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Research Article

Targeted delivery of insulin-modified immunoliposomes in vivo

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Pages 116-121 | Received 04 Sep 2008, Accepted 03 Nov 2008, Published online: 01 Jun 2009

References

  • Cheng, W. W., and Allen, T. M. Targeted delivery of anti-CD19 liposomal doxorubicin in B-cell lymphoma: a comparison of whole monoclonal antibody, Fab’ fragments and single chain Fv. J Contr Rel 2008;126:50–58.
  • Datta, S. R., Brunet, A., and Greenberg, M. E. Cellular survival:a play in three Akts. Genes Dev 1999;13:2905–2927.
  • Denley, A., Wallace, J. C., Cosgrove, L. J., and Forbes, B. E.The insulin receptor isoform exon 11- (IR-A) in cancer and other diseases: a review. Horm Metab Res 2003;35:778–785.
  • Douglas, R. S., Gianoukakis, A. G., Kamat, S., and Smith, T. J. Aberrant expression of the insulin-like growth factor-1 receptor by T cells from patients with Graves’ disease may carry functional consequences for disease pathogenesis. J Immunol 2007;178:3281–3287.
  • Elbayoumi, T. A., and Torchilin, V. P. Enhanced cytotoxicity of monoclonal anticancer antibody 2C5-modified doxorubicin-loaded PEGylated liposomes against various tumor cell lines. Eur J Pharm Sci 2007;32:159–168.
  • Frittitta, L., Cerrato, A., Sacco, M. G., Weidner, N., Goldfine, I. D., and Vigneri, R. The insulin receptor content is increased in breast cancers initiated by three different oncogenes in transgenic mice. Breast Cancer Res Treat 1997;45:141–147.
  • Gabizon, A., Horowitz, A. T., Goren, D., Tzemach, D., Mandelbaum-Shavit, F., Qazen, M. M., et al. Targeting folate receptor with folate linked to extremities of poly(ethyleneglycol)-grafted liposomes: in vitro studies. Bioconj Chem 1999;10:289–298.
  • Gabizon, A., Horowitz, A. T., Goren, D., Tzemach, D., Shmeeda, H., and Zalipsky, S. In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing ice. Clin Cancer Res 2003;17:6551–6559.
  • Gherzi, R., Sesti, G., Andraghetti, G., De Pirro, R., Lauro, R., Adezati, L., et al. An extracellular domain of the insulin receptor beta-subunit with regulatory function on protein-tyrosine kinase. J Biol Chem 1989;264:8627–3865.
  • Haluska, P., Carboni, J. M., Loegering, D. A., Lee, F. Y., Wittman, M., Saulnier, M. G., et al. In vitro and in vivo antitumor effects of the dual insulin-like growth factor-I/insulin receptor inhibitor, BMS-554417. Cancer Res 2006;66:362–371.
  • Han, H. D., Lee, A., Song, C. K., Hwang, T., Seong, H., Lee, C. O., et al. In vivo distribution and antitumor activity of heparin-stabilized doxorubicin-loaded liposomes. Int J Pharm 2006;313:181–188.
  • Hatakeyama, H., Akita, H., Ishida, E., Hashimoto, K., Kobayashi, H., Aoki, T., et al. Tumor targeting of doxorubicin by anti-MT1- MMP antibody-modified PEG liposomes. Int J Pharm 2007;342:194–200.
  • Iden, D. L., and Allen, T. M. In vitro and in vivo comparison of immunoliposomes made by conventional coupling techniques with those made by a new post-insertion approach. Biochim Biophys Acta 2001;1513:207–216.
  • Kennel, S. J., Woodward, J. D., Rondinone, A. J., Wall, J., Huang,Y.,and Mirzadeh,S. The fate of MAb-targeted Cd(125m)Te/ZnS nanoparticles in vivo. Nucl Med Biol 2008;35:501–514.
  • Kirpotin, D. B., Drummond, D. C., Shao, Y., Shalaby, M. R., Hong, K., Nielsen, U. B., et al. Antibody targeting of long- circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006;66:6732–6740.
  • Klibanov, A. L., Maruyama, K., Torchilin, V. P., and Hunag, L. Amphipathic polyethy-lenglycols effectively prolong the circulation time of liposomes. FEBS Lett 1990;268:235–237.
  • Kojima, N., Biao, L., Nakayama, T., Ishii, M., Ikehara, Y., and Tsujimura, K. Oligomannose-coated liposomes as a therapeutic antigen-delivery and an adjuvant vehicle for induction of in vivo tumor immunity. J Contr Rel 2008;129:26–32.
  • Liu, W. S., Huang, Y., and Zhang, Z. R. Synthesis and characterization of the tumor targeting mitoxantrone-insulin conjugate. Arch Pharm Res 2003;26:892–897.
  • Lukyanov, A. N., Elbayoumi, T. A., Chakilam, A. R., and Torchilin, V. P. Tumor- targeted liposomes: doxorubicin-loaded long-circulating liposomes modified with anti-cancer antibody. J Contr Rel 2004;100:135–144.
  • Mulligan, C., Rochford, J., Denyer, G., Stephens, R., Yeo, G., Freeman, T., et al. Microarray analysis of insulin and insulin-like growth factor-1 (IGF-1) receptor signaling reveals the selective up-regulation of the mitogen heparin-binding EGF-like growth factor by IGF-1. J Biol Chem 2002;277:42480–42487.
  • Osborne, C. K., Bolan, G., Monaco, M. E., and Lippman, M. E. Hormone responsive human breast cancer in long-term tissue culture: effect of insulin. Proc Natl Acad Sci 1976;73:4536–4540.
  • Palakurthi, S., Wilson, J., McQuarrie, S. A., Suresh, M. R., Mercer, J. R., and Miller, G. G. Target specificity of 188Re-labeled B27.1 monoclonal antibodies to ovarian cancer cells in vivo. In Vivo 2008;22:321–326.
  • Papa, V., and Belfiore, A. Insulin receptors in breast cancer: biological and clinical role. J Endocrinol Invest 1996;19:324–333.
  • Park, J. W., Hong, K., Kirpotin, D. B., Colbern, G., Shalaby, R., Baselga, J., et al. Anti-HER2 immunoliposomes: enhanced efficacy attributable to targeted delivery. Clin Cancer Res 2002;8:1172–1181.
  • Poznasky, M. J., Singh, R., Singh, B., and Fantus, G. Insulin: carrier potential for enzyme and durg therapy. Science 1984;223:1304–1306.
  • Peterson, G.A simplification of the protein assay method of Lowry et al., which is generally more applicable. Anal Biochem 1977;83:346–356.
  • Sachdev, D., Singh, R., Fujita-Yamaguchi, Y., and Yee D. Down-regulation of insulin receptor by antibodies against the type I insulin-like growth factor receptor: implications for anti-insulin-like growth factor therapy in breast cancer. Cancer Res 2006;66:2391–2402.
  • Sapra, P., and Allen, T. M. Internalizing antibodies are necessary for improved therapeutic efficacy of antibody-targeted liposomal drugs. Cancer Res 2002;62:7190–7194.
  • Sun, W., Zou, W., Huang, G., Li, A., and Zhang, N. Pharmacokinetics and targeting property of TFu-loaded liposomes with different sizes after intravenous and oral administration. J Drug Target 2008;16:357–365.
  • Tanaka, S., Sugimachi, K., and Maehara, S. Oncogenic signal transduction and therapeutic strategy for hepatocellular carcinoma. Surgery 2002;131:142–147.
  • Taylor, S. I., and Marcus-Samuels, B. Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells. J Clin Endocrinol Metab 1984;58:182–186.
  • Van Obberghen E., Ksauga, M., Le Cam, A., Hedo, J.A., Itin, A., and Harrison, L. C. Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci 1981;78:1052–1056.
  • Wang,, Y., Hailey, J., Williams, D., Wang, Y., Lipari, P., Malkowski, M. et al. Inhibition of insulin-like growth factor-I receptor (IGF-IR) signaling and tumor cell growth by a fully human neutralizing anti-IGF-IR antibody. Mol Cancer Ther 2005;4:1214–1221.
  • Yokoe, J., Sakuragi, S., Yamamoto, K., Teragaki, T., Ogawara, K., Higaki, K., Katayama, N., et al. Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats. Int J Pharm 2008;353:28–34.
  • Zhao, W., Chen, H., Xu, H., Moore, E., Meiri, N., Quon, M. J., et al. Brain insulin receptors and spatial memory. Correlated changes in gene expression, tyrosine phosphorylation, and signaling molecules in the hippocampus of water maze trained rats. J Biol Chem 1999;274:34893–34902.

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