Development of a screening protocol to identify persons who are responsive to wood smoke particle-induced airway inflammation with pilot assessment of GSTM1 genotype and asthma status as response modifiers

References

• Adetona O, Dunn K, Hall DB, Achtemeier G, Stock A, Naeher LP. 2011. Personal PM(2.5) exposure among wildland firefighters working at prescribed forest burns in southeastern United States. J Occup Environ Hyg. 8(8):503–511.
   PubMed Web of Science ®Google Scholar
• Aguilera R, Corringham T, Gershunov A, Benmarhnia T. 2021. Wildfire smoke impacts respiratory health more than fine particles from other sources: observational evidence from Southern California. Nat Commun. 12(1):1493.
   PubMed Web of Science ®Google Scholar
• Alexis NE, Huang YC, Rappold AG, Kehrl H, Devlin R, Peden DB. 2014. Patients with asthma demonstrate airway inflammation after exposure to concentrated ambient particulate matter. Am J Respir Crit Care Med. 190(2):235–237.
   PubMed Web of Science ®Google Scholar
• Alexis NE, Lay JC, Haczku A, Gong H, Linn W, Hazucha MJ, Harris B, Tal-Singer R, Peden DB. 2008. Fluticasone propionate protects against ozone-induced airway inflammation and modified immune cell activation markers in healthy volunteers. Environ Health Perspect. 116(6):799–805.
   PubMed Web of Science ®Google Scholar
• Alexis NE, Lay JC, Zhou H, Kim CS, Hernandez ML, Kehrl H, Hazucha MJ, Devlin RB, Diaz-Sanchez D, Peden DB. 2013. The glutathione-S-transferase mu 1 (GSTM1) null genotype and increased neutrophil response to low-level ozone (0.06 ppm). J Allergy Clin Immunol. 131(2):610–612.
   PubMed Web of Science ®Google Scholar
• Alexis NE, Zhou H, Lay JC, Harris B, Hernandez ML, Lu TS, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, et al. 2009. The glutathione-S-transferase Mu 1 null genotype modulates ozone-induced airway inflammation in human subjects. J Allergy Clin Immunol. 124(6):1222–1228.e5.
   PubMed Web of Science ®Google Scholar
• Allen RW, Mar T, Koenig J, Liu LJ, Gould T, Simpson C, Larson T. 2008. Changes in lung function and airway inflammation among asthmatic children residing in a woodsmoke-impacted urban area. Inhal Toxicol. 20(4):423–433.
   PubMed Web of Science ®Google Scholar
• Bennett WD, Ivins S, Alexis NE, Wu J, Bromberg PA, Brar SS, Travlos G, London SJ. 2016. Effect of obesity on acute ozone-induced changes in airway function, reactivity, and inflammation in adult females. PLoS One. 11(8):e0160030.
   PubMed Web of Science ®Google Scholar
• Bromberg PA, Koren HS. 1995. Ozone-induced human respiratory dysfunction and disease. Toxicol Lett. 82–83:307–316.
   PubMed Web of Science ®Google Scholar
• Burbank AJ, Vadlamudi A, Mills KH, Alt EM, Wells H, Zhou H, Alexis N, Hernandez ML, Peden DB. 2019. The glutathione-S-transferase mu-1 null genotype increases wood smoke-induced airway inflammation. J Allergy Clin Immunol. 143(6):2299–2302.e3.
   PubMed Web of Science ®Google Scholar
• Cascio WE. 2018. Wildland fire smoke and human health. Sci Total Environ. 624:586–595.
   PubMed Web of Science ®Google Scholar
• Cleland SE, West JJ, Jia Y, Reid S, Raffuse S, O’Neill S, Serre ML. 2020. Estimating wildfire smoke concentrations during the October 2017 California Fires through BME Space/time data fusion of observed, modeled, and Satellite-derived PM2.5. Environ Sci Technol. 54(21):13439–13447.
   PubMed Web of Science ®Google Scholar
• Fry RC, Rager JE, Bauer R, Sebastian E, Peden DB, Jaspers I, Alexis NE. 2014. Air toxics and epigenetic effects: ozone altered microRNAs in the sputum of human subjects. Am J Physiol Lung Cell Mol Physiol. 306(12):L1129–37.
   PubMed Web of Science ®Google Scholar
• Fry RC, Rager JE, Zhou H, Zou B, Brickey JW, Ting J, Lay JC, Peden DB, Alexis NE. 2012. Individuals with increased inflammatory response to ozone demonstrate muted signaling of immune cell trafficking pathways. Respir Res. 13:89.
   PubMed Web of Science ®Google Scholar
• Ghio AJ, Soukup JM, Case M, Dailey LA, Richards J, Berntsen J, Devlin RB, Stone S, Rappold A. 2012. Exposure to wood smoke particles produces inflammation in healthy volunteers. Occup Environ Med. 69(3):170–175.
   PubMed Web of Science ®Google Scholar
• Gilliland FD, Li YF, Gong H, Jr., Diaz-Sanchez D. 2006. Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. Am J Respir Crit Care Med. 174(12):1335–1341.
   PubMed Web of Science ®Google Scholar
• Gilliland FD, Li YF, Saxon A, Diaz-Sanchez D. 2004. Effect of glutathione-S-transferase M1 and P1 genotypes on xenobiotic enhancement of allergic responses: randomised, placebo-controlled crossover study. Lancet. 363(9403):119–125.
   PubMed Web of Science ®Google Scholar
• Hernandez M, Brickey WJ, Alexis NE, Fry RC, Rager JE, Zhou B, Ting JP, Zhou H, Peden DB. 2012. Airway cells from atopic asthmatic patients exposed to ozone display an enhanced innate immune gene profile. J Allergy Clin Immunol. 129(1):259–261.
   PubMed Web of Science ®Google Scholar
• Hernandez ML, Lay JC, Harris B, Esther CR Jr., Brickey WJ, Bromberg PA, Diaz-Sanchez D, Devlin RB, Kleeberger SR, Alexis NE, et al. 2010. Atopic asthmatic subjects but not atopic subjects without asthma have enhanced inflammatory response to ozone. J Allergy Clin Immunol. 126(3):537–544.
   PubMed Web of Science ®Google Scholar
• Holz O, Khalilieh S, Ludwig-Sengpiel A, Watz H, Stryszak P, Soni P, Tsai M, Sadeh J, Magnussen H. 2010. SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects. Eur Respir J. 35(3):564–570.
   PubMed Web of Science ®Google Scholar
• Holz O, Tal-Singer R, Kanniess F, Simpson KJ, Gibson A, Vessey RSJ, Janicki S, Magnussen H, Jörres RA, Richter K. 2005. Validation of the human ozone challenge model as a tool for assessing anti-inflammatory drugs in early development. J Clin Pharmacol. 45(5):498–503.
   PubMed Web of Science ®Google Scholar
• Jones CG, Rappold AG, Vargo J, Cascio WE, Kharrazi M, McNally B, Hoshiko S, with the CSG. 2020. Out-of-Hospital cardiac arrests and wildfire-related particulate matter during 2015–2017 California Wildfires. J Am Heart Assoc. 9(8):e014125.
   PubMed Web of Science ®Google Scholar
• Kim CS, Alexis NE, Rappold AG, Kehrl H, Hazucha MJ, Lay JC, Schmitt MT, Case M, Devlin RB, Peden DB, et al. 2011. Lung function and inflammatory responses in healthy young adults exposed to 0.06 ppm Ozone for 6.6 Hours. Am J Respir Crit Care Med. 183(9):1215–1221.
   PubMed Web of Science ®Google Scholar
• Kirsten A, Watz H, Pedersen F, Holz O, Smith R, Bruin G, Koehne-Voss S, Magnussen H, Waltz DA. 2013. The anti-IL-17A antibody secukinumab does not attenuate ozone-induced airway neutrophilia in healthy volunteers. Eur Respir J. 41(1):239–241.
   PubMed Web of Science ®Google Scholar
• Kodgule R, Salvi S. 2012. Exposure to biomass smoke as a cause for airway disease in women and children. Curr Opin Allergy Clin Immunol. 12(1):82–90.
   PubMed Web of Science ®Google Scholar
• Laumbach RJ, Kipen HM. 2012. Respiratory health effects of air pollution: update on biomass smoke and traffic pollution. J Allergy Clin Immunol. 129(1):3–11.
   PubMed Web of Science ®Google Scholar
• Lay JC, Alexis NE, Kleeberger SR, Roubey RA, Harris BD, Bromberg PA, Hazucha MJ, Devlin RB, Peden DB. 2007. Ozone enhances markers of innate immunity and antigen presentation on airway monocytes in healthy individuals. J Allergy Clin Immunol. 120(3):719–722.
   PubMed Web of Science ®Google Scholar
• Lay JC, Peden DB, Alexis NE. 2011. Flow cytometry of sputum: assessing inflammation and immune response elements in the bronchial airways. Inhal Toxicol. 23(7):392–406.
   PubMed Web of Science ®Google Scholar
• Lazaar AL, Sweeney LE, MacDonald AJ, Alexis NE, Chen C, Tal-Singer R. 2011. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol. 72(2):282–293.
   PubMed Web of Science ®Google Scholar
• Naeher LP, Smith KR, Leaderer BP, Mage D, Grajeda R. 2000. Indoor and outdoor PM2.5 and CO in high- and low-density Guatemalan villages. J Expo Anal Environ Epidemiol. 10(6 Pt 1):544–551.
   PubMedGoogle Scholar
• Navarro K. 2020. Working in smoke: Wildfire impacts on the health of firefighters and outdoor workers and mitigation strategies. Clin Chest Med. 41(4):763–769.
   PubMed Web of Science ®Google Scholar
• Rappold AG, Stone SL, Cascio WE, Neas LM, Kilaru VJ, Carraway MS, Szykman JJ, Ising A, Cleve WE, Meredith JT, et al. 2011. Peat bog wildfire smoke exposure in rural North Carolina is associated with cardiopulmonary emergency department visits assessed through syndromic surveillance. Environ Health Perspect. 119(10):1415–1420.
   PubMed Web of Science ®Google Scholar
• Rebuli ME, Speen AM, Martin EM, Addo KA, Pawlak EA, Glista-Baker E, Robinette C, Zhou H, Noah TL, Jaspers I. 2019. Wood smoke exposure alters human inflammatory responses to viral infection in a sex-specific manner. A randomized, placebo-controlled study. Am J Respir Crit Care Med. 199(8):996–1007.
   PubMed Web of Science ®Google Scholar
• Rice MB, Henderson SB, Lambert AA, Cromar KR, Hall JA, Cascio WE, Smith PG, Marsh BJ, Coefield S, Balmes JR, et al. 2021. Respiratory impacts of wildland fire smoke: future challenges and policy opportunities. An official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 18(6):921–930.
   PubMed Web of Science ®Google Scholar
• Schwartz C, Bolling AK, Carlsten C. 2020. Controlled human exposures to wood smoke: a synthesis of the evidence. Part Fibre Toxicol. 17(1):49.
   PubMed Web of Science ®Google Scholar
• Smith KR, McCracken JP, Weber MW, Hubbard A, Jenny A, Thompson LM, Balmes J, Diaz A, Arana B, Bruce N. 2011. Effect of reduction in household air pollution on childhood pneumonia in Guatemala (RESPIRE): a randomised controlled trial. Lancet. 378(9804):1717–1726.
   PubMed Web of Science ®Google Scholar
• Steerenberg PA, van Amelsvoort L, Lovik M, Hetland RB, Alberg T, Halatek T, Bloemen HJ, Rydzynski K, Swaen G, Schwarze P, et al. 2006. Relation between sources of particulate air pollution and biological effect parameters in samples from four European cities: an exploratory study. Inhal Toxicol. 18(5):333–346.
   PubMed Web of Science ®Google Scholar
• Swiston JR, Davidson W, Attridge S, Li GT, Brauer M, Van Eeden SF. 2008. Wood smoke exposure induces a pulmonary and systemic inflammatory response in firefighters. Eur Respir J. 32(1):129–138.
   PubMed Web of Science ®Google Scholar
• Team RC. 2019. R: A language and environment for statistical computing. R Foundation for Statistical Computing 2019. accessed from: https://www.r-project.org.
   Google Scholar
• Thurston GD, Balmes JR, Garcia E, Gilliland FD, Rice MB, Schikowski T, Van Winkle LS, Annesi-Maesano I, Burchard EG, Carlsten C, et al. 2020. Outdoor Air pollution and new-onset airway disease. An Official American Thoracic Society Workshop Report. Ann Am Thorac Soc. 17(4):387–398.
   PubMed Web of Science ®Google Scholar
• Wettstein ZS, Hoshiko S, Fahimi J, Harrison RJ, Cascio WE, Rappold AG. 2018. Cardiovascular and cerebrovascular emergency department visits associated with wildfire smoke exposure in California in 2015. J Am Heart Assoc. 7(8):e007492.
   PubMed Web of Science ®Google Scholar
• Wu W, Peden D, Diaz-Sanchez D. 2012. Role of GSTM1 in resistance to lung inflammation. Free Radic Biol Med. 53(4):721–729.
   PubMed Web of Science ®Google Scholar