References
- Fahy JV, Dickey BF. Airway mucus function and dysfunction. N. Engl. J. Med. 2010;363:2233–2247.10.1056/NEJMra0910061
- Button B, Cai LH, Ehre C, et al. A periciliary brush promotes the lung health by separating the mucus layer from airway epithelia. Science. 2012;337:937–941.10.1126/science.1223012
- Aikawa T, Shimura S, Sasaki H, et al. Marked goblet cell hyperplasia with mucus accumulation in the airways of patients who died of severe acute asthma attack. Chest. 1992;101:916–921.10.1378/chest.101.4.916
- Vestbo J. Epidemiological studies in mucus hypersecretion. Novartis Found. Symp. 2002;248:3–12; discussion 12–19, 277–282.
- Rose MC, Voynow JA. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 2006;86:245–278.10.1152/physrev.00010.2005
- Fahy JV. Goblet cell and mucin gene abnormalities in asthma. Chest. 2002;122:320S–326S.10.1378/chest.122.6_suppl.320S
- Lai HY, Rogers DF. Mucus hypersecretion in asthma: intracellular signalling pathways as targets for pharmacotherapy. Curr. Opin. Allergy Clin. Immunol. 2010;10:67–76.10.1097/ACI.0b013e328334643a
- Davies JR, Svitacheva N, Lannefors L, et al. Identification of MUC5B, MUC5AC and small amounts of MUC2 mucins in cystic fibrosis airway secretions. Biochem. J. 1999;344:321–330.10.1042/0264-6021:3440321
- Chen Y, Zhao YH, Di YP, et al. Characterization of human mucin 5B gene expression in airway epithelium and the genomic clone of the amino-terminal and 5′-flanking region. Am. J. Respir. Cell Mol. Biol. 2001;25:542–553.10.1165/ajrcmb.25.5.4298
- Roy MG, Livraghi-Butrico A, Fletcher AA, et al. Muc5b is required for airway defence. Nature. 2014;505:412–416.
- Song KS, Lee WJ, Chung KC, et al. Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J. Biol. Chem. 2003;278:23243–23250.10.1074/jbc.M300096200
- Iwashita J, Ose K, Ito H, et al. Inhibition of E-cadherin dependent cell–cell contact promotes MUC5AC mucin production through the activation of epidermal growth factor receptors. Biosci. Biotechnol. Biochem. 2011;75:688–693.10.1271/bbb.100830
- Iwashita J, Yamamoto T, Sasaki Y, et al. MUC5AC production is downregulated in NCI-H292 lung cancer cells cultured on type-IV collagen. Mol. Cell. Biochem. 2010;337:65–75.10.1007/s11010-009-0286-z
- Ingber DE, Dike L, Hansen L, et al. Cellular tensegrity: exploring how mechanical changes in the cytoskeleton regulate cell growth, migration, and tissue pattern during morphogenesis. Int. Rev. Cytol. 1994;150:173–224.
- Johnson PR. Role of human airway smooth muscle in altered extracellular matrix production in asthma. Clin. Exp. Pharmacol. Physiol. 2001;28:233–236.10.1046/j.1440-1681.2001.03426.x
- Johnson PR, Black JL, Carlin S, et al. The production of extracellular matrix proteins by human passively sensitized airway smooth-muscle cells in culture: the effect of beclomethasone. Am. J. Respir. Crit. Care Med. 2000;162:2145–2151.10.1164/ajrccm.162.6.9909111
- Johnson PR, Burgess JK, Underwood PA, et al. Extracellular matrix proteins modulate asthmatic airway smooth muscle cell proliferation via an autocrine mechanism. J. Allergy Clin. Immunol. 2004;113:690–696.10.1016/j.jaci.2003.12.312
- Sasaki T, Fassler R, Hohenester E. Laminin: the crux of basement membrane assembly. J. Cell Biol. 2004;164:959–963.10.1083/jcb.200401058
- Heino J, Kapyla J. Cellular receptors of extracellular matrix molecules. Curr. Pharm. Des. 2009;15:1309–1317.10.2174/138161209787846720
- De Arcangelis A, Georges-Labouesse E. Integrin and ECM functions: roles in vertebrate development. Trends Genet. 2000;16:389–395.10.1016/S0168-9525(00)02074-6
- McCall-Culbreath KD, Zutter MM. Collagen receptor integrins: rising to the challenge. Curr. Drug Targets. 2008;9:139–149.
- Roskelley CD, Srebrow A, Bissell MJ. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr. Opin. Cell Biol. 1995;7:736–747.10.1016/0955-0674(95)80117-0
- Yee KL, Weaver VM, Hammer DA. Integrin-mediated signalling through the MAP-kinase pathway. IET Syst. Biol. 2008;2:8–15.10.1049/iet-syb:20060058
- Aikawa R, Nagai T, Kudoh S, et al. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension. 2002;39:233–238.10.1161/hy0202.102699
- Iwashita J, Ito Y, Yokoo M, et al. Akt induces down regulation of MUC5AC production in NCI-H292 human airway epithelial cells cultured on extracellular matrix. Biosci. Biotechnol. Biochem. 2014;78:212–221.10.1080/09168451.2014.877829
- Ge B, Gram H, Di Padova F, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science. 2002;295:1291–1294.10.1126/science.1067289
- Rogers DF, Barnes PJ. Treatment of airway mucus hypersecretion. Ann. Med. 2006;38:116–125.10.1080/07853890600585795
- Christie PE, Jonas M, Tsai CH, et al. Increase in laminin expression in allergic airway remodelling and decrease by dexamethasone. Eur. Respir. J. 2004;24:107–115.10.1183/09031936.04.00013303
- Woodruff PG, Modrek B, Choy DF, et al. T-helper type 2-driven inflammation defines major subphenotypes of asthma. Am. J. Respir. Crit. Care Med. 2009;180:388–395.10.1164/rccm.200903-0392OC