Advanced search
Publication Cover
Baylor University Medical Center Proceedings
The peer-reviewed journal of Baylor Scott & White Health
Volume 37, 2024 - Issue 4
Submit an article Journal homepage
26
Views
1
CrossRef citations to date
0
Altmetric
Featured Article

Burden of delirium on mortality and healthcare resource utilization in geriatric patients hospitalized for inflammatory bowel disease

Mohammad Aldiabata Department of Epidemiology, Harvard T. H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA;b Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USACorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0002-4536-2799
, MDORCID Icon,
Wesam Aleyadehc Department of Medicine, Akron General Hospital, Akron, Ohio, USA
, MD,
Tabeer Ranad Department of Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA
, DO,
Omar Al Ta’anid Department of Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania, USA
, MD,
Majd Alahmade Department of Medicine, University of Missouri–Columbia, Columbia, Missouri, USA
, MD,
Malek Ayoubb Department of Medicine, Washington University in St. Louis, St. Louis, Missouri, USA
, MD,
Fouad Jaberf Department of Medicine, University of Missouri–Kansas City, Kansas City, Missouri, USA
, MD,
Adham Obeidatg Presbyterian Health System, Albuquerque, New Mexico, USA
, MD,
Laith Numanh Division of Gastroenterology, SSM Health Saint Louis University Hospital, St. Louis, Missouri, USA
, MD,
Amar Manvari Division of Gastroenterology, NYU Langone Health, Mineola, New York, USA
, MD &
Laith Alhuneafatj Department of Cardiovascular Disease, University of Minnesota, Minneapolis, Minnesota, USA
, MD show all
Pages 509-515 | Received 25 Feb 2024, Accepted 28 Mar 2024, Published online: 22 Apr 2024

  • Fong TG, Tulebaev SR, Inouye SK. Delirium in elderly adults: diagnosis, prevention and treatment. Nat Rev Neurol. 2009;5(4):210–220. doi:10.1038/nrneurol.2009.24.
  • Riazi K, Galic MA, Kentner AC, Reid AY, Sharkey KA, Pittman QJ. Microglia-dependent alteration of glutamatergic synaptic transmission and plasticity in the hippocampus during peripheral inflammation. J Neurosci. 2015;35(12):4942–4952. doi:10.1523/JNEUROSCI.4485-14.2015.
  • Hollerbach SH, Kullmann F, Geissler A, Schoelmerich J, Andus T. Impairment of short-term memory function and morphologic brain abnormalities in inflammatory bowel disease (IBD). Gastroenterology. 2000;118(4):A313. doi:10.1016/S0016-5085(00)83343-0.
  • Fan W, Zhang S, Hu J, et al. Aberrant brain function in active-stage ulcerative colitis patients: a resting-state functional MRI study. Front Hum Neurosci. 2019;13:107. doi:10.3389/FNHUM.2019.00107.
  • Agostini A, Ballotta D, Righi S, et al. Stress and brain functional changes in patients with Crohn’s disease: a functional magnetic resonance imaging study. Neurogastroenterol Motil. 2017;29(10):1–10. doi:10.1111/NMO.13108.
  • van Langenberg DR, Yelland GW, Robinson SR, Gibson PR. Cognitive impairment in Crohn’s disease is associated with systemic inflammation, symptom burden and sleep disturbance. United European Gastroenterol J. 2017;5(4):579–587. doi:10.1177/2050640616663397.
  • Agostini A, Filippini N, Cevolani D, et al. Brain functional changes in patients with ulcerative colitis: A functional magnetic resonance imaging study on emotional processing. Inflamm Bowel Dis. 2011;17(8):1769–1777. doi:10.1002/IBD.21549.
  • Li S, Liu M, Cao S, et al. The mechanism of the gut-brain axis in regulating food intake. Nutrients. 2023;15(17):3728. doi:10.3390/NU15173728.
  • Oudman E, Wijnia JW, Oey MJ, van Dam M, Postma A. Wernicke’s encephalopathy in Crohn’s disease and ulcerative colitis. Nutrition. 2021;86:111182. doi:10.1016/J.NUT.2021.111182.
  • Hildenbrand FF, Murray FR, von Känel R, et al. Predisposing and precipitating risk factors for delirium in gastroenterology and hepatology: subgroup analysis of 718 patients from a hospital-wide prospective cohort study. Front Med (Lausanne). 2022;9:1004407. doi:10.3389/FMED.2022.1004407/FULL.
  • Zhang B, Wang HE, Bai YM, et al. Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study. Gut. 2021;70(1):85–91. doi:10.1136/GUTJNL-2020-320789.
  • Zingel R, Bohlken J, Kostev K. Association between inflammatory bowel disease and dementia: a retrospective cohort study. J Alzheimers Dis. 2021;80(4):1471–1478. doi:10.3233/JAD-210103.
  • Rønnow Sand J, Troelsen FS, Horváth-Puhó E, Henderson VW, Sørensen HT, Erichsen R. Risk of dementia in patients with inflammatory bowel disease: a Danish population‐based study. Aliment Pharmacol Ther. 2022;56(5):831–843. doi:10.1111/APT.17119.
  • Cooper J, Pastorello Y, Slevin M. A meta-analysis investigating the relationship between inflammation in autoimmune disease, elevated CRP, and the risk of dementia. Front Immunol. 2023;14:1087571. doi:10.3389/FIMMU.2023.1087571/BIBTEX.
  • Nimmons D, Limdi JK. Elderly patients and inflammatory bowel disease. World J Gastrointest Pharmacol Ther. 2016;7(1):51–65. http://www.wjgnet.com/. doi:10.4292/WJGPT.V7.I1.51.
  • von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. Strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies. BMJ. 2007;335(7624):806–808. doi:10.1136/BMJ.39335.541782.AD.
  • Kelley KA, Tsikitis VL, Clinical research using the National Inpatient Sample: a brief review of colorectal studies utilizing the NIS database. Clin Colon Rectal Surg. 2019;32(1):33–40. doi:10.1055/S-0038-1673352.
  • National (Nationwide) Inpatient Sample (NIS). Accessed September 19, 2023. https://hcup-us.ahrq.gov/news/exhibit_booth/nis_brochure.jsp.
  • Ritter SRF, Cardoso AF, Lins MMP, Zoccoli TLV, Freitas MPD, Camargos EF. Underdiagnosis of delirium in the elderly in acute care hospital settings: lessons not learned. Psychogeriatrics. 2018;18(4):268–275. doi:10.1111/PSYG.12324.
  • Mart MF, Williams Roberson S, Salas B, Pandharipande PP, Ely EW. Prevention and management of delirium in the intensive care unit. Semin Respir Crit Care Med. 2021;42(1):112–126. doi:10.1055/S-0040-1710572.
  • Lakatos PL, David G, Pandur T, et al. IBD in the elderly population: results from a population-based study in Western Hungary, 1977–2008. J Crohns Colitis. 2011;5(1):5–13. doi:10.1016/J.CROHNS.2010.08.004.
  • Leslie DL, Marcantonio ER, Zhang Y, Leo-Summers L, Inouye SK. One-year health care costs associated with delirium in the elderly population. Arch Intern Med. 2008;168(1):27–32. doi:10.1001/ARCHINTERNMED.2007.4.
  • John ES, Katz K, Saxena M, Chokhavatia S, Katz S. Management of inflammatory bowel disease in the elderly. Curr Treat Options Gastroenterol. 2016;14(3):285–304. doi:10.1007/S11938-016-0099-6.
  • Ananthakrishnan AN, Donaldson T, Lasch K, Yajnik V. Management of inflammatory bowel disease in the elderly patient: challenges and opportunities. Inflamm Bowel Dis. 2017;23(6):882–893. doi:10.1097/MIB.0000000000001099.
  • Goldberg TE, Chen C, Wang Y, et al. Association of delirium with long-term cognitive decline: a meta-analysis. JAMA Neurol. 2020;77(11):1373–1381. doi:10.1001/JAMANEUROL.2020.2273.
  • Pandharipande PP, Girard TD, Jackson JC, et al. Long-term cognitive impairment after critical illness. N Engl J Med. 2013;369(14):1306–1316. doi:10.1056/NEJMOA1301372.
  • Wilcox ME, Girard TD, Hough CL. Delirium and long term cognition in critically ill patients. BMJ. 2021;373:n1007. doi:10.1136/BMJ.N1007.
  • Malouf R, Grimley EJ, Areosa SA. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst Rev. 2003;(4):CD004514. doi:10.1002/14651858.CD004514.
  • Sevuk U, Baysal E, Ay N, et al. Relationship between cobalamin deficiency and delirium in elderly patients undergoing cardiac surgery. Neuropsychiatr Dis Treat. 2015;11:2033–2039. doi:10.2147/NDT.S87888.
  • Hshieh TT, Inouye SK, Oh ES. Delirium in the elderly. Clin Geriatr Med. 2020;36(2):183–199. doi:10.1016/j.cger.2019.11.001.
  • Korevaar JC, Van Munster BC, De Rooij SE. Risk factors for delirium in acutely admitted elderly patients: a prospective cohort study. BMC Geriatr. 2005;5(1):6. doi:10.1186/1471-2318-5-6.
  • Meagher D. Delirium: the role of psychiatry. Adv Psychiatr Treat. 2001;7(6):433–442. doi:10.1192/apt.7.6.433.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.