled products to toxicology: An integrated methodology for particle sampling, extraction, dispersion and dosing. Toxicological Sciences. doi: 10.1093/toxsci/kfv095.
   Google Scholar
• Pant V, Deshpande CG, Kamra AK. 2010. Changes in concentration and size distribution of aerosols during fog over the south Indian Ocean. J Earth Syst Sci. 119(4):479–487.
   Web of Science ®Google Scholar
• Park DU, Paik NW 2002. Effect on blood lead of airborne lead particles characterized by size. Ann Occup Hyg. 46(2):237–243.
   PubMed Web of Science ®Google Scholar
• Park J, Ham S, Jang M, Lee J, Kim S, Kim S, Lee K, Park D, Kwon J, Kim H, et al. 2017. Spatial–temporal dispersion of aerosolized nanoparticles during the use of consumer spray products and estimates of inhalation exposure. Environ Sci Technol. 51(13):7624–7638.
   PubMed Web of Science ®Google Scholar
• Park J, Yoon C, Lee K. 2018. Comparison of modeled estimates of inhalation exposure to aerosols during use of consumer spray products. Int J Hyg Environ Health. 221(6):941–950.
   PubMed Web of Science ®Google Scholar
• Pflücker F, Hohenberg H, Hölzle E, Will T, Pfeiffer S, Wepf R, Diembeck W, Wenck H, Gers‐Barlag H. 1999. The outermost stratum corneum layer is an effective barrier against dermal uptake of topically applied micronized titanium dioxide. Int J Cosmet Sci. 21(6):399–411.
   PubMedGoogle Scholar
• Pirela SV, Pyrgiotakis G, Bello D, Thomas T, Castranova V, Demokritou P. 2014. Development and characterization of an exposure platform suitable for physico-chemical, morphological and toxicological characterization of printer-emitted particles (PEPs). Inhal Toxicol. 26(7):400–408.
   PubMed Web of Science ®Google Scholar
• Pirela SV, Sotiriou GA, Bello D, Shafer M, Bunker KL, Castranova V, Thomas T, Demokritou P. 2015. Consumer exposures to laser printer-emitted engineered nanoparticles: a case study of life-cycle implications from nano-enabled products. Nanotoxicology. 9(6):760–768.
   PubMed Web of Science ®Google Scholar
• Présumé M, Attoui M, Maisser A, Petit G, Lanone S. 2015. Design and characterization of an inhalation system of iron and manganese oxide nanoparticles for rodent exposure. Aerosol Sci Technol. 49(8):580–588.
   Web of Science ®Google Scholar
• Quadros ME, Marr LC. 2011. Silver nanoparticles and total aerosols emitted by nanotechnology-related consumer spray products. Environ Sci Technol. 45(24):10713–10719.
   PubMed Web of Science ®Google Scholar
• Raj S, Jose S, Sumod US, Sabitha M. 2012. Nanotechnology in cosmetics: opportunities and challenges. J Pharm Bioall Sci. 4(3):186–193.
   PubMedGoogle Scholar
• Remya NS, Syama S, Sabareeswaran A, Mohanan PV. 2016. Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications. Int J Pharm. 511(1):586–598.
   PubMedGoogle Scholar
• Rothe H, Fautz R, Gerber E, Neumann L, Rettinger K, Schuh W, Gronewold C. 2011. Special aspects of cosmetic spray safety evaluations: principles on inhalation risk assessment. Toxicol Lett. 205(2):97–104.
   PubMed Web of Science ®Google Scholar
• Royce SG, Mukherjee D, Cai T, Xu SS, Alexander JA, Mi Z, Calderon L, Mainelis G, Lee K, Lioy PJ. 2014. Modeling population exposures to silver nanoparticles present in consumer products. J Nanoparticle Res Interdiscip Forum Nanoscale Sci Technol. 16(11):2724.
   PubMed Web of Science ®Google Scholar
• Sadrieh N, Wokovich AM, Gopee NV, Zheng J, Haines D, Parmiter D, Siitonen PH, Cozart CR, Patri AK, McNeil SE, et al. 2010. Lack of significant dermal penetration of titanium dioxide from sunscreen formulations containing nano- and submicron-size TiO2 particles. Toxicol Sci. 115(1):156–166.
   PubMed Web of Science ®Google Scholar
• Schmoll LH, Elzey S, Grassian VH, O'Shaughnessy PT. 2009. Nanoparticle aerosol generation methods from bulk powders for inhalation exposure studies. Nanotoxicology. 3(4):265–275.
   Web of Science ®Google Scholar
• Schulz J, Hohenberg H, Pflücker F, Gärtner E, Will T, Pfeiffer S, Wepf R, Wendel V, Gers-Barlag H, Wittern KP. 2002. Distribution of sunscreens on skin. Adv Drug Deliv Rev. 54(Suppl 1):S157–S163.
   PubMed Web of Science ®Google Scholar
• Shi H, Magaye R, Castranova V, Zhao J. 2013. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol. 10(1):15.
   PubMedGoogle Scholar
• Skocaj M, Filipic M, Petkovic J, Novak S. 2011. Titanium dioxide in our everyday life; is it safe? Radiol Oncol. 45(4):227–247.
   PubMed Web of Science ®Google Scholar
• Steiling W, Bascompta M, Carthew P, Catalano G, Corea N, D’Haese A, Jackson P, Kromidas L, Meurice P, Rothe H, et al. 2014. Principle considerations for the risk assessment of sprayed consumer products. Toxicol Lett. 227(1):41–49.
   PubMed Web of Science ®Google Scholar
• Tungittiplakorn W, Lion LW, Cohen C, Kim JY. 2004. Engineered polymeric nanoparticles for soil remediation. Environ Sci Technol. 38(5):1605–1610.
   PubMed Web of Science ®Google Scholar
• US EPA National Center for Environmental Assessment WD 2011. Exposure Factors Handbook 2011 Edition (Final Report). [accessed 2019 Jul 21]. https://cfpub.epa.gov/ncea/risk/recordisplay.cfm?deid=236252.
   Google Scholar
• [US NNI] United States National Nanotechnology Initiative 2018. Benefits and Applications | Nano. [accessed Feb 19]. https://www.nano.gov/you/nanotechnology-benefits.
   Google Scholar
• Valavanidis A, Vlachogianni T. 2016. Engineered nanomaterials for pharmaceutical and biomedical products new trends, benefits and opportunities. J Pharmacol Rep. 1(1).
   PubMedGoogle Scholar
• Wang Y, Aker WG, Hwang H, Yedjou CG, Yu H, Tchounwou PB. 2011. A study of the mechanism of in vitro cytotoxicity of metal oxide nanoparticles using catfish primary hepatocytes and human HepG2 cells. Sci Total Environ. 409(22):4753–4762.
   PubMed Web of Science ®Google Scholar
• Wawrzynczak A, Nowak I. 2011. Synthesis and characterization of metallic oxides with potential use in cosmetic products. Chemtik. 65(2):82–87.
   Google Scholar
• Whyte W, Agricola K, Derks M. 2015. Airborne particle deposition in cleanrooms: deposition mechanisms. Clean Air Contain Rev. 24:4–9.
   Google Scholar
• Xia T, Li N, Nel AE. 2009. Potential health impact of nanoparticles. Annu Rev Public Health. 30(1):137–150.
   PubMed Web of Science ®Google Scholar
• Zeidler-Erdely PC, Antonini JM, Meighan TG, Young S-H, Eye TJ, Hammer MA, Erdely A. 2016. Comparison of cell counting methods in rodent pulmonary toxicity studies: automated and manual protocols and considerations for experimental design. Inhal Toxicol. 28(9):410–420.
   PubMed Web of Science ®Google Scholar
• Zhang XQ, Xu X, Bertrand N, Pridgen E, Swami A, Farokhzad OC. 2012. Interactions of nanomaterials and biological systems: implications to personalized nanomedicine. Adv Drug Deliv Rev. 64(13):1363–1384.
   PubMed Web of Science ®Google Scholar