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Original

Ethanol-mediated expression of connective tissue growth factor (CCN2) in mouse pancreatic stellate cells

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Pages 91-99 | Received 03 Oct 2008, Accepted 29 Jan 2009, Published online: 11 Jul 2009

References

  • Apte MV, Phillips PA, Fahmy RG, Darby SJ, Rodgers SC, McCaughan GW, Korsten MA, Pirola RC, Naidoo D, Wilson JS. Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cells. Gastroenterology 2000; 118: 780–794
  • Apte MV, Pirola RC, Wilson JS. Molecular mechanisms of alcoholic pancreatitis. Dig Dis 2005; 23: 232–240
  • Apte MV, Pirola RC, Wilson JS. Battle-scarred pancreas: Role of alcohol and pancreatic stellate cells in pancreatic fibrosis. J Gastroenterol Hepatol 2006; 21(Suppl. 3)S97–S101
  • Bachem MG, Schneider E, Gross H, Weidenbach H, Schmid RM, Menke A, Siech M, Beger H, Grunert A, Adler G. Identification, culture, and characterization of pancreatic stellate cells in rats and humans. Gastroenterology 1998; 115: 421–432
  • Ball DK, Moussad EE, Rageh MA, Kemper SA, Brigstock DR. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction 2003; 125: 271–284
  • Braganza JM. The pathogenesis of chronic pancreatitis. QJM 1996; 89: 243–250
  • Casini A, Cunningham M, Rojkind M, Lieber CS. Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism. Hepatology 1991; 13: 758–765
  • Casini A, Ceni E, Salzano R, Milani S, Schuppan D, Surrenti C. Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and -2 in human fat-storing cells. Life Sci 1994; 55: 1311–1316
  • Chen A. Acetaldehyde stimulates the activation of latent transforming growth factor-beta1 and induces expression of the type II receptor of the cytokine in rat cultured hepatic stellate cells. Biochem J 2002; 368: 683–693
  • di Mola FF, Friess H, Martignoni ME, Di Sebastiano P, Zimmermann A, Innocenti P, Graber H, Gold LI, Korc M, Buchler MW. Connective tissue growth factor is a regulator for fibrosis in human chronic pancreatitis. Ann Surg 1999; 230: 63–71
  • di Mola FF, Friess H, Riesle E, Koliopanos A, Buchler P, Zhu Z, Brigstock DR, Korc M, Buchler MW. Connective tissue growth factor is involved in pancreatic repair and tissue remodeling in human and rat acute necrotizing pancreatitis. Ann Surg 2002; 235: 60–67
  • di Mola FF, Di Sebastiano P, Gardini A, Hartel M, Buchler MW, Friess H, Innocenti P. Expression of connective tissue growth factor (CTGF) in pancreatic cancer. Tumori 2003; 89: 58–59
  • Ding Z, Maubach G, Masamune A, Zhuo L. Glial fibrillary acidic protein promoter targets pancreatic stellate cells. Dig Liver Dis 2008, Jul 3. [Epub ahead of print]; doi:10.1016/j.dld.2008.05.001
  • Gao R, Brigstock DR. Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: Integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology 2005; 129: 1019–1030
  • Gao R, Brigstock DR. A novel integrin {alpha}5{beta}1 binding domain in module 4 of connective tissue growth factor (CCN2/CTGF) promotes adhesion and migration of activated pancreatic stellate cells. Gut 2006; 55: 856–862
  • Gao R, Ball DK, Perbal B, Brigstock DR. Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells. J Hepatol 2004; 40: 431–438
  • Hartel M, Di Mola F, Gardini A, Zimmermann A, Di Sebastiano P, Guweidhi A, Innocenti P, Giese T, Giese N, Buchler MW, Friess H. Desmoplastic reaction influences pancreatic cancer growth behavior. World J Surg 2004; 28: 818–825
  • Jaster R. Molecular regulation of pancreatic stellate cell function. Mol Cancer 2004; 3: 26
  • Kunzli BM, Nuhn P, Enjyoji K, Banz Y, Smith RN, Csizmadia E, Schuppan D, Berberat PO, Friess H, Robson SC. Disordered pancreatic inflammatory responses and inhibition of fibrosis in CD39-null mice. Gastroenterology 2008; 134: 292–305
  • Leask A, Chen S, Pala D, Brigstock DR. Regulation of CCN2 mRNA expression and promoter activity in activated hepatic stellate cells. J Cell Commun Signal 2008; 2: 49–56
  • Masamune A, Kikuta K, Satoh M, Satoh A, Shimosegawa T. Alcohol activates activator protein-1 and mitogen-activated protein kinases in rat pancreatic stellate cells. J Pharmacol Exp Ther 2002; 302: 36–42
  • Masamune A, Satoh M, Kikuta K, Suzuki N, Shimosegawa T. Establishment and characterization of a rat pancreatic stellate cell line by spontaneous immortalization. World J Gastroenterol 2003; 9: 2751–2758
  • Masamune A, Satoh M, Kikuta K, Suzuki N, Satoh K, Shimosegawa T. Ellagic acid blocks activation of pancreatic stellate cells. Biochem Pharmacol 2005; 70: 869–878
  • Masamune A, Suzuki N, Kikuta K, Satoh M, Satoh K, Shimosegawa T. Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem 2006; 97: 1080–1093
  • Masamune A, Watanabe T, Kikuta K, Satoh K, Shimosegawa T. NADPH oxidase plays a crucial role in the activation of pancreatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2008; 294: G99–G108
  • McCarroll JA, Phillips PA, Park S, Doherty E, Pirola RC, Wilson JS, Apte MV. Pancreatic stellate cell activation by ethanol and acetaldehyde: Is it mediated by the mitogen-activated protein kinase signaling pathway?. Pancreas 2003; 27: 150–160
  • Mello T, Ceni E, Surrenti C, Galli A. Alcohol induced hepatic fibrosis: Role of acetaldehyde. Mol Aspects Med 2008; 29: 17–21
  • Neuschwander-Tetri BA, Talkad V, Otis Stephen F. Induced thrombospondin expression in the mouse pancreas during pancreatic injury. Int J Biochem Cell Biol 2006; 38: 102–109
  • Omary MB, Lugea A, Lowe AW, Pandol SJ. The pancreatic stellate cell: A star on the rise in pancreatic diseases. J Clin Invest 2007; 117: 50–59
  • Park SK, Kim J, Seomun Y, Choi J, Kim DH, Han IO, Lee EH, Chung SK, Joo CK. Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem Biophys Res Commun 2001; 284: 966–971
  • Phillips PA, McCarroll JA, Park S, Wu MJ, Pirola R, Korsten M, Wilson JS, Apte MV. Rat pancreatic stellate cells secrete matrix metalloproteinases: Implications for extracellular matrix turnover. Gut 2003; 52: 275–282
  • Porubsky S, Schmid H, Bonrouhi M, Kretzler M, Malle E, Nelson PJ, Grone HJ. Influence of native and hypochlorite-modified low-density lipoprotein on gene expression in human proximal tubular epithelium. Am J Pathol 2004; 164: 2175–2187
  • Ruperez M, Lorenzo O, Blanco-Colio LM, Esteban V, Egido J, Ruiz-Ortega M. Connective tissue growth factor is a mediator of angiotensin II-induced fibrosis. Circulation 2003; 108: 1499–1505
  • Shek FW, Benyon RC, Walker FM, McCrudden PR, Pender SL, Williams EJ, Johnson PA, Johnson CD, Bateman AC, Fine DR, Iredale JP. Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol 2002; 160: 1787–1798
  • Shimada I, Matsui K, Brinkmann B, Hohoff C, Hiraga K, Tabuchi Y, Takasaki I, Kato I, Kawaguchi H, Takasawa K, Iida R, Takizawa H, Matsuki T. Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: Normalization by glyceraldehyde 3-phosphate dehydrogenase. Int J Legal Med 2008; 122: 373–383
  • Shi-Wen X, Leask A, Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev 2008; 19: 133–144
  • Shinji T, Ujike K, Ochi K, Kusano N, Kikui T, Matsumura N, Emori Y, Seno T, Koide N. Establishment of a novel collagenase perfusion method to isolate rat pancreatic stellate cells and investigation of their gene expression of TGF-beta1, type I collagen, and CTGF in primary culture or freshly isolated cells. Acta Med Okayama 2002; 56: 211–218
  • Van Beek JP, Kennedy L, Rockel JS, Bernier SM, Leask A. The induction of CCN2 by TGFbeta1 involves Ets-1. Arthritis Res Ther 2006; 8: R36
  • Wenger C, Ellenrieder V, Alber B, Lacher U, Menke A, Hameister H, Wilda M, Iwamura T, Beger HG, Adler G, Gress TM. Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oncogene 1999; 18: 1073–1080
  • Wilson JS, Apte MV. Role of alcohol metabolism in alcoholic pancreatitis. Pancreas 2003; 27: 311–315
  • Xia Z, Kuo KH, Nagareddy PR, Wang F, Guo Z, Guo T, Jiang J, McNeill JH. N-acetylcysteine attenuates PKCbeta(2) overexpression and myocardial hypertrophy in streptozotocin-induced diabetic rats. Cardiovasc Res 2007; 73: 770–782
  • Yoo BM, Yeo M, Oh TY, Choi JH, Kim WW, Kim JH, Cho SW, Kim SJ, Hahm KB. Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling. Pancreas 2005; 30: e71–e79
  • Yumei F, Zhou Y, Zheng S, Chen A. The antifibrogenic effect of ( − )-epigallocatechin gallate results from the induction of de novo synthesis of glutathione in passaged rat hepatic stellate cells. Lab Invest 2006; 86: 697–709

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