References
- Schaffner F, Thaler H. Nonalcoholic fatty liver disease. Prog. Liver Dis. 1986;8:283–298.
- Kotronen A, Yki-Järvinen H. Fatty Liver: A novel component of the metabolic syndrome. Arterioscler. Thromb. Vasc. Biol. 2007;28:27–38.10.1161/ATVBAHA.107.147538
- Bedogni G, Miglioli L, Masutti F, et al. Prevalence of and risk factors for nonalcoholic fatty liver disease: The dionysos nutrition and liver study. Hepatology. 2005;42:44–52.10.1002/(ISSN)1527-3350
- Cohen JC, Horton JD, Hobbs HH. Human fatty liver disease: old questions and new insights. Science. 2011;332:1519–1523.10.1126/science.1204265
- Faidon M, Xiong S, David B, et al. Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects. Gastroenterology. 2012;142:1444–1446.
- Naoki K, Derek ME, Dongyan Z. Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease. Proc. Natl. Acad. Sci. USA. 2011;108:16381–16385.
- Fantuzzi G. Adipose tissue, adipokines, and inflammation. J. Allergy Clin. Immunol. 2005;115:911–919.10.1016/j.jaci.2005.02.023
- Boden G. Free fatty acids-the link between obesity and insulin resistance. Endocr. Pract. 2001;7:44–51.10.4158/EP.7.1.44
- Nishii N, Maeda H, Murahata Y, et al. Experimental hyperlipemia induces insulin resistance in cats. J. Vet. Med. Sci. 2012;74:267–269.10.1292/jvms.11-0266
- Després Jean-Pierre, Lemieux Isabelle. Abdominal obesity and metabolic syndrome. Nature. 2006;444:881–887.10.1038/nature05488
- Chen W, Yu M, Zhu M, et al. Clinical analysis on metabolic syndrome in the elderly cadres. J. Shanghai Med. 2004;31:199–201.
- Wilson PW, D’Agostino RB, Parise H, et al. Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation. 2005;112:3066–3072.10.1161/CIRCULATIONAHA.105.539528
- Elena VK, Natalia ET, Alla VR. Gender differences in lipid metabolism of the young patients with metabolic syndrome longtime living in the North. Life Sci J. 2014;11:270–274.
- Mohamed A, François RJ. Metabolic syndrome and nonalcoholic fatty liver disease: Is insulin resistance the link? Mol. Cell. Endocrinol. 2015;S0303–7207:00094–00095.
- Standerfer SB, Handler P. Fatty liver induced by orotic acid feeding. Exp. Biol. Med. 1955;90:270–271.10.3181/00379727-90-22005
- Zhang B, Xue C, Hu X, et al. Dietary sea cucumber cerebroside alleviates orotic acid-induced excess hepatic adipopexisin rats. Lipids Health Dis. 2012;8:11–48.
- Cha JY, Mameda Y, Yamamoto K, et al. Association between hepatic triacylglycerol accumulation induced by administering orotic acid and enhanced phosphatidate phosphohydrolase activity in rats. Biosci. Biotechnol. Biochem. 1998;62:508–513.10.1271/bbb.62.508
- Wang Y, Hu X, Xue Y, et al. Study on possible mechanism of orotic acid–induced fatty liver in rats. Nutrition. 2011;27:571–575.10.1016/j.nut.2010.03.005
- Ken-ichiro K, Yumie T, Hirofumi M, et al. Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease. J. Diabetes Investig. 2015;6:158–163.
- Asai A, Chou PM, Bu HF, et al. Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2014;306:G496–G504.10.1152/ajpgi.00291.2013
- Samuel VT1, Liu ZX, Qu. X, et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J. Biol. Chem. 2004;279:32345-32353.10.1074/jbc.M313478200
- Padiya R, Khatua TN, Bagul PK, et al. Banerjee garlic improves insulin sensitivity and associated metabolic syndromes in fructose fed rats nutrition and metabolism. Nutr. Metab. (Lond). 2011;27:8–53.
- Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation purification of total lipids from animal tissues. J. Biol. Chem. 1957;226:497–509.
- Bartlett GR. Phosphorous assay in column chromatography. J. Biol. Chem. 1959;234:466–468.
- Cohen P. Control of Enzyme Activity. New York, NY: Chapman and Hall; 1983.10.1007/978-94-009-5981-1
- Cohen P, Frame S. The renaissance of GSK3. Nat. Rev. Mol. Cell Biol. 2001;2:769–776.10.1038/35096075
- Angulo P. Nonalcoholic fatty liver disease. N. Engl. J. Med. 2002;346:1221–1231.10.1056/NEJMra011775
- Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51:679–689.10.1002/hep.23280
- Shulman GI. Cellular mechanisms of insulin resistance. J. Clin. Invest. 2000;106:171–176.10.1172/JCI10583
- Srivastava AK, Pandey SK. Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin. Mol. Cell. Biochem. 1998;182:135–141.10.1023/A:1006857527588
- Lochhead PA, Salt IP, Walker KS, et al. 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase. Diabetes. 2000;49:896–903.10.2337/diabetes.49.6.896
- Lee JM, Seo WY, Song KH. AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB CRTC2 complex by orphan nuclear receptor small heterodimer partner. J. Biol. Chem. 2010;285:32182–32191.10.1074/jbc.M110.134890
- Barthel A, Schmoll D. Novel concepts in insulin regulation of hepatic gluconeogenesis. Am. J. Physiol. Endocrinol. Metab. 2003;285:E685–E692.10.1152/ajpendo.00253.2003
- Asai A, Chou PM, Bu HF. Dissociation of hepatic insulin resistance from susceptibility of nonalcoholic fatty liver disease induced by a high-fat and high-carbohydrate diet in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2014;306:G496–G504.10.1152/ajpgi.00291.2013
- Kotani K, Peroni OD, Minokoshi Y, et al. GLUT4 glucose transporter deficiency increases hepatic lipid production and peripheral lipid utilization. J. Clin. Invest. 2004;114:1666–1675.10.1172/JCI200421341
- Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology. 2014;59:713–723.10.1002/hep.v59.2