Advanced search
Publication Cover
Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 16, 2003 - Issue 1
Submit an article Journal homepage
250
Views
14
CrossRef citations to date
0
Altmetric
Articles

Quinine Allergy Causing Acute Severe Systemic Illness: Report of 4 Patients Manifesting Multiple Hematologic, Renal, and Hepatic Abnormalities

Mark A. Howard
, BS,
Andrea B. Hibbard
, BA,
Deirdra R. Terrell
, MPH,
Patrick J. Medina
, PharmD,
Sara K. Vesely
, PhD &
James N. GeorgeCorrespondence[email protected]
, MD
Pages 21-26 | Published online: 11 Dec 2017

  • Quinine bark. Available at http://www.rain-treecom/quinine.htm. Accessed July 23, 2002.
  • Kreig M. The incredible history of quinine. In Green Medicine: The Search for Plants That Heal. Chicago: Rand-McNally, 1964: 165–206.
  • Kojouri K, Perdue JJ, Medina PJ, George JN. Occult quinine-induced thrombocytopenia. J Okla State Med Assoc 2000;93: 519–521.
  • Moss HK, Herrmann LG. The use of quinine for the relief of “night cramps” in the extremities. JAMA 1940;115: 1358–1359.
  • Oboler SK, Prochazka AV, Meyer TJ. Leg symptoms in outpatient veterans. West J Med 1991;155: 256–259.
  • Drug products for the treatment and/or prevention of nocturnal leg muscle cramps for over-the-counter human use. Federal Register 1994;59: 43234–43252.
  • Brinker AD, Beitz J. Spontaneous reports of thrombocytopenia in association with quinine: clinical attributes and timing related to regulatory action. Am J Hematol 2002;70: 313–317.
  • Vipan WH. Quinine as a cause of purpura. Lancet 1865;2: 37.
  • Elliott HL, Trash DB. Intravascular coagulation induced by quinine. Unexpected hazard of “bitter lemon.” Scott Med J 1979;24: 244–245.
  • Belkin GA. Cocktail purpura. An unusual case of quinine sensitivity. Ann Intern Med 1967;66: 583–586.
  • Korbitz BC, Eisner E. Cocktail purpura. Quinine-dependent thrombocytopenia. Rocky Mt Med J 1973;70: 38–41.
  • Barrett AP, Tversky J, Griffiths CJ. Thrombocytopenia induced by quinine. Oral Surg Oral Med Oral Pathol 1983;55: 351–354.
  • Wagner GH, Diffey BL, Ive FA. “I'll have mine with a twist of lemon.” Quinine photosensitivity from excessive intake of tonic water. Br J Dermatol 1994;131: 734–735.
  • Brasic JR. Quinine-induced thrombocytopenia in a 64-year-old man who consumed tonic water to relieve nocturnal leg cramps. Mayo Clin Proc 2001;76: 863–864.
  • Barr E, Douglas JF, Hill CM. Recurrent acute hypersensitivity to quinine. BMJ 1990;301: 323.
  • Gottschall JL, Elliot W, Lianos E, McFarland JG, Wolfmeyer K, Aster RH. Quinine-induced immune thrombocytopenia associated with hemolytic uremic syndrome: a new clinical entity. Blood 1991;77: 306–310.
  • Freiman JP. Fatal quinine-induced thrombocytopenia. Ann Intern Med 1990;112: 308–309.
  • Kojouri K, Vesely SK, George JN. Quinine-associated thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: frequency, clinical features, and long-term outcomes. Ann Intern Med 2001;135: 1047–1051.
  • George JN. How I treat patients with thrombotic thrombocytopenic purpura–hemolytic uremic syndrome. Blood 2000;96: 1223–1229.
  • George JN, Vesely SK. Thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: diagnosis and treatment. Cleve Clin J Med 2001;68: 857–878.
  • Visentin GP, Wolfmeyer K, Newman PJ, Aster RH. Detection of drug-dependent, platelet-reactive antibodies by antigen-capture ELISA and flow cytometry. Transfusion 1990;30: 694–700.
  • Cohen JA, Brecher ME, Bandarenko N. Cellular source of serum lactate dehydrogenase elevation in patients with thrombotic thrombocytopenic purpura. J Clin Apheresis 1998;13: 16–19.
  • Gottschall JL, Neahring B, McFarland JG, Wu GG, Weitekamp LA, Aster RH. Quinine-induced immune thrombocytopenia with hemolytic uremic syndrome: clinical and serological findings in nine patients and review of literature. Am J Hematol 1994;47: 283–289.
  • Schattner A. Quinine hypersensitivity simulating sepsis. Am J Med 1998;104: 488–490.
  • Rizvi MA, Vesely SK, George JN, Chandler L, Duvall D, Smith JW, Gilcher RO. Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura–hemolyticuremic syndrome. Transfusion 2000;40: 896–901.
  • Kaptchuk TJ, Eisenberg DM. Varieties of healing. 1: medical pluralism in the United States. Ann Intern Med 2001;135: 189–195.
  • George JN, Raskob GE, Shah SR, Rizvi MA, Hamilton SA, Osborne S, Vondracek T. Drug-induced thrombocytopenia: a systematic review of published case reports. Ann Intern Med 1998;129: 886–890.
  • Webb RF, Ramirez AM, Hocken AG, Pettit JE. Acute intravascular haemolysis due to quinine. N Z Med J 1980;91: 14–16.
  • Medina PJ, Sipols JM, George JN. Drug-associated thrombotic thrombocytopenic purpura–hemolytic uremic syndrome. Curr Opin Hematol 2001;8: 286–293.
  • Bell WR, Tomasulo PA, Alving BM, Duffy TP. Thrombocytopenia occurring during the administration of heparin. A prospective study in 52 patients. Ann Intern Med 1976;85: 155–160.
  • Burgess JK, Lopez JA, Berndt MC, Dawes I, Chesterman CN, Chong BH. Quinine-dependent antibodies bind a restricted set of epitopes on the glycoprotein Ib-IX complex: characterization of the epitopes. Blood 1998;92: 2366–2373.
  • Glynne P, Salama A, Chaudhry A, Swirsky D, Lightstone L. Quinine-induced immune thrombocytopenic purpura followed by hemolytic uremic syndrome. Am J Kidney Dis 1999;33: 133–137.
  • Spearing RL, Hickton CM, Sizeland P, Hannah A, Bailey RR. Quinine-induced disseminated intravascular coagulation. Lancet 1990;336: 1535–1537.
  • Curtis BR, McFarland JG, Wu GG, Visentin GP, Aster RH. Antibodies in sulfonamide-induced immune thrombocytopenia recognize calcium-dependent epitopes on the glycoprotein IIb/IIIa complex. Blood 1994;84: 176–183.
  • Stroncek DF, Vercellotti GM, Hammerschmidt DE, Christie DJ, Shankar RA, Jacob HS. Characterization of multiple quinine-dependent antibodies in a patient with episodic hemolytic uremic syndrome and immune agranulocytosis. Blood 1992;80: 241–248.
  • Maguire RB, Stroncek DF, Campbell AC. Recurrent pancytopenia, coagulopathy, and renal failure associated with multiple quinine-dependent antibodies. Ann Intern Med 1993;119: 215–217.
  • Sutherland R, Vincent PC, Raik E, Burgess K. Quinine-induced agranulocytosis: toxic effect of quinine bisulphate on bone marrow cultures in vitro. Br Med J 1977;1: 605–607.
  • Hou M, Horney E, Stockelberg D, Jacobsson S, Kutti J, Wadenvik H. Multiple quinine-dependent antibodies in a patient with episodic thrombocytopenia, neutropenia, lymphocytopenia, and granulomatous hepatitis. Blood 1997;90: 4806–4811.
  • Farver DK, Lavin MN. Quinine-induced hepatotoxicity. Ann Pharmacother 1999;33: 32–34.
  • Waddell K. Blindness from quinine as an antimalarial. Trans R Soc Trop Med Hyg 1996;90: 331–332.
  • Verghese C. Quinine psychosis. Br J Psychiatry 1988;153: 575–576.
  • Limburg PJ, Katz H, Grant CS, Service FJ. Quinine-induced hypoglycemia. Ann Intern Med 1993;119: 218–219.
  • Schlutz M, Zinneman HH, Hall WH. Drug fever caused by quinine and quinidine. Minn Med 1973;56: 668–670.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.