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Food & Nutrition Science

Geranylgeraniol enhances testosterone production via the cAMP/protein kinase A pathway in testis-derived I-10 tumor cells

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Pages 791-797 | Received 09 Oct 2015, Accepted 06 Nov 2015, Published online: 13 Jan 2016

References

  • Ahlquist L, Bergström G, Liljenberg C. Acyclic diterpene alcohols: occurrence and synthesis of geranylcitronellol, phytol and geranylgeraniol. Prog. Chem. Fats Other Lipids. 1978;16:231–255.10.1016/0079-6832(78)90046-0
  • Masuda Y, Maeda S, Watanabe A, et al. A novel 21-kDa cytochrome c-releasing factor is generated upon treatment of human leukemia U937 cells with geranylgeraniol. Biochem. Biophys. Res. Commun. 2006;346:454–460.10.1016/j.bbrc.2006.05.161
  • Fernandes NV, Yeganehjoo H, Katuru R, et al. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase. Exp. Biol. Med. (Maywood). 2013; 238: 1265–1274.10.1177/1535370213492693
  • Ohizumi H, Masuda Y, Nakajo S, et al. Geranylgeraniol is a potent inducer of apoptosis in tumor cells. J. Biochem. 1995;117:11–13.
  • Giriwono PE, Shirakawa H, Ohsaki Y, et al. Dietary supplementation with geranylgeraniol suppresses lipopolysaccharide-induced inflammation via inhibition of nuclear factor-κB activation in rats. Eur. J. Nutr. 2013;52:1191–1199.10.1007/s00394-012-0429-y
  • Okamura K, Ando F, Shimokata H. Serum total and free testosterone level of Japanese men: a population-based study. Int. J. Urol. 2005;12:810–814.10.1111/iju.2005.12.issue-9
  • Huhtaniemi I. Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment. Asian J. Androl. 2014;16:192–202.10.4103/1008-682X.122336
  • Shores MM, Matsumoto AM, Sloan KL, et al. Low serum testosterone and mortality in male veterans. Arch. Intern. Med. 2006;166:1660–1665.10.1001/archinte.166.15.1660
  • Akishita M, Hashimoto M, Ohike Y, et al. Low testosterone level as a predictor of cardiovascular events in Japanese men with coronary risk factors. Atherosclerosis. 2010;210:232–236.10.1016/j.atherosclerosis.2009.10.037
  • Ma RC, Tong PC. Testosterone levels and cardiovascular disease. Heart. 2010;96:1787–1788.10.1136/hrt.2010.207068
  • Beatrice AM, Dutta D, Kumar M, et al. Testosterone levels and type 2 diabetes in men: current knowledge and clinical implications. Diabetes Metab. Syndr. Obes. 2014;7:481–486.
  • Payne AH. Steroidogenic enzymes in Leydig cells. In: The Leydig Cell in Health and Disease. Payne AH, Hardy MP, editors. Totowa, NJ: Human Press; 2007. p. 157–171.10.1007/978-1-59745-453-7
  • Ito A, Shirakawa H, Takumi N, et al. Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells. Lipids Health Dis. 2011;10:158.10.1186/1476-511X-10-158
  • Suemori H, Kadodawa Y, Goto K, et al. A mouse embryonic stem cell line showing pluripotency of differentiation in early embryos and ubiquitous β-galactosidase expression. Cell Differ. Dev. 1990;29:181–186.10.1016/0922-3371(90)90120-L
  • Ohsaki Y, Shirakawa H, Miura A, et al. Vitamin K suppresses the lipopolysaccharide-induced expression of inflammatory cytokines in cultured macrophage-like cells via the inhibition of the activation of nuclear factor κB through the repression of IKKα/β phosphorylation. J. Nutr. Biochem. 2010;21:1120–1126.10.1016/j.jnutbio.2009.09.011
  • Shin S-I. Studies on interstitial cells in tissue culture: steroid biosynthesis in monolayers of mouse testicular interstitial cells. Endocrinology. 1967;81:440–448.10.1210/endo-81-3-440
  • Ascoli M. Immortalized Leydig cell lines as models for studying Leydig cell physiology. In: The leydig cell in health and disease. Payne AH, Hardy MP, editors. Totowa, NJ: Human Press; 2007. p. 373–381.10.1007/978-1-59745-453-7
  • Ownby SE. and Hohl RJ. Farnesol and geranylgeraniol: Prevention and reversion of lovastatin-induced effects in NIH3T3 cells. Lipids. 2002;37:185–192.10.1007/s11745-002-0879-1
  • Campia I, Lussiana C, Pescarmona G, et al. Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis. Br. J. Pharmacol. 2009;158:1777–1786.10.1111/j.1476-5381.2009.00465.x
  • Holstein SA, Hohl RJ. Isoprenoids: remarkable diversity of form and function. Lipids. 2004;39:293–309.10.1007/s11745-004-1233-3
  • Joo JH, Jetten AM. Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett. 2010;287:123–135.10.1016/j.canlet.2009.05.015
  • Chowdhury RR, Ghosh SK. Phytol-derived novel isoprenoid immunostimulants. Front. Immunol. 2012;3:49.
  • Gancedo JM. Biological roles of cAMP: variations on a theme in the different kingdoms of life. Biol. Rev. Camb. Philos. Soc. 2013;88:645–668.10.1111/brv.2013.88.issue-3
  • Steegborn C. Structure, mechanism, and regulation of soluble adenylyl cyclases-similarities and differences to transmembrane adenylyl cyclases. Biochim. Biophys. Acta. 2014;1842:2535–2547.10.1016/j.bbadis.2014.08.012
  • Hacker BM, Tomlinson JE, Wayman GA, et al. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Genomics. 1998;50:97–104.10.1006/geno.1998.5293
  • Stocco DM, Wang X, Jo Y, et al. Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol. Endocrinol. 2005;19:2647–2659.10.1210/me.2004-0532

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