- Placidi GF, Masuoka D, Alcaraz A, Taylor JA, Earle R. Distribution and metabolism of 14C-metronidazole in mice. Arch Int Pharmacodyn Ther. 1970;188(1):168–179.
- Ings RM, McFadzean MJ, Ormerod WE. The fate of metronidazole and its implications in chemotherapy. Xenobiotica. 1975;5(4):223–235. doi:10.3109/00498257509052069.
- Manthei RW, Feo LG, Stambaugh JE. Identification of the metabolites of metronidazole in the human vagina. Wiadomosci Parazytologiczne. 1969;15(3):403–405. http://www.ncbi.nlm.nih.gov/pubmed/5349981.
- Lamp KC, Freeman CD, Klutman NE, Lacy MK. Pharmacokinetics and pharmacodynamics of the nitroimidazole antimicrobials. Clin Pharmacokinet. 1999;36(5):353–373. doi:10.2165/00003088-199936050-00004.
- Bunz D, Gupta S, Jewesson P. Metronidazole cost containment: a two-stage intervention. Hosp Fomulary. 1990;25(11):1167–1169. http://www.ncbi.nlm.nih.gov/pubmed/10107821.
- Richardson WS, Wilson MC, Nishikawa J, Hayward RS. The well-built clinical question: a key to evidence-based decisions. ACP J Club. 1995;123(3):A12–A13.
- Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372(71). doi:10.1136/bmj.n71.
- Wells GA, Shea B, O’Connell D, et al. The Newcastle-Ottawa scale for assessing the quality of nonrandomized studies in meta-analyses. https://www.ohri.ca/programs/clinical_epidemiology/oxford.asp. Updated 2021. Accessed May 9, 2023.
- Agency for Healthcare Research and Quality. Assessing the risk of bias of individual studies in systematic review of health care interventions. https://effectivehealthcare.ahrq.gov/products/methods-guidance-bias-individual-studies/methods. Updated 2019. Accessed May 15, 2023.
- StataCorp. Stata statistical software. 2021.
- Earl P, Sisson PR, Ingham HR. Twelve-hourly dosage schedule for oral and intravenous metronidazole. J Antimicrob Chemother. 1989;23(4):619–621. doi:10.1093/jac/23.4.619.
- Ibrahim KH, Gunderson BW, Hermsen ED, Hoyde LB, Rotschafer JC. Pharmacodynamics of pulse dosing versus standard dosing: in vitro metronidazole activity against bacteroides fragilis and bacteroides thetaiotaomicron. Antimicrob Agents Chemother. 2004;48(11):4195–4199. doi:10.1128/AAC.48.11.4195-4199.2004.
- Lloyd CJ, Earl PD. Metronidazole: two or three times daily—a comparative controlled clinical trial of the efficacy of two different dosing schedules of metronidazole for chemoprophylaxis following third molar surgery. Br J Oral Maxillofac Surg. 1994;32(3):165–167. doi:10.1016/0266-4356(94)90102-3.
- Wang S, Cunha B, Hamid N, Amato B, Feuerman M, Malone B. Metronidazole single versus multiple daily dosing in serious intraabdominal/pelvic and diabetic foot infections. J Chemother. 2007;19(4):410–416. doi:10.1179/joc.2007.19.4.410.
- Soule AF, Green SB, Blanchette LM. Clinical efficacy of 12-h metronidazole dosing regimens in patients with anaerobic or mixed anaerobic infections. Ther Adv Infect Dis. 2018;5(3):57–62. doi:10.1177/2049936118766462.
- Shah S, Adams K, Merwede J, McManus D, Topal J. Three is a crowd: clinical outcomes of a twice daily versus thrice daily metronidazole dosing strategy from a multicenter study. Anaerobe. 2021;71. doi:10.1016/j.anaerobe.2021.102378.
- Dingsdag SA, Hunter N. Metronidazole: an update on metabolism, structure, cytotoxicity, and resistance mechanisms. J Antimicrob Chemother. 2018;73(2):265–279. doi:10.1093/jac/dkx351.
A comparison of clinical outcomes associated with dosing metronidazole every 8 hours versus every 12 hours: a systematic review and metaanalysis
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