416
Views
94
CrossRef citations to date
0
Altmetric
Original Article

IL-9 and its Receptor: From Signal Transduction to Tumorigenesis

&
Pages 207-215 | Received 04 Jun 2004, Published online: 07 Aug 2009

References

  • Aldinucci, D., Poletto, D., Gloghini, A., Nanni, P., Degan, M., Perin, T., Ceolin, P., Rossi, F.M. Gattei, V., Carbone, A. and Pinto, A. (2002) "Expression of functional interleukin-3 receptors on Hodgkin and Reed-Sternberg cells", Am. J. Pathol. 160, 585–596.
  • Asao, H., Okuyama, C., Kumaki, S., Ishii, N., Tsuchiya, S., Foster, D. and Sugamura, K. (2001) "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex", J. Immunol. 167, 1–5.
  • Bauer, J.H. Liu, K.D. You, Y., Lai, S.Y. and Goldsmith, M.A. (1998) "Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis", J. Biol. Chem. 273, 9255–9260.
  • Bittner, C., Feller, A.C. Renauld, J.C. Lange, K., Pietrzik, R., Jenetzky, C., Briese, J., Gaiser, T., Muller, A., Wiedemann, G.J. Van Snick, J. and Merz, H. (2000) "An animal model for anaplastic large cell lymphoma in the immunocompetent syngeneic C57Bl/6 mouse", Lab. Investig. 80, 1523–1531.
  • Bourette, R.P. Royet, J., Mouchiroud, G., Schmitt, E. and Blanchet, J.P. (1992) "Murine interleukin 9 stimulates the proliferation of mouse erythroid progenitor cells and favors the erythroid differentiation of multipotent FDCP-mix cells", Exp. Hematol. 20, 868–873.
  • Brennscheidt, U., Riedel, D., Kolch, W., Bonifer, R., Brach, M.A. Ahlers, A., Mertelsmann, R.H. and Herrmann, F. (1994) "Raf-1 is a necessary component of the mitogenic response of the human megakaryoblastic leukemia cell line MO7 to human stem cell factor, granulocyte-macrophage colony-stimulating factor, interleukin 3, and interleukin 9", Cell Growth Differ. 5, 367–372.
  • Bromberg, J. (2002) "Stat proteins and oncogenesis", J. Clin. Investig. 109, 1139–1142.
  • Chung, H.K. Young, H.A. Goon, P.K. Heidecker, G., Princler, G.L. Shimozato, O., Taylor, G.P. Bangham, C.R. and Derse, D. (2003) "Activation of interleukin-13 expression in T cells from HTLV-1- infected individuals and in chronically infected cell lines", Blood 102, 4130–4136.
  • Demoulin, J.B. and Renauld, J.C. (1998) "Signalling by cytokines interacting with the interleukin-2 receptor gamma chain", Cytokines Cell. Mol. Ther. 4, 243–256.
  • Demoulin, J.B. Uyttenhove, C., Van Roost, E., de Lestre, B., Donckers, D., Van Snick, J. and Renauld, J.C. (1996) "A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9", Mol Cell. Biol. 16, 4710–4716.
  • Demoulin, J.B. Van Roost, E., Stevens, M., Groner, B. and Renauld, J.C. (1999) "Distinct roles for STAT1, STAT3, and STAT5 in differentiation gene induction and apoptosis inhibition by inter-leukin-9", J. Biol. Chem. 274, 25855–25861.
  • Demoulin, J.B. Grasso, L., Atkins, J.M. Stevens, M., Louahed, J., Levitt, R.C. Nicolaides, N.C. and Renauld, J.C. (2000a) "Role of insulin receptor substrate-2 in interleukin-9-dependent proliferation", FEBS Lett. 482, 200–204.
  • Demoulin, J.B. Uyttenhove, C., Lejeune, D., Mui, A., Groner, B. and Renauld, J.C. (2000b) "STAT5 activation is required for interleukin-9-dependent growth and transformation of lymphoid cells", Cancer Res. 60, 3971–3977.
  • Demoulin, J.B. Van Snick, J. and Renauld, J.C. (2001) "Interleukin-9 (IL-9) induces cell growth arrest associated with sustained signal transducer and activator of transcription activation in lymphoma cells overexpressing the IL-9 receptor", Cell Growth Differ. 12, 169–174.
  • Demoulin, J.B. Louahed, J., Dumoutier, L., Stevens, M. and Renauld, J.C. (2003) "MAP kinase activation by interleukin-9 in lymphoid and mast cell lines", Oncogene 22, 1763–1770.
  • Donahue, R.E. Yang, Y.C. and Clark, S.C. (1990) "Human P40 T-cell growth factor (interleukin-9) supports erythroid colony formation", Blood 75, 2271–2275.
  • Fischer, M., Bijman, M., Molin, D., Cormont, F., Uyttenhove, C., Van Snick, J., Sundstrom, C., Enblad, G. and Nilsson, G. (2003) "Increased serum levels of interleukin-9 correlate to negative prognostic factors in Hodgkin's lymphoma", Leukemia 17, 2513–2516.
  • Flubacher, M.M. Bear, S.E. and Tsichlis, P.N. (1994) "Replacement of interleukin-2 (IL-2)-generated mitogenic signals by a mink cell focus-forming (MCF) or xenotropic virus-induced IL-9-dependent autocrine loop: implications for MCF virus-induced leukemo-genesis", J. Virol. 68, 7709–7716.
  • Godfraind, C., Louahed, J., Faulkner, H., Vink, A., Warnier, G., Grencis, R. and Renauld, J.C. (1998) "Intraepithelial infiltration by mast cells with both connective tissue-type and mucosal-type characteristics in gut, trachea, and kidneys of IL-9 transgenic mice", J. Immunol. 160, 3989–3996.
  • Gruss, H.J. Brach, M.A. Drexler, H.G. Bross, K.J. and Herrmann, F. (1992) "Interleukin 9 is expressed by primary and cultured Hodgkin and Reed-Sternberg cells", Cancer Res. 52, 1026–1031.
  • Herzenberg, L.A. Stall, A.M. Lalor, P.A. Sidman, C., Moore, W.A. and Parks, D.R. (1986) "The Ly-1 B cell lineage", Immunol. Rev. 93, 81–102.
  • Holbrook, S.T. Ohls, R.K. Schibler, K.R. Yang, Y.C. and Christensen, R.D. (1991) "Effect of interleukin-9 on clonogenic maturation and cell-cycle status of fetal and adult hematopoietic progenitors", Blood 77, 2129–2134.
  • Houssiau, F.A. Renauld, J.C. Stevens, M., Lehmann, F., Lethe, B., Coulie, P.G. and Van Snick, J. (1993) "Human T cell lines and clones respond to IL-9", J. Immunol. 150, 2634–2640.
  • Hultner, L. and Moeller, J. (1990) "Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline", Exp. Hematol. 18, 873–877.
  • Imbert, V., Reichenbach, P. and Renauld, J.C. (1999) "Duration of STAT5 activation influences the response of interleukin-2 receptor alpha gene to different cytokines", Eur. Cytokine Netw. 10, 71–78.
  • Kapp, U., Yeh, W.C. Patterson, B., Elia, A.J. Kagi, D., Ho, A., Hessel, A., Tipsword, M., Williams, A., Mirtsos, C., Itie, A., Moyle, M. and Mak, T.W. (1999) "Interleukin 13 is secreted by and stimulates the growth of Hodgkin and Reed-Sternberg cells", J. Exp. Med. 189, 1939–1946.
  • Kelleher, K., Bean, K., Clark, S.C. Leung, W.Y. Yang-Feng, T.L. Chen, J.W. Lin, P.F. Luo, W. and Yang, Y.C. (1991) "Human interleukin-9: genomic sequence, chromosomal location, and sequences essential for its expression in human T-cell leukemia virus (HTLV)-I-transformed human T cells", Blood 77, 1436–1441.
  • Knoops, L., Louahed, J. and Renauld, J.-C. (2004) "IL-9-induced expansion of B-1b cells restores numbers but not function of B-1 lymphocytes in xid mice", J. Immunol. 172, 6101–6106.
  • Kubota, S., Siomi, H., Hatanaka, M. and Pomerantz, R.J. (1996) "Cis/trans-activation of the interleukin-9 receptor gene in an HTLV-I-transformed human lymphocytic cell", Oncogene 12, 1441–1447.
  • Lange, K., Uckert, W., Blankenstein, T., Nadrowitz, R., Bittner, C., Renauld, J.C. Van Snick, J., Feller, A.C. and Merz, H. (2003) "Overexpression of NPM-ALK induces different types of malignant lymphomas in IL-9 transgenic mice", Oncogene 22, 517–527.
  • Lejeune, D., Demoulin, J.B. and Renauld, J.C. (2001) "Interleukin 9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin 9 signalling", Biochem. J. 353, 109–116.
  • Lemoli, R.M. Fortuna, A., Tafuri, A., Fogli, M., Amabile, M., Grande, A., Ricciardi, M.R. Petrucci, M.T. Bonsi, L., Bagnara, G., Visani, G., Martinelli, G., Ferrari, S. and Tura, S. (1996) "Interleukin-9 stimulates the proliferation of human myeloid leukemic cells", Blood 87, 3852–3859.
  • Lemoli, R.M. Fortuna, A., Tafuri, A., Grande, A., Amabile, M., Martinelli, G., Ferrari, S. and Tura, S. (1997) "Interleukin-9 in human myeloid leukemia cells", Leuk. Lymphoma 26, 563–573.
  • Louahed, J., Grasso, L., De Smet, C., Van Roost, E., Wildmann, C., Nicolaides, N.C. Levitt, R.C. and Renauld, J.C. (1999) "Interleukin-9-induced expression of M-Ras/R-Ras3 oncogene in T-helper clones", Blood 94, 1701–1710.
  • Lu, L., Leemhuis, T., Srour, E.F. and Yang, Y.C. (1992) "Human interleukin (IL)-9 specifically stimulates proliferation of CD34+ + + DR + CD33-erythroid progenitors in normal human bone marrow in the absence of serum", Exp. Hematol. 20, 418–424.
  • Matsushita, K., Arima, N., Ohtsubo, H., Fujiwara, H., Hidaka, S., Fukumori, J. and Tanaka, H. (1997) "Frequent expression of interleukin-9 mRNA and infrequent involvement of interleukin-9 in proliferation of primary adult T-cell leukemia cells and HTLV-I infected T-cell lines", Leuk. Res. 21, 211–216.
  • Merz, H., Houssiau, F.A. Orscheschek, K., Renauld, J.C. Fliedner, A., Herin, M., Noel, H., Kadin, M., Mueller-Hermelink, H.K. Van Snick, J., et al. (1991) "Interleukin-9 expression in human malignant lymphomas: unique association with Hodgkin's disease and large cell anaplastic lymphoma", Blood 78, 1311–1317.
  • Miyazawa, K., Hendrie, P.C. Kim, Y.J. Mantel, C., Yang, Y.C. Kwon, B.S. and Broxmeyer, H.E. (1992) "Recombinant human interleukin-9 induces protein tyrosine phosphorylation and synergizes with steel factor to stimulate proliferation of the human factor-dependent cell line, M07e", Blood 80, 1685–1692.
  • Palacios, R. and Steinmetz, M. (1985) "IL-3-dependent mouse clones that express B-220 surface antigen, contain Ig genes in germ-line configuration, and generate B lymphocytes in vivo", Cell 41, 727–734.
  • Rebollo, A., Dumoutier, L., Renauld, J.C. Zaballos, A., Ayllon, V. and Martinez, A.C. (2000) "Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors", Mol. Cell. Biol. 20, 3407–3416.
  • Renauld, J.-C. and Van Snick, J. (2003) "Interleukin-9", In: Thompson, A., eds, The Cytokine Handbook, (London), pp 347–358.
  • Renauld, J.C. Druez, C., Kermouni, A., Houssiau, F., Uyttenhove, C., Van Roost, E. and Van Snick, J. (1992) "Expression cloning of the murine and human interleukin 9 receptor cDNAs", Proc. Natl Acad. Sci. USA 89, 5690–5694.
  • Renauld, J.C. van der Lugt, N., Vink, A., van Roon, M., Godfraind, C., Warnier, G., Merz, H., Feller, A., Berns, A. and Van Snick, J. (1994) "Thymic lymphomas in interleukin 9 transgenic mice", Oncogene 9, 1327–1332.
  • Renauld, J.C. Kermouni, A., Vink, A., Louahed, J. and Van Snick, J. (1995a) "Interleukin-9 and its receptor: involvement in mast cell differentiation and T cell oncogenesis", J. Leukoc. Biol. 57, 353–360.
  • Renauld, J.C. Vink, A., Louahed, J. and Van Snick, J. (1995b) "Interleukin-9 is a major anti-apoptotic factor for thymic lympho-mas", Blood 85, 1300–1305.
  • Rich, B.E. Campos-Torres, J., Tepper, R.I. Moreadith, R.W. and Leder, P. (1993) "Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice", J. Exp. Med. 177, 305–316.
  • Richard, M., Louahed, J., Demoulin, J.B. and Renauld, J.C. (1999) "Interleukin-9 regulates NF-kappaB activity through BCL3 gene induction", Blood 93, 4318–4327.
  • Schaafsma, M.R. Falkenburg, J.H. Duinkerken, N., Van Snick, J., Landegent, J.E. Willemze, R. and Fibbe, W.E. (1993) "Interleukin-9 stimulates the proliferation of enriched human erythroid progenitor cells: additive effect with GM-CSF", Ann. Hematol. 66, 45–49.
  • Skinnider, B.F. and Mak, T.W. (2002) "The role of cytokines in classical Hodgkin lymphoma", Blood 99, 4283–4297.
  • Sliva, D., Zhu, Y.X. Tsai, S., Kamine, J. and Yang, Y.C. (1999) "Tip60 interacts with human interleukin-9 receptor alpha-chain", Biochem. Biophys. Res. Commun. 263, 149–155.
  • Sliva, D., Gu, M., Zhu, Y.X. Chen, J., Tsai, S., Du, X. and Yang, Y.C. (2000) "14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor", Biochem. J. 345, 741–747.
  • Sonoda, Y., Maekawa, T., Kuzuyama, Y., Clark, S.C. and Abe, T. (1992) "Human interleukin-9 supports formation of a subpopulation of erythroid bursts that are responsive to interleukin-3", Am. J. Hematol. 41, 84–91.
  • Sthoeger, Z.M. Wakai, M., Tse, D.B. Vinciguerra, V.P. Allen, S.L. Budman, D.R. Lichtman, S.M. Schulman, P., Weiselberg, L.R. and Chiorazzi, N. (1989) "Production of autoantibodies by CD5- expressing B lymphocytes from patients with chronic lymphocytic leukemia", J. Exp. Med. 169, 255–268.
  • Suda, T., Murray, R., Guidos, C. and Zlotnik, A. (1990a) "Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3 + /CD3 - double-negative thymocytes", J. Immunol. 144, 3039–3045.
  • Suda, T., Murray, R., Fischer, M., Yokota, T. and Zlotnik, A. (1990b) "Tumor necrosis factor-alpha and P40 induce day 15 murine fetal thymocyte proliferation in combination with IL-2", J. Immunol. 144, 1783–1787.
  • Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T. and Kishimoto, T. (1992) "Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice", Proc. Natl Acad. Sci. USA 89, 232–235.
  • Sun, X.J. Wang, L.M. Zhang, Y., Yenush, L., Myers, M.G. Jr., Glasheen, E., Lane, W.S. Pierce, J.H. and White, M.F. (1995) "Role of IRS-2 in insulin and cytokine signalling", Nature 377, 173–177.
  • Tanner, J.W. Chen, W., Young, R.L. Longmore, G.D. and Shaw, A.S. (1995) "The conserved box 1 motif of cytokine receptors is required for association with JAK kinases", J. Biol. Chem. 270, 6523–6530.
  • Thomas, R.K. Re, D., Wolf, J. and Diehl, V. (2004) "Part I: Hodgkin's lymphoma-molecular biology of Hodgkin and Reed-Sternberg cells", Lancet Oncol. 5, 11–18.
  • Trumper, L.H. Brady, G., Bagg, A., Gray, D., Loke, S.L. Griesser, H., Wagman, R., Braziel, R., Gascoyne, R.D. Vicini, S., et al. (1993) "Single-cell analysis of Hodgkin and Reed-Sternberg cells: molecular heterogeneity of gene expression and p53 mutations", Blood 81, 3097–3115.
  • Uyttenhove, C., Druez, C., Renauld, J.C. Herin, M., Noel, H. and Van Snick, J. (1991) "Autonomous growth and tumorigenicity induced by P40/interleukin 9 cDNA transfection of a mouse P40-dependent T cell line", J. Exp. Med. 173, 519–522.
  • Uyttenhove, C., Simpson, R.J. and Van Snick, J. (1988) "Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity", Proc. Natl Acad. Sci. USA 85, 6934–6938.
  • Vink, A., Renauld, J.C. Warnier, G. and Van Snick, J. (1993) "Interleukin-9 stimulates in vitro growth of mouse thymic lymphomas", Eur. J. Immunol. 23, 1134–1138.
  • Vink, A., Warnier, G., Brombacher, F. and Renauld, J.C. (1999) "Interleukin 9-induced in vivo expansion of the B-1 lymphocyte population", J. Exp. Med. 189, 1413–1423.
  • Wang, L.M. Myers, M.G. Jr., Sun, X.J. Aaronson, S.A. White, M. and Pierce, J.H. (1993) "IRS-1: essential for insulin- and IL-4-stimulated mitogenesis in hematopoietic cells", Science 261, 1591–1594.
  • Xiao, H., Yin, T., Wang, X.Y. Uchida, T., Chung, J., White, M.F. and Yang, Y.C. (2002) "Specificity of interleukin-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway", J. Biol. Chem. 277, 8091–8098.
  • Xiao, H., Chung, J., Kao, H.Y. and Yang, Y.C. (2003) "Tip60 is a co-repressor for STAT3", J. Biol. Chem. 278, 11197–11204.
  • Yang, Y.C. Ricciardi, S., Ciarletta, A., Calvetti, J., Kelleher, K. and Clark, S.C. (1989) "Expression cloning of cDNA encoding a novel human hematopoietic growth factor: human homologue of murine T-cell growth factor P40", Blood 74, 1880–1884.
  • Yen, C.H. Yang, Y.C. Ruscetti, S.K. Kirken, R.A. Dai, R.M. and Li, C.C. (2000) "Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin", J. Immunol. 165, 6372–6380.
  • Yin, T., Keller, S.R. Quelle, F.W. Witthuhn, B.A. Tsang, M.L. Lienhard, G.E. Ihle, J.N. and Yang, Y.C. (1995) "Interleukin-9 induces tyrosine phosphorylation of insulin receptor substrate-1 via JAK tyrosine kinases", J. Biol. Chem. 270, 20497–20502.
  • Zhu, Y.X. Sun, H.B. Tsang, M.L. McMahel, J., Grigsby, S., Yin, T. and Yang, Y.C. (1997) "Critical cytoplasmic domains of human interleukin-9 receptor alpha chain in interleukin-9-mediated cell proliferation and signal transduction", J. Biol. Chem. 272, 21334–21340.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.