Lipid mediators of inhalation exposure-induced pulmonary toxicity and inflammation

References

• Adamko DJ, Nair P, Mayers I, Tsuyuki RT, Regush S, Rowe BH. 2015. Metabolomic profiling of asthma and chronic obstructive pulmonary disease: a pilot study differentiating diseases. J Allergy Clin Immunol. 136(3):571–580.e573. doi: 10.1016/j.jaci.2015.05.022.
   PubMed Web of Science ®Google Scholar
• Agarwal AR, Kadam S, Brahme A, Agrawal M, Apte K, Narke G, Kekan K, Madas S, Salvi S. 2019. Systemic Immuno-metabolic alterations in chronic obstructive pulmonary disease (COPD). Respir Res. 20(1):171. doi: 10.1186/s12931-019-1139-2.
   PubMedGoogle Scholar
• Alqahtani S, Kobos LM, Xia L, Ferreira C, Franco J, Du X, Shannahan JH. 2020. Exacerbation of nanoparticle-induced acute pulmonary inflammation in a mouse model of metabolic syndrome. Front Immunol. 11:818. doi: 10.3389/fimmu.2020.00818.
   PubMed Web of Science ®Google Scholar
• Alqahtani S, Xia L, Jannasch A, Ferreira C, Franco J, Shannahan JH. 2021. Disruption of pulmonary resolution mediators contribute to exacerbated silver nanoparticle-induced acute inflammation in a metabolic syndrome mouse model. Toxicol Appl Pharmacol. 431:115730. doi: 10.1016/j.taap.2021.115730.
   PubMed Web of Science ®Google Scholar
• Alqahtani S, Xia L, Shannahan JH. 2022. Enhanced silver nanoparticle-induced pulmonary inflammation in a metabolic syndrome mouse model and resolvin D1 treatment. Part Fibre Toxicol. 19(1):54. doi: 10.1186/s12989-022-00495-6.
   PubMed Web of Science ®Google Scholar
• Amiri Khosroshahi R, Heidari Seyedmahalle M, Zeraattalab-Motlagh S, Fakhr L, Wilkins S, Mohammadi H. 2024. The effects of omega-3 fatty acids supplementation on inflammatory factors in cancer patients: a systematic review and dose-response meta-analysis of randomized clinical trials. Nutr Cancer. 76(1):1–16. doi: 10.1080/01635581.2023.2274135.
   PubMed Web of Science ®Google Scholar
• Andreakos E, Papadaki M, Serhan CN. 2021. Dexamethasone, pro-resolving lipid mediators and resolution of inflammation in COVID-19. Allergy. 76(3):626–628. doi: 10.1111/all.14595.
   PubMed Web of Science ®Google Scholar
• Bai JW, Chen XX, Liu S, Yu L, Xu JF. 2017. Smoking cessation affects the natural history of COPD. Int J Chron Obstruct Pulmon Dis. 12:3323–3328. doi: 10.2147/COPD.S150243.
   PubMed Web of Science ®Google Scholar
• Balluff B, Hopf C, Porta Siegel T, Grabsch HI, Heeren RMA. 2021. Batch effects in MALDI mass spectrometry imaging. J Am Soc Mass Spectrom. 32(3):628–635. doi: 10.1021/jasms.0c00393.
   PubMed Web of Science ®Google Scholar
• Balode L, Strazda G, Jurka N, Kopeika U, Kislina A, Bukovskis M, Beinare M, Gardjušina V, Taivāns I. 2011. Lipoxygenase-derived arachidonic acid metabolites in chronic obstructive pulmonary disease. Medicina (Kaunas). 48(6):43. doi: 10.3390/medicina48060043.
   Web of Science ®Google Scholar
• Bennet RV, Gamage CM, Fernández FM. 2013. Imaging of biological tissues by desorption electrospray ionization mass spectrometry. J Vis Exp. 12(77):e50575. doi: 10.3791/50575.
   PubMed Web of Science ®Google Scholar
• Bensussan AV, Lin J, Guo C, Katz R, Krishnamurthy S, Cressman E, Eberlin LS. 2020. Distinguishing non-small cell lung cancer subtypes in fine needle aspiration biopsies by desorption electrospray ionization mass spectrometry imaging. Clin Chem. 66(11):1424–1433. doi: 10.1093/clinchem/hvaa207.
   PubMed Web of Science ®Google Scholar
• Bhat TA, Kalathil SG, Bogner PN, Lehmann PV, Thatcher TH, Sime PJ, Thanavala Y. 2021. AT-RvD1 mitigates secondhand smoke-exacerbated pulmonary inflammation and restores secondhand smoke-suppressed antibacterial immunity. J Immunol. 206(6):1348–1360. doi: 10.4049/jimmunol.2001228.
   PubMed Web of Science ®Google Scholar
• Bhat TA, Kalathil SG, Miller A, Thatcher TH, Sime PJ, Thanavala Y. 2020. Specialized proresolving mediators overcome immune suppression induced by exposure to secondhand smoke. J Immunol. 205(11):3205–3217. doi: 10.4049/jimmunol.2000711.
   PubMed Web of Science ®Google Scholar
• Blanksby SJ, Mitchell TW. 2010. Advances in mass spectrometry for lipidomics. Annu Rev Anal Chem (Palo Alto Calif). 3(1):433–465. doi: 10.1146/annurev.anchem.111808.073705.
   PubMedGoogle Scholar
• Bligh EG, Dyer WJ. 1959. A rapid method of total lipid extraction and purification. Can J Biochem Physiol. 37(8):911–917. doi: 10.1139/o59-099.
   PubMedGoogle Scholar
• Bowman AP, Blakney GT, Hendrickson CL, Ellis SR, Heeren RMA, Smith DF. 2020. Ultra-high mass resolving power, mass accuracy, and dynamic range MALDI mass spectrometry imaging by 21-T FT-ICR MS. Anal Chem. 92(4):3133–3142. doi: 10.1021/acs.analchem.9b04768.
   PubMed Web of Science ®Google Scholar
• Bozinovski S, Anthony D, Anderson GP, Irving LB, Levy BD, Vlahos R. 2013. Treating neutrophilic inflammation in COPD by targeting ALX/FPR2 resolution pathways. Pharmacol Ther. 140(3):280–289. doi: 10.1016/j.pharmthera.2013.07.007.
   PubMed Web of Science ®Google Scholar
• Bozza PT, Viola JPB. 2010. Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids. 82(4-6):243–250. doi: 10.1016/j.plefa.2010.02.005.
   PubMed Web of Science ®Google Scholar
• Brightling CE, Brusselle G, Altman P. 2020. The impact of the prostaglandin D(2) receptor 2 and its downstream effects on the pathophysiology of asthma. Allergy. 75(4):761–768. doi: 10.1111/all.14001.
   PubMed Web of Science ®Google Scholar
• Callan N, Hanes D, Bradley R. 2020. Early evidence of efficacy for orally administered SPM-enriched marine lipid fraction on quality of life and pain in a sample of adults with chronic pain. J Transl Med. 18(1):401. doi: 10.1186/s12967-020-02569-5.
   PubMed Web of Science ®Google Scholar
• Capra V, Thompson MD, Sala A, Cole DE, Folco G, Rovati GE. 2007. Cysteinyl-leukotrienes and their receptors in asthma and other inflammatory diseases: critical update and emerging trends. Med Res Rev. 27(4):469–527. doi: 10.1002/med.20071.
   PubMed Web of Science ®Google Scholar
• Carraro S, Bozzetto S, Giordano G, El Mazloum D, Stocchero M, Pirillo P, Zanconato S, Baraldi E. 2018. Wheezing preschool children with early-onset asthma reveal a specific metabolomic profile. Pediatr Allergy Immunol. 29(4):375–382. doi: 10.1111/pai.12879.
   PubMed Web of Science ®Google Scholar
• Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. 2002. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax. 57(3):226–230. doi: 10.1136/thorax.57.3.226.
   PubMed Web of Science ®Google Scholar
• Chiurchiù V, Leuti A, Maccarrone M. 2018. Bioactive Lipids and Chronic Inflammation: managing the Fire Within [Review. Front Immunol. 9:38. English. doi: 10.3389/fimmu.2018.00038.
   PubMed Web of Science ®Google Scholar
• Chu HW, Balzar S, Westcott JY, Trudeau JB, Sun Y, Conrad DJ, Wenzel SE. 2002. Expression and activation of 15-lipoxygenase pathway in severe asthma: relationship to eosinophilic phenotype and collagen deposition. Clin Exp Allergy. 32(11):1558–1565. doi: 10.1046/j.1365-2222.2002.01477.x.
   PubMedGoogle Scholar
• Ciaccia L. 2011. Fundamentals of Inflammation. The Yale J Biol Med. 84(1):64–65.
   Google Scholar
• Croasdell A, Thatcher TH, Kottmann RM, Colas RA, Dalli J, Serhan CN, Sime PJ, Phipps RP. 2015. Resolvins attenuate inflammation and promote resolution in cigarette smoke-exposed human macrophages. Am J Physiol Lung Cell Mol Physiol. 309(8):L888–901. doi: 10.1152/ajplung.00125.2015.
   PubMed Web of Science ®Google Scholar
• Dalli J, Ramon S, Norris PC, Colas RA, Serhan CN. 2015. Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways. Faseb J. 29(5):2120–2136. doi: 10.1096/fj.14-268441.
   PubMed Web of Science ®Google Scholar
• Davies P, Sornberger GC, Engel EE, Huber GL. 1978. Stereology of lavaged populations of alveolar macrophages: effects of in vivo exposure to tobacco smoke. Exp Mol Pathol. 29(2):170–182. doi: 10.1016/0014-4800(78)90037-0.
   PubMed Web of Science ®Google Scholar
• de Lima CB, Ferreira CR, Milazzotto MP, Sobreira TJP, Vireque AA, Cooks RG. 2018. Comprehensive lipid profiling of early stage oocytes and embryos by MRM profiling. J Mass Spectrom. 53(12):1247–1252. doi: 10.1002/jms.4301.
   PubMed Web of Science ®Google Scholar
• Dexter A, Steven RT, Patel A, Dailey LA, Taylor AJ, Ball D, Klapwijk J, Forbes B, Page CP, Bunch J. 2019. Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis. Anal Bioanal Chem. 411(30):8023–8032. doi: 10.1007/s00216-019-02151-z.
   PubMed Web of Science ®Google Scholar
• Diamant Z, Mantzouranis E, Bjermer L. 2009. Montelukast in the treatment of asthma and beyond. Expert Rev Clin Immunol. 5(6):639–658. doi: 10.1586/eci.09.62.
   PubMed Web of Science ®Google Scholar
• Dobri AM, Dudău M, Enciu AM, Hinescu ME. 2021. CD36 in Alzheimer’s disease: an overview of molecular mechanisms and therapeutic targeting. Neuroscience. 453:301–311. doi: 10.1016/j.neuroscience.2020.11.003.
   PubMed Web of Science ®Google Scholar
• Dudek SE, Nitzsche K, Ludwig S, Ehrhardt C. 2016. Influenza A viruses suppress cyclooxygenase-2 expression by affecting its mRNA stability. Sci Rep. 6(1):27275. doi: 10.1038/srep27275.
   PubMedGoogle Scholar
• Duvall MG, Fuhlbrigge ME, Reilly RB, Walker KH, Kılıç A, Levy BD. 2020. Human NK Cell Cytoskeletal Dynamics and Cytotoxicity Are Regulated by LIM Kinase. J Immunol. 205(3):801–810. doi: 10.4049/jimmunol.2000186.
   PubMed Web of Science ®Google Scholar
• Duvall MG, Levy BD. 2016. DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. Eur J Pharmacol. 785:144–155. doi: 10.1016/j.ejphar.2015.11.001.
   PubMed Web of Science ®Google Scholar
• Ellis SR, Hall E, Panchal M, Flinders B, Madsen J, Koster G, Heeren RMA, Clark HW, Postle AD. 2021. Mass spectrometry imaging of phosphatidylcholine metabolism in lungs administered with therapeutic surfactants and isotopic tracers. J Lipid Res. 62:100023. doi: 10.1016/j.jlr.2021.100023.
   PubMed Web of Science ®Google Scholar
• Fahy E, Subramaniam S, Brown HA, Glass CK, Merrill AH, Murphy RC, Raetz CRH, Russell DW, Seyama Y, Shaw W, et al. 2005. A comprehensive classification system for lipids. J Lipid Res. 46(5):839–861. doi: 10.1194/jlr.E400004-JLR200.
   PubMed Web of Science ®Google Scholar
• Fahy E, Subramaniam S, Murphy RC, Nishijima M, Raetz CR, Shimizu T, Spener F, van Meer G, Wakelam MJ, Dennis EA. 2009. Update of the LIPID MAPS comprehensive classification system for lipids. J Lipid Res. 50:S9–S14. doi: 10.1194/jlr.R800095-JLR200.
   PubMed Web of Science ®Google Scholar
• Fajt ML, Gelhaus SL, Freeman B, Uvalle CE, Trudeau JB, Holguin F, Wenzel SE. 2013. Prostaglandin D2 pathway upregulation: relation to asthma severity, control, and TH2 inflammation. J Allergy Clin Immunol. 131(6):1504–1512. doi: 10.1016/j.jaci.2013.01.035.
   PubMed Web of Science ®Google Scholar
• Fauroux B, Sampil M, QuNel P, Lemoullec Y. 2000. Ozone: a trigger for hospital pediatric asthma emergency room visits. Pediatr Pulmonol. 30(1):41–46. doi: 10.1002/1099-0496(200007)30:1<41::AID-PPUL7>3.3.CO;2-W.
   PubMed Web of Science ®Google Scholar
• Folch J, Lees M, Sloane Stanley GH. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 226(1):497–509. doi: 10.1016/S0021-9258(18)64849-5.
   PubMed Web of Science ®Google Scholar
• Gaki E, Papatheodorou G, Ischaki E, Grammenou V, Papa I, Loukides S. 2007. Leukotriene E(4) in urine in patients with asthma and COPD–the effect of smoking habit. Respir Med. 101(4):826–832. doi: 10.1016/j.rmed.2006.06.031.
   PubMed Web of Science ®Google Scholar
• Gao X, Coull B, Lin X, Vokonas P, Schwartz J, Baccarelli AA. 2020. Nonsteroidal antiinflammatory drugs modify the effect of short-term air pollution on lung function. Am J Respir Crit Care Med. 201(3):374–378. doi: 10.1164/rccm.201905-1003LE.
   PubMed Web of Science ®Google Scholar
• Garikapati V, Karnati S, Bhandari DR, Baumgart-Vogt E, Spengler B. 2019. High-resolution atmospheric-pressure MALDI mass spectrometry imaging workflow for lipidomic analysis of late fetal mouse lungs. Sci Rep. 9(1):3192. doi: 10.1038/s41598-019-39452-3.
   PubMedGoogle Scholar
• Ghlichloo I, Gerriets V. 2022. Nonsteroidal anti-inflammatory drugs (NSAIDs). StatPearls. Treasure Island (FL): StatPearls Publishing Copyright © 2022, StatPearls Publishing LLC.
   Google Scholar
• Gilbert NC, Newcomer ME, Werz O. 2021. Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: the battle between pro- and anti-inflammatory lipid mediators. Biochem Pharmacol. 193:114759. doi: 10.1016/j.bcp.2021.114759.
   PubMed Web of Science ®Google Scholar
• Giouleka P, Papatheodorou G, Lyberopoulos P, Karakatsani A, Alchanatis M, Roussos C, Papiris S, Loukides S. 2011. Body mass index is associated with leukotriene inflammation in asthmatics. Eur J Clin Invest. 41(1):30–38. doi: 10.1111/j.1365-2362.2010.02371.x.
   PubMed Web of Science ®Google Scholar
• Girdhar A, Kumar V, Singh A, Menon B, Vijayan VK. 2011. Systemic inflammation and its response to treatment in patients with asthma. Respir Care. 56(6):800–805. doi: 10.4187/respcare.00601.
   PubMed Web of Science ®Google Scholar
• Godson C. 2020. Balancing the Effect of Leukotrienes in Asthma. N Engl J Med. 382(15):1472–1475. doi: 10.1056/NEJMcibr2000118.
   PubMed Web of Science ®Google Scholar
• Gong J, Zhao H, Liu T, Li L, Cheng E, Zhi S, Kong L, Yao HW, Li J. 2019. Cigarette smoke reduces fatty acid catabolism, leading to apoptosis in lung endothelial cells: implication for pathogenesis of COPD. Front Pharmacol. 10:941. doi: 10.3389/fphar.2019.00941.
   PubMed Web of Science ®Google Scholar
• Gouveia-Figueira S, Karimpour M, Bosson JA, Blomberg A, Unosson J, Pourazar J, Sandström T, Behndig AF, Nording ML. 2017. Mass spectrometry profiling of oxylipins, endocannabinoids, and N-acylethanolamines in human lung lavage fluids reveals responsiveness of prostaglandin E2 and associated lipid metabolites to biodiesel exhaust exposure. Anal Bioanal Chem. 409(11):2967–2980. doi: 10.1007/s00216-017-0243-8.
   PubMed Web of Science ®Google Scholar
• Griffiths WJ, Ogundare M, Williams CM, Wang Y. 2011. On the future of "omics": lipidomics. J Inherit Metab Dis. 34(3):583–592. doi: 10.1007/s10545-010-9274-4.
   PubMed Web of Science ®Google Scholar
• Gwinn MR, Vallyathan V. 2006. Respiratory burst: role in signal transduction in alveolar macrophages. J Toxicol Environ Health B Crit Rev. 9(1):27–39. doi: 10.1080/15287390500196081.
   PubMed Web of Science ®Google Scholar
• Hall LM, Murphy RC. 1998. Analysis of stable oxidized molecular species of glycerophospholipids following treatment of red blood cell ghosts witht-butylhydroperoxide. Anal Biochem. 258(2):184–194. doi: 10.1006/abio.1998.2602.
   PubMed Web of Science ®Google Scholar
• Hannan SE, Harris JO, Sheridan NP, Patel JM. 1989. Cigarette smoke alters plasma membrane fluidity of rat alveolar macrophages. Am Rev Respir Dis. 140(6):1668–1673. doi: 10.1164/ajrccm/140.6.1668.
   PubMedGoogle Scholar
• Harrington LS, Lucas R, McMaster SK, Moreno L, Scadding G, Warner TD, Mitchell JA. 2008. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. Faseb J. 22(11):4005–4010. doi: 10.1096/fj.08-107979.
   PubMed Web of Science ®Google Scholar
• Henkel FDR, Friedl A, Haid M, Thomas D, Bouchery T, Haimerl P, de Los Reyes Jiménez M, Alessandrini F, Schmidt-Weber CB, Harris NL, et al. 2019. House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions. Allergy. 74(6):1090–1101. doi: 10.1111/all.13700.
   PubMed Web of Science ®Google Scholar
• Hirai H, Tanaka K, Yoshie O, Ogawa K, Kenmotsu K, Takamori Y, Ichimasa M, Sugamura K, Nakamura M, Takano S, et al. 2001. Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J Exp Med. 193(2):255–261. doi: 10.1084/jem.193.2.255.
   PubMed Web of Science ®Google Scholar
• Holčapek M, Liebisch G, Ekroos K. 2018. Lipidomic analysis. Anal Chem. 90(7):4249–4257. doi: 10.1021/acs.analchem.7b05395.
   PubMed Web of Science ®Google Scholar
• Ichiyama T, Hasegawa S, Umeda M, Terai K, Matsubara T, Furukawa S. 2003. Pranlukast inhibits NF-κB activation in human monocytes/macrophages and T cells. Clin Exp Allergy. 33(6):802–807. doi: 10.1046/j.1365-2222.2003.01673.x.
   PubMed Web of Science ®Google Scholar
• Ishinaga H, Takeuchi K, Kishioka C, Suzuki S, Basbaum C, Majima Y. 2005. Pranlukast inhibits NF-kappaB activation and MUC2 gene expression in cultured human epithelial cells. Pharmacology. 73(2):89–96. doi: 10.1159/000081294.
   PubMed Web of Science ®Google Scholar
• Jones EE, Quiason C, Dale S, Shahidi-Latham SK. 2017. Feasibility assessment of a MALDI FTICR imaging approach for the 3D reconstruction of a mouse lung. J Am Soc Mass Spectrom. 28(8):1709–1715. doi: 10.1007/s13361-017-1658-3.
   PubMed Web of Science ®Google Scholar
• Jousilahti P, Salomaa V, Hakala K, Rasi V, Vahtera E, Palosuo T. 2002. The association of sensitive systemic inflammation markers with bronchial asthma. Ann Allergy Asthma Immunol. 89(4):381–385. doi: 10.1016/S1081-1206(10)62039-X.
   PubMed Web of Science ®Google Scholar
• Julliard WA, Myo YPA, Perelas A, Jackson PD, Thatcher TH, Sime PJ. 2022. Specialized pro-resolving mediators as modulators of immune responses. Semin Immunol. 59:101605. doi: 10.1016/j.smim.2022.101605.
   PubMed Web of Science ®Google Scholar
• Kabashima K, Narumiya S. 2003. The DP receptor, allergic inflammation and asthma. Prostaglandins Leukot Essent Fatty Acids. 69(2-3):187–194. doi: 10.1016/s0952-3278(03)00080-2.
   PubMed Web of Science ®Google Scholar
• Kadesch P, Quack T, Gerbig S, Grevelding CG, Spengler B. 2019. Lipid topography in schistosoma mansoni cryosections, revealed by microembedding and high-resolution atmospheric-pressure matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging. Anal Chem. 91(7):4520–4528. doi: 10.1021/acs.analchem.8b05440.
   PubMed Web of Science ®Google Scholar
• Kang YP, Lee SB, Lee JM, Kim HM, Hong JY, Lee WJ, Choi CW, Shin HK, Kim DJ, Koh ES, et al. 2016. Metabolic profiling regarding pathogenesis of idiopathic pulmonary fibrosis. J Proteome Res. 15(5):1717–1724. doi: 10.1021/acs.jproteome.6b00156.
   PubMed Web of Science ®Google Scholar
• Khan NA, Lawyer G, McDonough S, Wang Q, Kassem NO, Kas-Petrus F, Ye D, Singh KP, Kassem NO, Rahman I. 2020. Systemic biomarkers of inflammation, oxidative stress and tissue injury and repair among waterpipe, cigarette and dual tobacco smokers. Tob Control. 29(Suppl 2):s102–s109. doi: 10.1136/tobaccocontrol-2019-054958.
   PubMedGoogle Scholar
• Kilburg-Basnyat B, Reece SW, Crouch MJ, Luo B, Boone AD, Yaeger M, Hodge M, Psaltis C, Hannan JL, Manke J, et al. 2018. Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation. Toxicol Sci. 163(2):466–477. doi: 10.1093/toxsci/kfy040.
   PubMed Web of Science ®Google Scholar
• Kilk K, Aug A, Ottas A, Soomets U, Altraja S, Altraja A. 2018. Phenotyping of chronic obstructive pulmonary disease based on the integration of metabolomes and clinical characteristics. Int J Mol Sci. 19(3):666.
   PubMed Web of Science ®Google Scholar
• Kobos L, Ferreira CR, Sobreira TJP, Rajwa B, Shannahan J. 2021. A novel experimental workflow to determine the impact of storage parameters on the mass spectrometric profiling and assessment of representative phosphatidylethanolamine lipids in mouse tissues. Anal Bioanal Chem. 413(7):1837–1849. doi: 10.1007/s00216-020-03151-0.
   PubMed Web of Science ®Google Scholar
• Kühn H, O'Donnell VB. 2006. Inflammation and immune regulation by 12/15-lipoxygenases. Prog Lipid Res. 45(4):334–356. doi: 10.1016/j.plipres.2006.02.003.
   PubMed Web of Science ®Google Scholar
• Kupczyk M, Kuna P. 2017. Targeting the PGD(2)/CRTH2/DP1 signaling pathway in asthma and allergic disease: current status and future perspectives. Drugs. 77(12):1281–1294. doi: 10.1007/s40265-017-0777-2.
   PubMed Web of Science ®Google Scholar
• Lanekoff I, Thomas M, Laskin J. 2014. Shotgun approach for quantitative imaging of phospholipids using nanospray desorption electrospray ionization mass spectrometry. Anal Chem. 86(3):1872–1880. doi: 10.1021/ac403931r.
   PubMed Web of Science ®Google Scholar
• Langlois A, Ferland C, Tremblay GM, Laviolette M. 2006. Montelukast regulates eosinophil protease activity through a leukotriene-independent mechanism. J Allergy Clin Immunol. 118(1):113–119. doi: 10.1016/j.jaci.2006.03.010.
   PubMed Web of Science ®Google Scholar
• Lazarus SC, Chinchilli VM, Rollings NJ, Boushey HA, Cherniack R, Craig TJ, Deykin A, DiMango E, Fish JE, Ford JG, et al. 2007. Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma. Am J Respir Crit Care Med. 175(8):783–790. doi: 10.1164/rccm.200511-1746OC.
   PubMed Web of Science ®Google Scholar
• Lee S-H, Hong S-H, Tang C-H, Ling YS, Chen K-H, Liang H-J, Lin C-Y. 2018. Mass spectrometry-based lipidomics to explore the biochemical effects of naphthalene toxicity or tolerance in a mouse model. PLoS One. 13(10):e0204829. doi: 10.1371/journal.pone.0204829.
   PubMed Web of Science ®Google Scholar
• Levy M, Futerman AH. 2010. Mammalian ceramide synthases [Review]. IUBMB Life. 62(5):347–356. doi: 10.1002/iub.319.
   PubMed Web of Science ®Google Scholar
• Levy M, Khan E, Careaga M, Goldkorn T. 2009. Neutral sphingomyelinase 2 is activated by cigarette smoke to augment ceramide-induced apoptosis in lung cell death. Am J Physiol Lung Cell Mol Physiol. 297(1):L125–L133. doi: 10.1152/ajplung.00031.2009.
   PubMed Web of Science ®Google Scholar
• Liang X, Cao S, Xie P, Hu X, Lin Y, Liang J, Zhang S, Xian B, Cao H, Luan T, et al. 2021. Three-dimensional imaging of whole-body zebrafish revealed lipid disorders associated with niemann–pick disease type C1. Anal Chem. 93(23):8178–8187. doi: 10.1021/acs.analchem.1c00196.
   PubMed Web of Science ®Google Scholar
• Lim CS, Porter DW, Orandle MS, Green BJ, Barnes MA, Croston TL, Wolfarth MG, Battelli LA, Andrew ME, Beezhold DH, et al. 2020. Resolution of pulmonary inflammation induced by carbon nanotubes and fullerenes in mice: role of macrophage polarization. Front Immunol. 11:1186. doi: 10.3389/fimmu.2020.01186.
   PubMed Web of Science ®Google Scholar
• Liu C, Xu D, Liu L, Schain F, Brunnström A, Björkholm M, Claesson HE, Sjöberg J. 2009. 15-Lipoxygenase-1 induces expression and release of chemokines in cultured human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 297(1):L196–203. doi: 10.1152/ajplung.00036.2008.
   PubMed Web of Science ®Google Scholar
• Löfgren L, Ståhlman M, Forsberg GB, Saarinen S, Nilsson R, Hansson GI. 2012. The BUME method: a novel automated chloroform-free 96-well total lipid extraction method for blood plasma. J Lipid Res. 53(8):1690–1700. doi: 10.1194/jlr.D023036.
   PubMed Web of Science ®Google Scholar
• Lovins HB, Bathon BE, Shaikh SR, Gowdy KM. 2023. Inhaled toxicants and pulmonary lipid metabolism: biological consequences and therapeutic interventions. Toxicol Sci. 196(2):141–151. doi: 10.1093/toxsci/kfad100.
   PubMed Web of Science ®Google Scholar
• Loxham M, Nieuwenhuijsen MJ. 2019. Health effects of particulate matter air pollution in underground railway systems - a critical review of the evidence. Part Fibre Toxicol. 16(1):12. doi: 10.1186/s12989-019-0296-2.
   PubMedGoogle Scholar
• Lundström SL, Levänen B, Nording M, Klepczynska-Nyström A, Sköld M, Haeggström JZ, Grunewald J, Svartengren M, Hammock BD, Larsson B-M, et al. 2011. Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure. PLoS One. 6(8):e23864. doi: 10.1371/journal.pone.0023864.
   PubMed Web of Science ®Google Scholar
• Madison MC, Landers CT, Gu BH, Chang CY, Tung HY, You R, Hong MJ, Baghaei N, Song LZ, Porter P, et al. 2020. Electronic cigarettes disrupt lung lipid homeostasis and innate immunity independent of nicotine. J Clin Invest. 129(10):4290–4304. doi: 10.1172/JCI128531.
   Web of Science ®Google Scholar
• Manickam M, Meenakshisundaram S, Pillaiyar T. 2022. Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID-19. Arch Pharm (Weinheim). 355(3):e2100367. doi: 10.1002/ardp.202100367.
   PubMed Web of Science ®Google Scholar
• Martínez-García MA, Perpiñá-Tordera M, Román-Sánchez P, Soler-Cataluña JJ, Carratalá A, Yago M, Pastor MJ. 2008. [The association between bronchiectasis, systemic inflammation, and tumor necrosis factor alpha]. Arch Bronconeumol. 44(1):8–14. spa. doi: 10.1016/s1579-2129(08)60003-8.
   PubMed Web of Science ®Google Scholar
• Matsuoka T, Hirata M, Tanaka H, Takahashi Y, Murata T, Kabashima K, Sugimoto Y, Kobayashi T, Ushikubi F, Aze Y, et al. 2000. Prostaglandin D2 as a mediator of allergic asthma. Science. 287(5460):2013–2017. doi: 10.1126/science.287.5460.2013.
   PubMed Web of Science ®Google Scholar
• Matyash V, Liebisch G, Kurzchalia TV, Shevchenko A, Schwudke D. 2008. Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics. J Lipid Res. 49(5):1137–1146. doi: 10.1194/jlr.D700041-JLR200.
   PubMed Web of Science ®Google Scholar
• McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan ES, Sordillo JE, Al-Garawi A, Martinez FD, et al. 2015. The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis. 3(3):224–238. doi: 10.1002/iid3.61.
   PubMed Web of Science ®Google Scholar
• Michael JA, Mutuku SM, Ucur B, Sarretto T, Maccarone AT, Niehaus M, Trevitt AJ, Ellis SR. 2022. Mass spectrometry imaging of lipids using MALDI coupled with plasma-based post-ionization on a trapped ion mobility mass spectrometer. Anal Chem. 94(50):17494–17503. doi: 10.1021/acs.analchem.2c03745.
   PubMed Web of Science ®Google Scholar
• Morissette MC, Shen P, Thayaparan D, Stämpfli MR. 2015. Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice. Eur Respir J. 46(5):1451–1460. doi: 10.1183/09031936.00216914.
   PubMed Web of Science ®Google Scholar
• Müller-Ladner U, Gay RE, Gay S. 2002. Role of nuclear factor κb in synovial inflammation. Curr Rheumatol Rep. 4(3):201–207. doi: 10.1007/s11926-002-0066-1.
   PubMedGoogle Scholar
• Murakami M, Sato H, Taketomi Y. 2020. Updating phospholipase A2 biology. Biomolecules. 10(10):1457. doi: 10.3390/biom10101457.
   PubMed Web of Science ®Google Scholar
• Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. 1991. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 87(4):1139–1145. doi: 10.1172/JCI115110.
   PubMed Web of Science ®Google Scholar
• Nagata K, Hirai H, Tanaka K, Ogawa K, Aso T, Sugamura K, Nakamura M, Takano S. 1999. CRTH2, an orphan receptor of T-helper-2-cells, is expressed on basophils and eosinophils and responds to mast cell-derived factor(s). FEBS Lett. 459(2):195–199. doi: 10.1016/s0014-5793(99)01251-x.
   PubMed Web of Science ®Google Scholar
• Nagata K, Tanaka K, Ogawa K, Kemmotsu K, Imai T, Yoshie O, Abe H, Tada K, Nakamura M, Sugamura K, et al. 1999. Selective expression of a novel surface molecule by human Th2 cells in vivo. J Immunol. 162(3):1278–1286. doi: 10.4049/jimmunol.162.3.1278.
   PubMed Web of Science ®Google Scholar
• Nagata N, Iwanari H, Kumagai H, Kusano-Arai O, Ikeda Y, Aritake K, Hamakubo T, Urade Y. 2017. Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. PLoS One. 12(4):e0175452. doi: 10.1371/journal.pone.0175452.
   PubMed Web of Science ®Google Scholar
• Nambiar S, Clynick B, How BS, King A, Walters EH, Goh NS, Corte TJ, Trengove R, Tan D, Moodley Y. 2021. There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF). Respir Res. 22(1):105. doi: 10.1186/s12931-021-01682-3.
   PubMed Web of Science ®Google Scholar
• Naz S, Kolmert J, Yang M, Reinke SN, Kamleh MA, Snowden S, Heyder T, Levänen B, Erle DJ, Sköld CM, et al. 2017. Metabolomics analysis identifies sex-associated metabotypes of oxidative stress and the autotaxin-lysoPA axis in COPD. Eur Respir J. 49(6):1602322. doi: 10.1183/13993003.02322-2016.
   PubMed Web of Science ®Google Scholar
• Nguyen SN, Kyle JE, Dautel SE, Sontag R, Luders T, Corley R, Ansong C, Carson J, Laskin J. 2019. Lipid coverage in nanospray desorption electrospray ionization mass spectrometry imaging of mouse lung tissues. Anal Chem. 91(18):11629–11635. doi: 10.1021/acs.analchem.9b02045.
   PubMed Web of Science ®Google Scholar
• Nishiuma T, Nishimura Y, Okada T, Kuramoto E, Kotani Y, Jahangeer S, Nakamura S. 2008. Inhalation of sphingosine kinase inhibitor attenuates airway inflammation in asthmatic mouse model. Am J Physiol Lung Cell Mol Physiol. 294(6):L1085–1093. doi: 10.1152/ajplung.00445.2007.
   PubMed Web of Science ®Google Scholar
• Nomani S, Cockcroft DW, Davis BE. 2016. Allergen inhalation challenge, refractoriness and the effects of ibuprofen. Allergy Asthma Clin Immunol. 12(1):24. doi: 10.1186/s13223-016-0127-z.
   PubMedGoogle Scholar
• Nording ML, Yang J, Hegedus CM, Bhushan A, Kenyon NJ, Davis CE, Hammock BD. 2010. Endogenous levels of five fatty acid metabolites in exhaled breath condensate to monitor asthma by high-performance liquid chromatography: electrospray tandem mass spectrometry. IEEE Sens J. 10(1):123–130. doi: 10.1109/JSEN.2009.2035736.
   PubMed Web of Science ®Google Scholar
• Orach J, Hemshekhar M, Rider CF, Spicer V, Lee AH, Yuen ACY, Mookherjee N, Carlsten C. 2023. Concentration-dependent alterations in the human plasma proteome following controlled exposure to diesel exhaust. Environ Pollut. 342:123087. doi: 10.1016/j.envpol.2023.123087.
   PubMed Web of Science ®Google Scholar
• Osthues T, Sisignano M. 2019. Oxidized lipids in persistent pain states [Review]. Front Pharmacol. 10:1147. English. doi: 10.3389/fphar.2019.01147.
   PubMed Web of Science ®Google Scholar
• Parikh R, Shah TG, Tandon R. 2016. COPD exacerbation care bundle improves standard of care, length of stay, and readmission rates. Int J Chron Obstruct Pulmon Dis. 11:577–583. doi: 10.2147/COPD.S100401.
   PubMed Web of Science ®Google Scholar
• Park J, Choi J, Kim DD, Lee S, Lee B, Lee Y, Kim S, Kwon S, Noh M, Lee MO, et al. 2021. Bioactive lipids and their derivatives in biomedical applications. Biomol Ther (Seoul). 29(5):465–482. doi: 10.4062/biomolther.2021.107.
   PubMed Web of Science ®Google Scholar
• Peters-Golden M, Henderson WR. Jr. 2007. Leukotrienes. N Engl J Med. 357(18):1841–1854. doi: 10.1056/NEJMra071371.
   PubMed Web of Science ®Google Scholar
• Peters-Golden M, Swern A, Bird SS, Hustad CM, Grant E, Edelman JM. 2006. Influence of body mass index on the response to asthma controller agents. Eur Respir J. 27(3):495–503. doi: 10.1183/09031936.06.00077205.
   PubMed Web of Science ®Google Scholar
• Petrache I, Natarajan V, Zhen L, Medler TR, Richter AT, Cho C, Hubbard WC, Berdyshev EV, Tuder RM. 2005. Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat Med. 11(5):491–498. doi: 10.1038/nm1238.
   PubMed Web of Science ®Google Scholar
• Pettipher R, Hansel TT, Armer R. 2007. Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov. 6(4):313–325. doi: 10.1038/nrd2266.
   PubMed Web of Science ®Google Scholar
• Peuschel H, Sydlik U, Grether-Beck S, Felsner I, Stöckmann D, Jakob S, Kroker M, Haendeler J, Gotić M, Bieschke C, et al. 2012. Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation. Part Fibre Toxicol. 9(1):48. doi: 10.1186/1743-8977-9-48.
   PubMedGoogle Scholar
• Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, et al. 2018a. Surfactant protein D deficiency aggravates cigarette smoke-induced lung inflammation by upregulation of ceramide synthesis [Original Research]. Front Immunol. 9:3013. English. doi: 10.3389/fimmu.2018.03013.
   PubMed Web of Science ®Google Scholar
• Pilecki B, Wulf-Johansson H, Støttrup C, Jørgensen PT, Djiadeu P, Nexøe AB, Schlosser A, Hansen SWK, Madsen J, Clark HW, et al. 2018b. Surfactant protein D deficiency aggravates cigarette smoke-induced lung inflammation by upregulation of ceramide synthesis. Front Immunol. 9[accessed 2018]:[:3013. p.]. http://europepmc.org/abstract/MED/30619359. doi: 10.3389/fimmu.2018.03013.
   PubMed Web of Science ®Google Scholar
• Prentice BM, Chumbley CW, Caprioli RM. 2015. High-speed MALDI MS/MS imaging mass spectrometry using continuous raster sampling. J Mass Spectrom. 50(4):703–710. doi: 10.1002/jms.3579.
   PubMed Web of Science ®Google Scholar
• Price D, Popov TA, Bjermer L, Lu S, Petrovic R, Vandormael K, Mehta A, Strus JD, Polos PG, Philip G. 2013. Effect of montelukast for treatment of asthma in cigarette smokers. J Allergy Clin Immunol. 131(3):763–771. doi: 10.1016/j.jaci.2012.12.673.
   PubMed Web of Science ®Google Scholar
• Rago B, Fu C. 2013. Development of a high-throughput ultra performance liquid chromatography-mass spectrometry assay to profile 18 eicosanoids as exploratory biomarkers for atherosclerotic diseases. J Chromatogr B Analyt Technol Biomed Life Sci. 936:25–32. doi: 10.1016/j.jchromb.2013.08.001.
   PubMed Web of Science ®Google Scholar
• RamalloGuevara C, Paulssen D, Popova AA, Hopf C, Levkin PA. 2021. Fast Nanoliter-Scale Cell Assays Using Droplet Microarray–Mass Spectrometry Imaging. Adv Biol (Weinh). 5(3):e2000279. doi: 10.1002/adbi.202000279.
   PubMedGoogle Scholar
• Ramires R, Caiaffa MF, Tursi A, Haeggström JZ, Macchia L. 2004. Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast. Biochem Biophys Res Commun. 324(2):815–821. doi: 10.1016/j.bbrc.2004.09.125.
   PubMed Web of Science ®Google Scholar
• Recchiuti A, Mattoscio D, Isopi E. 2019. Roles, actions, and therapeutic potential of specialized pro-resolving lipid mediators for the treatment of inflammation in cystic fibrosis. Front Pharmacol. 10:252. doi: 10.3389/fphar.2019.00252.
   PubMed Web of Science ®Google Scholar
• Reinke SN, Gallart-Ayala H, Gómez C, Checa A, Fauland A, Naz S, Kamleh MA, Djukanović R, Hinks TS, Wheelock CE. 2017. Metabolomics analysis identifies different metabotypes of asthma severity. Eur Respir J. 49(3):1601740. doi: 10.1183/13993003.01740-2016.
   PubMed Web of Science ®Google Scholar
• Reville K, Crean JK, Vivers S, Dransfield I, Godson C. 2006. Lipoxin A4 redistributes myosin IIA and Cdc42 in macrophages: implications for phagocytosis of apoptotic leukocytes. J Immunol. 176(3):1878–1888. doi: 10.4049/jimmunol.176.3.1878.
   PubMed Web of Science ®Google Scholar
• Ricciotti E, FitzGerald GA. 2011. Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 31(5):986–1000. doi: 10.1161/ATVBAHA.110.207449.
   PubMed Web of Science ®Google Scholar
• Rindlisbacher B, Schmid C, Geiser T, Bovet C, Funke-Chambour M. 2018. Serum metabolic profiling identified a distinct metabolic signature in patients with idiopathic pulmonary fibrosis - a potential biomarker role for LysoPC. Respir Res. 19(1):7. doi: 10.1186/s12931-018-0714-2.
   PubMedGoogle Scholar
• Rius M, Hummel-Eisenbeiss J, Keppler D. 2008. ATP-dependent transport of leukotrienes B4 and C4 by the multidrug resistance protein ABCC4 (MRP4). J Pharmacol Exp Ther. 324(1):86–94. doi: 10.1124/jpet.107.131342.
   PubMed Web of Science ®Google Scholar
• Rubenfeld GD, Caldwell E, Peabody E, Weaver J, Martin DP, Neff M, Stern EJ, Hudson LD. 2005. Incidence and outcomes of acute lung injury. N Engl J Med. 353(16):1685–1693. doi: 10.1056/NEJMoa050333.
   PubMed Web of Science ®Google Scholar
• Rudulier CD, Tonti E, James E, Kwok WW, Larché M. 2019. Modulation of CRTh2 expression on allergen-specific T cells following peptide immunotherapy. Allergy. 74(11):2157–2166. doi: 10.1111/all.13867.
   PubMed Web of Science ®Google Scholar
• Salvi S, Blomberg A, Rudell B, Kelly F, Sandström T, Holgate ST, Frew A. 1999. Acute inflammatory responses in the airways and peripheral blood after short-term exposure to diesel exhaust in healthy human volunteers. Am J Respir Crit Care Med. 159(3):702–709. doi: 10.1164/ajrccm.159.3.9709083.
   PubMed Web of Science ®Google Scholar
• Sandra K, Sandra P. 2013. Lipidomics from an analytical perspective. Curr Opin Chem Biol. 17(5):847–853. doi: 10.1016/j.cbpa.2013.06.010.
   PubMed Web of Science ®Google Scholar
• Sansbury BE, Spite M. 2016. Resolution of acute inflammation and the role of resolvins in immunity, thrombosis, and vascular biology. Circ Res. 119(1):113–130. doi: 10.1161/CIRCRESAHA.116.307308.
   PubMed Web of Science ®Google Scholar
• Schweitzer KS, Chen SX, Law S, Demark MV, Poirier C, Justice MJ, Hubbard WC, Kim ES, Lai X, Wang M, et al. 2015. Endothelial disruptive proinflammatory effects of nicotine and e-cigarette vapor exposures. Am J Physiol Lung Cell Mol Physiol. 309(2):L175–L187. doi: 10.1152/ajplung.00411.2014.
   PubMed Web of Science ®Google Scholar
• Serhan CN. 2017. Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms. Faseb J. 31(4):1273–1288. doi: 10.1096/fj.201601222R.
   PubMed Web of Science ®Google Scholar
• Serhan CN, Chiang N, Dalli J, Levy BD. 2014. Lipid mediators in the resolution of inflammation. Cold Spring Harb Perspect Biol. 7(2):a016311. doi: 10.1101/cshperspect.a016311.
   PubMed Web of Science ®Google Scholar
• Serhan CN, Chiang N, Van Dyke TE. 2008. Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators. Nat Rev Immunol. 8(5):349–361. doi: 10.1038/nri2294.
   PubMed Web of Science ®Google Scholar
• Shaheen HM, Onoda A, Shinkai Y, Nakamura M, El-Ghoneimy AA, El-Sayed YS, Takeda K, Umezawa M. 2016. The ceramide inhibitor fumonisin B1 mitigates the pulmonary effects of low-dose diesel exhaust inhalation in mice. Ecotoxicol Environ Saf. 132:390–396. doi: 10.1016/j.ecoenv.2016.06.025.
   PubMed Web of Science ®Google Scholar
• Singh KP, Lawyer G, Muthumalage T, Maremanda KP, Khan NA, McDonough SR, Ye D, McIntosh S, Rahman I. 2019. Systemic biomarkers in electronic cigarette users: implications for noninvasive assessment of vaping-associated pulmonary injuries. ERJ Open Res. 5(4):00182–2019. doi: 10.1183/23120541.00182-2019.
   PubMedGoogle Scholar
• Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, Gaggar A, Shastry S, Rowe SM, Shim YM, Hussell T, et al. 2010. A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation. Science. 330(6000):90–94. doi: 10.1126/science.1190594.
   PubMed Web of Science ®Google Scholar
• Sohouli MH, Magalhães E, Ghahramani S, Nasresfahani M, Ezoddin N, Sharifi P, Rohani P. 2023. Impact of omega-3 supplementation on children and adolescents patients with cystic fibrosis: a systematic review and meta-analysis of randomized-controlled trials. Pediatr Pulmonol. 58(8):2219–2228. doi: 10.1002/ppul.26491.
   PubMed Web of Science ®Google Scholar
• Sokolowska M, Rovati GE, Diamant Z, Untersmayr E, Schwarze J, Lukasik Z, Sava F, Angelina A, Palomares O, Akdis CA, et al. 2021. Current perspective on eicosanoids in asthma and allergic diseases: EAACI Task Force consensus report, part I. Allergy. 76(1):114–130. doi: 10.1111/all.14295.
   PubMed Web of Science ®Google Scholar
• Solomon JJ, Olson AL, Fischer A, Bull T, Brown KK, Raghu G. 2013. Scleroderma lung disease. Eur Respir Rev. 22(127):6–19. doi: 10.1183/09059180.00005512.
   PubMedGoogle Scholar
• Sorgi CA, Peti APF, Petta T, Meirelles AFG, Fontanari C, Moraes L, Faccioli LH. 2018. Comprehensive high-resolution multiple-reaction monitoring mass spectrometry for targeted eicosanoid assays. Sci Data. 5(1):180167. doi: 10.1038/sdata.2018.167.
   PubMedGoogle Scholar
• Spengler B. 2015. Mass Spectrometry Imaging of Biomolecular Information. Anal Chem. 87(1):64–82. doi: 10.1021/ac504543v.
   PubMed Web of Science ®Google Scholar
• Stevens NC, Brown VJ, Domanico MC, Edwards PC, Van Winkle LS, Fiehn O. 2022. Alteration of glycosphingolipid metabolism by ozone is associated with exacerbation of allergic asthma characteristics in mice. Toxicol Sci. 191(1):79–89. doi: 10.1093/toxsci/kfac117.
   Web of Science ®Google Scholar
• Straumann A, Hoesli S, Bussmann C, Stuck M, Perkins M, Collins LP, Payton M, Pettipher R, Hunter M, Steiner J, et al. 2013. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 68(3):375–385. doi: 10.1111/all.12096.
   PubMed Web of Science ®Google Scholar
• Swedin L, Neimert-Andersson T, Hjoberg J, Jonasson S, van Hage M, Adner M, Ryrfeldt A, Dahlén SE. 2009. Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice. Eur Respir J. 34(1):200–208. doi: 10.1183/09031936.00030908.
   PubMed Web of Science ®Google Scholar
• Tahan F, Jazrawi E, Moodley T, Rovati GE, Adcock IM. 2008. Montelukast inhibits tumour necrosis factor-alpha-mediated interleukin-8 expression through inhibition of nuclear factor-kappaB p65-associated histone acetyltransferase activity. Clin Exp Allergy. 38(5):805–811. doi: 10.1111/j.1365-2222.2008.02963.x.
   PubMed Web of Science ®Google Scholar
• Takats Z, Strittmatter N, McKenzie JS. 2017. Ambient mass spectrometry in cancer research. Adv Cancer Res. 134:231–256.
   PubMed Web of Science ®Google Scholar
• Takáts Z, Wiseman JM, Cooks RG. 2005. Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology. J Mass Spectrom. 40(10):1261–1275. doi: 10.1002/jms.922.
   PubMed Web of Science ®Google Scholar
• Takáts Z, Wiseman JM, Gologan B, Cooks RG. 2004. Mass spectrometry sampling under ambient conditions with desorption electrospray ionization. Science. 306(5695):471–473. doi: 10.1126/science.1104404.
   PubMed Web of Science ®Google Scholar
• Tashkin DP, Murray RP. 2009. Smoking cessation in chronic obstructive pulmonary disease. Respir Med. 103(7):963–974. doi: 10.1016/j.rmed.2009.02.013.
   PubMed Web of Science ®Google Scholar
• Telenga ED, Hoffmann RF, Ruben tK, Hoonhorst SJ, Willemse BW, van Oosterhout AJ, Heijink IH, van den Berge M, Jorge L, Sandra P et al. 2014. Untargeted lipidomic analysis in chronic obstructive pulmonary disease. Uncovering sphingolipids. Am J Respir Crit Care Med. 190(2):155–164. doi: 10.1164/rccm.201312-2210OC.
   PubMed Web of Science ®Google Scholar
• Titz B, Luettich K, Leroy P, Boue S, Vuillaume G, Vihervaara T, Ekroos K, Martin F, Peitsch MC, Hoeng J. 2016. Alterations in serum polyunsaturated fatty acids and eicosanoids in patients with mild to moderate chronic obstructive pulmonary disease (COPD). Int J Mol Sci. 17(9):1583. doi: 10.3390/ijms17091583.
   PubMed Web of Science ®Google Scholar
• van der Does AM, Heijink M, Mayboroda OA, Persson LJ, Aanerud M, Bakke P, Eagan TM, Hiemstra PS, Giera M. 2019. Dynamic differences in dietary polyunsaturated fatty acid metabolism in sputum of COPD patients and controls. Biochim Biophys Acta Mol Cell Biol Lipids. 1864(3):224–233. doi: 10.1016/j.bbalip.2018.11.012.
   PubMed Web of Science ®Google Scholar
• Walther TC, Farese RV. Jr. 2012. Lipid droplets and cellular lipid metabolism. Annu Rev Biochem. 81(1):687–714. doi: 10.1146/annurev-biochem-061009-102430.
   PubMedGoogle Scholar
• Wang Y, Armando AM, Quehenberger O, Yan C, Dennis EA. 2014. Comprehensive ultra-performance liquid chromatographic separation and mass spectrometric analysis of eicosanoid metabolites in human samples. J Chromatogr A. 1359:60–69. doi: 10.1016/j.chroma.2014.07.006.
   PubMed Web of Science ®Google Scholar
• Warner D, Vatsalya V, Zirnheld KH, Warner JB, Hardesty JE, Umhau JC, McClain CJ, Maddipati K, Kirpich IA. 2021. Linoleic acid-derived oxylipins differentiate early stage alcoholic hepatitis from mild alcohol-associated liver injury. Hepatol Commun. 5(6):947–960. doi: 10.1002/hep4.1686.
   PubMed Web of Science ®Google Scholar
• Won JS, Im YB, Khan M, Singh AK, Singh I. 2004. The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase [Article. J Neurochem. 88(3):583–593. doi: 10.1046/j.1471-4159.2003.02165.x.
   PubMed Web of Science ®Google Scholar
• Woszczek G, Chen LY, Alsaaty S, Nagineni S, Shelhamer JH. 2010. Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists. J Immunol. 184(4):2219–2225. doi: 10.4049/jimmunol.0900071.
   PubMed Web of Science ®Google Scholar
• Xia L, Noh Y, Whelton AJ, Boor BE, Cooper B, Lichti NI, Park JH, Shannahan JH. 2023. Pulmonary and neurological health effects associated with exposure to representative composite manufacturing emissions and corresponding alterations in circulating metabolite profiles. Toxicol Sci. 193(1):62–79. doi: 10.1093/toxsci/kfad029.
   PubMed Web of Science ®Google Scholar
• Xie Z, Gonzalez LE, Ferreira CR, Vorsilak A, Frabutt D, Sobreira TJP, Pugia M, Cooks RG. 2019a. Multiple reaction monitoring profiling (MRM-Profiling) of lipids to distinguish strain-level differences in microbial resistance in Escherichia coli. Anal Chem. 91(17):11349–11354. doi: 10.1021/acs.analchem.9b02465.
   PubMed Web of Science ®Google Scholar
• Xu Z, Zhou J, McCoy DM, Mallampalli RK. 2005. LASS5 is the predominant ceramide synthase isoform involved in de novo sphingolipid synthesis in lung epithelia. J Lipid Res. 46(6):1229–1238. doi: 10.1194/jlr.M500001-JLR200.
   PubMed Web of Science ®Google Scholar
• Yaeger MJ, Reece SW, Kilburg-Basnyat B, Hodge MX, Pal A, Dunigan-Russell K, Luo B, You DJ, Bonner JC, Spangenburg EE, et al. 2021. Sex differences in pulmonary eicosanoids and specialized pro-resolving mediators in response to ozone exposure. Toxicol Sci. 183(1):170–183. doi: 10.1093/toxsci/kfab081.
   PubMed Web of Science ®Google Scholar
• Yang Y, Li X, An X, Zhang L, Li X, Wang L, Zhu G. 2020. Continuous exposure of PM2.5 exacerbates ovalbumin-induced asthma in mouse lung via a JAK-STAT6 signaling pathway. Adv Clin Exp Med. 29(7):825–832. doi: 10.17219/acem/121009.
   PubMed Web of Science ®Google Scholar
• Yedgar S, Krimsky M, Cohen Y, Flower RJ. 2007. Treatment of inflammatory diseases by selective eicosanoid inhibition: a double-edged sword? Trends Pharmacol Sci. 28(9):459–464. doi: 10.1016/j.tips.2007.07.005.
   PubMed Web of Science ®Google Scholar
• Yhee JY, Im J, Nho RS. 2016. Advanced therapeutic strategies for chronic lung disease using nanoparticle-based drug delivery. J Clin Med. 5(9):82. doi: 10.3390/jcm5090082.
   PubMed Web of Science ®Google Scholar
• Yu H, Su X, Lei T, Zhang C, Zhang M, Wang Y, Zhu L, Liu J. 2021. Effect of omega-3 fatty acids on chronic obstructive pulmonary disease: a systematic review and meta-analysis of randomized controlled trials. Int J Chron Obstruct Pulmon Dis. 16:2677–2686. doi: 10.2147/COPD.S331154.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang T, Liang Y, Jiang L, Sui X. 2021. Dietary bioactive lipids: a review on absorption, metabolism, and health properties. J Agric Food Chem. 69(32):8929–8943. doi: 10.1021/acs.jafc.1c01369.
   PubMed Web of Science ®Google Scholar
• Zhao YD, Yin L, Archer S, Lu C, Zhao G, Yao Y, Wu L, Hsin M, Waddell TK, Keshavjee S, et al. 2017. Metabolic heterogeneity of idiopathic pulmonary fibrosis: a metabolomic study. BMJ Open Respir Res. 4(1):e000183. doi: 10.1136/bmjresp-2017-000183.
   PubMed Web of Science ®Google Scholar
• Zheng J, Liu S, Peng J, Peng H, Wang Z, Deng Z, Li C, Li N, Tang L, Xu J, et al. 2022. Traffic-related air pollution is a risk factor in the development of chronic obstructive pulmonary disease. Front Public Health. 10:1036192. doi: 10.3389/fpubh.2022.1036192.
   PubMed Web of Science ®Google Scholar
• Zhou YY, Wang Y, Wang L, Jiang H. 2024. The efficacy of Omega-3 polyunsaturated fatty acids for severe burn patients: A systematic review and trial sequential meta-analysis of randomized controlled trials. Clin Nutr ESPEN. 59:126–134. doi: 10.1016/j.clnesp.2023.11.019.
   PubMed Web of Science ®Google Scholar