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Inhalation Toxicology
International Forum for Respiratory Research
Volume 10, 1998 - Issue 5
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Research Article

A MOUSE MODEL FOR STUDY OF LOCALIZED TOLUENE DIISOCYANATE ADDUCTS FOLLOWING INTRABRONCHIAL ADMINISTRATION OF THE CHEMICAL: INFLAMMATION AND ANTIBODY PRODUCTION

Pages 503-529 | Published online: 01 Oct 2008

References

  • Cibulas, W., Jr., Murlas, C. G., Miller, M. L., Vinegar, A., Schmidt, D. J., McKay, R. T., Bernstein, I. L., and Brooks, S. M. 1986. Toluene diisocyanate-induced airway hyperreactivity and patholo-gy in the guinea pig.]. Allergy Clin. Immunol. 77: 828–834.
  • Day, B. W., Jin, R., and Karol, M. H. 1996. In vivo and in vitro reactions of toluene diisocyanate iso-mers with guinea pig hemoglobin. Chem. Res. Toxicol. 9:568–573.
  • Day, B. W., Jin, R., Basalyga, D. M., Kramarik, J. A., and Karol, M. H. 1997. Formation, solvolysis, and transcarbamoylation reactions of bis(5-glutathionyl) adducts of 2,4- and 2,6-di isocyanato-toluene. Chem. Res. Toxicol. 10:424–431.
  • Fabbri, L. M. 1994. Airway inflammation in occupational asthma. Am. J. Respir. Crit. Care Med. 150:S80—S82.
  • Fabbri, L. M., Dan ieli, D., Crescioli, S., Bevilacqua, P., Meli, S., Saetta, M., and Mapp, C. E. 1988. Fatal asthma in a subject sensitized to toluene diisocyanate. Am. Rev. Respir. Dis. 137:1494–1498.
  • Finotto, S., Fabbri, L. M., Rado, V., Mapp, C. E., and Maestrelli, P. 1991. Increase in numbers of CD8 positive lymphocytes and eosinophils in peripheral blood of subjects with late asthmatic reac-tions induced by toluene diisocyanate. Br.]. Ind. Med. 48:116–121.
  • Garssen, J., Nijkamp, F. P., Van Der Vliet, H., and Van Loveren, H. 1991. T-cell-mediated induction of airway hyperreactivity in mice. Am. Rev. Respir. Dis. 144:931–938.
  • Garssen, J., Van Loveren, H., Van Der Vliet, H., Bot, H., and Nijkamp, F. P. 1993. T cell-mediated induction of airway hyperresponsiveness and altered lung functions in mice are independent of increased vascular permeability and mononuclear cell infiltration. Am. Rev. Respir. Dis. 147: 307–313.
  • Gordon, T., Sheppard, D., McDonald, D. M., DiStefano, S., and Scypinski, L. 1985. Airway hyperre-sponsiveness and inflammation induced by toluene diisocyanate in guinea pigs. Am. Rev. Respir. Dis. 132:1106–1112.
  • Jin R., Day, B. W., and Karol, M. H. 1993. Toluene diisocyanate protein adducts in the bron-cheoalveolar lavage of guinea pigs exposed to vapors of the chemical. Chem. Res. Toxicol. 6(6): 906–912.
  • Karol, M. H. 1986. Respiratory effects of inhaled isocyanates. CRC Crit. Rev. Toxicol. 16:349–379.
  • Karol, M. H., Jin, R., and Lantz, R. C. 1997. Immunohistochemical detection of toluene diisocyanate (TDI) adducts in pulmonary tissue of guinea pigs following inhalation exposure. Inhal. Toxicol. 9:63–83.
  • Mapp, C. E., Di Giacomo, G. R., Omini, C., Broseghini, C., and Fabbri, L. M. 1986. Late, but not early, asthmatic reactions induced by toluene-diisocyanate are associated with increased airway responsiveness to methacholine. Eur. J. Respir. Dis. 69:276–284.
  • Mapp, C. E., Saetta, M., Maestrelli, P., Di Stefano, A., Chitano, P., Boschetto, P., Ciaccia, A., and Fabbri, L. M. 1994. Mechanisms and pathology of occupational asthma. Eur. Respir. J. 7:544–554.
  • Mapp, C. E., Lapa, E., Silva, J. R., Lucchini, R. E., Chitano, P., Rado, V., Saetta, M., Pretolani, M., Karol, M. H., Maestrelli, P., and Fabbri, L. M. 1996. Inflammatory events in the blood and air-ways of guinea pigs immunized to toluene diisocyanate. Am.]. Respir. Crit. Care Med. 154: 201–208.
  • Musk, A. W., Peters, J. M., and Wegman, D. H. 1988. Isocyanates and respiratory disease: Current status. Am. J. Ind. Med. 13:331–349.
  • Niimi, A., Amitani, R., Yamada, K., Tanaka, K., and Kuze, F. 1996. Late respiratory response and associated eosinophilic inflammation induced by repeated exposure to toluene diisocyanate in guinea pigs.]. Allergy Clin. ImmunoL 97:1308–1319.
  • Saetta, M., Di Stefano, A., Maestrelli, P., De Marzo, N., Milani, G. F., Pivirotto, F., Mapp, C. E., and Fabbri, L. M. 1992. Airway mucosal inflammation in occupational asthma induced by toluene di isocyanate. Am. Rev. Respir. Dis. 145:160–168.
  • Satoh, T., Kramarik, J. A., Tollerud, D. J., and Karol, M. H. 1995. A murine model for assessing the respiratory hypersensitivity potential of chemical allergens. Toxicol. Lett. 78:57–66.
  • Scheerens, H., Buckley, T. L., Davidse, E. M., Garssen, J., Nijkamp, F. P., and Van Loveren, H. 1996. Toluene diisocyanate-induced in vitro tracheal hyperreactivity in the mouse. Am.]. Respir. Crit. Care Med. 154:858–865.
  • Sugawara, Y., Okamoto, Y., Sawahata, T., and Tanaka, K. 1993. An asthma model developed in the guinea pig by intranasal application of 2,4-toluene diisocyanate. Int. Arch. Allergy Immunol. 101: 95–101.
  • Vandenplas, O., Maio, J.-L., Saetta, M., Mapp, C. E., and Fabbri, L. M. 1993. Occupational asthma and extrinsic alveolitis due to isocyanates: Current status and perspectives. Br. J. Ind. Med. 50: 213–228.

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