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Research Article

“Smart” Drug Carriers: PEGylated TATp-Modified pH-Sensitive Liposomes

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Pages 197-203 | Received 31 May 2007, Accepted 06 Jun 2007, Published online: 09 Dec 2008

References

  • Kale A. A., Torchilin V. P. Enhanced transfection of tumor cells in vivo using “smart” pH-Sensitive TAT-Modified PEGylated liposomes. J. Drug Target 2007a; 15: 538–545
  • Kale A. A., Torchilin V. P. Design, synthesis, and characterization of pH-sensitive PEG-PE conjugates for stimuli-sensitive pharmaceutical nanocarriers: the effect of substitutes at the hydrazone linkage on the ph stability of PEG-PE conjugates. Bioconjug. Chem. 2007b; 18: 363–70
  • Moghimi S. M., Hunter A. C., Murray J. C. Nanomedicine: current status and future prospects. Faseb. J. 2005; 19: 311–330
  • Sawant R. M., Hurley J. P., Salmaso S., Kale A. A., Tolcheva E., Levchenko T., Torchilin V. P. “Smart” drug delivery systems: double-targeted pH-responsive pharmaceutical nanocarriers. Bioconjug. Chem. 2006; 17: 943–49
  • Torchilin V. P. Multifunctional nanocarriers. Adv. Drug Deliv. Rev. 2006; 58: 1532–1555
  • Torchilin V. P., Levchenko T. S., Rammohan R., Volodina N., Papahadjopoulos-Sternberg B., D'souza G. G. M. Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome-DNA complexes. Proc. Natl. Acad. Sci. USA 2003; 100: 1972–1977
  • Verma D. D., Hartner W. C., Levchenko T. S., Bernstein E. A., Torchilin V. P. ATP-loaded liposomes effectively protect the myocardium in rabbits with an acute experimental myocardial infarction. Pharm. Res. 2005; 22: 2115–2120

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