Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 32, 2020 - Issue 7
185
Views
7
CrossRef citations to date
0
Altmetric
Research Articles

Numerical modeling of nanoparticle deposition in realistic monkey airway and human airway models: a comparative study

ORCID Icon, ORCID Icon & ORCID Icon
Pages 311-325 | Received 24 Mar 2020, Accepted 20 Jul 2020, Published online: 30 Jul 2020

References

  • Abe K, Kondoh T, Nagano Y. 1994. A new turbulence model for predicting fluid flow and heat transfer in separating and reattaching Flow field calculations. Int J Heat Mass Transf. 37(1):139–151.
  • Allen JL, Oberdorster G, Morris-Schaffer K, Wong C, Klocke C, Sobolewski M, Conrad K, Mayer-Proschel M, Cory-Slechta DA. 2017. Developmental neurotoxicity of inhaled ambient ultrafine particle air pollution: parallels with neuropathological and behavioral features of autism and other neurodevelopmental disorders. Neurotoxicology. 59:140–154.
  • Anjilvel S, Asgharian B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam Appl Toxicol. 28(1):41–50.
  • Asgharian B, Hofmann W, Bergmann R. 2001. Particle deposition in a multiple-path model of the human lung. Aerosol Sci Tech. 34(4):332–339.
  • Asgharian B, Price O, McClellan G, Corley R, Einstein DR, Jacob RE, Harkema J, Carey SA, Schelegle E, Hyde D, et al. 2012. Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans. Inhal Toxicol. 24(13):869–899.
  • Asgharian B, Price OT, Oldham M, Chen LC, Saunders EL, Gordon T, Mikheev VB, Minard KR, Teeguarden JG. 2014. Computational modeling of nanoscale and microscale particle deposition, retention and dosimetry in the mouse respiratory tract. Inhal Toxicol. 26(14):829–842.
  • Cheng KH, Cheng YS, Yeh HC, Guilmette RA, Simpson SQ, Yang YH, Swift DL. 1996. In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways. J Aerosol Sci. 27(5):785–801.
  • Cheng KH, Cheng YS, Yeh HC, Swift DL. 1995. Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath holding using replicate human upper airway casts. Aerosol Sci Technol. 23(3):465–474.
  • Cheng YS, Irshad H, Kuehl P, Holmes TD, Sherwood R, Hobbs CH. 2008. Lung deposition of droplet aerosols in monkeys. Inhal Toxicol. 20(11):1029–1036.
  • Cheng YS, Yamada Y, Yeh HC, Swift DL. 1988. Diffusional deposition of ultrafine aerosols in a human nasal cast. Aerosol Sci. 19(6):741–751.
  • De Hartog JJ, Hoek G, Peters A, Timonen KL, Ibald-Mulli A, Brunekreef B, Heinrich J, Tiittanen P, Van Wijnen JH, Kreyling W, et al. 2003. Effects of fine and ultrafine particles on cardiorespiratory symptoms in elderly subjects with coronary heart disease: the ultra study. Am J Epidemiol. 157(7):613–623.
  • Donaldson K, Li XY, MacNee W. 1998. Ultrafine (nanometre) particle mediated lung injury. J Aerosol Sci. 29(5–6):553–560.
  • Dong J, Shang Y, Inthavong K, Chan HK, Tu J. 2018. Partitioning of dispersed nanoparticles in a realistic nasal passage for targeted drug delivery. Int J Pharm. 543(1–2):83–95.
  • Doorly DJ, Taylor DJ, Schroter RC. 2008. Mechanics of airflow in the human nasal airways. Respir Physiol Neurobiol. 163(1–3):100–110.
  • Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, et al. 2006. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 114(8):1172–1178.
  • Frampton MW. 2001. Systemic and cardiovascular effects of airway injury and inflammation: ultrafine particle exposure in humans. Environ Health Perspect. 109(4):529–532.
  • Ge QJ, Inthavong K, Tu J. 2012. Local deposition fractions of ultrafine particles in a human nasal-sinus cavity CFD model. Inhal Toxicol. 24(8):492–505.
  • Guo H, Morawska L, He C, Gilbert D. 2008. Impact of ventilation scenario on air exchange rates and on indoor particle number concentrations in an air-conditioned classroom. Atmos Environ. 42(4):757–768.
  • Guyton AC. 1947. Measurement of the respiratory volumes of laboratory animals. Am J Physiol. 150(1):70–77.
  • Harkema JR, Plopper CG, Hyde DM, St George JA, Dungworth DL. 1987. Effects of an ambient level of ozone on primate nasal epithelial mucosubstances: quantitative histochemistry. Am J Pathol. 127(1):90–96.
  • Hinds WC. 1999. Aerosol technology, properties, behavior, and measurement of airborne particles. New York (NY): Wiley Press.
  • Inthavong K, Ge QJ, Li X, Tu J. 2013. Source and trajectories of inhaled particles from a surrounding environment and its deposition in the respiratory airway. Inhal Toxicol. 25(5):280–291.
  • Ito K. 2014. Integrated numerical approach of computational fluid dynamics and epidemiological model for multi-scale transmission analysis in indoor spaces. Indoor Built Environ. 23(7):1029–1049.
  • Ito K, Inthavong K, Kurabuchi T, Ueda T, Endo T, Omori T, Ono H, Kato S, Sakai K, Suwa Y, et al. 2015a. CFD benchmark tests for indoor environmental problems: part 1, isothermal/non-isothermal flow in 2d and 3d room model. Int J Archit Eng Technol. 2(1):01–22.
  • Ito K, Inthavong K, Kurabuchi T, Ueda T, Endo T, Omori T, Ono H, Kato S, Sakai K, Suwa Y, et al. 2015b. CFD benchmark tests for indoor environmental problems: part 2, cross-ventilation airflows and floor heating systems. Int J Archit Eng Technol. 2(1):23–49.
  • Ito K, Inthavong K, Kurabuchi T, Ueda T, Endo T, Omori T, Ono H, Kato S, Sakai K, Suwa Y, et al. 2015c. CFD benchmark tests for indoor environmental problems: part 3, numerical thermal manikins. Int J Archit Eng Technol. 2(1):50–75.
  • Ito K, Mitsumune K, Kuga K, Phuong NL, Tani K, Inthavong K. 2017. Prediction of convective heat transfer coefficients for the upper respiratory tracts of rat, dog, monkey, and humans. Indoor Built Environ. 26(6):828–840.
  • Kelly JT, Asgharian B, Kimbell JS, Wong BA. 2004. Particle deposition in human nasal airway replicas manufactured by different methods. Part II: ultrafine particles. Aerosol Sci Technol. 38(11):1072–1079.
  • Kelly JT, Asgharian B, Wong BA. 2005. Inertial particle deposition in a monkey nasal mold compared with that in human nasal replicas. Inhal Toxicol. 17(14):823–830.
  • Kim JW, Phuong NL, Aramaki S, Ito K. 2018. Flow visualization through particle image velocimetry in realistic model of rhesus monkey’s upper airway. Respir Physiol Neurobiol. 251:16–27.
  • Li A, Ahmadi G. 1992. Dispersion and deposition of spherical particles from point sources in a turbulent channel flow. Aerosol Sci Technol. 16(4):209–226.
  • Li N, Georas S, Alexis N, Fritz P, Xia T, Williams MA, Horner E, Nel A. 2016. A work group report on ultrafine particle (AAAAI) why ambient ultrafine and engineered nanoparticles should receive special attention for possible adverse health outcomes in humans. J Allergy Clin Immunol. 138(2):386–396.
  • Liu JY, Hsiao TC, Lee KY, Chuang HC, Cheng TJ, Chuang KJ. 2018. Association of ultrafine particles with cardiopulmonary health among adult subjects in the urban areas of northern Taiwan. Sci Total Environ. 627:211–215.
  • Lonati G, Ozgen S, Luraghi I, Giugliano M. 2010. Particle number concentration at urban microenvironments. Chem Eng Trans. 22:137–142.
  • Longest PW, Xi J. 2007. Computational investigation of particle inertia effects on submicron aerosol deposition in the respiratory tract. J Aerosol Sci. 38(1):111–130.
  • Manojkumar N, Srimuruganandam B, Shiva Nagendra SM. 2019. Application of multiple-path particle dosimetry model for quantifying age specified deposition of particulate matter in human airway. Ecotoxicol Environ Saf. 168:241–248.
  • Martonen TB, Katz IM, Musante C. 2001. A nonhuman primate aerosol deposition model for toxicological and pharmaceutical studies. Inhal Toxicol. 13(4):307–356.
  • Mullen NA, Liu C, Zhang Y, Wang S, Nazaroff WW. 2011. Ultrafine particle concentrations and exposures in four high-rise Beijing apartments. Atmos Environ. 45(40):7574–7582.
  • National Research Council. 1991. Comparative dosimetry of Radon in mines and homes. Washington (DC): National Academies Press.
  • Oberdörster G, Kuhlbusch TAJ. 2018. In vivo effect: methodologies and biokinetics of inhaled nanomaterials. NanoImpact. 10(C):38–60.
  • Oberdörster G, Oberdörster E, Oberdörster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 113(7):823–839.
  • Phuong NL, Ito K. 2013. Experimental and numerical study of airflow pattern and particle dispersion in a vertical ventilation duct. Build Environ. 59:466–481.
  • Phuong NL, Ito K. 2015. Investigation of flow pattern in upper human airway including oral and nasal inhalation by PIV and CFD. Build Environ. 94(2):504–515.
  • Phuong NL, Khoa ND, Inthavong K, Ito K. 2018. Particle and inhalation exposure in human and monkey computational airway models. Inhal Toxicol. 30(11–12):416–428.
  • Phuong NL, Quang TV, Khoa ND, Kim JW, Ito K. 2020. CFD analysis of the flow structure in a monkey upper airway validated by PIV experiments. Respir Physiol Neurobiol. 271:103304.
  • Phuong NL, Yamashita M, Yoo SJ, Ito K. 2016. Prediction of convective heat transfer coefficient of human upper and lower airway surfaces in steady and unsteady breathing conditions. Build Environ. 100:172–185.
  • Saffman PG. 1965. The lift on a small sphere in a slow shear flow. J Fluid Mech. 22(2):385–400.
  • Saha PK, Robinson ES, Shah RU, Zimmerman N, Apte JS, Robinson AL, Presto AA. 2018. Reduced ultrafine particle concentration in urban air: changes in nucleation and anthropogenic emissions. Environ Sci Technol. 52(12):6798–6806.
  • Schroeter JD, Asgharian B, Price OT, McClellan GE. 2013. Computational fluid dynamics simulations of inhaled nano- and microparticle deposition in the rhesus monkey nasal passages. Inhal Toxicol. 25(12):691–701.
  • Seaton A, Godden D, MacNee W, Donaldson K. 1995. Particulate air pollution and acute health effects. Lancet. 345(8943):176–178.
  • Swift DL, Montassier N, Hopke PK, Kim KH, Cheng YS, Ying FS, Yeh HC, Strong JC. 1992. Inspiratory deposition of ultrafine particles in human nasal replicate cast. J Aerosol Sci. 23(1):65–72.
  • Terzano C, Di Stefano F, Conti V, Graziani E, Petroianni A. 2010. Air pollution ultrafine particles: toxicity beyond the lung. Eur Rev Med Pharmacol Sci. 14(10):809–821.
  • Tian L, Shang Y, Dong J, Inthavong K, Tu J. 2017. Human nasal olfactory deposition of inhaled nanoparticles at low to moderate breathing rate. J Aerosol Sci. 113:189–200.
  • Wang SM, Inthavong K, Wen J, Tu JY, Xue CL. 2009. Comparison of micron- and nanoparticle deposition patterns in a realistic human nasal cavity. Respir Physiol Neurobiol. 166(3):142–151.
  • Xi J, Longest PW. 2008. Numerical predictions of submicrometer aerosol deposition in the nasal cavity using a novel drift flux approach. Int J Heat Mass Transf. 51(23–24):5562–5577.
  • Yeh HC, Cheng YS, Su YF, Morgan KT. 1992. Deposition of radon progeny in nonhuman primate nasal airways. In: Cross IFT, editor. Indoor radon and lung cancer: reality or myth. Richland (WA): Battelle Press.
  • Yeh HC, Muggenburg BA, Harkema JR. 1997. In vivo deposition of inhaled ultrafine particles in the respiratory tract of rhesus monkeys. Aerosol Sci Technol. 27(4):465–470.
  • Yoon J Y, Lee J-D, Joo S W, Kang D R. 2016. Indoor radon exposure and lung cancer: a review of ecological studies. Ann of Occup and Environ Med. 28(1):1–9.
  • Zhang Z, Kleinstreuer C. 2004. Airflow structures and nano-particle deposition in a human upper airway model. Comput Phys. 198(1):178–210.
  • Zhang Z, Kleinstreuer C. 2011. Computational analysis of airflow and nanoparticle deposition in a combined nasal-oral-tracheobronchial airway model. J Aerosol Sci. 42(3):174–194.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.