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Inhalation Toxicology
International Forum for Respiratory Research
Volume 10, 1998 - Issue 6
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Research Article

PREDICTIONS OF PARTICLE DEPOSITION PATTERNS IN HUMAN AND RAT AIRWAYS

Pages 557-583 | Published online: 01 Oct 2008

References

  • Anjilvel, S., and Asgharian, B. 1995. A multiple-path model of particle deposition in the rat lung. Fundam. Appl. Toxicol. 28:41–50.
  • Bergmann, R., Hofmann, W., and Koblinger, L. 1997. Particle deposition modeling in the human lung: Comparison between Monte Carlo and ICRP model predictions./ Aerosol Sci. 28\(suppl. 1): S433–5434.
  • Cheng, Y. S., Hansen, G. K., Su, Y. F., Yeh, H. C., and Morgan, K. T. 1990. Deposition of ultrafine aerosols in rat nasal molds. Toxicol. Appl. Pharmacol. 106:222–233.
  • Cheng, K. H, Cheng, Y. S., Yeh, H. C., Guilmette, R. A., Simpson, S. Q., Yang, Y. H., and Swift, D. K. 1996. In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways.]. Aerosol Sci. 27:785–801.
  • Cohen, B. S., and Asgharian, B. 1990. Deposition of ultrafine particles in the upper airways: An empirical analysis.]. Aerosol Sci. 21:789–797.
  • Costa, D. L., and Tepper, J. S. 1988. Approaches to lung function assessment in small mammals. In Toxicology of the lung, eds. D. E. Gardner, J. D. Crapo, and E. J. Massaro, pp. 147–174. New York: Raven Press.
  • Cross, F. T. 1988. Radon Inhalation Studies in Animals. Report DOE/ER. Washington, DC: U.S. Department of Energy.
  • Gerde, P., Cheng, Y. S., and Medinsky, M. A. 1991. In vivo deposition of ultrafine aerosols in the nasal airway of the rat. Fundam. Appl. Toxicol. 16:330–336.
  • Haefeli-Bleuer, B., and Weibel, E. R. 1988. Morphometry of the human pulmonary acinus. Anat. Rec. 220:401–414.
  • Heyder, J., Gebhart, J., and Scheuch, G. 1988. Influence of human lung morphology on particle deposition.]. Aerosol Med. 1:81–88.
  • Hofmann, W., and Koblinger, L. 1990. Monte Carlo modeling of aerosol deposition in human lungs. Part II: Deposition fractions and their sensitivity to parameter variations.]. Aerosol Sci. 21:675–688.
  • Hofmann, W., and Koblinger, L. 1992. Monte Carlo modeling of aerosol deposition in human lungs. Part III: Comparison with experimental data. J. Aerosol Sci. 23:51–63.
  • Hofmann, W., and Koblinger, L. 1994. Comparison of particle deposition patterns in human and rat lungs.]. Aerosol Sci. 25\(suppl. 1):5505–5506.
  • Hofmann, W., Koblinger, L., and Martonen, T. B. 1989. Structural differences between human and rat lungs: Implications for Monte Carlo modeling of aerosol deposition. Health Phys. 57\(suppl. 1): 41–47.
  • Hofmann, W., Martonen, T. B., and Ménache, M. G. 1990. A dosimetric model for localised radon progeny accumulations at tracheobronchial bifurcations. Radiat. Prot. Dosim. 30: 245–259.
  • Hofmann, W., Ménache, M. G., and Graham, R. C. 1993. Radon progeny dosimetry in the rat lung. Health Phys. 64: 279–290.
  • Hofmann, W., Balashazy, I., Heistracher, T., and Koblinger, L. 1996. The significance of particle deposition patterns in bronchial airway bifurcations for extrapolation modeling. Aerosol Sci. Technol. 25:305–327.
  • International Commission on Radiological Protection. 1994. Human respiratory tract model for radio-logical protection. ICRP Publication 66, Ann. ICRP 24. Oxford: Pergamon.
  • Kim, C. S., and Iglesias, A. J. 1989. Deposition of inhaled particles in bifurcating airway models: I. Inspiratory deposition.]. Aerosol Med. 2:1–14.
  • Koblinger, L., and Hofmann, W. 1985. Analysis of human lung morphometric data for stochastic aerosol deposition calculations. Phys. Med. Biol. 30:541–556.
  • Koblinger, L., and Hofmann, W. 1988. Stochastic morphological model of the rat lung. Anat. Rec. 221:533–539.
  • Koblinger, L., and Hofmann, W. 1990. Monte Carlo modeling of aerosol deposition in human lungs. Part I: Simulation of particle transport in a stochastic lung structure.]. Aerosol Sci. 21:661–674.
  • Koblinger, L., and Hofmann, W. 1995. Aerosol inhalation in the rat lung. Part II: Theoretical predictions of particle deposition patterns.]. Aerosol Med. 8:21–32.
  • Koblinger, L., Hofmann, W., Graham, R. C., and Mercer, R. R. 1995. Aerosol inhalation in the rat lung. Part I: Analysis of the rat acinus morphometry and construction of a stochastic lung model. J. Aerosol Med. 8:7–19.
  • Martin, D., and Jacobi, W. 1972. Diffusion deposition of small-sized particles in the bronchial tree. Health Phys. 23:23–29.
  • Martonen, T. B., and Hofmann, W. 1986. Factors to be considered in a dosimetry model for risk assessment of inhaled particles. Radiat. Prot. Dosim. 15:225–232.
  • Martonen, T. B., and Miller, J. F. 1986. Dosimetry and species sensitivity: Key factors in hazard eval-uation using animal exposure data./ Aerosol ScL 17:316–319.
  • Martonen, T. B., Zhang, Z., and Yang, Y. 1992. lnterspecies modeling of inhaled particle deposition patterns./ Aerosol ScL 23:389–406.
  • Ménache, M. G., Miller, F. J., and Raabe, 0. G. 1995. Particle inhalability curves for humans and small laboratory animals. Ann. Occup. Hyg. 39: 317–328.
  • Mercer, R. R., and Crapo, J. D. 1987. Three-dimensional reconstruction of the rat acinus. J. AppL PhysioL 63:785–794.
  • Oberdörster, G. 1991. Lung dosimetry and extrapolation of results from animal inhalation studies to man.]. Aerosol Med. 4:335–347.
  • Pich, J. 1972. Theory of gravitational deposition of particles from laminar flow in channels.]. Aerosol ScL 3:351–361.
  • Raabe, 0. G., Yeh, H. C., Schum, G. M., and Phalen, R. F. 1976. Tracheobronchial Geometry: Human, Dog, Rat, Hamster. Lovelace Foundation Report LF-53. Albuquerque, NM: Lovelace Foundation.
  • Schlesinger, R. B., and Lippmann, M. 1978. Selective particle deposition and bronchogenic carcinoma. Environ. Res. 15:424–431.
  • Schum, M., and Yeh, H. C. 1980. Theoretical evaluation of aerosol deposition in anatomical models of mammalian lung airways. Bull. Math. Biol. 42:1–15.
  • Stahlhofen, W., Rudolf, G., and James, A. C. 1989. Intercompariscn of experimental regional aerosol deposition data./ Aerosol Med. 2:285–308.
  • Swift, D. L., Cheng, Y. S., Su, Y. F., and Yeh, H. C. 1994. Ultrafine aerosol deposition in human nasal and oral passages. Ann. Occup. Hyg. 38\(suppl. 1):77–81.
  • Tepper, J. S., Wiester, M. J., King, M. E., Weber, M. F., and Costa, D. L. 1988. Use of carbon dioxide challenge to detect toxicant-induced changes in cardiopulmonary function of awake rats. InhaL ToxicoL Premier issue:79-95.
  • Weibel, E. R. 1963. Morphometry of the human lung. New York: Academic Press.
  • Yeh, H. C., and Schum, G. M. 1980. Models of human lung airways and their application to inhaled particle deposition. Bull. Math. Biol. 42:461–480.
  • Yeh, H. C., Schum, G. M., and Duggan, M. T. 1979. Anatomic models of the tracheobronchial and pulmonary regions of the rat. Anat. Rec. 195:483–492.
  • Yu, C. P., and Xu, G. B. 1987. Predictive models of deposition of diesel exhaust particulates in human and rat lungs. Aerosol ScL Technol. 5:337–347.
  • Zhang, L., and Yu, C. P. 1993. Empirical equations for nasal deposition of inhaled particles in small laboratory animals and humans. Aerosol ScL Technol. 19:51–56.

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