The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling

References

• Adachi T, Pazdrak K, Stafford S, Alam R. The mapping of the Lyn kinase binding site of the common beta subunit of IL-3/granulocyte-macrophage colonystimulating factor/IL-5 receptor. J Immunol 1999; 162: 1496–1501
   PubMedGoogle Scholar
• Agosti V, Corbacioglu S, Ehlers I, Waskow C, Sommer G, Berrozpe G, Kissel H, Tucker CM, Manova K, Moore MA, Rodewald HR, Besmer P. Critical role for kit-mediated Src kinase but not PI 3-kinase signaling in pro T and pro B cell development. J Exp Med 2004; 199: 867–878
   PubMedGoogle Scholar
• Alonso G, Koegl M, Mazurenko N, Courtneidge SA. Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors. J Biol Chem 1995; 270: 9840–9848
   PubMed Web of Science ®Google Scholar
• Anderson SM, Jorgensen B. Activation of src-related tyrosine kinases by IL-3. J Immunol 1995; 155: 1660–1670
   PubMed Web of Science ®Google Scholar
• Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O. CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. J Biol Chem 2001; 276: 33282–33290
   PubMedGoogle Scholar
• Asai K, Kitaura J, Kawakami Y, Yamagata N, Tsai M, Carbone DP, Liu FT, Galli SJ, Kawakami T. Regulation of mast cell survival by IgE. Immunity 2001; 14: 791–800
   PubMedGoogle Scholar
• Baran CP, Tridandapani S, Helgason CD, Humphries RK, Krystal G, Marsh CB. The inositol 5′-phosphatase SHIP-1 and the Src kinase Lyn negatively regulate macrophage colony-stimulating factor-induced Akt activity. J Biol Chem 2003; 278: 38628–38636
   PubMed Web of Science ®Google Scholar
• Beavitt S-JE, Harder KW, Kemp JM, Jones J, Quilici C, Casagranda F, Lam E, Turner D, Brennan S, Sly PD, Tarlinton DM, Anderson GP, Hibbs ML. Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol 2005; 175: 1867–1875
   Google Scholar
• Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001; 411: 355–365
   PubMed Web of Science ®Google Scholar
• Brown MT, Cooper JA. Regulation, substrates and functions of src. Biochim Biophys Acta 1996; 1287: 121–149
   PubMed Web of Science ®Google Scholar
• Brunati AM, Bordin L, Clari G, James P, Quadroni M, Baritono E, Pinna LA, Donella-Deana A. Sequential phosphorylation of protein band 3 by Syk and Lyn tyrosine kinases in intact human erythrocytes: Identification of primary and secondary phosphorylation sites. Blood 2000; 96: 1550–1557
   PubMed Web of Science ®Google Scholar
• Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B. p62(dok): A constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997; 88: 197–204
   PubMed Web of Science ®Google Scholar
• Chan VWF, Lowell CA, DeFranco AL. Defective negative regulation of antigen receptor signaling in lyn-deficient B lymphocytes. Curr Biol 1998; 8: 545–553
   PubMed Web of Science ®Google Scholar
• Chan VWF, Meng F, Soriano P, DeFranco AL, Lowell CA. Characterization of the B lymphocyte populations in lyn deficient mice and the role of lyn in signal initiation and down regulation. Immunity 1997; 7: 69–81
   PubMed Web of Science ®Google Scholar
• Chin H, Arai A, Wakao H, Kamiyama R, Miyasaka N, Miura O. Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway. Blood 1998; 91: 3734–3745
   PubMed Web of Science ®Google Scholar
• Corey S, Eguinoa A, Puyana-Theall K, Bolen JR, Cantley L, Mollinedo F, Jackson TR, Hawkins PT, Stephens LR. Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J 1993; 12: 2681–2690
   PubMed Web of Science ®Google Scholar
• Corey SJ, Burkhardt AL, Bolen JB, Geahlen RL, Tkatch LS, Tweardy DJ. Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci USA 1994; 91: 4683–4687
   PubMed Web of Science ®Google Scholar
• Corey SJ, Dombrosky-Ferlan PM, Zuo S, Krohn E, Donnenberg AD, Zorich P, Romero G, Takata M, Kurosaki T. Requirement of Src kinase Lyn for induction of DNA synthesis by granulocyte colony-stimulating factor. J Biol Chem 1998; 273: 3230–3235
   PubMed Web of Science ®Google Scholar
• Cornall RJ, Cyster JG, Hibbs ML, Dunn AR, Otipoby KL, Clark EA, Goodnow CC. Polygenic regulation of complex traits in autoimmunity: Lyn kinase, CD22, and SHP-1 phosphatase are limiting elements of a biochemical pathway that regulates BCR signaling and selection. Immunity 1998; 8: 1–20
   Google Scholar
• Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF. Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor. EMBO J 1993; 12: 943–950
   PubMed Web of Science ®Google Scholar
• Dahl ME, Arai KI, Watanabe S. Association of Lyn tyrosine kinase to the GMCSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis. Genes Cells 2000; 5: 143–153
   PubMed Web of Science ®Google Scholar
• Daigle I, Yousefi S, Colonna M, Green DR, Simon HU. Death receptors bind SHP-1 and block cytokine-induced anti-apoptotic signaling in neutrophils. Nat Med 2002; 8: 61–67
   PubMed Web of Science ®Google Scholar
• Ding Q, Stewart J, Jr., Olman MA, Klobe MR, Gladson CL. The pattern of enhancement of Src kinase activity on platelet-derived growth factor stimulation of glioblastoma cells is affected by the integrin engaged. J Biol Chem 2003; 278: 39882–39891
   PubMed Web of Science ®Google Scholar
• Donato NJ, Wu JY, Stapley J, Gallick G, Lin H, Arlinghaus R, Talpaz M. BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood 2003; 101: 690–698
   PubMed Web of Science ®Google Scholar
• Drexler HG, Quentmeier H. FLT3: Receptor and ligand. Growth Factors 2004; 22: 71–73
   PubMed Web of Science ®Google Scholar
• Fishley B, Alexander WS. Thrombopoietin signalling in physiology and disease. Growth Factors 2004; 22: 151–155
   Web of Science ®Google Scholar
• Gardai S, Whitlock BB, Helgason C, Ambruso D, Fadok V, Bratton D, Henson PM. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. J Biol Chem 2002; 277: 5236–5246
   PubMed Web of Science ®Google Scholar
• Gresham HD, Dale BM, Potter JW, Chang PW, Vines CM, Lowell CA, Lagenaur CF, Willman CL. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member, Fgr. J Exp Med 2000; 191: 515–528
   PubMed Web of Science ®Google Scholar
• Grishin A, Sinha S, Roginskaya V, Boyer MJ, Gomez-Cambronero J, Zuo S, Kurosaki T, Romero G, Corey SJ. Involvement of Shc and Cbl-PI 3-kinase in Lyn-dependent proliferative signaling pathways for G-CSF. Oncogene 2000; 19: 97–105
   PubMedGoogle Scholar
• Harashima A, Suzuki M, Okochi A, Yamamoto M, Matsuo Y, Motoda R, Yoshioka T, Orita K. CD45 tyrosine phosphatase inhibits erythroid differentiation of umbilical cord blood CD34+ cells associated with selective inactivation of Lyn. Blood 2002; 100: 4440–4445
   PubMed Web of Science ®Google Scholar
• Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson GS, Dunn AR, Hibbs ML. Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity 2001; 15: 603–615
   PubMed Web of Science ®Google Scholar
• Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, Turner A, Zlatic K, Tarlinton DM, Hibbs ML. Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1. Blood 2004; 104: 3901–3910
   PubMed Web of Science ®Google Scholar
• Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM. The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol 2004a; 75: 143–151
   PubMedGoogle Scholar
• Hernandez-Hansen V, Smith AJ, Surviladze Z, Chigaev A, Mazel T, Kalesnikoff J, Lowell CA, Krystal G, Sklar LA, Wilson BS, Oliver JM. Dysregulated FcepsilonRI signaling and altered Fyn and SHIP activities in Lyn-deficient mast cells. J Immunol 2004b; 173: 100–112
   PubMed Web of Science ®Google Scholar
• Hibbs ML, Harder KW, Armes J, Kountouri N, Quilici C, Casagranda F, Dunn AR, Tarlinton DM. Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med 2002; 196: 1593–1604
   PubMed Web of Science ®Google Scholar
• Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR. Multiple defects in the immune system of lyn-deficient mice, culminating in autoimmune disease. Cell 1995; 83: 301–311
   PubMed Web of Science ®Google Scholar
• Ho LH, Uehara T, Chen CC, Kubagawa H, Cooper MD. Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B. Proc Natl Acad Sci USA 1999; 96: 15086–15090
   PubMed Web of Science ®Google Scholar
• Hu Y, Liu Y, Pelletier S, Buchdunger E, Warmuth M, Fabbro D, Hallek M, Van Etten RA, Li S. Requirement of Src kinases Lyn, Hck and Fgr for BCR-ABL1- induced B-lymphoblastic leukemia but not chronic myeloid leukemia. Nat Genet 2004; 36: 453–461
   PubMed Web of Science ®Google Scholar
• Ingley E, McCarthy DJ, Pore JR, Sarna MK, Adenan AS, Wright MJ, Erber W, Tilbrook PA, Klinken SP. Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis. Oncogene 2005; 24: 336–343
   PubMed Web of Science ®Google Scholar
• Janas ML, Hodgkin P, Hibbs ML, Tarlinton DM. Genetic evidence for Lyn as a negative regulator of IL-4 signaling. J Immunol 1999; 163: 4192–4198
   Google Scholar
• Kaabeche K, Lemonnier J, Le Mee S, Caverzasio J, Marie PJ. Cbl-mediated degradation of Lyn and Fyn induced by constitutive fibroblast growth factor receptor-2 activation supports osteoblast differentiation. J Biol Chem 2004; 279: 36259–36267
   PubMedGoogle Scholar
• Kalesnikoff J, Huber M, Lam V, Damen JE, Zhang J, Siraganian RP, Krystal G. Monomeric IgE stimulates signaling pathways in mast cells that lead to cytokine production and cell survival. Immunity 2001; 14: 801–811
   PubMed Web of Science ®Google Scholar
• Kalesnikoff J, Sly LM, Hughes MR, Buchse T, Rauh MJ, Cao LP, Lam V, Mui A, Huber M, Krystal G. The role of SHIP in cytokine-induced signaling. Rev Physiol Biochem Pharmacol 2003; 149: 87–103
   PubMed Web of Science ®Google Scholar
• Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD. Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615–675
   PubMed Web of Science ®Google Scholar
• Kawakami Y, Kitaura J, Satterthwaite AB, Kato RM, Asai K, Hartman SE, Maeda- Yamamoto M, Lowell CA, Rawlings DJ, Witte ON, Kawakami T. Redundant and opposing functions of two tyrosine kinases, Btk and Lyn, in mast cell activation. J Immunol 2000; 165: 1210–1219
   PubMed Web of Science ®Google Scholar
• Kelley TW, Graham MM, Doseff AI, Pomerantz RW, Lau SM, Ostrowski MC, Franke TF, Marsh CB. Macrophage colony-stimulating factor promotes cell survival through Akt/protein kinase B. J Biol Chem 1999; 274: 26393–26398
   PubMedGoogle Scholar
• Kohno M, Yamasaki S, Tybulewicz VL, Saito T. Rapid and large amount of autocrine IL-3 production is responsible for mast cell survival by IgE in the absence of antigen. Blood 2005; 105: 2059–2065
   PubMedGoogle Scholar
• Kopf M, Brombacher F, Hodgkin PD, Ramsay AJ, Milbourne EA, Dai WJ, Ovington KS, Behm CA, Kohler G, Young IG, Matthaei KI. IL-5-deficient mice have a developmental defect in CD5+B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 1996; 4: 15–24
   PubMed Web of Science ®Google Scholar
• Lannutti BJ, Drachman JG. Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood 2004; 103: 3736–3743
   PubMed Web of Science ®Google Scholar
• Lannutti BJ, Shim MH, Blake N, Reems JA, Drachman JG. Identification and activation of Src family kinases in primary megakaryocytes. Exp Hematol 2003; 31: 1268–1274
   Google Scholar
• Latour S, Veillette A. Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol 2001; 13: 299–306
   PubMed Web of Science ®Google Scholar
• Lennartsson J, Blume-Jensen P, Hermanson M, Ponten E, Carlberg M, Ronnstrand L. Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/MAP kinase pathway and c-fos induction. Oncogene 1999; 18: 5546–5553
   PubMed Web of Science ®Google Scholar
• Lennartsson J, Jelacic T, Linnekin D, Shivakrupa R. Normal and oncogenic forms of the receptor tyrosine kinase kit. Stem Cells 2005; 23: 16–43
   PubMed Web of Science ®Google Scholar
• Li H-L, Davis WW, Whiteman EL, Birnbaum MJ, Pure E. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. Proc Natl Acad Sci USA 1999; 96: 6890–6895
   Google Scholar
• Li Y, Shen BF, Karanes C, Sensenbrenner L, Chen B. Association between lyn protein tyrosine kinase (P53/56lyn) and the β subunit of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human megakaryocytic leukemia cell line (M-07e). J Immunol 1995; 155: 2165–2174
   PubMed Web of Science ®Google Scholar
• Liang X, Wisniewski D, Strife A, Shivakrupa, Clarkson B, Resh MD. Phosphatidylinositol 3-kinase and Src family kinases are required for phosphorylation and membrane recruitment of Dok-1 in c-Kit signaling. J Biol Chem 2002; 277: 13732–13738
   PubMed Web of Science ®Google Scholar
• Linnekin D, DeBerry CS, Mou S. Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells. J Biol Chem 1997; 272: 27450–27455
   PubMed Web of Science ®Google Scholar
• Lowell CA. Src-family kinases: Rheostats of immune cell signaling. Mol Immunol 2004; 41: 631–643
   PubMedGoogle Scholar
• Maeda A, Scharenberg AM, Tsukada S, Bolen JB, Kinet J-P, Kurosaki T. Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene 1999; 18: 2291–2297
   PubMed Web of Science ®Google Scholar
• Martinez-Moczygemba M, Huston DP. Biology of common beta receptor signaling cytokines: IL-3, IL-5, and GM-CSF. J Allergy Clin Immunol 2003; 112: 653–665
   PubMed Web of Science ®Google Scholar
• Mayer BJ. SH3 domains: Complexity in moderation. J Cell Sci 2001; 114: 1253–1263
   PubMed Web of Science ®Google Scholar
• Moon BG, Takaki S, Nishizumi H, Yamamoto T, Takatsu K. Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene. Cell Immunol 2004; 228: 110–118
   Google Scholar
• Munugalavadla V, Kapur R. Role of c-Kit and erythropoietin receptor in erythropoiesis. Crit Rev Oncol Hematol 2005; 54: 63–75
   PubMed Web of Science ®Google Scholar
• Niki M, Di Cristofano A, Zhao M, Honda H, Hirai H, Van Aelst L, Cordon-Cardo C, Pandolfi PP. Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med 2004; 200: 1689–1695
   PubMedGoogle Scholar
• Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T. A double-edged kinase Lyn: A positive and negative regulator for antigen receptor-mediated signals. J Exp Med 1998; 187: 1343–1348
   PubMed Web of Science ®Google Scholar
• Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, IIic D, Mori S, Watanabe T, Yamamoto T. Impaired proliferation of peripheral B cells and indication of autoimmune disease in Lyn-deficient mice. Immunity 1995; 3: 549–560
   PubMed Web of Science ®Google Scholar
• Nishizumi H, Yamamoto T. Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol 1997; 158: 2350–2355
   PubMedGoogle Scholar
• O'Laughlin-Bunner B, Radosevic N, Taylor ML, Shivakrupa, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D. Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood 2001; 98: 343–350
   PubMed Web of Science ®Google Scholar
• Odom S, Gomez G, Kovarova M, Furumoto Y, Ryan JJ, Wright HV, Gonzalez- Espinosa C, Hibbs ML, Harder KW, Rivera J. Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J Exp Med 2004; 199: 1491–1502
   PubMed Web of Science ®Google Scholar
• Okkenhaug K, Vanhaesebroeck B. PI3K in lymphocyte development, differentiation and activation. Nat Rev Immunol 2003; 3: 317–330
   PubMed Web of Science ®Google Scholar
• Parravicini V, Gadina M, Kovarova M, Odom S, Gonzalez-Espinosa C, Furumoto Y, Saitoh S, Samelson LE, O'Shea JJ, Rivera J. Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation. Nat Immunol 2002; 3: 741–748
   PubMed Web of Science ®Google Scholar
• Pawson T. Specificity in signal transduction: From phosphotyrosine-SH2 domain interactions to complex cellular systems. Cell 2004; 116: 191–203
   PubMed Web of Science ®Google Scholar
• Pazdrak K, Olszewska-Padzrak B, Stafford S, Garofalo RP, Alam R. Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation. J Exp Med 1998; 188: 421–429
   PubMed Web of Science ®Google Scholar
• Pazdrak K, Schreiber D, Forsythe P, Justement L, Alam R. The intracellular signal transduction mechanism of interleukin 5 in eosinophils: The involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway. J Exp Med 1995; 181: 1827–1834
   PubMed Web of Science ®Google Scholar
• Pendaries C, Tronchere H, Plantavid M, Payrastre B. Phosphoinositide signaling disorders in human diseases. FEBS Lett 2003; 546: 25–31
   PubMed Web of Science ®Google Scholar
• Pereira S, Zhang H, Takai T, Lowell CA. The inhibitory receptor PIR-B negatively regulates neutrophil and macrophage integrin signaling. J Immunol 2004; 173: 5757–5765
   PubMed Web of Science ®Google Scholar
• Pixley FJ, Stanley ER. CSF-1 regulation of the wandering macrophage: Complexity in action. Trends Cell Biol 2004; 14: 628–638
   PubMed Web of Science ®Google Scholar
• Ptasznik A, Nakata Y, Kalota A, Emerson SG, Gewirtz AM. Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells. Nat Med 2004; 10: 1187–1189
   PubMed Web of Science ®Google Scholar
• Ravetch JV, Lanier LL. Immune inhibitory receptors. Science 2000; 290: 84–89, [In Process Citation]
   PubMed Web of Science ®Google Scholar
• Resh MD. Myristylation and palmitylation of src family members: The fats of the matter. Cell 1994; 76: 411–413
   PubMed Web of Science ®Google Scholar
• Richmond TD, Chohan M, Barber DL. Turning cells red: Signal transduction mediated by erythropoietin. Trends Cell Biol 2005; 15: 146–155
   PubMed Web of Science ®Google Scholar
• Robinson LJ, Xue J, Corey SJ. Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations. Exp Hematol 2005; 33: 469–479
   PubMed Web of Science ®Google Scholar
• Roginskaya V, Zuo S, Caudell E, Nambudiri G, Kraker AJ, Corey SJ. Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth. Leukemia 1999; 13: 855–861
   PubMed Web of Science ®Google Scholar
• Satterthwaite AB, Lowell CA, Khan WN, Sideras P, Alt FW, Witte ON. Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med 1998; 188: 833–844
   PubMed Web of Science ®Google Scholar
• Shivakrupa R, Linnekin D. Lyn contributes to regulation of multiple kit-dependent signaling pathways in murine bone marrow mast cells. Cell Signal 2005; 17: 103–109
   Google Scholar
• Sicheri F, Moarefi I, Kuriyan J. Crystal structure of the Src family kinase Hck. Nature 1997; 385: 602–609
   PubMed Web of Science ®Google Scholar
• Smith KGC, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT. Inhibition of the B cell by CD22: A requirement for Lyn. J Exp Med 1998; 187: 807–811
   PubMed Web of Science ®Google Scholar
• Stafford S, Lowell C, Sur S, Alam R. Lyn tyrosine kinase is important for IL-5-stimulated eosinophil differentiation. J Immunol 2002; 168: 1978–1983
   PubMed Web of Science ®Google Scholar
• Tan BL, Hong L, Munugalavadla V, Kapur R. Functional and biochemical consequences of abrogating the activation of multiple diverse early signaling pathways in kit. Role for Src kinase pathway in kit-induced cooperation with erythropoietin receptor. J Biol Chem 2003; 278: 11686–11695
   PubMedGoogle Scholar
• Tilbrook PA, Ingley E, Williams JH, Hibbs ML, Klinken SP. Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J 1997; 16: 1610–1619
   PubMed Web of Science ®Google Scholar
• Tilbrook PA, Palmer GA, Bittorf T, McCarthy DJ, Wright MJ, Sarna MK, Linnekin D, Cull VS, Williams JH, Ingley E, Schneider-Mergener J, Krystal G, Klinken SP. Maturation of erythroid cells and erythroleukemia development are affected by the kinase activity of Lyn. Cancer Res 2001; 61: 2453–2458
   PubMed Web of Science ®Google Scholar
• Timokhina I, Kissel H, Stella G, Besmer P. Kit signaling through PI 3-kinase and Src kinase pathways: An essential role for Rac1 and JNK activation in mast cell proliferation. EMBO J 1998; 17: 6250–6262
   PubMed Web of Science ®Google Scholar
• Torigoe T, O'Connor R, Santoli D, Reed JC. Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines. Blood 1992; 80: 617–624
   PubMed Web of Science ®Google Scholar
• Ueda S, Mizuki M, Ikeda H, Tsujimura T, Matsumura I, Nakano K, Daino H, Honda ZZ, Sonoyama J, Shibayama H, Sugahara H, Machii T, Kanakura Y. Critical roles of c-Kit tyrosine residues 567 and 719 in stem cell factor-induced chemotaxis: Contribution of src family kinase and PI3-kinase on calcium mobilization and cell migration. Blood 2002; 99: 3342–3349
   PubMedGoogle Scholar
• Uehara T, Blery M, Kang DW, Chen CC, Ho LH, Gartland GL, Liu FT, Vivier E, Cooper MD, Kubagawa H. Inhibition of IgE-mediated mast cell activation by the paired Ig-like receptor PIR-B. J Clin Invest 2001; 108: 1041–1050
   Google Scholar
• Ujike A, Takeda K, Nakamura A, Ebihara S, Akiyama K, Takai T. Impaired dendritic cell maturation and increased T(H)2 responses in PIR- B( − / − ) mice. Nat Immunol 2002; 3: 542–548
   Google Scholar
• van de Geijn GJ, Aarts LH, Erkeland SJ, Prasher JM, Touw IP. Granulocyte colony-stimulating factor and its receptor in normal hematopoietic cell development and myeloid disease. Rev Physiol Biochem Pharmacol 2003; 149: 53–71
   PubMed Web of Science ®Google Scholar
• van Dijk TB, van den Akker E, Parren-van Amelsvoort M, Mano H, Lowenberg B, von Lindern M. Stem cell factor induces phosphatidylinositol-kinase-dependent Lyn/Tec/Dok-1 complex formation in hematopoietic cells. Blood 2000; 96: 3406–3413
   PubMedGoogle Scholar
• Veillette A, Latour S, Davidson D. Negative regulation of immunoreceptor signaling. Annu Rev Immunol 2002; 20: 669–707
   PubMed Web of Science ®Google Scholar
• Vines CM, Potter JW, Xu Y, Geahlen RL, Costello PS, Tybulewicz VL, Lowell CA, Chang PW, Gresham HD, Willman CL. Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity 2001; 15: 507–519
   PubMed Web of Science ®Google Scholar
• Wang J, Koizumi T, Watanabe T. Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med 1996; 184: 831–838
   PubMed Web of Science ®Google Scholar
• Wei S, Liu JH, Epling-Burnette PK, Gamero AM, Ussery D, Pearson EW, Elkabani ME, Diaz JI, Djeu JY. Critical role of Lyn kinase in inhibition of neutrophil apoptosis by granulocyte-macrophage colony-stimulating factor. J Immunol 1996; 157: 5155–5162
   PubMed Web of Science ®Google Scholar
• Wheadon H, Paling NR, Welham MJ. Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cell Signal 2002; 14: 219–229
   Google Scholar
• Williams JC, Wierenga RK, Saraste M. Insights into Src kinase functions: Structural comparisons. Trends Biochem Sci 1998; 23: 179–184
   PubMed Web of Science ®Google Scholar
• Wilson MB, Schreiner SJ, Choi HJ, Kamens J, Smithgall TE. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene 2002; 21: 8075–8088
   PubMed Web of Science ®Google Scholar
• Witthuhn BA, Quelle FW, Silvennoinen O, Yi T, Tang B, Miura O, Ihle JN. JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell 1993; 74: 227–236
   PubMed Web of Science ®Google Scholar
• Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J, Grandis JR. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. J Biol Chem 2003; 278: 31574–31583
   PubMed Web of Science ®Google Scholar
• Xu W, Harrison SC, Eck MJ. Three-dimensional structure of the tyrosine kinase c-Src. Nature 1997; 385: 595–602
   PubMed Web of Science ®Google Scholar
• Xu Y, Beavitt SJ, Harder KW, Hibbs ML, Tarlinton DM. The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. J Immunol 2002; 169: 6910–6918
   PubMedGoogle Scholar
• Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM. Lyn tyrosine kinase; accentuating the positive and the negative. Immunity 2005; 22: 9–18
   PubMed Web of Science ®Google Scholar
• Yamanashi Y, Fukushige S-I, Semba K, Sukegawa J, Miyajima N, Matsubara K-I, Yamamoto T, Toyoshima K. The yes-related cellular gene encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol 1987; 7: 237–243
   PubMedGoogle Scholar
• Yasuda T, Shirakata M, Iwama A, Ishii A, Ebihara Y, Osawa M, Honda K, Shinohara H, Sudo K, Tsuji K, Nakauchi H, Iwakura Y, Hirai H, Oda H, Yamamoto T, Yamanashi Y. Role of Dok-1 and Dok-2 in myeloid homeostasis and suppression of leukemia. J Exp Med 2004; 200: 1681–1687
   PubMed Web of Science ®Google Scholar
• Yasue T, Nishizumi H, Aizawa S, Yamamoto T, Miyake K, Mizoguchi C, Uehara S, Kikuchi Y, Takatsu K. A critical role of lyn and fyn for B cell responses to CD38 ligation and interleukin 5. Proc Natl Acad Sci USA 1997; 94: 10307–10312
   PubMed Web of Science ®Google Scholar
• Yousefi S, Hoessli DC, Blaser K, Mills GB, Simon HU. Requirement of Lyn and Src tyrosine kinases for the the prevention of apoptosis by cytokines in human eosinophils. J Exp Med 1996; 183: 1407–1414
   PubMed Web of Science ®Google Scholar
• Yu CC, Mamchak AA, DeFranco AL. Signaling mutations and autoimmunity. Curr Dir Autoimmun 2003; 6: 61–88
   PubMedGoogle Scholar
• Zhang H, Meng F, Chu CL, Takai T, Lowell CA. The Src family kinases Hck and Fgr negatively regulate neutrophil and dendritic cell chemokine signaling via PIR-B. Immunity 2005; 22: 235–246
   Google Scholar
• Zhang J, Somani AK, Siminovitch KA. Roles of SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Semin Immunol 2000; 12: 361–378
   PubMedGoogle Scholar
• Zhu QS, Robinson LJ, Roginskaya V, Corey SJ. G-CSF-induced tyrosine phosphorylation of Gab2 is Lyn kinase dependent and associated with enhanced Akt and differentiative, not proliferative, responses. Blood 2004; 103: 3305–3312
   PubMedGoogle Scholar
• Zocchi MR, Pellegatta F, Pierri I, Gobbi M, Poggi A. Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor-dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur J Immunol 2001; 31: 3667–3675
   Google Scholar