Advanced search
Publication Cover
Inhalation Toxicology
International Forum for Respiratory Research
Volume 10, 1998 - Issue 1
Submit an article Journal homepage
43
Views
8
CrossRef citations to date
0
Altmetric
Research Article

IN VITRO HEPATIC METABOLISM OF PCBTF: DEVELOPMENT OF Vmax AND Km VALUES AND PARTITION COEFFICIENTS AND THEIR USE IN AN INHALATION PBPK MODEL

B. Knaak James Occidental Chemical Corporation, Dallas, Texas, USA
,
W. Smith Ladd Department of Pharmacology and Toxicology, State University of New York, Buffalo, New York, USA
,
D. Fitzpatrick Richard Pharmacol LSR, East Millstone, New Jersey, USA
,
R. Olson James Occidental Chemical Corporation, Dallas, Texas, USA
&
E. Newton Paul Occidental Chemical Corporation, Dallas, Texas, USA
Pages 65-85 | Published online: 01 Oct 2008

References

  • Clement International. 1990. Development and Validation of Methods for Applying Pharmaco-kinetic Data In Risk Assessment. Final Report. Volume V: Vinyl Chloride. AAMRL-TR-90-072. Prepared for the Department of the Air Force, Armstrong Aerospace Medical Research Laboratory, Wright-Patterson Air Force Base, OH.
  • Csanady, G. A., Guengerich, F. P., and Bond, J. A. 1992. Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice. Carcinogenesis 13(7):1143–1153.
  • Gargas, M. L., Burgess, R. J., Voisard, D. E., Cason, G. H., and Andersen, M. E. 1989. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98:87–99.
  • International Life Sciences Institute—Risk Science Institute. 1994. Physiological Parameter Values for PBPK Models. Report prepared under a cooperative agreement with OHEA, EPA. Washing-ton, DC.
  • Knaak, J. B., Al-Bayati, M. A., and Raabe, O. G. 1995. Development of partition coefficients, 14,„„ and Km values, and allometric relationships. Toxicol. Lett. 79: 87–98.
  • National Toxicology Program. 1991. Toxicity Studies of p-Chloro-a,a,a-Trifluorotoluene in F344/N Rats and Mice—Comparative Fourteen-Day Gavage Studies in Corn Oil and a-Cyclodextrin. March. Washington, DC: U.S. Department of Health and Human Services/NIH.
  • Newton, P. E., Bolte, H. F., Richter, W. R., Akinsanya, M. B., Knaak, J. B., and Smith, L. W. 1998. Inhalation toxicity, neurotoxicity and toxicokinetic studies of p-chlorobenzotrifluoride. lnhal. Toxicol. 10:33–48.
  • Pelosi, G. D., Oberdoerster, J., Olson, J. R., Knaak, J. B., Smith, L. W., Newton, P. E. 1998. Characterization of rat hepatic cytochrome CYP450 activities following inhalation exposure to p-chlorobenzotrifluoride. lnhal. Toxicol. 10:49–63.
  • Pharmaco [SR. 1994. A Subchronic (3-Month) Inhalation Toxicity and Neurobehavioral Study of PCBTF in the Rat. October 24. Prepared for Occidental Chemical Corporation, Dallas, TX.
  • Quistad, G. B., and Mulholland, K. M. 1983. Metabolism of PCBTF by rats.]. Agric. Food Chem. 31:585–589.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.