TWO-WEEK INHALATION TOXICITY OF POLYMERIC DIPHENYLMETHANE-4,4'-DIISOCYANATE (PMDI) IN RATS: Analysis of Biochemical and Morphological Markers of Early Pulmonary Response

References

• Alarie, Y. 1973. Sensory irritation by airborne chemicals. CRC Crit. Rev. ToxicoL 2:299–363.
   PubMedGoogle Scholar
• ASTM. 1984. Standard Test Method for Estimating Sensory Irritancy of Airborne Chemicals. Test Method E 981–84. Philadelphia, PA: American Society For Testing of Materials.
   Google Scholar
• Coleridge, J. C. G., and Coleridge, H. M. 1984. Afferent vagal C fibre innervation in the lungs and airways and its functional significance. Rev. Physiol. Biochem. PharmacoL 99:1–110.
   PubMed Web of Science ®Google Scholar
• Day, B. J., Carlson, G. P., and De Nicola, D. B. 1990. y-Glutamyltranspeptidase in the rat bron-choalveolar lavage fluid as a probe for 4-ipomeanol and a-naphthylthiourea-induced pneumo-toxic ity. J. PharmacoL Methods 24:1–8.
   PubMedGoogle Scholar
• Diamond, L., and O'Donnell, M. 1977. Pulmonary mechanics in normal rats.]. Appl. PhysioL Respir. Environ. Exercise Physiol. 43: 942–948.
   Google Scholar
• Dunlap, K. L., Sandridge, R. L., and Keller, J. 1976. Determination of isocyanates in working atmos-phere by high performance liquid chromatography. Anal. Chem. 48:497–499.
   Web of Science ®Google Scholar
• European Community. 1986. EC Directive 86/609/EC. Guideline of the Council dated November 24, 1986, on the Reconciliaticn of Legal and Administrative Regulations of the Member Countries for the Protection of Animals Used for Studies and Other Scientific Purposes. J. Eur. Commun. Legal Spec. L358:29.
   Google Scholar
• Emura, M. 1997. Stem cells of the respiratory epithelium and their in vitro cultivation. In Vitro CelL Dev. Biol. Anim. 33:3–14.
   PubMed Web of Science ®Google Scholar
• Fischer, J., Lüllmann-Rauch, R., Stubbe, E., and von Witzendorff, B. 1996. Lysosomal storage of sul-fated glycosaminoglycans induced by two bis-aminomethyl anthrachinones. Arch. Toxicol. 70: 373–379.
   PubMed Web of Science ®Google Scholar
• Hook, G. E. R. 1991. Alveolar proteinosis and phospholipidosis of the lungs. ToxicoL PathoL 19:482–513.
   PubMed Web of Science ®Google Scholar
• Lee, C., Rajini, P., Pinkerton, K. E., and Witschi, H. 1995. Correlation between cumulative labeling indices measured in the terminal bronchioles and the centriacinar region in the lungs of rats exposed to oxidant air pollutants. ToxicoL Lett. 80:25–28.
   PubMed Web of Science ®Google Scholar
• Mason, J. M., Walker, S. R., Shields, B. A., Henson, J. E., and Williams, M. C. 1985. Identification of rat alveolar type II epithelial cells with tannic acid and polychrome stain. Am. Rev. Respir. Dis. 131:786–788.
   PubMed Web of Science ®Google Scholar
• Mason, R. J., and Voelker, D. R. 1998. Regulatory mechanisms of surfactant secretion. Biochim. Biophys. Acta 408:226–240.
   Google Scholar
• Mauderly, F. L. 1989. Effect of inhaled toxicants on pulmonary function. In Concepts in inhalation toxicology, eds. R. 0. McClellan and R. F. Henerson, pp. 347-401. New York: Hemisphere.
   Google Scholar
• Organization for Economic Cooperation and Development. 1983. Publication of the German version of the OECD Principles of Good Laboratory Practice (GLP). Bundesanzeiger 35(42a), dated 2 March.
   Google Scholar
• Paintal, A. S. 1969. Mechanism of stimulation of type J receptors.]. Physiol. 203:511–532.
   PubMed Web of Science ®Google Scholar
• Paintal, A. S. 1981. Effects of drugs on chemoreceptcrs, pulmonary and cardiovascular receptors. In
   Google Scholar
• International encyclopedia of pharmacology and therapeutics, ed. J. G. Widdicombe, Section 104, Respiratory Pharmacology,pp. 217–239. Oxford: Pergamon Press.
   Google Scholar
• Paiva, M., Yernault, J. C., van Eer de Weghe, P., and Englert, M. 1975. A sigmoid model of the static volume—pressure curve of human lung. Respir. Physiol. 23: 317–323.
   Google Scholar
• Palecek, F. 1969. Measurementof ventilatory mechanics in rats.]. Appl. Physiol. 27:149-156. Pauluhn, J. 1994. Validation of an improved nose-only exposure system for rodents.]. Appl. Toxicol. 14:55–62.
   Google Scholar
• Pauluhn, J. 1997. Assessment of respiratory hypersensitivity in guinea pigs sensitized to toluene di iso-cyanate: Improvements on analysis of response. Fundam. Appl. Toxicol. 40:211–219.
   PubMedGoogle Scholar
• Pauluhn, J., and Mohr, U. 1999. Repeated 4-week inhalation exposure of rats: Effect of low-, interme-diate, and h igh-hum idity chamber atmospheres. Exp. Toxicol. Pathol. 51:178–187.
   PubMed Web of Science ®Google Scholar
• Pauluhn, J., Riingeler, W., and Mohr, U. 1995. Phenyl isocyanate-induced asthma in rats following a 2-week exposure period. Fundam. AppL Toxicol. 24:217–228.
   PubMedGoogle Scholar
• Reuzel, P. G. J., Arts, J. H. E., Lomax, L. G., Kuper, C. F., Gembardt, C., Feron, V. J., Kuijrers, M. H. M., and Loser, E. 1994a. Chronic inhalation toxicity and carcinogenicity study of respirable polymeric methylene diphenyl di isocyanate (polymeric MDI) aerosol in rats. Fundam. AppL Toxicol. 22 :195–210.
   PubMedGoogle Scholar
• Reuzel, P. G. J., Kuper, C. F., Feron, V. J., Appelman, L. M., and Löser, E. 1994b. Acute, subacute, and subchronic inhalation toxicity studies of respirable polymeric methylene diphenyl di isocyanate (polymeric MDI) aerosol in rats. Fundam. AppL Toxicol. 22: 186–194.
   Google Scholar
• Richards, R. J., and Oreffo, V. I. C. 1993. Respiratory tract epithelium and neoplasia. Respir. Med. 87:175–181.
   PubMed Web of Science ®Google Scholar
• Richardson, K. C., Jarett, L., and Finke, E. H. 1960. Embedding in epoxy resins for ultrathin section-ing in electron microscopy. Stain TechnoL 35:313–325.
   PubMed Web of Science ®Google Scholar
• Takayama, M., Itoh, S., Nagasaki, T., and Tan imizu, I. 1977. A new enzymatic method for determina-tion of serum choline-containing phospholipids. Clin. Chim. Acta 79:93–98.
   PubMed Web of Science ®Google Scholar
• Takezawa, J., Miller, F. J., O'Neil, J. J. 1980. Single-breath diffusing capacity and lung volumes in small laboratory animals.]. Appl. Physiol. Respir. Environ. Exercise Physiol. 48: 1052–1059.
   Google Scholar
• Young, J. T. 1981. Histopathologic examination of the rat nasal cavity. Fundam. AppL Toxicol. 1:309–312.
   PubMedGoogle Scholar