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Baylor University Medical Center Proceedings
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Volume 37, 2024 - Issue 2
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Reviews

A clearer vision: insights into juvenile idiopathic arthritis–associated uveitis

Ihda M. Bani Khalafa Faculty of Medicine, Jordan University of Science and Technology, Irbid, JordanORCID Iconhttps://orcid.org/0000-0001-9283-1546
, MBBSORCID Icon,
Hritvik Jainb Department of Medicine, All India Institute of Medical Sciences, Jodhpur, IndiaORCID Iconhttps://orcid.org/0000-0001-5608-4299
, MBBSORCID Icon,
Nilofar M. Vorac Department of Medicine, Terna Speciality Hospital and Research Centre, Navi Mumbai, IndiaORCID Iconhttps://orcid.org/0009-0003-0098-7327
, MBBSORCID Icon,
Noor ul Aind Department of Medicine, Jinnah Sindh Medical University, Karachi, PakistanORCID Iconhttps://orcid.org/0000-0002-5118-8109
, MBBSORCID Icon,
Farhan Murtazae Department of Medicine, Allama Iqbal Medical College, Lahore, PakistanORCID Iconhttps://orcid.org/0009-0009-0847-3025
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Muskaan Doulat Ramf Department of Medicine, Dow University of Health Sciences, Karachi, PakistanORCID Iconhttps://orcid.org/0000-0002-5701-6906
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Avinash Nankanif Department of Medicine, Dow University of Health Sciences, Karachi, PakistanORCID Iconhttps://orcid.org/0000-0001-9527-7085
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Jatin Motwanig Department of Medicine, Liaquat National Hospital and Medical College, Karachi, PakistanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-7281-6453
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Pages 303-311 | Received 24 Oct 2023, Accepted 02 Jan 2024, Published online: 29 Jan 2024

  • Tugal-Tutkun I, Quartier P, Bodaghi B. Disease of the year: Juvenile idiopathic arthritis-associated uveitis—classification and diagnostic approach. Ocular Immunol Inflammation. 2014;22(1):56–63. doi:10.3109/09273948.2013.871565.
  • Consolaro A, Giancane G, Alongi A, et al. Phenotypic variability and disparities in treatment and outcomes of childhood arthritis throughout the world: an observational cohort study. Lancet Child Adolesc Health. 2019;3(4):255–263. doi:10.1016/s2352-4642(19)30027-6.
  • Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis. Best Pract Res Clin Rheumatol. 2017;31(4):517–534. doi:10.1016/j.berh.2018.01.002.
  • Melin-Aldana H, Giannini EH, Taylor J, et al. Human leukocyte antigen-DRB1*1104 in the chronic iridocyclitis of pauciarticular juvenile rheumatoid arthritis. J Pediatr. 1992;121(1):56–60. doi:10.1016/s0022-3476(05)82541-7.
  • Sabri K, Saurenmann RK, Silverman ED, et al. Course, complications, and outcome of juvenile arthritis–related uveitis. J AAPOS. 2008;12(6):539–545. doi:10.1016/j.jaapos.2008.03.007.
  • Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis. Clin Immunol. 2020;211:108322. doi:10.1016/j.clim.2019.108322.
  • Wildschütz L, Ackermann D, Witten A, et al. Transcriptomic and proteomic analysis of iris tissue and aqueous humor in juvenile idiopathic arthritis-associated uveitis. J Autoimmun. 2019;100:75–83. doi:10.1016/j.jaut.2019.03.004.
  • Edelsten C, Reddy MA, Stanford M, et al. Visual loss associated with pediatric uveitis in English primary and referral centers. Am J Ophthalmol. 2003;135(5):676–680. doi:10.1016/s0002-9394(02)02148-7.
  • De Boer JH, Wulffraat NM, Rothova A. Visual loss in uveitis of childhood. Br J Ophthalmol. 2003;87(7):879–884. doi:10.1136/bjo.87.7.879.
  • Holland GN, Stiehm ER. Special considerations in the evaluation and management of uveitis in children. Am J Ophthalmol. 2003;135(6):867–878. doi:10.1016/s0002-9394(03)00314-3.
  • BenEzra D, Cohen É, Maftzir G. Uveitis in children and adolescents. Br J Ophthalmol. 2005;89(4):444–448. doi:10.1136/bjo.2004.050609.
  • Kump LI, Cervantes-Castañeda RA, Androudi S, et al. Analysis of pediatric uveitis cases at a tertiary referral center. Ophthalmology. 2005;112(7):1287–1292. doi:10.1016/j.ophtha.2005.01.044.
  • Heiligenhaus A, Heinz C, Edelsten C, et al. Review for disease of the year: Epidemiology of juvenile idiopathic arthritis and its associated uveitis: The probable risk factors. Ocul Immunol Inflamm. 2013;21(3):180–191. doi:10.3109/09273948.2013.791701.
  • Giancane G, Alongi A, Ravelli A. Update on the pathogenesis and treatment of juvenile idiopathic arthritis. Curr Opin Rheumatol. 2017;29(5):523–529. doi:10.1097/bor.0000000000000417.
  • Haasnoot AMJW, Schilham MW, Kamphuis S, et al. Identification of an amino acid motif in HLA-DRB1 that distinguishes uveitis in patients with juvenile idiopathic arthritis. Arthritis Rheumatol. 2018;70(7):1155–1165. doi:10.1002/art.40484.
  • Busch M, Wefelmeyer KL, Walscheid K, et al. Identification of ocular autoantigens associated with juvenile idiopathic arthritis-associated uveitis. Front Immunol. 2019;10:1793. doi:10.3389/fimmu.2019.01793.
  • Vanderlugt CJ, Miller SD. Epitope spreading. Curr Opin Immunol. 1996;8(6):831–836. doi:10.1016/s0952-7915(96)80012-4.
  • Parikh J, Tawansy KA, Rao NA. Immunohistochemical study of chronic nongranulomatous anterior uveitis in juvenile idiopathic arthritis. Ophthalmology. 2008;115(10):1833–1836. doi:10.1016/j.ophtha.2008.03.027.
  • Tappeiner C, Klotsche J, Sengler C, et al. Risk factors and biomarkers for the occurrence of uveitis in juvenile idiopathic arthritis. Arthritis Rheumatol. 2018;70(10):1685–1694. doi:10.1002/art.40544.
  • Angeles-Han ST, Pelajo CF, Vogler LB, et al. Risk markers of juvenile idiopathic arthritis-associated uveitis in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry. J Rheumatol. 2013;40(12):2088–2096. doi:10.3899/jrheum.130302.
  • Caspi RR. A look at autoimmunity and inflammation in the eye. J Clin Invest. 2010;120(9):3073–3083. doi:10.1172/jci42440.
  • Ayuso VK, Makhotkina N, Van Tent-Hoeve M, et al. Pathogenesis of juvenile idiopathic arthritis associated uveitis: the known and unknown. Surv Ophthalmol. 2014;59(5):517–531. doi:10.1016/j.survophthal.2014.03.002.
  • Akioka S. Interleukin-6 in juvenile idiopathic arthritis. Mod Rheumatol. 2019;29(2):275–286. doi:10.1080/14397595.2019.1574697.
  • Ooi Kj, Galatowicz G, Calder VL, et al. Cytokines and chemokines in uveitis—is there a correlation with clinical phenotype? Clin Med Res. 2006;4(4):294–309. doi:10.3121/cmr.4.4.294.
  • Saurenmann R, Levin AV, Feldman BM, et al. Risk factors for development of uveitis differ between girls and boys with juvenile idiopathic arthritis. Arthritis Rheum. 2010;62(6):1824–1828. doi:10.1002/art.27416.
  • Ayuso VK, Cate HATT, Van Der Does P, et al. Male gender as a risk factor for complications in uveitis associated with juvenile idiopathic arthritis. Am J Ophthalmol. 2010;149(6):994–999.e5. doi:10.1016/j.ajo.2010.01.016.
  • Haasnoot AMJW, Kuiper JJW, De Boer JH. Predicting uveitis in juvenile idiopathic arthritis: from biomarkers to clinical practice. Expert Rev Clin Immunol. 2019;15(6):657–666. doi:10.1080/1744666x.2019.1593139.
  • Ravelli A, Felici E, Magni-Manzoni S, et al. Patients with antinuclear antibody-positive juvenile idiopathic arthritis constitute a homogeneous subgroup irrespective of the course of joint disease. Arthritis Rheum. 2005;52(3):826–832. doi:10.1002/art.20945.
  • Edelsten C, Lee V, Bentley C, et al. An evaluation of baseline risk factors predicting severity in juvenile idiopathic arthritis associated uveitis and other chronic anterior uveitis in early childhood. Br J Ophthalmol. 2002;86(1):51–56. doi:10.1136/bjo.86.1.51.
  • Vastert SJ, Bhat P, Goldstein DA. Pathophysiology of JIA-associated uveitis. Ocul Immunol Inflamm. 2014;22(5):414–423. doi:10.3109/09273948.2014.926937.
  • Giannini EH, Malagón C, Van Kerckhove C, et al. Longitudinal analysis of HLA associated risks for iridocyclitis in juvenile rheumatoid arthritis. J Rheumatol. 1991;18(9):1394–1397. https://pubmed.ncbi.nlm.nih.gov/1757943.
  • Clarke SLN, Sen ES, Ramanan AV. Juvenile idiopathic arthritis-associated uveitis. Pediatr Rheumatol Online J. 2016;14(1):27. doi:10.1186/s12969-016-0088-2.
  • Murray K, Moroldo MB, Donnelly P, et al. Age-specific effects of juvenile rheumatoid arthritis-associated HLA alleles. Arthritis Rheum. 1999;42(9):1843–1853. doi:10.1002/1529-0131(199909)42:9.
  • Lee RW, Dick AD. Current concepts and future directions in the pathogenesis and treatment of non-infectious intraocular inflammation. Eye (Lond). 2011;26(1):17–28. doi:10.1038/eye.2011.255.
  • Angeles-Han ST, Ringold S, Beukelman T, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the screening, monitoring, and treatment of juvenile idiopathic arthritis–associated uveitis. Arthritis Rheumatol. 2019;71(6):864–877. doi:10.1002/art.40885.
  • Sen ES, Dick AD, Ramanan AV. Uveitis associated with juvenile idiopathic arthritis. Nat Rev Rheumatol. 2015;11(6):338–348. doi:10.1038/nrrheum.2015.20.
  • Tappeiner C, Heinz C, Roesel M, et al. Elevated laser flare values correlate with complicated course of anterior uveitis in patients with juvenile idiopathic arthritis. Acta Ophthalmol. 2011;89(6):e521–e527. doi:10.1111/j.1755-3768.2011.02162.x.
  • Heinz C, Schumacher C, Roesel M, et al. Elevated intraocular pressure in uveitis associated with juvenile idiopathic arthritis-associated uveitis, often detected after achieving inactivity: Table 1. Br J Ophthalmol. 2011;96(1):140–141. doi:10.1136/bjophthalmol-2011-300731.
  • Papadopoulou M, Zetterberg M, Oskarsdottir S, et al. Assessment of the outcome of ophthalmological screening for uveitis in a cohort of Swedish children with juvenile idiopathic arthritis. Acta Ophthalmol. 2017;95(7):741–747. doi:10.1111/aos.13388.
  • Lee JJ, Duffy CM, Guzman J, et al. Prospective determination of the incidence and risk factors of new‐onset uveitis in juvenile idiopathic arthritis: The research in arthritis in Canadian children emphasizing outcomes cohort. Arthritis Care Res (Hoboken). 2019;71(11):1436–1443. doi:10.1002/acr.23783.
  • Castro C, Gourley MF. Diagnostic testing and interpretation of tests for autoimmunity. J Allergy Clin Immunol. 2010;125(Suppl 2):S238–S247. doi:10.1016/j.jaci.2009.09.041.
  • Mullins RF, Russell SR, Anderson DH, et al. Drusen associated with aging and age‐related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J. 2000;14(7):835–846. doi:10.1096/fasebj.14.7.835.
  • Packham JC, Hall MA. Long-term follow-up of 246 adults with juvenile idiopathic arthritis: functional outcome. Rheumatology (Oxford). 2002;41(12):1428–1435. doi:10.1093/rheumatology/41.12.1428.
  • Ghosh S, Padmanabhan A, Vaidya T, Watson AM, Bhutto IA, Hose S, Shang P. Neutrophils homing into the retina trigger pathology in early age-related macular degeneration. Commun Biol. 2019;2(1):348. doi:10.1038/s42003-019-0588-y.
  • Ayuso VK, De Boer JH, Byers HL, et al. Intraocular biomarker identification in uveitis associated with juvenile idiopathic arthritis. Invest Ophthalmol Vis Sci. 2013;54(5):3709–3720. doi:10.1167/iovs.12-10865.
  • Buxbaum JN, Reixach N. Transthyretin: the servant of many masters. Cell Mol Life Sci. 2009;66(19):3095–3101. doi:10.1007/s00018-009-0109-0.
  • Angeles-Han ST, Yeh S, Patel P, et al. Discovery of tear biomarkers in children with chronic non-infectious anterior uveitis: a pilot study. J Ophthalmic Inflamm Infect. 2018;8(1):17. doi:10.1186/s12348-018-0156-5.
  • Carreño E, Portero A, Herreras JM, et al. Cytokine and chemokine tear levels in patients with uveitis. Acta Ophthalmol. 2016;95(5):e405–e414. doi:10.1111/aos.13292.
  • Rutkowska-Sak L, Gietka P. Uveitis associated juvenile idiopathic arthritis – presentation of recently published international recommendations for diagnostic and therapeutic procedures. Reumatologia. 2020;58(5):277–281. doi:10.5114/reum.2020.100169.
  • Heiligenhaus A, Minden K, Föll D, et al. Uveitis in juvenile idiopathic arthritis. Dtsch Arztebl Int. 2015;112(6):92–100. doi:10.3238/arztebl.2015.0092.
  • Yasumura J, Yashiro M, Okamoto N, et al. Clinical features and characteristics of uveitis associated with juvenile idiopathic arthritis in Japan: first report of the pediatric rheumatology association of Japan (PRAJ). Pediatr Rheumatol Online J. 2019;17(1):15. doi:10.1186/s12969-019-0318-5.
  • Angeles-Han ST, Srivastava SK. Screening, monitoring, and treating children with juvenile idiopathic arthritis-associated uveitis: Visualizing better outcomes. J Rheumatol. 2022;50(3):300–303. doi:10.3899/jrheum.221092.
  • Angeles-Han ST, McCracken C, Yeh S, et al. Characteristics of a cohort of children with juvenile idiopathic arthritis and JIA-associated uveitis. Pediatr Rheumatol Online J. 2015;13(1):19. doi:10.1186/s12969-015-0018-8.
  • Angeles-Han ST, Yeh S. Prevention and management of cataracts in children with juvenile idiopathic arthritis–associated uveitis. Curr Rheumatol Rep. 2011;14(2):142–149. doi:10.1007/s11926-011-0229-z.
  • Nascimento H, Yasuta MK, Marquezan MC, et al. Uveitic band keratopathy: child and adult. J Ophthalmic Inflamm Infect. 2015;5(1):35. doi:10.1186/s12348-015-0062-z.
  • Chang JH, McCluskey PJ, Grigg JR. Recurrent hypopyon in chronic anterior uveitis of pauciarticular juvenile idiopathic arthritis. Br J Ophthalmol. 2006;90(10):1327–1328. doi:10.1136/bjo.2006.096313.
  • Ying Q, Acharya NR. Juvenile idiopathic arthritis-associated uveitis. Curr Opin Ophthalmol. 2010;21(6):468–472. doi:10.1097/icu.0b013e32833eab83.
  • Bou R, Adán A, Borrás F, et al. Clinical management algorithm of uveitis associated with juvenile idiopathic arthritis: interdisciplinary panel consensus. Rheumatol Int. 2015;35(5):777–785. doi:10.1007/s00296-015-3231-3.
  • Heiligenhaus A, Michels H, Schumacher C, et al. Evidence-based, interdisciplinary guidelines for anti-inflammatory treatment of uveitis associated with juvenile idiopathic arthritis. Rheumatol Int. 2011;32(5):1121–1133. doi:10.1007/s00296-011-2126-1.
  • Hawkins MJ, Dick AD, Lee RW, et al. Managing juvenile idiopathic arthritis–associated uveitis. Surv Ophthalmol. 2016;61(2):197–210. doi:10.1016/j.survophthal.2015.10.005.
  • Simonini G, Cantarini L, Bresci C, et al. Current therapeutic approaches to autoimmune chronic uveitis in children. Autoimmun Rev. 2010;9(10):674–683. doi:10.1016/j.autrev.2010.05.017.
  • Foster CS, Alter G, Debarge LR, et al. Efficacy and safety of rimexolone 1% ophthalmic suspension vs 1% prednisolone acetate in the treatment of uveitis. Am J Ophthalmol. 1996;122(2):171–182. doi:10.1016/s0002-9394(14)72008-2.
  • Wakefield D, McCluskey P, Penny R. Intravenous pulse methylprednisolone therapy in severe inflammatory eye disease. Arch Ophthalmol. 1986;104(6):847–851. doi:10.1001/archopht.1986.01050180081035.
  • Ramanan AV, Dick AD. Blinded by lack of evidence. Rheumatology (Oxford). 2012;52(5):765–766. doi:10.1093/rheumatology/kes340.
  • Sharma SM, Dick AD, Ramanan AV. Non-infectious pediatric uveitis. Paediatr Drugs. 2009;11(4):229–241. doi:10.2165/00148581-200911040-00002.
  • Ramanan AV, Dick AD, Benton D, et al. A randomised controlled trial of the clinical effectiveness, safety and cost-effectiveness of adalimumab in combination with methotrexate for the treatment of juvenile idiopathic arthritis associated uveitis (SYCAMORE Trial). Trials. 2014;15(1):14. doi:10.1186/1745-6215-15-14.
  • Smith JA, Thompson DJS, Whitcup SM, et al. A randomized, placebo-controlled, double-masked clinical trial of etanercept for the treatment of uveitis associated with juvenile idiopathic arthritis. Arthritis Rheum. 2005;53(1):18–23. doi:10.1002/art.20904.
  • Simonini G, Druce KL, Cimaz R, et al. Current evidence of anti-tumor necrosis factor α treatment efficacy in childhood chronic uveitis: A systematic review and meta-analysis approach of individual drugs. Arthritis Care Res (Hoboken). 2014;66(7):1073–1084. doi:10.1002/acr.22214.
  • Simonini G, Taddio A, Cattalini M, et al. Prevention of flare recurrences in childhood-refractory chronic uveitis: An open-label comparative study of adalimumab versus infliximab. Arthritis Care Res (Hoboken). 2011;63(4):612–618. doi:10.1002/acr.20404.
  • Quiñones K, Cervantes-Castañeda RA, Hynes AY, et al. Outcomes of cataract surgery in children with chronic uveitis. J Cataract Refract Surg. 2009;35(4):725–731. doi:10.1016/j.jcrs.2008.12.014.
  • Freedman SF, Rodriguez-Rosa RE, Rojas MC, et al. Goniotomy for glaucoma secondary to chronic childhood uveitis. Am J Ophthalmol. 2002;133(5):617–621. doi:10.1016/s0002-9394(02)01344-2.
  • Lanz S, Seidel G, Skrabl-Baumgartner A. Golimumab in juvenile idiopathic arthritis-associated uveitis unresponsive to Adalimumab. Pediatr Rheumatol Online J. 2021;19(1):132. doi:10.1186/s12969-021-00630-1.
  • Iannone C, Marelli L, Costi S, et al. Tocilizumab in juvenile idiopathic arthritis associated uveitis, a narrative review. Children (Basel). 2023;10(3):434. doi:10.3390/children10030434.
  • Burlo F, Tumminelli C, Pastore S, et al. Subcutaneous tocilizumab in the management of non-infectious uveitis in children: a brief report. Pediatr Rheumatol Online J. 2023;21(1):99. doi:10.1186/s12969-023-00883-y.
  • Marino A, Marelli L, Nucci P, et al. Subcutaneous tocilizumab in juvenile idiopathic arthritis associated uveitis. Ocul Immunol Inflamm. 2023;31(10):1997–2000. doi:10.1080/09273948.2022.2161916.
  • Baquet-Walscheid K, Heinz C, Rath T, et al. Beneficial effect of upadacitinib in an adult patient with juvenile idiopathic arthritis-associated uveitis after unsatisfactory response to tofacitinib: A case report. Ocul Immunol Inflamm. 2022;31(5):1079–1080. doi:10.1080/09273948.2022.2069128.
  • Maccora I, Land P, Utz VM, et al. Therapeutic potential of JAK inhibitors in juvenile idiopathic arthritis-associated uveitis. Expert Rev Clin Immunol. 2023;19(7):689–692. doi:10.1080/1744666x.2023.2207823.
  • Arve-Butler S, Mossberg A, Kahn F, et al. Identification of novel autoantigens as potential biomarkers in juvenile idiopathic arthritis associated uveitis. Front Pediatr. 2022;10:1091308. doi:10.3389/fped.2022.1091308.
  • Angeles-Han ST, Ringold S, Beukelman T, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the screening, monitoring, and treatment of juvenile idiopathic arthritis–associated uveitis. Arthritis Care Res (Hoboken). 2019;71(6):703–716. doi:10.1002/acr.23871.
  • Chen JL, Abiri P, Tsui E. Recent advances in the treatment of juvenile idiopathic arthritis–associated uveitis. Ther Adv Ophthalmol. 2021;13:2515841420984572. doi:10.1177/2515841420984572.
  • Carlsson E, Beresford MW, Ramanan AV, et al. Juvenile idiopathic arthritis associated uveitis. Children (Basel). 2021;8(8):646. doi:10.3390/children8080646.
  • Gueudry J, Touhami S, Quartier P, et al. Therapeutic advances in juvenile idiopathic arthritis–associated uveitis. Curr Opin Ophthalmol. 2019;30(3):179–186. doi:10.1097/icu.0000000000000559.

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