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Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 33, 2020 - Issue 4
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Review Articles

The dynamic treatment of SARS-CoV-2 disease

, MD, MSORCID Icon, , PharmDORCID Icon, , PharmD, , MD & , MD
Pages 572-579 | Received 08 May 2020, Accepted 05 Jun 2020, Published online: 23 Jun 2020

  • Jin Y , Yang H , Ji W , et al. Virology, epidemiology, pathogenesis, and control of COVID-19. Viruses . 2020;12(4):372. doi:10.3390/v12040372.
  • Fu Y , Cheng Y , Wu Y. Understanding SARS-CoV-2–mediated inflammatory responses: from mechanisms to potential therapeutic tools. Virol Sin . 2020. doi:10.1007/s12250-020-00207-4.
  • Ye Q , Wang B , Mao J. The pathogenesis and treatment of the ‘cytokine storm’ in COVID-19. J Infect . 2020;80(6):607–613. doi:10.1016/j.jinf.2020.03.037.
  • Sanders JM , Monogue ML , Jodlowski TZ , Cutrell JB. Pharmacologic treatments for coronavirus disease 2019 (COVID-19): a review. JAMA . 2020; doi:10.1001/jama.2020.6019.
  • Bhimraj A , Morgan RL , Shumaker AH , et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. Clin Infect Dis . 2020;ciaa478. doi:10.1093/cid/ciaa478.
  • Wu Z , McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA . 2020;323(13):1239. doi:10.1001/jama.2020.2648.
  • Alhazzani W , Møller MH , Arabi YM , et al. Surviving Sepsis campaign: guidelines on the management of critically ill adults with coronavirus disease 2019 (COVID-19). Intensive Care Med . 2020;46(5):854–887. doi:10.1007/s00134-020-06022-5.
  • Wang Y , Wang Y , Chen Y , Qin Q. Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures. J Med Virol . 2020;92(6):568–576. doi:10.1002/jmv.25748.
  • Chu CM , Cheng VC , Hung IF , et al ; HKU/UCH SARS Study Group . Role of lopinavir/ritonavir in the treatment of SARS: initial virological and clinical findings. Thorax . 2004;59(3):252–256. doi:10.1136/thorax.2003.012658.
  • de Wilde AH , Jochmans D , Posthuma CC , et al. Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture. Antimicrob Agents Chemother . 2014;58(8):4875–4884. doi:10.1128/AAC.03011-14.
  • Cao B , Wang Y , Wen D , et al. A trial of lopinavir-ritonavir in adults hospitalized with severe COVID-19. N Engl J Med . 2020;382(19):1787–1799. doi:10.1056/NEJMoa2001282.
  • Devaux CA , Rolain JM , Colson P , Raoult D. New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? Int J Antimicrob Agents . 2020;55(5):105938. doi:10.1016/j.ijantimicag.2020.105938.
  • Liu J , Cao R , Xu M , et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov . 2020;6(1):16. doi:10.1038/s41421-020-0156-0.
  • Taccone FS , Gorham J , Vincent JL. Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base. Lancet Respir Med . 2020;S2213-2600(20)30172-7. doi:10.1016/S2213-2600(20)30172-7.
  • Gautret P , Lagier JC , Parola P , et al. Clinical and microbiological effect of a combination of hydroxychloroquine and azithromycin in 80 COVID-19 patients with at least a six-day follow up: a pilot observational study. Travel Med Infect Dis . 2020;34:101663. doi:10.1016/j.tmaid.2020.101663.
  • Magagnoli j , Narendran S , Pereira F , et al. Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19. Med . 2020. doi:10.1016/j.medj.2020.06.001.
  • Rosenberg ES , Dufort EM , Udo T , et al. Association of treatment with hydroxychloroquine or azithromycin with in-hospital mortality in patients with COVID-19 in New York State. JAMA . 2020. doi:10.1001/jama.2020.8630.
  • Delang L , Abdelnabi R , Neyts J. Favipiravir as a potential countermeasure against neglected and emerging RNA viruses. Antiviral Res . 2018;153:85–94. doi:10.1016/j.antiviral.2018.03.003.
  • Furuta Y , Komeno T , Nakamura T. Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase. Proc Jpn Acad, Ser B, Phys Biol Sci . 2017;93(7):449–463. doi:10.2183/pjab.93.027.
  • Siegel D , Hui HC , Doerffler E , et al. Discovery and synthesis of a phosphoramidate prodrug of a pyrrolo[2,1-f][triazin-4-amino] adenine C-nucleoside (GS-5734) for the treatment of Ebola and emerging viruses. J Med Chem . 2017;60(5):1648–1661. doi:10.1021/acs.jmedchem.6b01594.
  • Wang M , Cao R , Zhang L , et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Res . 2020;30(3):269–271. doi:10.1038/s41422-020-0282-0.
  • Zhai P , Ding Y , Wu X , Long J , Zhong Y , Li Y. The epidemiology, diagnosis and treatment of COVID-19. Int J Antimicrob Agents . 2020;55(5):105955. doi:10.1016/j.ijantimicag.2020.105955.
  • Agostini ML , Andres EL , Sims AC , et al. Coronavirus susceptibility to the antiviral remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease. MBio . 2018;9(2):e00221–18. doi:10.1128/mBio.00221-18.
  • Holshue ML , DeBolt C , Lindquist S , et al; Washington State 2019-nCoV Case Investigation Team. First case of 2019 novel coronavirus in the United States. N Engl J Med . 2020;382(10):929–936. doi:10.1056/NEJMoa2001191.
  • Grein J , Ohmagari N , Shin D , et al. Compassionate use of remdesivir for patients with severe Covid-19. N Engl J Med . 2020;NEJMoa2007016. doi:10.1056/NEJMoa2007016.
  • Wang Y , Zhang D , Du G , et al. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial. Lancet . 2020. doi:10.1016/S0140-6736(1020)31022-31029.
  • Beigel JH , Tomashek KM , Dodd LE , et al ; ACTT-1 study group members . Remdesivir for the treatment of Covid-19—preliminary report. N Engl J Med . 2020;NEJMoa2007764. doi:10.1056/NEJMoa2007764.
  • Hinton DM. Letter to A. Rhoades, Gilead sciences, granting emergency use authorization from the US Food and Drug Administration for remdesivir. https://www.fda.gov/media/137564/download. Published May 1, 2020.
  • Goldman JD , Lye DCB , Hui DS , et al ; GS-US-540-5773 Investigators. Remdesivir for 5 or 10 days in patients with severe Covid-19. N Engl J Med . 2020;NEJMoa2015301. doi:10.1056/NEJMoa2015301.
  • Bloch EM , Shoham S , Casadevall A , et al. Deployment of convalescent plasma for the prevention and treatment of COVID-19. J Clin Invest . 2020;130(6):2757–2765. doi:10.1172/JCI138745.
  • Mair-Jenkins J , Saavedra-Campos M , Baillie JK , et al ; Convalescent Plasma Study Group . The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis. J Infect Dis . 2015;211(1):80–90. doi:10.1093/infdis/jiu396.
  • Duan K , Liu B , Li C , et al. Effectiveness of convalescent plasma therapy in severe COVID-19 patients. Proc Natl Acad Sci USA . 2020;117(17):9490–9496. doi:10.1073/pnas.2004168117.
  • Shen C , Wang Z , Zhao F , et al. Treatment of 5 critically ill patients with COVID-19 with convalescent plasma. JAMA . 2020;323(16):1582. doi:10.1001/jama.2020.4783.
  • Zhang B , Liu S , Tan T , et al. Treatment with convalescent plasma for critically ill patients with SARS-CoV-2 infection. Chest . 2020. doi:10.1016/j.chest.2020.03.039.
  • Li L , Zhang W , Hu Y , et al. Effect of convalescent plasma therapy on time to clinical improvement in patients with severe and life-threatening COVID-19: a randomized clinical trial. JAMA . 2020. doi:10.1001/jama.2020.10044.
  • Liu STH , Lin HM , Baine I , et al. Convalescent plasma treatment of severe COVID-19: a matched control study. medRxiv . 2020. doi:10.1101/2020.05.20.20102236.
  • Tanne JH. Covid-19: FDA approves use of convalescent plasma to treat critically ill patients. BMJ . 2020;368:m1256. doi:10.1136/bmj.m1256.
  • Arabi YM , Hajeer AH , Luke T , et al. Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia. Emerging Infect Dis . 2016;22(9):1554–1561. doi:10.3201/eid2209.151164.
  • Wan Y , Shang J , Sun S , et al. Molecular mechanism for antibody-dependent enhancement of coronavirus entry. J Virol . 2020;94(5):e02015–19. doi:10.1128/JVI.02015-19.
  • Casadevall A , Pirofski LA. The convalescent sera option for containing COVID-19. J Clin Invest . 2020;130(4):1545–1548. doi:10.1172/JCI138003.
  • Conti P , Ronconi G , Caraffa A , et al. Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies. J Biol Regul Homeost Agents . 2020;34(2):1.
  • Li X , Geng M , Peng Y , Meng L , Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal . 2020;10(2):102–108. doi:10.1016/j.jpha.2020.03.001.
  • Tanaka T , Narazaki M , Kishimoto T. Immunotherapeutic implications of IL-6 blockade for cytokine storm. Immunotherapy . 2016;8(8):959–970. doi:10.2217/imt-2016-0020.
  • Assistance Publique–Hôpitaux de Paris . Tocilizumab improves significantly clinical outcomes of patients with moderate or severe COVID-19 pneumonia. https://www.aphp.fr/contenu/tocilizumab-improves-significantly-clinical-outcomes-patients-moderate-or-severe-covid-19. Published April 27, 2020. Accessed June 5, 2020.
  • BioSpace . Regeneron and Sanofi provide update on U.S. phase 2/3 adaptive-designed trial of Kevzara® (sarilumab) in hospitalized COVID-19 patients. https://www.biospace.com/article/releases/regeneron-and-sanofi-provide-update-on-u-s-phase-2-3-adaptive-designed-trial-of-kevzara-sarilumab-in-hospitalized-covid-19-patients. Published April 27, 2020. Accessed June 5, 2020.
  • Ni YN , Chen G , Sun J , Liang BM , Liang ZA. The effect of corticosteroids on mortality of patients with influenza pneumonia: a systematic review and meta-analysis. Crit Care . 2019;23(1):99. doi:10.1186/s13054-019-2395-8.
  • Russell CD , Millar JE , Baillie JK. Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury. Lancet . 2020;395(10223):473–475. doi:10.1016/S0140-6736(20)30317-2.
  • Wu C , Chen X , Cai Y , et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med . 2020; e200994. doi:10.1001/jamainternmed.2020.0994.
  • Uccelli A , de Rosbo NK. The immunomodulatory function of mesenchymal stem cells: mode of action and pathways. Ann N Y Acad Sci . 2015;1351(1):114–126. doi:10.1111/nyas.12815.
  • Golchin A , Seyedjafari E , Ardeshirylajimi A. Mesenchymal stem cell therapy for COVID-19: present or future. Stem Cell Rev Rep . 2020;16(3):427–433. doi:10.1007/s12015-020-09973-w.
  • Lee JW , Fang X , Krasnodembskaya A , Howard JP , Matthay MA. Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells . 2011;29(6):913–919. doi:10.1002/stem.643.
  • Shanmugaraj B , Siriwattananon K , Wangkanont K , Phoolcharoen W. Perspectives on monoclonal antibody therapy as potential therapeutic intervention for coronavirus disease-19 (COVID-19). Asian Pac J Allergy Immunol . 2020;38(1):10–18. doi:10.12932/AP-200220-0773.
  • Cockrell AS , Yount BL , Scobey T , et al. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol . 2016;2(2):16226. doi:10.1038/nmicrobiol.2016.226.
  • Han H , Yang L , Liu R , et al. Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clin Chem Lab Med . 2020. doi:10.1515/cclm-2020-0188.
  • Tang N , Li D , Wang X , Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost . 2020;18(4):844–847. doi:10.1111/jth.14768.
  • Guo T , Fan Y , Chen M , et al. Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019 (COVID-19). JAMA Cardiol . 2020. doi:10.1001/jamacardio.2020.1017.
  • Bikdeli B , Madhavan MV , Jimenez D , et al. COVID-19 and thrombotic or thromboembolic disease: implications for prevention, anti-thrombotic therapy, and follow-up. J Am Coll Cardiol . 2020;75(23):2950–2973.
  • Gold JAW , Wong KK , Szablewski CM , et al. Characteristics and clinical outcomes of adult patients hospitalized with COVID-19—Georgia, March 2020. MMWR Morb Mortal Wkly Rep . 2020;69(18):545–550. doi:10.15585/mmwr.mm6918e1.
  • Rello J , Storti E , Belliato M , Serrano R. Clinical phenotypes of SARS-CoV-2: implications for clinicians and researchers. Eur Respir J . 2020;55(5):2001028. doi:10.1183/13993003.01028-2020.
  • Siddiqi HK , Mehra MR. COVID-19 illness in native and immunosuppressed states: A clinical-therapeutic staging proposal. J Heart Lung Transplant . 2020;39(5):405–407. doi:10.1016/j.healun.2020.03.012.
  • Gilead Sciences . Gilead announces results from Phase 3 trial of remdesivir in patients with moderate COVID-19. https://www.gilead.com/news-and-press/press-room/press-releases/2020/6/gilead-announces-results-from-phase-3-trial-of-remdesivir-in-patients-with-moderate-covid-19. Published June 1, 2020. Accessed June 5, 2020.
  • Faure E , Poissy J , Goffard A , et al. Distinct immune response in two MERS-CoV-infected patients: can we go from bench to bedside? PLoS One . 2014;9(2):e88716. doi:10.1371/journal.pone.0088716.

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