- Konidala S, Gutterman DD. Coronary vasospasm and the regulation of coronary blood flow. Prog Cardiovasc Dis. 2004;46(4):349–373. doi:https://doi.org/10.1016/j.pcad.2003.10.001.
- Prinzmetal M, Kennamer R, Merliss R, Wada T, Bor N. Angina pectoris. I. A variant form of angina pectoris; preliminary report. Am J Med. 1959;27:375–388. doi:https://doi.org/10.1016/0002-9343(59)90003-8.
- Bertrand ME, LaBlanche JM, Tilmant PY, et al. Frequency of provoked coronary arterial spasm in 1089 consecutive patients undergoing coronary arteriography. Circulation. 1982;65(7):1299–1306. doi:https://doi.org/10.1161/01.cir.65.7.1299.
- Koneru J, Cholankeril M, Patel K, et al. Postpartum coronary vasospasm with literature review. Case Rep Cardiol. 2014;2014:523023. doi:https://doi.org/10.1155/2014/523023.
- Shimokawa H, Nagasawa K, Irie T, et al. Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations. Int J Cardiol. 1988;18(3):331–349. doi:https://doi.org/10.1016/0167-5273(88)90052-6.
- Ogawa H, Yasue H, Oshima S, Okumura K, Matsuyama K, Obata K. Circadian variation of plasma fibrinopeptide A level in patients with variant angina. Circulation. 1989;80(6):1617–1626. doi:https://doi.org/10.1161/01.cir.80.6.1617.
- JCS Joint Working Group. Guidelines for diagnosis and treatment of patients with vasospastic angina (coronary spastic angina) (JCS 2013). Circ J. 2014;78(11):2779–2801. doi:https://doi.org/10.1253/circj.cj-66-0098.
- Matsue Y, Yoshida K, Hoshino M, et al. Clinical features and prognosis of type 2 myocardial infarction in vasospastic angina. Am J Med. 2015;128(4):389–395. doi:https://doi.org/10.1016/j.amjmed.2014.10.055.
- Ong P, Athanasiadis A, Hill S, Vogelsberg H, Voehringer M, Sechtem U. Coronary artery spasm as a frequent cause of acute coronary syndrome: the CASPAR (Coronary Artery Spasm in Patients with Acute Coronary Syndrome) study. J Am Coll Cardiol. 2008;52(7):523–527. doi:https://doi.org/10.1016/j.jacc.2008.04.050.
- Takagi Y, Yasuda S, Tsunoda R, et al. Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association. Circ Arrhythm Electrophysiol. 2011;4(3):295–302. doi:https://doi.org/10.1161/CIRCEP.110.959809.
- de Luna AB, Cygankiewicz I, Baranchuk A, et al. Prinzmetal angina: ECG changes and clinical considerations: a consensus paper. Ann Noninvasive Electrocardiol. 2014;19(5):442–453. doi:https://doi.org/10.1111/anec.12194.
- Bayes de Luna A, Carreras F, Cladellas M, Oca F, Sagues F, Garcia Moll M. Holter ECG study of the electrocardiographic phenomena in Prinzmetal angina attacks with emphasis on the study of ventricular arrhythmias. J Electrocardiol. 1985;18(3):267–275. doi:https://doi.org/10.1016/S0022-0736(85)80051-0.
- Kugiyama K, Yasue H, Okumura K, et al. Nitric oxide activity is deficient in spasm arteries of patients with coronary spastic angina. Circulation. 1996;94(3):266–271. doi:https://doi.org/10.1161/01.cir.94.3.266.
- Egashira K, Katsuda Y, Mohri M, et al. Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina. J Am Coll Cardiol. 1996;27(6):1444–1449. doi:https://doi.org/10.1016/0735-1097(96)00021-6.
- Miwa K, Igawa A, Inoue H. Soluble E-selectin, ICAM-1 and VCAM-1 levels in systemic and coronary circulation in patients with variant angina. Cardiovasc Res. 1997;36(1):37–44. doi:https://doi.org/10.1016/S0008-6363(97)00143-0.
- Shimokawa H, Seto M, Katsumata N, et al. Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm. Cardiovasc Res. 1999;43(4):1029–1039. doi:https://doi.org/10.1016/S0008-6363(99)00144-3.
- Ito A, Shimokawa H, Nakaike R, et al. Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model. Circulation. 1994;90(5):2425–2431. doi:https://doi.org/10.1161/01.cir.90.5.2425.
- Fujihara J, Yasuda T, Kawai Y, et al. First survey of the three gene polymorphisms (PON1 Q192R, eNOS E298D and eNOS C-786T) potentially associated with coronary artery spasm in African populations and comparison with worldwide data. Cell Biochem Funct. 2011;29(2):156–163. doi:https://doi.org/10.1002/cbf.1721.
- Murase Y, Yamada Y, Hirashiki A, et al. Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women. Eur Heart J. 2004;25(11):970–977. doi:https://doi.org/10.1016/j.ehj.2004.02.020.
- Takaoka K, Yoshimura M, Ogawa H, et al. Comparison of the risk factors for coronary artery spasm with those for organic stenosis in a Japanese population: role of cigarette smoking. Int J Cardiol. 2000;72(2):121–126. doi:https://doi.org/10.1016/S0167-5273(99)00172-2.
- Morrow JD, Frei B, Longmire AW, et al. Increase in circulating products of lipid peroxidation (F2-isoprostanes) in smokers. Smoking as a cause of oxidative damage. N Engl J Med. 1995;332(18):1198–1203. doi:https://doi.org/10.1056/NEJM199505043321804.
- Sugiishi M, Takatsu F. Cigarette smoking is a major risk factor for coronary spasm. Circulation. 1993;87(1):76–79. doi:https://doi.org/10.1161/01.CIR.87.1.76.
- Yoshimura M, Yasue H, Nakayama M, et al. Genetic risk factors for coronary artery spasm: significance of endothelial nitric oxide synthase gene T-786–>C and missense Glu298Asp variants. J Investig Med. 2000;48(5):367–374.
- Miwa K, Yoshida N, Nakagawa K, Inoue H. High-density lipoprotein particles are large in patients with variant angina. Cardiovasc Res. 1998;37(3):729–737. doi:https://doi.org/10.1016/S0008-6363(97)00286-1.
- Miwa K. Low density lipoprotein particles are small in patients with coronary vasospasm. Int J Cardiol. 2003;87(2-3):193–201. doi:https://doi.org/10.1016/S0167-5273(02)00250-4.
- Satake K, Lee JD, Shimizu H, Ueda T, Nakamura T. Relation between severity of magnesium deficiency and frequency of anginal attacks in men with variant angina. J Am Coll Cardiol. 1996;28(4):897–902. doi:https://doi.org/10.1016/S0735-1097(96)00256-2.
- Memon S, Chhabra L, Masrur S, Parker MW. Allergic acute coronary syndrome (Kounis syndrome). Proc (Bayl Univ Med Cent). 2015;28(3):358–362. doi:https://doi.org/10.1080/08998280.2015.11929274.
- Fischell TA, Derby G, Tse TM, Stadius ML. Coronary artery vasoconstriction routinely occurs after percutaneous transluminal coronary angioplasty. A quantitative arteriographic analysis. Circulation. 1988;78(6):1323–1334. doi:https://doi.org/10.1161/01.cir.78.6.1323.
- El Menyar AA. Drug-induced myocardial infarction secondary to coronary artery spasm in teenagers and young adults. J Postgrad Med. 2006;52(1):51–56.
- Chong JH, Ghosh AK. Coronary artery vasospasm induced by 5-fluorouracil: proposed mechanisms, existing management options and future directions. Interv Cardiol. 2019;14(2):89–94. doi:https://doi.org/10.15420/icr.2019.12.
- Sueda S, Kohno H. Overview of complications during pharmacological spasm provocation tests. J Cardiol. 2016;68(1):1–6. doi:https://doi.org/10.1016/j.jjcc.2016.03.005.
- Widmer RJ, Samuels B, Samady H, et al. The functional assessment of patients with non-obstructive coronary artery disease: expert review from an international microcirculation working group. EuroIntervention. 2019;14(16):1694–1702. doi:https://doi.org/10.4244/EIJ-D-18-00982.
- Beltrame JF, Crea F, Kaski JC, et al. International standardization of diagnostic criteria for vasospastic angina. Eur Heart J. 2017;38(33):2565–2568. doi:https://doi.org/10.1093/eurheartj/ehv351.
- Miwa K, Fujita M, Miyagi Y. Beneficial effects of smoking cessation on the short-term prognosis for variant angina—validation of the smoking status by urinary cotinine measurements. Int J Cardiol. 1994;44(2):151–156. doi:https://doi.org/10.1016/0167-5273(94)90019-1.
- Robertson RM, Wood AJ, Vaughn WK, Robertson D. Exacerbation of vasotonic angina pectoris by propranolol. Circulation. 1982;65(2):281–285. doi:https://doi.org/10.1161/01.cir.65.2.281.
- Tilmant PY, Lablanche JM, Thieuleux FA, Dupuis BA, Bertrand ME. Detrimental effect of propranolol in patients with coronary arterial spasm countered by combination with diltiazem. Am J Cardiol. 1983;52(3):230–233. doi:https://doi.org/10.1016/0002-9149(83)90113-3.
- Park JY, Rha SW, Poddar KL, et al. Impact of low-dose aspirin on coronary artery spasm as assessed by intracoronary acetylcholine provocation test in Korean patients. J Cardiol. 2012;60(3):187–191. doi:https://doi.org/10.1016/j.jjcc.2012.02.007.
- Humbert X, Roule V, Milliez P, Alexandre J. Verapamil and vasospastic angina: underuse in the elderly population. J Geriatr Cardiol. 2017;14(7):430–435. doi:https://doi.org/10.11909/j.issn.1671-5411.2017.07.004.
- Nayler WG, Gu XH. Vascular and myocardial effects of amlodipine: an overview. Postgrad Med J. 1991;67(Suppl 5):S41–S43.
- May DC, Popma JJ, Black WH, et al. In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries. N Engl J Med. 1987;317(13):805–809. doi:https://doi.org/10.1056/NEJM198709243171305.
- Hung MJ, Cherng WJ, Cheng CW, Yang NI. Effect of antispastic agents (calcium antagonists and/or isosorbide dinitrate) on high-sensitivity C-reactive protein in patients with coronary vasospastic angina pectoris and no hemodynamically significant coronary artery disease. Am J Cardiol. 2005;95(1):84–87. doi:https://doi.org/10.1016/j.amjcard.2004.08.064.
- Choi BG, Jeon SY, Rha SW, et al. Impact of renin-angiotensin system inhibitors on long-term clinical outcomes of patients with coronary artery spasm. JAHA. 2016;5(7):e003217. doi:https://doi.org/10.1161/JAHA.116.003217.
- Hernandez-Perera O, Perez-Sala D, Navarro-Antolin J, et al. Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J Clin Invest. 1998;101(12):2711–2719. doi:https://doi.org/10.1172/JCI1500.
- Yasue H, Mizuno Y, Harada E, et al. Effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on coronary spasm after withdrawal of calcium-channel blockers. J Am Coll Cardiol. 2008;51(18):1742–1748. doi:https://doi.org/10.1016/j.jacc.2007.12.049.
- Masumoto A, Mohri M, Shimokawa H, Urakami L, Usui M, Takeshita A. Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation. 2002;105(13):1545–1547. doi:https://doi.org/10.1161/hc1002.105938.
- Shimizu H, Lee JD, Ogawa KB, et al. Efficacy of denopamine, a beta 1 adrenoceptor agonist, in preventing coronary artery spasm. Jpn Circ J. 1993;57(3):175–182. doi:https://doi.org/10.1253/jcj.57.175.
- Krishnan U, Win W, Fisher M. First report of the successful use of bosentan in refractory vasospastic angina. Cardiology. 2010;116(1):26–28. doi:https://doi.org/10.1159/000313365.
- Yoo SY, Song SG, Lee JH, et al. Efficacy of cilostazol on uncontrolled coronary vasospastic angina: a pilot study. Cardiovasc Ther. 2013;31(3):179–185. doi:https://doi.org/10.1111/j.1755-5922.2012.00312.x.
- Tarkin JM, Kaski JC. Nicorandil and long-acting nitrates: vasodilator therapies for the management of chronic stable angina pectoris. Eur Cardiol. 2018;13(1):23–28. doi:https://doi.org/10.15420/ecr.2018.9.2.
- Rutitzky B, Girotti AL, Rosenbaum MB. Efficacy of chronic amiodarone therapy in patients with variant angina pectoris and inhibition of ergonovine coronary constriction. Am Heart J. 1982;103(1):38–43. doi:https://doi.org/10.1016/0002-8703(82)90526-9.
- Mata-Bourcart LA, Waters DD, Bouchard A, Miller DD, Theroux P. Failure of ketanserin, a serotonin inhibitor, to prevent spontaneous or ergonovine-induced attacks of variant angina. Can J Cardiol. 1985;1(3):168–171.
- Teragawa H, Kato M, Yamagata T, Matsuura H, Kajiyama G. The preventive effect of magnesium on coronary spasm in patients with vasospastic angina. Chest. 2000;118(6):1690–1695. doi:https://doi.org/10.1378/chest.118.6.1690.
- Khitri A, Jayasuriya S, Habibzadeh MR, Movahed MR. Coronary stenting in patients with medically resistant vasospasm. Rev Cardiovasc Med. 2010;11(4):264–270.
- Bertrand ME, Lablanche JM, Rousseau MF, Warembourg HH Jr, Stankowtak C, Soots G. Surgical treatment of variant angina: use of plexectomy with aortocoronary bypass. Circulation. 1980;61(5):877–882. doi:https://doi.org/10.1161/01.cir.61.5.877.
- Ahn JM, Lee KH, Yoo SY, et al. Prognosis of variant angina manifesting as aborted sudden cardiac death. J Am Coll Cardiol. 2016;68(2):137–145. doi:https://doi.org/10.1016/j.jacc.2016.04.050.
- Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol. 2018;72(14):e91–e220. doi:https://doi.org/10.1016/j.jacc.2017.10.054.
- Koplan BA, Stevenson WG. Ventricular tachycardia and sudden cardiac death. Mayo Clin Proc. 2009;84(3):289–297. doi:https://doi.org/10.1016/S0025-6196(11)61149-X.
- Takagi Y, Takahashi J, Yasuda S, et al. Prognostic stratification of patients with vasospastic angina: a comprehensive clinical risk score developed by the Japanese Coronary Spasm Association. J Am Coll Cardiol. 2013;62(13):1144–1153. doi:https://doi.org/10.1016/j.jacc.2013.07.018.
- Waters DD, Bouchard A, Theroux P. Spontaneous remission is a frequent outcome of variant angina. J Am Coll Cardiol. 1983;2(2):195–199. doi:https://doi.org/10.1016/S0735-1097(83)80153-3.
Pathobiology and evolving therapies of coronary artery vasospasm
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