In vitro and in vivo evaluation of osteoinductivity and bone fusion ability of an activin a/BMP2 chimera (AB204): a comparison study between AB204 and rhBMP-2

References

• Boden SD, Schimandle JH, Hutton WC. 1995. An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics. Spine 20:412–420.
   PubMed Web of Science ®Google Scholar
• Burastero G, Scarfi S, Ferraris C, Fresia C, Sessarego N, Fruscione F, Monetti F, et al. 2010. The association of human mesenchymal stem cells with BMP-7 improves bone regeneration of critical-size segmental bone defects in athymic rats. Bone 47:117–126.
   PubMed Web of Science ®Google Scholar
• Burkus JK, Gornet MF, Dickman CA, Zdeblick TA. 2002. Anterior lumbar interbody fusion using rhBMP-2 with tapered interbody cages. J Spinal Disord Tech 15:337–349.
   PubMed Web of Science ®Google Scholar
• Burkus JK, Gornet MF, Schuler TC, Kleeman TJ, Zdeblick TA. 2009. Six-year outcomes of anterior lumbar interbody arthrodesis with use of interbody fusion cages and recombinant human bone morphogenetic protein-2. J Bone Joint Surg Am 91:1181–1189.
   PubMed Web of Science ®Google Scholar
• Carragee EJ, Hurwitz EL, Weiner BK. 2011. A critical review of recombinant human bone morphogenetic protein-2 trials in spinal surgery: emerging safety concerns and lessons learned. Spine J 11:471–491.
   PubMed Web of Science ®Google Scholar
• Chen Y, Bhushan A, Vale W. 1997. Smad8 mediates the signaling of the ALK-2 [corrected] receptor serine kinase. Proc Natl Acad Sci USA 94:12938–12943.
   PubMed Web of Science ®Google Scholar
• Cordonnier T, Langonne A, Corre P, Renaud A, Sensebe L, Rosset P, Layrolle P, et al. 2014. Osteoblastic differentiation and potent osteogenicity of three-dimensional hBMSC-BCP particle constructs. J Tissue Eng Regene Med 8:364–376.
   PubMed Web of Science ®Google Scholar
• Crandall DG, Revella J, Patterson J, Huish E, Chang M, Mclemore R. 2013. Transforaminal lumbar interbody fusion with rhBMP-2 in spinal deformity, spondylolisthesis, and degenerative disease–part 1: Large series diagnosis related outcomes and complications with 2- to 9-year follow-up. Spine 38:1128–1136.
   PubMed Web of Science ®Google Scholar
• Derynck R, Feng XH. 1997. TGF-beta receptor signaling. Biochim Biophys Acta 1333:F105–F150.
   PubMed Web of Science ®Google Scholar
• Fu R, Selph S, Mcdonagh M, Peterson K, Tiwari A, Chou R, Helfand M. 2013. Effectiveness and harms of recombinant human bone morphogenetic protein-2 in spine fusion: a systematic review and meta-analysis. Ann Int Med 158:890–902.
   PubMed Web of Science ®Google Scholar
• Gray PC, Greenwald J, Blount AL, Kunitake KS, Donaldson CJ, Choe S, Vale W. 2000. Identification of a binding site on the type II activin receptor for activin and inhibin. J Biol Chem 275:3206–3212.
   PubMed Web of Science ®Google Scholar
• Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL. 1996. MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85:489–500.
   PubMed Web of Science ®Google Scholar
• Hoffmann MF, Jones CB, Sietsema DL. 2016. Recombinant human bone morphogenetic protein-2 in posterolateral spinal fusion: what’s the right dose? Asian Spine J 10:457–464.
   PubMed Web of Science ®Google Scholar
• Kang Y, Kim S, Fahrenholtz M, Khademhosseini A, Yang Y. 2013. Osteogenic and angiogenic potentials of monocultured and co-cultured human-bone-marrow-derived mesenchymal stem cells and human-umbilical-vein endothelial cells on three-dimensional porous beta-tricalcium phosphate scaffold. Acta Biomaterialia 9:4906–4915.
   PubMed Web of Science ®Google Scholar
• Knox JB, Dai JM, 3rd, Orchowski J. 2011. Osteolysis in transforaminal lumbar interbody fusion with bone morphogenetic protein-2. Spine 36:672–676.
   PubMed Web of Science ®Google Scholar
• Kong CB, Lee JH, Baek HR, Lee CK, Chang BS. 2014. Posterolateral lumbar fusion using Escherichia coli-derived rhBMP-2/hydroxyapatite in the mini pig. Spine J 14:2959–2967.
   PubMed Web of Science ®Google Scholar
• Kusumoto K, Bessho K, Fujimura K, Akioka J, Okubo Y, Wang Y, Iizuka T, et al. 2002. Osteoinduction by recombinant human bone morphogenetic protein-2 in muscles of non-human primates. J Int Med Res 30:251–259.
   PubMed Web of Science ®Google Scholar
• Lee JH, Baek HR, Lee KM, Zheng GB, Shin SJ, Jin YZ. 2015. The inhibitory effect of zoledronate on early-stage osteoinduction by recombinant human bone morphogenetic protein 2 in an osteoporosis model. Growth Factors 33:220–228.
   PubMed Web of Science ®Google Scholar
• Lee JH, Choe S, Han S. 2018. The cardiovascular effect of single injection and toxicologic effects of repetitive 2-week intravenous administration of activin A/BMP-2 chimera in Beagle dog. Cardiovasc Toxicol 18:76–83.
   PubMed Web of Science ®Google Scholar
• Lee JH, Chang BS, Jeung UO, Park KW, Kim MS, Lee CK. 2011. The first clinical trial of beta-calcium pyrophosphate as a novel bone graft extender in instrumented posterolateral lumbar fusion. Clin Orthop Surg 3:238–244.
   PubMedGoogle Scholar
• Lee JH, Kim J, Baek HR, Lee KM, Seo JH, Lee HK, Lee AY, et al. 2014. Fabrication of an rhBMP-2 loaded porous beta-TCP microsphere-hyaluronic acid-based powder gel composite and evaluation of implant osseointegration. J Mater Sci Mater Med 25:2141–2151.
   PubMed Web of Science ®Google Scholar
• Massague J, Weis-Garcia F. 1996. Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv 27:41–64.
   PubMedGoogle Scholar
• Mathews S, Gupta PK, Bhonde R, Totey S. 2011. Chitosan enhances mineralization during osteoblast differentiation of human bone marrow-derived mesenchymal stem cells, by upregulating the associated genes. Cell Prolif 44:537–549.
   PubMed Web of Science ®Google Scholar
• Meisel HJ, Schnoring M, Hohaus C, Minkus Y, Beier A, Ganey T, Mansmann U. 2008. Posterior lumbar interbody fusion using rhBMP-2. Eur Spine J 17:1735–1744.
   PubMed Web of Science ®Google Scholar
• Nishimura R, Kato Y, Chen D, Harris SE, Mundy GR, Yoneda T. 1998. Smad5 and DPC4 are key molecules in mediating BMP-2-induced osteoblastic differentiation of the pluripotent mesenchymal precursor cell line C2C12. J Biol Chem 273:1872–1879.
   PubMed Web of Science ®Google Scholar
• Okubo Y, Bessho K, Fujimura K, Konishi Y, Kusumoto K, Ogawa Y, Iizuka T. 2000. Osteoinduction by recombinant human bone morphogenetic protein-2 at intramuscular, intermuscular, subcutaneous and intrafatty sites. Int J Oral Maxillofac Surg 29:62–66.
   PubMed Web of Science ®Google Scholar
• Owens K, Glassman SD, Howard JM, Djurasovic M, Witten JL, Carreon LY. 2011. Perioperative complications with rhBMP-2 in transforaminal lumbar interbody fusion. Eur Spine J 20:612–617.
   PubMed Web of Science ®Google Scholar
• Siddiqui MM, Sta Ana AR, Yeo W, Yue WM. 2016. Bone morphogenic protein is a viable adjunct for fusion in minimally invasive transforaminal lumbar interbody fusion. Asian Spine J 10:1091–1099.
   PubMed Web of Science ®Google Scholar
• Simmonds MC, Brown JV, Heirs MK, Higgins JP, Mannion RJ, Rodgers MA, Stewart LA. 2013. Safety and effectiveness of recombinant human bone morphogenetic protein-2 for spinal fusion: a meta-analysis of individual-participant data. Ann Int Med 158:877–889.
   PubMed Web of Science ®Google Scholar
• Slosar PJ, Josey R, Reynolds J. 2007. Accelerating lumbar fusions by combining rhBMP-2 with allograft bone: a prospective analysis of interbody fusion rates and clinical outcomes. Spine J 7:301–307.
   PubMed Web of Science ®Google Scholar
• Smoljanovic T, Bicanic G, Bojanic I. 2010. Update of comprehensive review of the safety profile of bone morphogenetic protein in spine surgery. Neurosurgery 66:E1030.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Esquivies L, Ahn C, Gray PC, Ye SK, Kwiatkowski W, Choe S. 2014. An activin A/BMP2 chimera, AB204, displays bone-healing properties superior to those of BMP2. J Bone Mineral Res 29:1950–1959.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Lee JH, Na K, Ahn C, Cho J, Ahn HC, Choi J, et al. 2015a. The effects of a single intravenous injection of novel activin A/BMP-2 (AB204) on toxicity and the respiratory and central nervous systems. Drug Chem Toxicol 39:284–289.
   PubMed Web of Science ®Google Scholar
• Yoon BH, Lee JH, Na K, Cho J, Choe S. 2015b. The toxicological evaluation of repetitive 2- and 4-week intravenous injection of Activin A/BMP-2 chimera (AB204) into rats. Regul Toxicol Pharmacol 73:1–8.
   PubMed Web of Science ®Google Scholar
• Zheng GB, Yoon BH, Lee JH. 2017. Comparison of the osteogenesis and fusion rates between activin A/BMP-2 chimera (AB204) and rhBMP-2 in a beagle’s posterolateral lumbar spine model. Spine J: Off J North Am Spine Soc 17:1529–1536.
   PubMed Web of Science ®Google Scholar
• Zimmerman CM, Mathews LS. 1996. Activin receptors: cellular signalling by receptor serine kinases. Biochem Soc Symp 62:25–38.
   PubMedGoogle Scholar