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Research Articles

PEGylated trimethylchitosan emulsomes conjugated to octreotide for targeted delivery of sorafenib to hepatocellular carcinoma cells of HepG2

ORCID Icon, , &
Pages 383-398 | Received 06 Sep 2018, Accepted 04 Jan 2019, Published online: 14 Mar 2019

References

  • Aliabadi, H.S., Karimimanesh, A., and Varshosaz, J., 2013. Biological effects of letrozole-loaded lipid nanocapsules on MCF-7 cell line. Journal of Isfahan medical school, 30 (217), 2169–2177.
  • Amselem, S., et al., 1994. Emulsomes, a novel drug delivery technology. Proceeding of international symposium of controlled release of bioactive materials, 1368–1369.
  • Blaker, M., et al., 2004. Differential expression of somatostatin receptor subtypes in hepatocellular carcinomas. Journal of hepatology, 41 (1), 112–118.
  • Bruix, J. and Sherman, M., 2005. Management of hepatocellular carcinoma. Hepatology (Baltimore, Md.), 42 (5), 1208–1236.
  • Cheng, A.L., et al., 2009. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. The lancet oncology, 10 (1), 25–34.
  • Epelbaum, J., 1986. Somatostatin in the central nervous system: physiology and pathological modifications. Progress in neurobiology, 27 (1), 63–100.
  • Forner, A., Llovet, J.M., and Bruix, J., 2012. Hepatocellular carcinoma. Lancet (London, England), 379 (9822), 1245–1255.
  • Ganten, T.M., et al., 2017. Sorafenib in patients with hepatocellular carcinoma-results of the observational insight study. Clinical cancer research, 23 (19), 5720–5728.
  • Gill, B., et al., 2012. Emulsomes: an emerging vesicular drug delivery system. Asian journal of pharmaceutics, 6 (2), 87–94.
  • Guhagarkar, S.A., et al., 2010. Polyethylene sebacate–doxorubicin nanoparticles for hepatic targeting. International journal of pharmaceutics, 401 (1–2), 113–122.
  • Gulec, S.A., et al., 2001. Antitumor and antiangiogenic effects of somatostatin receptor-targeted in situ radiation with 111In-DTPA-JIC 2DL. Journal of surgical research, 97 (2), 131–137.
  • Gupta, L., et al., 2017. Dendrimer encapsulated and conjugated delivery of berberine: a novel approach mitigating toxicity and improving in vivo pharmacokinetics. International journal of pharmaceutics, 528 (1–2), 88–99.
  • Hua, Y.P., et al., 2009. Mechanisms and influence of octreotide-induced regulation of somatostatin receptor 2 on hepatocellular carcinoma. Chemotherapy, 55 (5), 312–320.
  • Jemal, A. and Torre, L.A., 2017. The global burden of cancer. In: The American Cancer Society (Editor). The American cancer society's principles of oncology: prevention to survivorship, Wiley-Blackwell Publisher, pp. 33–44.
  • Karami, N., et al., 2018. Liposomes as a novel drug delivery system: fundamental and pharmaceutical application. Asian journal of pharmaceutics, 12 (1), S31–S41.
  • Kim, D.H., et al., 2012. Antitumor activity of sorafenib-incorporated nanoparticles of dextran/poly (dl-lactide-co-glycolide) block copolymer. Nanoscale research letters, 7 (1), 91.
  • Kumar, R. and Seth, N., 2013. Emulsomes: an emerging vesicular drug delivery system. Journal of drug delivery and therapeutics, 3 (6), 133–142.
  • Kuo, Y.C. and Shih, K.H., 2009. Loading efficiency and surface conductance of heparin-modified poly(lactide-co-glycolide) nanoparticles. Colloidal surfaces B: biointerfaces, 71 (2), 282–287.
  • Lin, T.T., et al., 2016. Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis. Journal of controlled release, 221, 62–70.
  • Liu, C., et al., 2016. Improving oral bioavailability of sorafenib by optimizing the “spring and parachute based on molecular interaction mechanisms. Molecular pharmaceutics, 13 (2), 599–608.
  • Llovet, J.M., Burroughs, A., and Bruix, J., 2003. Hepatocellular carcinoma. Lancet (London, England), 362 (9399), 1907–1917.
  • Llovet, J.M., et al., 2008. Sorafenib in advanced hepatocellular carcinoma. The New England journal of medicine, 359 (4), 378–390.
  • Madhusudhan, A., et al., 2014. Efficient pH dependent drug delivery to target cancer cells by gold nanoparticles capped with carboxymethyl chitosan. International journal of molecular sciences, 15 (5), 8216–8234.
  • Maluccio, M. and Covey, A., 2012. Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA: a cancer journal of clinicians, 62 (6), 394–399.
  • Møller, L.N., et al., 2003. Somatostatin receptors. Biochimica et biophysica acta, 1616 (1), 1–84.
  • Mourya, V. and Inamdar, N.N., 2009. Trimethyl chitosan and its applications in drug delivery. Journal of materials science: materials in medicine, 20 (5), 1057–1079.
  • Nair, A., et al., 2013. Emulsomes: a novel liposomal formulation for sustained drug delivery. Interntional research journal of pharmaceutical applied sciences, 3 (5), 192–196.
  • Ranieri, G., et al., 2012. Sorafenib (BAY 43-9006) in hepatocellular carcinoma patients: from discovery to clinical development. Current medicinal chemistry, 19 (7), 938–944.
  • Reisine, T. and Bell, G., 1995. Molecular properties of somatostatin receptors. Neuroscience, 67 (4), 777–790.
  • Reubi, J.C., 2003. Peptide receptors as molecular targets for cancer diagnosis and therapy. Endocrine reviews, 24 (4), 389–427.
  • Rudra, A., et al., 2010. Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats. International journal of nanomedicine, 5, 811.
  • Saraswathy, M., et al., 2015. Multifunctional drug nanocarriers formed by cRGD-conjugated βCD-PAMAM-PEG for targeted cancer therapy. Colloidal surface B: biointerfaces, 126, 590–597.
  • Sieval, A., et al., 1998. Preparation and NMR characterization of highly substitutedN-trimethyl chitosan chloride. Carbohydrate polymer, 36 (2–3), 157–165.
  • Silva, J.O., et al., 2016. pH-sensitive, long-circulating liposomes as an alternative tool to deliver doxorubicin into tumors: a feasibility animal study. Molecular imaging and biology, 18 (6), 898–904.
  • Smith, J., Wood, E., and Dornish, M., 2004. Effect of chitosan on epithelial cell tight junctions. Pharmaceutical research, 21 (1), 43–49.
  • Sonvico, F., et al., 2006. Formation of self-organized nanoparticles by lecithin/chitosan ionic interaction. International journal of pharmaceutics, 324 (1), 67–73.
  • Sun, L.C. and Coy, D.H., 2011. Somatostatin receptor-targeted anti-cancer therapy. Current drug delivery, 8 (1), 2–10.
  • Sung, Y.C., et al., 2018. Combined delivery of sorafenib and a MEK inhibitor using CXCR4-targeted nanoparticles reduces hepatic fibrosis and prevents tumor development. Theranostics, 8 (4), 894–905.
  • Taylor, J.E., et al., 1994. Detection of somatostatin receptor subtype 2 (SSTR2) in established tumors and tumor cell lines: evidence for SSTR2 heterogeneity. Peptides, 15 (7), 1229–1236.
  • Thanou, M., et al., 2000. Intestinal absorption of octreotide: N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo. Journal of pharmaceutical sciences, 89 (7), 951–957.
  • Thanou, M.M., et al., 1999. Effects of N-trimethyl chitosan chloride, a novel absorption enhancer, on Caco-2 intestinal epithelia and the ciliary beat frequency of chicken embryo trachea. International journal of pharmaceutics, 185 (1), 73–82.
  • Ucisik, M.H., Sleytr, U.B., and Schuster, B., 2015. Emulsomes meet S-layer proteins: an emerging targeted drug delivery system. Current pharmaceutical biotechnology, 16 (4), 392–405.
  • Varshosaz, J., et al., 2014. Uptake of etoposide in CT-26 cells of colorectal cancer using folate targeted dextran stearate polymeric micelles. BioMedical research international, 2014, 1.
  • Varshosaz, J., et al., 2017. Synthesis of biotin-targeted chitosan/poly (methyl vinyl ether-alt-maleic acid) copolymeric micelles for delivery of doxorubicin. IET nanobiotechnology, 11 (7), 843–851.
  • Varshosaz, J., Davoudi, A., and Rasoul-Amini, S., 2018. Docetaxel-loaded nanostructured lipid carriers functionalized with trastuzumab (Herceptin) for HER2-positive breast cancer cells. Journal of liposome research, 28 (4), 285–295.
  • Varshosaz, J., et al., 2018. Poly (butylene adipate-co-terephthalate) electrospun nanofibers loaded with 5-fluorouracil and curcumin in treatment of colorectal cancer cells. Polymer testing, 65, 217–230.
  • Vyas, S.P., Rasika, S., and Sanyog, J., 2006. Development and characterization of emulsomes for sustained and targeted delivery of an antiviral agent to liver. The journal of pharmacy and pharmacology, 58 (3), 321–326.
  • Wang, S., et al., 2010. Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting. International journal of pharmaceutics, 386 (1–2), 249–255.
  • Wang, J.J., et al., 2011. Recent advances of chitosan nanoparticles as drug carriers. International journal of nanomedicine, 6, 765.
  • Watson, J., et al., 2001. Growing vascular endothelial cells express somatostatin subtype 2 receptors. British journal of cancer, 85 (2), 266.
  • Watt, H.L., Kharmate, G., and Kumar, U., 2008. Biology of somatostatin in breast cancer. Molecular and cellular endocrinology, 286 (1–2), 251–261.
  • Yao, X., et al., 2017. Graphene quantum dots‐capped magnetic mesoporous silica nanoparticles as a multifunctional platform for controlled drug delivery, magnetic hyperthermia, and photothermal therapy. Small, 13 (2), 1602225.
  • Zhang, Z. and Feng, S.S., 2006. The drug encapsulation efficiency, in vitro drug release, cellular uptake and cytotoxicity of paclitaxel-loaded poly (lactide)–tocopheryl polyethylene glycol succinate nanoparticles. Biomaterials, 27 (21), 4025–4033.
  • Zhang, J., et al., 2010. A novel octreotide modified lipid vesicle improved the anticancer efficacy of doxorubicin in somatostatin receptor 2 positive tumor models. Molecular pharmaceutics, 7 (4), 1159–1168.
  • Zhang, J., et al., 2016. iRGD decorated lipid-polymer hybrid nanoparticles for targeted co-delivery of doxorubicin and sorafenib to enhance anti-hepatocellular carcinoma efficacy. Nanomedicine, nanotechnology and biological medicine, 12 (5), 1303–1311.
  • Zhao, M., et al., 2014. Clickable protein nanocapsules for targeted delivery of recombinant p53 protein. Journal of the American chemical society, 136 (43), 15319–15325.
  • Zhu, M., et al., 2017. Self-targeted salinomycin-loaded DSPE-PEG-methotrexate nanomicelles for targeting both head and neck squamous cell carcinoma cancer cells and cancer stem cells. Nanomedicine (London, England), 12 (4), 295–315.

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