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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 31, 2018 - Issue 3
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Case Studies

Cutaneous toxicity of oral low-dose methotrexate

, MD & , MD
Pages 364-366 | Received 21 Jan 2018, Accepted 22 Mar 2018, Published online: 22 May 2018

  • Cronstein BN. Low-dose methotrexate: A mainstay in the treatment of rheumatoid arthritis. Pharmacol Rev. 2005;57:163–172. doi:10.1124/pr.57.2.3. PMID:15914465.
  • Varela CR, McNamara J, Antaya RJ. Acral erythema with oral methotrexate in a child. Pediatr Dermatol. 2007;24:541–546. doi:10.1111/j.1525-1470.2007.00513.x. PMID:17958806.
  • Baack BR, Burgdorf WH. Chemotherapy-induced acral erythema. J Am Acad Dermatol. 1991;24:457–461. PMID:2061446.
  • Lokich JJ, Moore C. Chemotherapy-associated palmar–plantar erythrodysesthesia syndrome. Ann Intern Med. 1984;101:798–799. PMID:6497196.
  • Vukelja SJ, Lombardo FA, James WD, Weiss RB. Pyridoxine for the palmar–plantar erythrodysesthesia syndrome. Ann Intern Med. 1989;111:688–689.
  • Tsuruta D, Mochida K, Hamada T, et al. Chemotherapy-induced acral erythema: Report of a case and immunohistochemical findings. Clin Exp Dermatol. 2000;25:386–388. PMID:11012591.
  • Ogawa H, Sugiyama H, Tani Y, et al. High incidence of chemotherapy-induced acral erythema in female patients with non-Hodgkin's lymphoma treated with the VACOP-B regimen. Leuk Lymphoma. 1998;29:171–177. doi:10.3109/10428199809058392. PMID:9638986.
  • Chang JC. Acute bullous dermatosis and onycholysis due to high-dose methotrexate and leucovorin calcium. Arch Dermatol. 1987;123:990–992. PMID:3307638.
  • Doyle LA, Berg C, Bottino G, Chabner B. Erythema and desquamation after high-dose methotrexate. Ann Intern Med. 1983;98(Pt 1):611–612. PMID:6601925.
  • Feizy V, Namazi MR, Barikbin B, Ehsani A. Methotrexate-induced acral erythema with bullous reaction. Dermatol Online J. 2003;9:14. PMID:12639472.
  • Hellier I, Bessis D, Sotto A, Margueritte G, Guilhou JJ. High-dose methotrexate-induced bullous variant of acral erythema. Arch Dermatol. 1996;132:590–591. PMID:8624164.
  • Millot F, Auriol F, Brecheteau P, Guilhot F. Acral erythema in children receiving high-dose methotrexate. Pediatr Dermatol. 1999;16:398–400. PMID:10571844.
  • Morrell DS, Challgren E, Eapen M, Esterly NB. Bullous acral erythema secondary to high-dose methotrexate. J Pediatr Hematol Oncol. 2002;24:240. PMID:11990316.
  • Postovsky S, Ben Arush MW. Acral erythema caused by high-dose methotrexate therapy in patients with osteogenic sarcoma. Pediatr Hematol Oncol. 2005;22:167–173. doi:10.1080/08880010590907320. PMID:15805003.
  • Werchniak AE, Chaffee S, Dinulos JG. Methotrexate-induced bullous acral erythema in a child. J Am Acad Dermatol. 2005;52(Suppl 1):S93–S95. doi:10.1016/j.jaad.2004.11.065. PMID:15858519.
  • Ikeda H, Kawano H, Kitaura T, Kimura A, Kihira K. Acral erythema associated with high-dose methotrexate infusion. Ann Pharmacother. 1999;33:646. PMID:10369634.
  • Kuruvila S, Dalal M, Sivanesan B. Bullous variant of acral erythema due to methotrexate. Indian J Dermatol Venereol Leprol. 2006;72:440–442. PMID:17179620.
  • Nagore E, Insa A, Sanmartin O. Antineoplastic therapy-induced palmar plantar erythrodysesthesia (“hand–foot”) syndrome. Incidence, recognition and management. Am J Clin Dermatol. 2000;1:225–234. PMID:11702367.
  • Cordonnier C, Roujeau JC, Vernant JP, Matheron S, Ganem G. Cancer chemotherapy and acral erythema. Ann Intern Med. 1982;97:783–783.
  • Diskin CJ, Stokes TJ, Dansby LM, Radcliff L, Carter TB. Removal of methotrexate by peritoneal dialysis and hemodialysis in a single patient with end-stage renal disease. Am J Med Sci. 2006;332:156–158. PMID:16969149.
  • Borchers AT, Keen CL, Cheema GS, Gershwin ME. The use of methotrexate in rheumatoid arthritis. Semin Arthritis Rheum. 2004;34:465–483.
  • Gutierrez-Urena S, Molina JF, Garcia CO, Cuellar ML, Espinoza LR. Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis. Arthritis Rheum. 1996;39:272–276. PMID:8849378.
  • American College of Rheumatology Ad Hoc Committee on Clinical Guidelines. Guidelines for the management of rheumatoid arthritis. Arthritis Rheum. 1996;39:713–722. PMID:8639167.
  • Bezabeh S, Mackey AC, Kluetz P, Jappar D, Korvick J. Accumulating evidence for a drug–drug interaction between methotrexate and proton pump inhibitors. Oncologist. 2012;17:550–554. doi:10.1634/theoncologist.2011-0431. PMID:22477728.

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