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Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 2
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Research Articles

TDZD-8 alleviates delayed neurological sequelae following acute carbon monoxide poisoning involving tau protein phosphorylation

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Pages 79-85 | Received 29 Oct 2019, Accepted 08 Mar 2020, Published online: 18 Mar 2020

References

  • Albayram O, Kondo A, Mannix R, Smith C, Tsai CY, Li C, Herbert MK, Qiu J, Monuteaux M, Driver J, et al. 2017. Cis P-tau is induced in clinical and preclinical brain injury and contributes to post-injury sequelae. Nat Commun. 8(1):1000.
  • Alosco ML, Stein TD, Tripodis Y, Chua AS, Kowall NW, Huber BR, Goldstein LE, Cantu RC, Katz DI, Palmisano JN, et al. 2019. Association of white matter rarefaction, arteriolosclerosis, and tau with dementia in chronic traumatic encephalopathy. JAMA Neurol. 76(11):1298.
  • American College of Emergency Physicians Clinical Policies Subcommittee on Carbon Monoxide Poisoning, Wolf SJ, Maloney GE, Shih RD, Shy BD, Brown MD, Brown MD, Byyny R, Diercks DB, Gemme SR, Gerardo CJ, et al. 2017. Clinical policy: critical issues in the evaluation and management of adult patients presenting to the emergency department with acute carbon monoxide poisoning. Ann Emerg Med. 69(1):98–107 e106.
  • Bi M, Li Q, Guo D, Ding X, Bi W, Zhang Y, Zou Y, 2017. Sulphoraphane improves neuronal mitochondrial function in brain tissue in acute carbon monoxide poisoning rats. Basic Clin Pharmacol Toxicol. 120(6):541–549.
  • Chen X, Kordich JK, Williams ET, Levine N, Cole-Strauss A, Marshall L, Labrie V, Ma J, Lipton JW, Moore DJ, 2019. Parkinson’s disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration. Proc Natl Acad Sci USA. 116(12):5765–5774.
  • Collino M, Thiemermann C, Mastrocola R, Gallicchio M, Benetti E, Miglio G, Castiglia S, Danni O, Murch O, Dianzani C, et al. 2008. Treatment with the glycogen synthase kinase-3beta inhibitor, TDZD-8, affects transient cerebral ischemia/reperfusion injury in the rat hippocampus. Shock. 30(3):299–307.
  • Cuadrado A, Kugler S, Lastres-Becker I, 2018. Pharmacological targeting of GSK-3 and NRF2 provides neuroprotection in a preclinical model of tauopathy. Redox Biol. 14:522–534.
  • Dey A, Hao S, Wosiski-Kuhn M, Stranahan AM, 2017. Glucocorticoid-mediated activation of GSK3beta promotes tau phosphorylation and impairs memory in type 2 diabetes. Neurobiol Aging. 57:75–83.
  • Du JJ, Liu ZQ, Yan Y, Xiong J, Jia XT, Di ZL, Ren JJ, 2019. The cannabinoid WIN 55,212-2 reduces delayed neurologic sequelae after carbon monoxide poisoning by promoting microglial M2 polarization through ST2 signaling. J Mol Neurosci. 70(3):422–432.
  • Duda P, Wiśniewski J, Wójtowicz T, Wójcicka O, Jaśkiewicz M, Drulis-Fajdasz D, Rakus D, McCubrey JA, Gizak A, 2018. Targeting GSK3 signaling as a potential therapy of neurodegenerative diseases and aging. Expert Opin Ther Targets. 22(10):833–848.
  • Fan DF, Hu HJ, Sun Q, Lv Y, Ye ZH, Sun XJ, Pan SY, 2016. Neuroprotective effects of exogenous methane in a rat model of acute carbon monoxide poisoning. Brain Res. 1633:62–72.
  • Fernandez-Albert J, Lipinski M, Lopez-Cascales MT, Rowley MJ, Martin-Gonzalez AM, Del Blanco B, Corces VG, Barco A, 2019. Immediate and deferred epigenomic signatures of in vivo neuronal activation in mouse hippocampus. Nat Neurosci. 22(10):1718–1730.
  • Fulga TA, Elson-Schwab I, Khurana V, Steinhilb ML, Spires TL, Hyman BT, Feany MB, 2007. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nat Cell Biol. 9(2):139–148.
  • Gawlikowski T, Golasik M, Gomółka E, Piekoszewski W, 2014. Proteins as biomarkers of carbon monoxide neurotoxicity. Inhal Toxicol. 26(14):885–890.
  • Goedert M, Eisenberg DS, Crowther RA, 2017. Propagation of Tau aggregates and neurodegeneration. Annu Rev Neurosci. 40(1):189–210.
  • Hampson NB, 2019. Racial and ethnic trends in unintentional carbon monoxide poisoning deaths. Undersea Hyperb Med. 46(4):495–501.
  • Hess DR, 2017. Inhaled carbon monoxide: from toxin to therapy. Respir Care. 62(10):1333–1342.
  • Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK, Pitstick R, Carlson GA, Lanier LM, Yuan L-L, et al. 2010. Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron. 68(6):1067–1081.
  • Hui-Jun H, Dan-Feng F, 2017. Should hyperbaric oxygen be used in acute carbon monoxide poisoning?. Am J Emerg Med. 35(7):1030.
  • Hur EM, Zhou FQ, 2010. GSK3 signalling in neural development. Nat Rev Neurosci. 11(8):539–551.
  • Jackson DA, Michael T, Vieira de Abreu A, Agrawal R, Bortolato M, Fisher SJ, 2018. Prevention of severe hypoglycemia-induced brain damage and cognitive impairment with verapamil. Diabetes. 67(10):2107–2112.
  • Jellestad L, Fink T, Pradarutti S, Kubulus D, Wolf B, Bauer I, Thiemermann C, Rensing H, 2014. Inhibition of glycogen synthase kinase (GSK)-3-beta improves liver microcirculation and hepatocellular function after hemorrhagic shock. Eur J Pharmacol. 724:175–184.
  • Jeon SB, Sohn CH, Seo DW, Oh BJ, Lim KS, Kang DW, Kim WY, 2018. Acute brain lesions on magnetic resonance imaging and delayed neurological sequelae in carbon monoxide poisoning. JAMA Neurol. 75(4):436–443.
  • Kelly S, Zhao H, Hua Sun G, Cheng D, Qiao Y, Luo J, Martin K, Steinberg GK, Harrison SD, Yenari MA, 2004. Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia. Exp Neurol. 188(2):378–386.
  • Kilicaslan I, Bildik F, Aksel G, Yavuz G, Gulbahar O, Keles A, Demircan A, 2012. Serum tau protein level for neurological injuries in carbon monoxide poisoning. Clin Toxicol (Phila). 50(6):497–502.
  • Koehler D, Shah ZA, Williams FE, 2019. The GSK3beta inhibitor, TDZD-8, rescues cognition in a zebrafish model of okadaic acid-induced Alzheimer’s disease. Neurochem Int. 122:31–37.
  • Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C, Mandelkow E, Zweckstetter M, 2009. Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol. 7(2):e34.
  • Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S, 2019. Plasma total-tau as a biomarker of stroke risk in the community. Ann Neurol. 86(3):463–467.
  • Pluta R, Ułamek-Kozioł M, Januszewski S, Czuczwar SJ, 2018. Tau protein dysfunction after brain ischemia. JAD. 66(2):429–437.
  • Rehman SU, Ikram M, Ullah N, Alam SI, Park HY, Badshah H, Choe K, Kim MO, 2019. Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK/CREB signaling. Cells. 8(7):760.
  • Rose JJ, Wang L, Xu Q, McTiernan CF, Shiva S, Tejero J, Gladwin MT, 2017. Carbon monoxide poisoning: pathogenesis, management, and future directions of therapy. Am J Respir Crit Care Med. 195(5):596–606.
  • Sekiya K, Nishihara T, Abe N, Konishi A, Nandate H, Hamada T, Ikemune K, Takasaki Y, Tanaka J, Asano M, et al. 2019. Carbon monoxide poisoning-induced delayed encephalopathy accompanies decreased microglial cell numbers: distinctive pathophysiological features from hypoxemia-induced brain damage. Brain Res. 1710:22–32.
  • Shi L, Westwood S, Baird AL, Winchester L, Dobricic V, Kilpert F, Hong S, Franke A, Hye A, Ashton NJ, 2019. Discovery and validation of plasma proteomic biomarkers relating to brain amyloid burden by SOMAscan assay. Alzheimers Dement. 15(11):1478–1488.
  • Sonmez BM, Iscanli MD, Parlak S, Dogan Y, Ulubay HG, Temel E, 2018. Delayed neurologic sequelae of carbon monoxide intoxication. Turk J Emerg Med. 18(4):167–169.
  • Sun Q, Cai J, Zhou J, Tao H, Zhang JH, Zhang W, Sun XJ, 2011. Hydrogen-rich saline reduces delayed neurologic sequelae in experimental carbon monoxide toxicity. Crit Care Med. 39(4):765–769.
  • Thies E, Mandelkow EM, 2007. Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci. 27(11):2896–2907.
  • Wang Y, Mandelkow E, 2016. Tau in physiology and pathology. Nat Rev Neurosci. 17(1):5–21.
  • Watt S, Prado CE, Crowe SF, 2018. Immediate and delayed neuropsychological effects of carbon monoxide poisoning: a meta-analysis. J Int Neuropsychol Soc. 24(4):405–415.
  • Weaver LK, Hopkins RO, Chan KJ, Churchill S, Elliott CG, Clemmer TP, Orme JF, Jr., Thomas FO, Morris AH. 2002. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med. 347(14):1057–1067.
  • Weaver LK. 2009. Clinical practice. Carbon monoxide poisoning. N Engl J Med. 360(12):1217–1225.
  • Yeh ZT, Tsai CF, Yip PK, Lo CY, Peng SM, Chen SY, Kung LY, 2014. Neuropsychological performance in patients with carbon monoxide poisoning. Appl Neuropsychol Adult. 21(4):278–287.
  • Yi JH, Brown C, Whitehead G, Piers T, Lee YS, Perez CM, Regan P, Whitcomb DJ, Cho K, 2017. Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus. Pharmacol Res. 121:42–51.
  • Yli-Karjanmaa M, Solevad Larsen K, Duhring Fenger C, Kellemann Kristensen L, Anne Martin N, Toft Jensen P, Breton A, Nathanson L, Vinther Nielsen P, Christiansen Lund M, et al. 2019. TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex. Brain Behav Immun. 82:279–297.
  • Zanier ER, Bertani I, Sammali E, Pischiutta F, Chiaravalloti MA, Vegliante G, Masone A, Corbelli A, Smith DH, Menon DK, et al. 2018. Induction of a transmissible tau pathology by traumatic brain injury. Brain. 141(9):2685–2699.
  • Zhang Y, Zhang J, Wang E, Qian W, Fan Y, Feng Y, Yin H, Li Y, Wang Y, Yuan T, 2018. Microcystin-leucine-arginine induces tau pathology through bα degradation via protein phosphatase 2A demethylation and associated glycogen synthase kinase-3β phosphorylation. Toxicol Sci. 162(2):475–487.

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