Effects induced by BMPS in cultures of human articular chondrocytes: Comparative studies

References

• Blanco FJ, Geng Y, Lotz M. Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol 1995; 154(8)4018–4026
   Google Scholar
• Bobacz K, Gruber R, Soleiman A, Erlacher L, Smolen JS, Graninger WB. Expression of Bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro. Arthritis Rheum 2003; 48(9)2501–2508
   Google Scholar
• Chandrasekhar S, Esterman MA, Hoffman HA. Microdetermination of proteoglycans and glycosaminoglycans in the presence of guanidine hydrochloride. Anal Biochem 1987; 161(1)103–108
   PubMed Web of Science ®Google Scholar
• Chubinskaya S, Frank BS, Michalska M, Kumar B, Merrihew CA, Thonar EJ-MA, Lenz ME, Otten L, Rueger DC, Block JA. Osteoarthritic protein-1 in synovial fluid from patients with rheumatoid arthritis or osteoarthritis: Relationship to disease and levels of hyaluronan and antigenic keratan sulfate. Arthritis Res Ther 2006; 8(3)R73
   Google Scholar
• Chubinskaya S, Hurtig M, Rueger DC. OP-1/BMP-7 in cartilage repair. Int Orthop 2007; 31(6)773–781
   PubMed Web of Science ®Google Scholar
• Chubinskaya S, Kumar B, Merrihew C, Heretis K, Rueger D, Kuettner KE. Age-related changes in cartilage endogenous BMP-7. Biochimica Biophysica Acta 2002; 1588(2)126–134, Molecular Basis of Disease
   Google Scholar
• Del Carlo M, Jr, Loeser RF. Nitric oxide-mediated chondrocyte cell death requires the generation of additional reactive oxygen species. Arthritis Rheum 2002; 46: 394–403
   PubMed Web of Science ®Google Scholar
• Dingle JT, Horner A, Shield M. The sensitivity of synthesis of human cartilage matrix to inhibition by IL-1 suggests a mechanism for the development of osteoarthritis. Cell Biochem Funct 1991; 9(2)99–102
   Google Scholar
• Elshaier AM, Hakimiyan A, Margulis A, Rueger DC, Chubinskaya S. Effect of IL-1β on OP-1 signaling in human adult articular chondrocytes. Trans 51st ORS 2005; 30: 4
   Google Scholar
• Flechtenmacher J, Huch K, Thonar EJ-MA, Mollenhauer JA, Davies SR, Schmid TM, Puhl W, Sampath TK, Aydelotte MB, Kuettner KE. Recombinant human osteogenic protein 1 is a potent stimulator of the synthesis of cartilage proteoglycans and collagens by human articular chondrocytes. Arthritis Rheum 1996; 39: 1896–1904
   PubMed Web of Science ®Google Scholar
• Glansbeek HL, van Beuningen HM, Vitters EL, Morris EA, van der Kraan PM, van den Berg WB. Bone morphogenetic protein-2 stimulates articular cartilage proteoglycan synthesis in vivo but does not counteract interleukin-1 alpha effects on proteoglycan synthesis and content. Arthritis Rheum 1997; 40(6)1020–1028
   Google Scholar
• Goumans MJ, Mummery C. Functional analysis of the TGFβ receptor/Smad pathway through gene ablation in mice. Int J Dev Biol 2000; 44: 253–265
   PubMed Web of Science ®Google Scholar
• Gründer T, Gaissmaier C, Fritz J, Stoop R, Hortschansky P, Mollenhauer J, Aicher WK. Bone morphogenetic protein (BMP-2) enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads. Osteoarthritis Cartilage 2004; 12: 559–567
   PubMed Web of Science ®Google Scholar
• Hogan BLM. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes Dev 1996; 10: 1580–1594
   PubMed Web of Science ®Google Scholar
• Huch K, Wilbrink B, Flechtenmacher J, Koepp HE, Aydelotte MB, Sampath TK, Kuettner KE, Mollenhauer JA, Thonar EJ-MA. Effects of recombinant human osteogenic protein 1 on the production of proteoglycan, prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1β. Arthritis Rheum 1997; 40: 2157–2161
   PubMed Web of Science ®Google Scholar
• Im HJ, Pacione C, Chubinskaya S, Van Wijnen AJ, Sun Y, Loeser RF. Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. J Biol Chem 2003; 278: 25386–25394
   Google Scholar
• Itoh S, Itoh F, Gourmans M-J, ten Dijke P. Signaling of transforming growth factor-β family members through Smad proteins. Eur J Biochem 2000; 267: 6954–6967
   PubMedGoogle Scholar
• Kim YJ, Sah RL, Doong JY, Grodzinsky AJ. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988; 174(1)168–176
   PubMed Web of Science ®Google Scholar
• Koepp HE, Sampath KT, Kuettner KE, Homandberg GA. Osteogenic protein-1 (BMP-7) blocks cartilage damage caused by fibronectin fragments and promotes repair by enhancing proteoglycan synthesis. Inflamm Res 1999; 47: 1–6
   Google Scholar
• Loeser RF, Pacione CA, Chubinskaya S. The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human chondrocytes. Arthritis Rheum 2003; 48(8)2188–2196
   PubMedGoogle Scholar
• Lotz M, Blanco FJ, von Kempis J, Dudler J, Maier R, Villiger PM, Geng Y. Cytokine regulation of chondrocyte functions. J Rheumatol Suppl 1995; 43: 104–108
   PubMedGoogle Scholar
• Luyten FP, Chen P, Paralkar V, Reddi AH. Recombinant bone morphogenetic protein-4, transforming growth factor-b, and activin A enhance the cartilage phenotype of articular chondrocytes in vitro. Exp Cell Res 1994; 210: 224–229
   PubMed Web of Science ®Google Scholar
• Luyten FP, Yu YM, Yanagishita M, Vukicevic S, Hammonds RG, Reddi AH. Natural bovine osteogenin and recombinant human bone morphogenetic protein-2B are equipotent in the maintenance of proteoglycans in bovine articular cartilage explant culture. J Biol Chem 1992; 267: 3691–3695
   PubMed Web of Science ®Google Scholar
• Massagué J, Chen YG. Controlling TGF-β signaling. Genes Dev 2000; 14: 627–644
   PubMed Web of Science ®Google Scholar
• Masuda K, Shirota H, Thonar EJ. Quantification of 35S-labeled proteoglycans complexed to alcian blue by rapid filtration in multiwell plates. Anal Biochem 1994; 217(2)167–175
   Google Scholar
• Merrihew C, Kumar B, Heretis K, Rueger DC, Kuettner KE, Chubinskaya S. Alterations in endogenous osteogenic protein-1 (BMP-7) with degeneration of human articular cartilage. J Ortho Res 2003a; 21(5)899–907
   PubMed Web of Science ®Google Scholar
• Merrihew C, Soeder S, Rueger DC, Kuettner KE, Chubinskaya S. Differential response of endogenous osteogenic protein-1 to interleukin-1β. J Bone Joint Surg Am 2003b; 85-A(Suppl 3)67–74
   Google Scholar
• Morris E. Differential effects of TGF-beta superfamily members on articular cartilage metabolism: Stimulation by rhBMP-9 and rhBMP-2 and inhibition by TGF-beta. Trans Ortho Res Soc 1996; 42: 175
   Google Scholar
• Nishida Y, Knudson CB, Knudson W. Osteogenic protein-1 inhibits matrix depletion in a hyaluronan hexasaccharide-induced model of osteoarthritis. Osteoarthritis Cart 2004; 12: 374–382
   PubMed Web of Science ®Google Scholar
• Petit B, Masuda K, D'Souza AL, Otten L, Pietryla D, Hartmann DJ, Morris NP, Uebelhart D, Schmid TM, Thonar EJ. Characterization of crosslinked collagens synthesized by mature articular chondrocytes cultured in alginate beads: Comparison of two distinct matrix compartments. Exp Cell Res 1996; 225(1)151–161
   Google Scholar
• Reddi AH. Cartilage morphogenetic proteins: Role in joint development, homeostasis, and regeneration. Ann Rheum Dis 2003; 62: 73–78
   Google Scholar
• Roberts AB, Sporn MB. The transforming growth factor-βs. Peptide growth factors and their receptors part I, MB Sporn, AB Roberts. Springer-Verlag, Berlin 1990; 95: 419–472
   Google Scholar
• Sailor LZ, Hewick RM, Morris EA. Recombinant human bone morphogenetic protein-2 maintains the articular chondrocyte phenotype in long-term culture. J Ortho Res 1996; 14: 937–945
   PubMed Web of Science ®Google Scholar
• Sampath TK, Reddi AH. Dissociative extraction and reconstitution of extracellular matrix components involved in local bone differentiation. Proc Natl Acad Sci USA 1981; 78: 7599–7603
   PubMed Web of Science ®Google Scholar
• Schier AF, Shen MM. Nodal signaling in vertebrate development. Nature 2000; 403: 385–389
   PubMed Web of Science ®Google Scholar
• Soeder S, Hakimiyan A, Rueger D, Kuettner KE, Aigner T, Chubinskaya S. Antisense inhibition of osteogenic protein-1 disturbs human articular cartilage integrity. Arthritis Rheum 2005; 52(2)468–478
   Google Scholar
• Stewart MC, Saunders KM, Burton-Wurster N, Macleod JN. Phenotypic stability of articular chondrocytes in vitro: The effect of culture models, bone morphogenetic protein 2, and serum supplementation. J Bone Miner Res 2000; 15: 166–174
   PubMed Web of Science ®Google Scholar
• Urist MR. Bone morphogenetic protein: The molecularization of skeletal system development. J Bone Miner Res 1997; 12(3)343–346
   Google Scholar
• Urist MR, Mikulski A, Lietze A. Solubilized and insolubilized bone morphogenetic protein. Proc Natl Acad Sci USA 1979; 76: 1828–1832
   PubMed Web of Science ®Google Scholar
• van der Kraan PM, Vitters EL, van Beuningen HM, van de Loo FAJ, van den Berg WB. Role of nitric oxide in the inhibition of BMP-2-mediated stimulation of proteoglycan synthesis in articular cartilage. Osteoarthritis Cartilage 2000; 8: 82–86
   Google Scholar
• van Susante JLC, Buma P, van Beuningen HM, van den Berg WB, Veth RPH. Responsiveness of bovine chondrocytes to growth factors in medium with different serum concentrations. J Ortho Res 2000; 18: 68–77
   PubMed Web of Science ®Google Scholar
• Vukicevic S, Luyten FP, Reddi AH. Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin. Proc Natl Acad Sci USA 1989; 86: 8793–8797
   PubMed Web of Science ®Google Scholar
• Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA. Novel regulators of bone formation: Molecular clones and activities. Science 1988; 242: 1528–1534
   PubMed Web of Science ®Google Scholar
• Yao J, Cole AA, Huch K, Kuettner KE. The effect of BMP-7 on IL-1beta induced gene expressions of matrix metalloproteinases and TIMP in human articular cartilage. Trans ORS 1996; 42: 305
   Google Scholar