Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 10, 1998 - Issue 7
44
Views
12
CrossRef citations to date
0
Altmetric
Research Article

PULMONARY RESPONSE TO TONER, TiO2 AND CRYSTALLINE SILICA UPON CHRONIC INHALATION EXPOSURE IN SYRIAN GOLDEN HAMSTERS

Pages 699-729 | Published online: 01 Oct 2008

References

  • Bellmann, B., Muhle, H., Creutzenberg, O., MacKenzie, J., Morrow, P., and Mermelstein, R. 1991. Lung clearance and retention of toner, utilizing a tracer technique during chronic inhalation exposure in rats. Fundam. Appl. Toxicol. 17:300–313.
  • Bellmann, B., Muhle, H., Creutzenberg, O., and Mermelstein, R. 1992. Irreversible pulmonary changes induced in rat lung by dust overload. Environ. Health Perspect. 97:189–191.
  • Bellmann, B., Muhle, H., Creutzenberg, O., and Mermelstein, R. 1998. The influence of lung burden on the toxicokinetics of inhaled insoluble particles upon cessation of exposure. lnhal. Toxicol., in press.
  • Bernfeld, P. 1979. Longevity of the Syrian hamster. Prog. Exp. Tumor Res. 24:118–126.
  • Creutzenberg, O., Bellmann, B., Muhle, H., Dasenbrock, C., Morrow, P., and Mermelstein, R. 1998a. Lung clearance and retention of toner, utilizing a tracer technique during chronic inhalation exposure in Syrian golden hamsters. lnhal. Toxicol. 10:731–751.
  • Creutzenberg, O., Muhle, H., Bellmann, B., Dasenbrock, C., Ernst, H., Morrow, P., and Mermelstein, R. 1998b. Time course of lung response upon cessation of insoluble particle exposure in rats. lnhal. Toxicol., in press.
  • Donaldson, K., Bolton, R. E., Jones, A., Brown, G. M., Robertson, M. D., Slight, J., Cowie, H. and Davis, J. M. G. 1988. Kinetics of the bronchoalveolar leucocyte response in rats during expo-sure to equal airborne mass concentrations of quartz, chrysotile asbestos, or titanium dioxide. Thorax 43:525–533.
  • Ernst, H., Heinrichs, M., Bargsten, G., Kittel, B., Rittinghausen, S., Dungworth, D. L., and Mohr, U. 1996. Neuroendocrine hyperplasias and tumors, larynx and trachea, Syrian hamster. In Respira-tory system, 2nd ed., eds. T. C. Jones, D. L. Dungworth, and U. Mohr, pp. 107–116. Berlin: Springer-Verlag.
  • Heinrich, U., Muhle, H., Takenaka, S., Ernst, H., Fuhst, R., Mohr, U., Pott, F., and Stöber, W. 1986. Chronic effects on the respiratory tract of hamsters, mice and rats after long-term inhalation of high concentrations of filtered and unfiltered diesel engine emissions.]. Appl. Toxicol. 6:383–395.
  • Heinrich, U., Fuhst, R., Rittinghausen, S., Creutzenberg, O., Bellmann, B., Koch, W., and Levsen, K. 1995. Chronic inhalation exposure of Wistar rats and two different strains of mice to diesel engine exhaust, carbon black, and titanium dioxide. InhaL ToxicoL 7:533–556.
  • Henderson, R. F., Benson, J. M., Hahn, F. F., Hobbs, C. H., Johns, R. K., Mauderly, J. L., McClellan, R. O., and Pickrell, J. A. 1985. New approaches for the evaluation of pulmonary toxicity bron-choalveolar lavage fluid analysis. Fundam. Appl. Toxicol. 5:451–458.
  • Henderson, R. F., Mauderly, J. L. Pickrell, J. A., Hahn, R. F., Muhle, H., and Rebar, A. H. 1987. Comparative study of bronchoalveolar lavage fluid: Effect of species, age and method of lavage. Exp. Lung Res. 13:329–342.
  • Henderson, R. F., Pickrell, J. A., Jones, R. K., Sun, J. D., Benson, J. M., Mauderly, J. L., and McClellan, R. O.1988. Response of rodents to inhaled diluted diesel exhaust: Biochemical and cytological changes in bronchoalveolar lavage fluid and in lung tissue. Fundam. Appl. ToxicoL 11:546–565.
  • Mauderly, J. L. 1996. Lung overload: The dilemma and opportunities for resolution. In Particle over-load in the rat lung and lung cancer: Relevance for human risk assessment, eds. J. L. Mauderly and R. J. McCunney, Inhal. Toxicol. 8(suppl.):1-28.
  • Mauderly, J. L., and McCunney, R. J. eds. 1996. Particle overload in the rat lung and lung cancer: rel-evance for human risk assessment. Inhal. Toxicol. 8(suppl.).
  • Mermelstein, R., and Simonson, A. 1994. Human exposure to insoluble isometric particles. In Toxic and carcinogenic effects of solid particles in the respiratory tract, ed. U. Mohr, pp. 277–290. Washington, DC: ILSI Press.
  • Mermelstein, R., Creutzenberg, O., Dasenbrock, C., Kilpper, R., Morrow, P., and Muhle, H. 1990. Long-term inhalation study of test toner in hamsters. Toxicologist10:802.
  • Mermelstein, R., Muhle, H., and Morrow, P.E. 1991. Induction of inflammation and fibrosis after exposure to insoluble and isometric particles. In Mechanisms in fibre carcinogen esis, ed. R. C. Brown, pp. 213-227. New York: Plenum Press.
  • Mermelstein, R., Creutzenberg, O., Dasenbrock, C., Ernst, H., Kuschner, M., Mohr, U., and Muhle, H. 1992. Hamster response to chronic test toner inhalation. Toxicologist12:839.
  • Mohr, U., Heinrich, U., Fuhst, R., Ketkar, M., and Muhle, H. 1984. The suitability of the Syrian golden hamster for chronic inhalation experiments. In Problems of inhalatory toxicity studies, ed. P. Grosdanoff, pp. 145–152. BGA-Schriften 5/84. München: MMV Medizin Verlag.
  • Morrow, P. E. 1988. Possible mechanisms to explain dust overloading of the lungs. Fundam. Appl. ToxicoL 10:369–384.
  • Morrow, P. E. 1992. Contemporary issues in toxicology. Dust overloading of the lungs: Update and appraisal. Toxicol. Appl. PharmacoL 113:1–12.
  • Morrow, P. E., Muhle, H., and Mermelstein, R. 1990. Chronic inhalation study findings as a basis for proposing a new occupational dust exposure lim it. J. Am. Coll. Toxicol. 10:279–290.
  • Muhle, H., Bellmann, B., Creutzenberg, O., Stöber, W., Kilpper, R., MacKenzie, J. C., Morrow, P., and Mermelstein, R. 1988. Pulmonary deposition clearance and retention of test toner, TiO2 and quartz during a long term inhalation study in rats. Toxicologist8:272.
  • Muhle, H., Takenaka, S., Mohr, U., Dasenbrock, C., and Mermelstein, R. 1989. Lung tumor induc-tion upon long-term low-level inhalation of crystalline silica. Am.]. Ind. Med. 15:343–346.
  • Muhle, H. Bellmann, B., Creutzenberg, 0., Fuhst, R., Kilpper, R., Koch, W., MacKenzie, J. C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. 1990a. Subchronic inhalation study of toner in rats. InhaL Toxicol. 2: 341–359.
  • Muhle, H., Creutzenberg, O., Bellmann, B., Heinrich, U., and Mermelstein, R. 1990b. Dust overload-ing of lungs: Investigations of various materials, species differences and irreversibility of effects. J. Aerosol Med. 3:S111–S128.
  • Muhle, H., Bellmann, B., Creutzenberg, O., Dasenbrock, C., Ernst, H., Kilpper, R., Mackenzie, J. C., Morrow, P., Mohr, U., Takenaka, S., and Mermelstein, R. 1991. Pulmonary response to toner upon chronic inhalation exposure in rats. Fundam. Appl. ToxicoL 17:280–299.
  • Niemeier, R. W., Mulligan, L. T., and Rowland, J. 1986. Cocarcinogenicity of foundry silica sand in hamsters. In Silica, silicosis & cancer, controversy in occupational medicine, ed. D. F. Goldsmith, pp. 215–227, New York: Praeger.
  • Pour, P., Althoff, J., Salmasi, S. Z., and Stepan, K. 1979. Spontaneous tumours and common diseases in three types of hamsters. JNCI 63:797–809.
  • Raabe, O. G., Al-Bayati, M. A., Teague, S. V., and Rasolt, A. 1988. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann. Occup. Hyg. 32 (Suppl. 1):53–63.
  • Redman, H. C., Hobbs, C. H., and Rebar, A. H. 1979. Survival distribution of Syrian hamsters. Prog. Exp. Tumor Res. 24:108–111.
  • SAS Institute. 1985. SAS User's Guide: Statistics, Version 5 ed. SAS Institute Inc., Cary, NC.
  • Sher, S. P. 1982. Tumors in control hamsters, rats and mice: Literature tabulation. CRC Crit. Rev. Toxicol. 10:49–79.
  • Takahashi, M., and Okamiya, H. 1996. Tumours of the oral cavity, buccal pouch, oesophagus, fore-stomach and salivary glands. In Pathology of tumours in laboratory animals, vol. 3, Tumours of the hamster, 2nd ed., eds. V. S. Turusov and U. Mohr, pp. 59–77, IARC No. 126. Lyon, France: ARC.
  • U.S. Environmental Protection Agency. 1986. Draft policy. Chem. Regul. Reporter May 9:158 (BNA).
  • Warheit, D. B., Hansen, J. F., Yuen, I. S., Snajdr, S. I., and Hartsky, M. A. 1996. Prolonged cellular proliferation and pulmonary inflammation are produced in rats inhaling high concentrations of low-toxicity insoluble particulates: Comparisons with cytotoxic dusts. In Particle overload in the rat lung and lung cancer: relevance for human risk assessment, eds. J. L. Mauderly and R. J. McCunney, Inhal. Toxicol. 8(suppl):155-167.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.