180
Views
1
CrossRef citations to date
0
Altmetric
Articles

QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer

, , , , , , , & ORCID Icon show all
Pages 154-169 | Received 12 Apr 2022, Accepted 23 Jul 2022, Published online: 10 Aug 2022

References

  • Abdel-Mottaleb, M.M.A., Neumann, D., and Lamprecht, A., 2010. In vitro drug release mechanism from lipid nanocapsules (LNC). International journal of pharmaceutics, 390 (2), 208–213.
  • Abed, O.S.A., et al., 2020. Novel oral pegylated polymeric nanoparticle for the delivery of trypsin targeted to the small intestine. International journal of pharmaceutics, 592, 120094.
  • Adiwidjaja, J., Boddy, A.V., and McLachlan, A.J., 2020. Physiologically-based pharmacokinetic predictions of the effect of curcumin on metabolism of imatinib and bosutinib: in vitro and in vivo disconnect. Pharmaceutical research, 37 (7), 128.
  • Akhouri, V., Kumari, M., and Kumar, A., 2020. Therapeutic effect of Aegle Marmelos fruit extract against DMBA induced breast cancer in rats. Scientific reports, 10 (1), 18016.
  • Andrade, D. F. d., et al., 2015. Assessing the in vitro drug release from lipid-core nanocapsules: a new strategy combining dialysis Sac and a continuous-flow system. AAPS PharmSciTech, 16 (6), 1409–1417.
  • Baghbani, F., et al., 2017. Ultrasonic nanotherapy of breast cancer using novel ultrasound-responsive alginate-shelled perfluorohexane nanodroplets: in vitro and in vivo evaluation. Materials science & engineering. C, materials for biological applications, 77, 698–707.
  • Barras, A., et al., 2009. Formulation and characterization of polyphenol-loaded lipid nanocapsules. International journal of pharmaceutics, 379 (2), 270–277.
  • Basu, S.M., et al., 2021. Lipid nanocapsules co-encapsulating paclitaxel and salinomycin for eradicating breast cancer and cancer stem cells. Colloids and surfaces. B, biointerfaces, 204, 111775.
  • Baydoun, S., et al., 2016. Microbial-catalysed derivatization of anti-cancer drug exemestane and cytotoxicity of resulting metabolites against human breast adenocarcinoma cell line (MCF-7) in vitro. Steroids, 115, 67–74.
  • Behdarvand, N., Bikhof Torbati, M., and Shaabanzadeh, M., 2020. Tamoxifen-loaded PLA/DPPE-PEG lipid-polymeric nanocapsules for inhibiting the growth of estrogen-positive human breast cancer cells through cell cycle arrest. Journal of nanoparticle research, 22 (9), 262.
  • Behzadi, S., et al., 2017. Cellular uptake of nanoparticles: journey inside the cell. Chemical society reviews, 46 (14), 4218–4244.
  • Bender, E.A., et al., 2012. Hemocompatibility of poly(ɛ-caprolactone) lipid-core nanocapsules stabilized with polysorbate 80-lecithin and uncoated or coated with chitosan. International journal of pharmaceutics, 426 (1–2), 271–279.
  • Blechinger, J., et al., 2013. Cellular uptake: uptake kinetics and nanotoxicity of silica nanoparticles are cell type dependent (Small 23/2013). Small, 9 (23), 3906–3906.
  • Briot, T., et al., 2019. Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity. International journal of nanomedicine, 14, 2091–2102.
  • Camargo, G.D.A., et al., 2021. Characterization and in vitro and in vivo evaluation of tacrolimus-loaded poly(ε-caprolactone) nanocapsules for the management of atopic dermatitis. Pharmaceutics, 13 (12), 2013–2019.
  • Carvalho, J.P.F., et al., 2021. Spherical cellulose micro and nanoparticles: a review of recent developments and applications. Nanomaterials, 11 (10), 2744.
  • Chouchou, A., et al., 2017. Lipid nanocapsules formulation and cellular activities evaluation of a promising anticancer agent: EAPB0503. International journal of pharmaceutical investigation, 7 (4), 155–163.
  • David-Naim, M.B., et al., 2017. Polymeric nanoparticles of SiRNA prepared by a double-emulsion solvent-diffusion technique: physicochemical properties, toxicity, biodistribution and efficacy in a mammary carcinoma mice model. Biomaterials, 145, 154–167.
  • Dergunov, S.A., et al., 2010. Synthesis, characterization, and long-term stability of hollow polymer nanocapsules with nanometer-thin walls. Macromolecules, 43 (18), 7785–7792.
  • Drozdek, S. and Bazylińska, U., 2016. Biocompatible oil core nanocapsules as potential co-carriers of paclitaxel and fluorescent markers: preparation, characterization, and bioimaging. Colloid and polymer science, 294 (1), 225–237.
  • Eedara, B.B. and Bandari, S., 2017. Lipid-based dispersions of exemestane for improved dissolution rate and intestinal permeability: in vitro and ex vivo characterization. Artificial cells, nanomedicine, and biotechnology, 45 (5), 917–927.
  • Eissa, M.M., et al., 2015. Miltefosine lipid nanocapsules for single dose oral treatment of Schistosomiasis Mansoni: a preclinical study. PLoS one, 10 (11), e0141788.
  • Eisvand, F., et al., 2022. Cardioprotective effects of Alpha-Mangostin on doxorubicin-induced cardiotoxicity in rats. Phytotherapy research, 36 (1), 506–524.
  • Elakkad, Y.E., Mohamed, S.N.S., and Abuelezz, N.Z., 2021. Potentiating the cytotoxic activity of a novel simvastatin-loaded cubosome against breast cancer cells: insights on dual cell death via ferroptosis and apoptosis. Breast cancer: targets and therapy, 13, 675–689.
  • El-Sheridy, N.A., et al., 2021. Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules. Drug delivery, 28 (1), 906–919.
  • Elzoghby, A.O., et al., 2017. Multi-reservoir phospholipid shell encapsulating protamine nanocapsules for co-delivery of letrozole and celecoxib in breast cancer therapy. Pharmaceutical research, 34 (9), 1956–1969.
  • Erdoğar, N., et al., 2021. Development of oral aprepitant-loaded chitosan–polyethylene glycol-coated cyclodextrin nanocapsules: formulation, characterization, and pharmacokinetic evaluation. Journal of pharmaceutical investigation, 51 (3), 297–310.
  • Feeney, O.M., et al., 2016. 50Years of oral lipid-based formulations: provenance, progress and future perspectives. Advanced drug delivery reviews, 101, 167–194.
  • Foglietta, J., et al., 2017. Cardiotoxicity of aromatase jnhibitors in breast cancer patients. Clinical breast cancer, 17 (1), 11–17.
  • Haggag, Y.A., Ibrahim, R.R., and Hafiz, A.A., 2020. Design, formulation and in vivo evaluation of novel Honokiol-loaded PEGylated PLGA nanocapsules for treatment of breast cancer. International journal of nanomedicine, 15, 1625–1642.
  • Hashemzadeh, H., Javadi, H., and Darvishi, M.H., 2020. Study of structural stability and formation mechanisms in DSPC and DPSM liposomes: a coarse-grained molecular dynamics simulation. Scientific reports, 10 (1), 1837.
  • Ibrahim, A.H., et al., 2022. Lyophilized tablets of felodipine-loaded polymeric nanocapsules to enhance aqueous solubility: formulation and optimization. Journal of drug delivery science and technology, 70, 103172.
  • Idlas, P., et al., 2021. Ferrocifen loaded lipid nanocapsules: a promising anticancer medication against multidrug resistant tumors. Cancers, 13 (10), 2291.
  • Ingle, J.N., 2002. Estrogen as therapy for breast cancer. Breast cancer research, 4 (4), 1–4.
  • Jänicke, P., et al., 2021. Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: synthesis, cellular uptake and anticancer activity. Materials science & engineering. C, materials for biological applications, 119, 111619.
  • Juan, R., et al., 2020. The essential oil of cymbopogon citratus stapt and carvacrol: an approach of the antitumor effect on 7,12-dimethylbenz-[α]-anthracene (DMBA)-induced breast cancer in female rats. Molecules, 25 (14), 3284.
  • Katiyar, S.S., et al., 2020. Lipid and biosurfactant based core–shell-type nanocapsules having high drug loading of paclitaxel for improved breast cancer therapy. ACS biomaterials science & engineering, 6 (12), 6760–6769.
  • Khalin, I., Heimburger, D., Melnychuk, N., Collot, M., Groschup, B., Hellal, F., Reisch, A., Plesnila, N. and Klymchenko, A.S., 2020. Ultrabright fluorescent polymeric nanoparticles with a stealth pluronic shell for live tracking in the mouse brain. ACS Nano, 14(8), 9755–9770.
  • Laranjeira, M.S., et al., 2022. Magnetic mesoporous silica nanoparticles as a theranostic approach for breast cancer: loading and release of the poorly soluble drug exemestane. International journal of pharmaceutics, 619, 121711.
  • Lin, M., et al., 2016. Curcumin-guided nanotherapy: a lipid-based nanomedicine for targeted drug delivery in breast cancer therapy. Drug delivery, 23 (4), 1420–1425.
  • Liu, H. and Talalay, P., 2013. Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. Proceedings of the national academy of sciences of the United States of America, 110 (47), 19065–19070.
  • Luo, X.-L., et al., 2020. Development and characterization of mammary intraductal (MIND) spontaneous metastasis models for triple-negative breast cancer in syngeneic mice. Scientific reports, 10 (1), 4681.
  • Ma, Z., et al., 2018. DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability. Oncology reports, 40 (3), 1632–1640.
  • Malik, S.N., Canaham, D.H., and Gouda, M.W., 1975. Effect of surfactants on absorption through membranes III: effects of dioctyl sodium sulfosuccinate and poloxalene on absorption of a poorly absorbable drug, phenolsulfonphthalein, in rats. Journal of pharmaceutical sciences, 64 (6), 987–990.
  • Malvia, S., et al., 2017. Epidemiology of breast cancer in Indian women. Asia-Pacific journal of clinical oncology, 13 (4), 289–295.
  • Mauras, N., et al., 2003. Pharmacokinetics and dose finding of a potent aromatase inhibitor, aromasin (exemestane), in young males. The journal of clinical endocrinology & metabolism, 88 (12), 5951–5956.
  • Maurya, P., et al., 2022. Appraisal of fluoroquinolone-loaded carubinose-linked hybrid nanoparticles for glycotargeting to alveolar macrophages. Drug delivery and translational research, 12 (7), 1640–1658.
  • Mishra, N., et al., 2019. Optimization of inositol hexaphosphate colon targeted formulation for anticarcinogenic marker modulation. AAPS PharmSciTech, 20 (8), 319.
  • Mohanty, S.S., Sahoo, C.R., and Padhy, R.N., 2022. Role of hormone receptors and HER2 as prospective molecular markers for breast cancer: an update. Genes & diseases, 9 (3), 648–658.
  • Mokhtar, S., et al., 2022. Methotrexate-lactoferrin targeted exemestane cubosomes for synergistic breast cancer therapy. Frontiers in chemistry, 10, 847573.
  • Neupane, Y.R., et al., 2013. Lipid drug conjugate nanoparticle as a novel lipid nanocarrier for the oral delivery of decitabine: ex vivo gut permeation studies. Nanotechnology, 24 (41), 415102.
  • Neupane, Y.R., et al., 2014. Lipid based nanocarrier system for the potential oral delivery of decitabine: formulation design, characterization, ex vivo, and in vivo assessment. International journal of pharmaceutics, 477 (1–2), 601–612.
  • Nisha, R., et al., 2021. Fabrication of imatinib mesylate-loaded lactoferrin-modified PEGylated liquid crystalline nanoparticles for mitochondrial-dependent apoptosis in hepatocellular carcinoma. Molecular pharmaceutics, 18 (3), 1102–1120.
  • Niu, Z., et al., 2016. Lipid-based nanocarriers for oral peptide delivery. Advanced drug delivery reviews, 106 (Pt B), 337–354.
  • Orlandi, A., et al., 2020. Palbociclib plus fulvestrant or everolimus plus exemestane for pretreated advanced breast cancer with lobular histotype in ER+/HER2- patients: a propensity score-matched analysis of a multicenter retrospective patient series. Journal of personalized medicine, 10 (4), 291.
  • Parashar, P., et al., 2018a. Hyaluronic acid decorated naringenin nanoparticles: appraisal of chemopreventive and curative potential for lung cancer. Pharmaceutics, 10 (1), 33.
  • Parashar, P., et al., 2018b. Biotinylated naringenin intensified anticancer effect of gefitinib in urethane-induced lung cancer in rats: favourable modulation of apoptotic regulators and serum metabolomics. Artificial cells, nanomedicine, and biotechnology, 46 (sup3), S598–S610.
  • Parashar, P., et al., 2019. A synergistic approach for management of lung carcinoma through folic acid functionalized co-therapy of capsaicin and gefitinib nanoparticles: enhanced apoptosis and metalloproteinase-9 down-regulation. Phytomedicine : international journal of phytotherapy and phytopharmacology, 53, 107–123.
  • Pitto-Barry, A. and Barry, N.P.E., 2014. Pluronic® block-copolymers in medicine: from chemical and biological versatility to rationalisation and clinical advances. Polymer chemistry, 5 (10), 3291–3297.
  • Rizwanullah, M., et al., 2021. Exemestane encapsulated polymer-lipid hybrid nanoparticles for improved efficacy against breast cancer: optimization, in vitro characterization and cell culture studies. Nanotechnology, 32 (41), 415101.
  • Roy, S., et al., 2017. Alpha-linolenic acid stabilizes HIF-1 α and downregulates FASN to promote mitochondrial apoptosis for mammary gland chemoprevention. Oncotarget, 8 (41), 70049–70071.
  • Russo, J. and Russo, I.H., 2006. The role of estrogen in the initiation of breast cancer. The journal of steroid biochemistry and molecular biology, 102 (1–5), 89–96.
  • Safwat, S., et al., 2017. Augmented simvastatin cytotoxicity using optimized lipid nanocapsules: a potential for breast cancer treatment. Journal of liposome research, 27 (1), 1–10.
  • Sathyamoorthy, N., et al., 2017. Optimization of paclitaxel loaded poly (ε-caprolactone) nanoparticles using Box Behnken design. Beni-Suef university journal of basic and applied sciences, 6 (4), 362–373.
  • Shah, V., et al., 2021. Thermoresponsive liquid crystalline formulation of exemestane: design and structural characterization. Colloids and surfaces. B, biointerfaces, 202, 111683.
  • Shumway, D.A., Sabolch, A., and Jagsi, R., 2020. Breast cancer. In: S. Lo, B. Teh, G.L. Jiang, and N. Mayr, eds. Controversies in Radiation Oncology, Cham, Switzerland: Springer, 1–43.
  • Singh G., et al., 2021. Exemestane encapsulated copolymers L121/F127/GL44 based mixed micelles: solubility enhancement and in vitro cytotoxicity evaluation using MCF-7 breast cancer cells. Journal of pharmaceutical investigation, 51 (6), 701–714.
  • Singh, A., et al., 2019. Nanostructured lipid carriers for oral bioavailability enhancement of exemestane: formulation design, in vitro, ex vivo, and in vivo studies. Journal of pharmaceutical sciences, 108 (10), 3382–3395.
  • Singh, A.K., et al., 2008. Exemestane loaded self-microemulsifying drug delivery system (SMEDDS): development and optimization. AAPS PharmSciTech, 9 (2), 628–634.
  • Singh, L., et al., 2020. “Repurposing combination therapy of voacamine with vincristine for down regulation of HIF-1α/FASN Co-axis and PHD2 activation in ER + mammary neoplasia.” Research Square, 4.
  • Singh, N., et al., 2017. Oral delivery of allopurinol niosomes in treatment of gout in animal model. Journal of liposome research, 27 (2), 130–138.
  • Tariq, M., et al., 2015. Biodegradable polymeric nanoparticles for oral delivery of epirubicin: in vitro, ex vivo, and in vivo investigations. Colloids and surfaces B: biointerfaces, 128, 448–456.
  • Tas, F., et al., 2005. Oxidative stress in breast cancer. Medical oncology, 22 (1), 011–015.
  • Tolg, C., Cowman, M., and Turley, E.A., 2018. Mouse mammary gland whole mount preparation and analysis. Bio-protocol, 8 (13), e2915.
  • Tripathi, C.B., et al., 2018. QbD-based development of α-linolenic acid potentiated nanoemulsion for targeted delivery of doxorubicin in DMBA-induced mammary gland carcinoma: in vitro and in vivo evaluation. Drug delivery and translational research, 8 (5), 1313–1334.
  • Trivedi, P.P., et al., 2011. Cardioprotective effects of hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat. Cardiovascular toxicology, 11 (3), 215–225.
  • Valle, M., et al., 2005. A predictive model for exemestane pharmacokinetics/pharmacodynamics incorporating the effect of food and formulation. British journal of clinical pharmacology, 59 (3), 355–364.
  • Valsalakumari, R., et al., 2021. Mechanism of cellular uptake and cytotoxicity of paclitaxel loaded lipid nanocapsules in breast cancer cells. International journal of pharmaceutics, 597, 120217.
  • van Vlerken, L.E., et al., 2008. Biodistribution and pharmacokinetic analysis of paclitaxel and ceramide administered in multifunctional polymer-blend nanoparticles in drug resistant breast cancer model. Molecular pharmaceutics, 5 (4), 516–526.
  • Vogel, R., et al., 2017. High-resolution single particle zeta potential characterisation of biological nanoparticles using tunable resistive pulse sensing. Scientific reports, 7 (1), 17479.
  • Wadhwa, J., et al., 2014. Development and optimization of polymeric self-emulsifying nanocapsules for localized drug delivery: design of experiment approach.” Edited by Sanjula Baboota. The scientific world journal, 2014, 516069.
  • Wang, Y., Jing, F., and Wang, H., 2022. Role of exemestane in the treatment of estrogen-receptor-positive breast cancer: a narrative review of recent evidence. Advances in therapy, 39 (2), 862–891.
  • Yang, Z., et al., 2010. Crystallization behavior of poly(ε-caprolactone)/layered double hydroxide nanocomposites. Journal of applied polymer science, 116 (5), 2658–2667.
  • Zucchini, G., et al., 2015. Clinical utility of exemestane in the treatment of breast cancer. International journal of women's health, 7, 551–563.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.