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Inhalation Toxicology
International Forum for Respiratory Research
Volume 9, 1997 - Issue 5
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Research Article

EFFECTS OF REPEATED EXPOSURES OF GERIATRIC RATS TO OZONE AND PARTICLE-CONTAINING ATMOSPHERES: AN ANALYSIS OF BRONCHOALVEOLAR LAVAG E AND PLASMA PROTEINS

Pages 423-434 | Published online: 01 Oct 2008

References

  • Bhalla, D. K., and Young, C. 1992. Effects of acute exposure to 03 on rats: Sequence of epithelial and inflammatory changes in the distal airways. InhaL Toxicol. 4:17–31.
  • Blumenstock, F. A., Weber, P. B., Saba, T. M., and Laffin, R. 1977. Electroimmunoassay of alpha-2-opsonic protein levels during reticuloendothelial blockade. Am.]. PhysioL 232:R80—R87. Bolarin, D. M. 1988. Serum prolyl hydroxylase protein in experimental liver cancer. Acta PhysioL 71:55–59.
  • Bouthillier, L., Vincent, R., Goegan, P., Bjarnasson, S., Guenette, J., Potvin, M., Stewart, M., Kumarathasan, P., and Poon, R. 1996. Acute lung responses to urban dust and ozone in Fischer 344 rats. Society of Toxicology, An nual Meeting (abstr. 499), p. 96.
  • Chichester, C. 0., and Fuller, G. C. 1980. Evidence for the presence of endogenous inhibitor of prolyl hydroxylase. Res. Commun. Chem. PathoL PharmacoL 29:329–333.
  • Crapo, J. D., Barry, B. E., Foscue, H. A., and Shelburne, J. 1980. Structural and biochemical changes in rats lungs occurring during exposures to lethal and adaptive doses of oxygen. Am. Rev. Respir. Dis. 122:123–143.
  • Crystal, R. G. 1974. Lung collagen: Definition, diversity and development. Fed. Proc. 33:2248–2255.
  • Devlin, R. B., McDonnal, W. F., Mann, R., Becker, S., House, D. E., Schreinmachers, D., and Koren, H. S. 1991. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am. J. Respir. Cell MoL BioL 4:72–81.
  • Dockery, D. W., Pope, C. A. III, Xiping, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., and Speizer, F. E. 1993. An association between air pollution and mortality in six US cities. N. Engl. J. Med. 329: 1753–1759.
  • Greenburg, L., Field, F., Erhardt, C., Glasser, M., and Reed, J. 1 967. Air pollution, influenza and mortality in New York city. Arch. Environ. Health 15:430–438.
  • Hesterberg, T. W., and Last, J. A. 1981. Ozone-induced acute pulmonary fibrosis in rats. Prevention of increased rates of collagen synthesis by methylprednisolone. Am. Rev. Respir. Dis. 123:47–52.
  • Hussain, M. Z., Cross, C. E., Mustafa, M. G., and Bhatnagar, R. S. 1 976. Hydroxyproline con-tents and prolyl hydroxylase activities in lungs of rats exposed to low levels of ozone. Life Sci. 18:897–904.
  • Kleinman, M. T., Bhalla, D. K., Mautz, W. J., and Phalen, R. F. 1995. Cellular and immunolog-ical injury with PM-10 inhalation. InhaL Toxicol. 7:589–602.
  • Knight, K., Leroux, B., Millar, J., and Petkau, A. J. 1989. Air Pollution and Human Health: A Study Based on Data from Prince George, British Columbia. Tech. Rep. 85, Department of Statistics, University of British Columbia, Vancouver, British Columbia, Canada.
  • Kodavanti, U. P., Hatch, G. E., Starcher, B., Gin, S. N., Winsett, D., and Costa, D. L. 1995. Ozone-induced pulmonary functional, pathological and biochemical changes in normal and vitamin C-deficient guinea pigs. Fundam.AppL Toxicol. 24:154–164.
  • Lafuma, C., Wegrowski, J., Labat-Robert, J., Legenfre, N., Metivier, H., and Masse, R. 1 987. Parallel increase of plasma fibronectin and perch lorosoluble serum glycoproteins in radiation-induced lung damage. Clin. PhysioL Biochem. 5:61–69.
  • Last, J. A., Hyde, D. M., and Chang, D. P. Y. 1 984a. A mechanism of synergistic lung damage by ozone and a respirable aerosol. Exp. Lung Res. 7:223–235.
  • Last, J. A., Reiser, K. M., Tyler, W. S., and Rucker, R. B. 1 984b. Long-term consequences of exposure to ozone. I. Lung collagen content. Toxicol. AppL PharmacoL 72:111–118.
  • Lippmann, M. 1989. Health effects of ozone-A critical review. J. Air Waste Manage. Assoc. 39:672–695.
  • Macy, E., Kemeny, M., and Saxon, A. 1988. Enhanced ELISA: How to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours. FASEB J. 2:3003-3009. Martin, A. E. 1964. Mortality and morbidity statistics and air pollution. Proc. R. Soc. Med. 57:967–975.
  • Murawaki, Y., Kusakabe, Y., and Hirayama, C. 1991. Serum lysyl oxidase activity in chronic liver disease in comparison with serum levels of prolyl hydroxylase and laminin. Hepatology 14:1167–1173.
  • Owens, M. R., and Cimino, C. D. 1982. Synthesis of fibronectin by isolated perfused rat liver. Blood 59:1305–1309.
  • Ozkaynak, H., and Spengler, J. D. 1985. Analysis of health effects resulting from population exposures to acid precipitation precursors. Environ. Health Perspect. 63:45–55.
  • Ozkaynak, H., and Thurston, G. D. 1987. Association between 1 980 US mortality rates and alternative measures of airborne particles concentration. Risk Anal. 7:449–461.
  • Pope, C. A. III, and Kanner, R. E. 1993. Acute effects of PM-10 pollution on pulmonary func-tion of smokers with mild to moderate chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 147:1336–1340.
  • Raffi, F., Boudart, D., Germaud, P., and Dabouis, G. 1983. Plasma fibronectin in patients with bronchopulmonary carcinoma. Presse Med. 12:304–305.
  • Saba, T. M., and Jaffe, E. 1980. Fibronectin (opsonic glycoprotein), its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticulo-endothelial function. Am.]. Med. 68:577–584.
  • Saba, T. M., Kiemer, J. L., and Holman, J. M. 1986. Fibronectin and the critically ill patient: Current status. Intensive Care Med. 12:350–358.
  • Samet, J. M., Bishop, Y., Speizer, F. E., Spengler, J. D., and Ferris, B. G., Jr. 1981. The rela-tionship between air pollution and emergency room visits in an industrial community.]. Air Pollut. Control Assoc. 31: 236–240.
  • Schenker, M. 1993. Air pollution and mortality (editorial). N. Engl.]. Med. 329:1807-1808. Schwartz, J. 1993. Particulate air pollution and chronic respiratory disease. Environ. Res. 62:7-13. Schwerer, B., Bach, M., and Bernheimer, H. 1987. ELISA for determination of albumin in the nanogram range: Assay in cerebrospinal fluid and comparison with radial immunodiffusion.
  • Clin. Chim. Acta 163:237–244.
  • Stern, B., Jones, L., Raizenne, M., Burnett, R., Meranger, J. C., and Franklin, C. A. 1989. Respiratory health effects associated with ambient sulfates and ozone in two rural Canadian communities. Environ. Res. 49:20–39.
  • Su, W. Y., Gordon, I., Chen, L. C., and Amdur, M. 1991. Is the protein leakage into the alveo-lar space after toxic injury size dependent or protein specific? Toxicology 11(1):88.
  • U.S. Environmental Protection Agency. 1986. Air quality criteria: Ozone and other photochemical oxidants, vols. IV, V. Research Triangle Park, NC: U.S. Environmental Protection Agency, EPA report no. EPA-600/8-84-0200 eF.
  • Villiger, B., Broekelmann, T., Kelley, D., Heymach, G. J. III, and Macdonald, J. A. 1981.
  • Bronchoalveolar fibronectin in smokers and nonsmokers. Am. Rev. Respir. Dis. 124:652-654. Yamada, K., and Olden, K. 1978. Fibronectins—Adhesive glycoproteins of cell surface and blood. Nature 275:179–184.
  • Yoshida, S., Bai, Y., Muragaki, Y., Ooshima, A., Inada, K., Nagai, Y., Obata, K., lwata, K., Hashida, S., and Ishikawa, E. 1986. A sandwich immunoassay for human prolyl 4-hydroxy-lase using monoclonal antibody. Clin. Chim. Acta 160:37–46.

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