1,238
Views
6
CrossRef citations to date
0
Altmetric
Food & Nutrition Science

Ascorbic acid deficiency decreases hepatic cytochrome P-450, especially CYP2B1/2B2, and simultaneously induces heme oxygenase-1 gene expression in scurvy-prone ODS rats

, , , , , & show all
Pages 1060-1066 | Received 23 Dec 2013, Accepted 18 Jan 2014, Published online: 28 May 2014

References

  • Horio F, Ozaki K, Kohmura M, Yoshida A, Makino S, Hayashi Y. Ascorbic acid requirement for the induction of microsomal drug-metabolizing enzymes in a rat mutant unable to synthesize ascorbic acid. J. Nutr. 1986;116:2278–2289.
  • Zannoni VG, Sato PH. Interaction with drugs and environmental chemicals. Effects of ascorbic acid on microsomal drug metabolism. Ann. N. Y. Acad. Sci. 1975;258:119–131.10.1111/nyas.1975.258.issue-1
  • Horio F, Ozaki K, Yoshida A, Makino S, Hayashi Y. Requirement for ascorbic acid in a rat mutant unable to synthesize ascorbic acid. J. Nutr. 1985;115:1630–1640.
  • Zannoni VG, Flynn EJ, Lynch M. Ascorbic acid and drug metabolism. Biochem. Pharmacol. 1972;21:1377–1392.10.1016/0006-2952(72)90362-0
  • Mori T, Kitamura R, Imaoka S, Funae Y, Matsubara T, Kamataki T. Increased CYP1A2 content and capacity to activate Glu-P-1 and Trp-P-2 in liver microsomes of scorbutic ODS rats. Carcinogenesis. 1993;14:2471–2475.10.1093/carcin/14.12.2471
  • Matsushita N, Kobayashi T, Oda H, Horio F, Yoshida A. Ascorbic acid deficiency reduces the level of mRNA for cytochrome P-450 on the induction by polychlorinated biphenyls. J. Nutr. Sci. Vitaminol. (Tokyo). 1993;39:289–302.10.3177/jnsv.39.289
  • Lu AY, West SB. Multiplicity of mammalian microsomal cytochromes P-450. Pharmacol. Rev. 1979;31:277–295.
  • Nebert DW, Gonzalez FJ. P450 genes: structure, evolution, and regulation. Annu. Rev. Biochem. 1987;56:945–993.10.1146/annurev.bi.56.070187.004501
  • Maines MD, Kappas A. Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc. Natl. Acad. Sci. U.S.A. 1974;71:4293–4297.10.1073/pnas.71.11.4293
  • Maines MD, Kappas A. The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system. J. Biol. Chem. 1975;250:2363–2369.
  • Drummond MD, Kappas A. Prevention of neonatal hyperbilirubinemia by tin protoporphyrin IX, a potent competitive inhibitor of heme oxidation. Proc. Natl. Acad. Sci U.S.A. 1981;78:6466–6470.
  • Converso DP, Taillé C, Carreras MC, Jaitovich A, Poderoso JJ, Boczkowski J. HO-1 is located in liver mitochondria and modulates mitochondrial heme content and metabolism. FASEB J. 2006;20:1236–1238.10.1096/fj.05-4204fje
  • Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y. Gene structure of a major form of phenobarbital-inducible cytochrome P-450 in rat liver. J. Biol. Chem. 1985;260:7980–7984.
  • Reeves PG, Nielsen FH, Fahey GC. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 1993;123:1939–1951.
  • Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 1964;239:2370–2378.
  • Doré S, Takahashi M, Ferris CD, Hester LD, Guastella D, Snyder SH. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury. Proc. Natl. Acad. Sci. U.S.A. 1999;96:2445–2450.10.1073/pnas.96.5.2445
  • Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science. 1987;235:1043–1046.10.1126/science.3029864
  • Keyse SM, Tyrrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc. Natl. Acad. Sci. U.S.A. 1989;86:99–103.10.1073/pnas.86.1.99
  • Tomaro ML, Frydman J, Frydman RB. Heme oxygenase induction by CoCl2, Co-protoporphyrin IX, phenylhydrazine, and diamide: evidence for oxidative stress involvement. Arch. Biochem. Biophys. 1991;286:610–617.10.1016/0003-9861(91)90088-Z
  • Vile GF, Tyrrell RM. Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin. J. Biol. Chem. 1993;268:14678–14681.
  • Yamaguchi T, Hashizume T, Tanaka M, Nakayama M, Sugimoto A, Ikeda S, Nakajima H, Horio F. Bilirubin oxidation provoked by endotoxin treatment is suppressed by feeding ascorbic acid in a rat mutant unable to synthesize ascorbic acid. Eur. J. Biochem. 1997;245:233–240.10.1111/ejb.1997.245.issue-2
  • Sultana S, Nirodi CS, Ram N, Prabhu L, Padmanaban G. A 65-kDa protein mediates the positive role of heme in regulating the transcription of CYP2B1/B2 gene in rat liver. J. Biol. Chem. 1997;272:8895–8900.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.